Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
3146
Gene name Gene Name - the full gene name approved by the HGNC.
High mobility group box 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
HMGB1
Synonyms (NCBI Gene) Gene synonyms aliases
HMG-1, HMG1, HMG3, SBP-1
Chromosome Chromosome number
13
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
13q12.3
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a protein that belongs to the High Mobility Group-box superfamily. The encoded non-histone, nuclear DNA-binding protein regulates transcription, and is involved in organization of DNA. This protein plays a role in several cellular proces
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT007157 hsa-miR-22-3p Luciferase reporter assay, qRT-PCR, Western blot 23303785
MIRT016305 hsa-miR-193b-3p Microarray 20304954
MIRT052166 hsa-let-7b-5p CLASH 23622248
MIRT051522 hsa-let-7e-5p CLASH 23622248
MIRT050047 hsa-miR-26b-5p CLASH 23622248
Transcription factors
Transcription factor Regulation Reference
NFIC Activation 11245470
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000122 Process Negative regulation of transcription by RNA polymerase II IGI 19158276
GO:0000122 Process Negative regulation of transcription by RNA polymerase II IMP 19158276
GO:0000400 Function Four-way junction DNA binding ISS
GO:0000405 Function Bubble DNA binding ISS
GO:0000793 Component Condensed chromosome IDA 12925773
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
163905 4983 ENSG00000189403
Protein
UniProt ID P09429
Protein name High mobility group protein B1 (High mobility group protein 1) (HMG-1)
Protein function Multifunctional redox sensitive protein with various roles in different cellular compartments. In the nucleus is one of the major chromatin-associated non-histone proteins and acts as a DNA chaperone involved in replication, transcription, chrom
PDB 2LY4 , 2RTU , 2YRQ , 6CG0 , 6CIJ , 6CIK , 6CIL , 6CIM , 6OEM , 6OEN , 6OEO , 8I9M
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF09011 HMG_box_2 6 78 HMG-box domain Domain
PF00505 HMG_box 95 163 HMG (high mobility group) box Domain
Tissue specificity TISSUE SPECIFICITY: Ubiquitous. Expressed in platelets (PubMed:11154118). {ECO:0000269|PubMed:11154118}.
Sequence
Sequence length 215
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Base excision repair
Autophagy - animal
Necroptosis
Neutrophil extracellular trap formation
  Apoptosis induced DNA fragmentation
TAK1 activates NFkB by phosphorylation and activation of IKKs complex
Regulation of TLR by endogenous ligand
Neutrophil degranulation
Advanced glycosylation endproduct receptor signaling
TRAF6 mediated NF-kB activation
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Cholestasis Cholestasis, Extrahepatic rs121909103, rs751511532, rs376368459, rs762702807, rs1578490102, rs1578499691, rs1578504946, rs1317656688, rs199791850, rs1452792080, rs1578491039 28789951
Esophagus neoplasm Squamous cell carcinoma of esophagus rs28934578, rs121918714, rs1567556006, rs1575166666 21517111
Neuropathy Neuropathy, Painful rs121913593, rs121913595, rs751050956, rs878853221, rs768554986, rs1553259568, rs1567973091, rs1560046845, rs1567969825, rs1567973088, rs756896276 27474498
Pulmonary fibrosis Pulmonary Fibrosis rs121918666, rs199422300, rs121917834, rs199422294, rs201159197, rs199422297, rs199422305, rs751381953, rs876661305, rs878853260, rs1555811762, rs1060502990, rs1555903332, rs1554038539, rs1554042899
View all (1 more)
27616297
Unknown
Disease term Disease name Evidence References Source
Myocardial infarction Myocardial Infarction 21113057 ClinVar
Mental retardation intellectual disability GenCC
Diabetes Diabetes GWAS
Gout Gout GWAS
Associations from Text Mining
Disease Name Relationship Type References
Achalasia Addisonianism Alacrimia syndrome Associate 27908811
Acute Kidney Injury Stimulate 33939645, 35587223
Acute Lung Injury Associate 29719300, 34745088, 39512354
Acute On Chronic Liver Failure Stimulate 26391982
Adenocarcinoma Associate 20332323, 26840258, 31399104
Adenocarcinoma Bronchiolo Alveolar Associate 35271544
Adenocarcinoma of Lung Associate 26042604, 26840258, 29617336, 39546155
Adenomyosis Associate 37967572, 38195505
Alcoholism Stimulate 34415075
Allergic Fungal Sinusitis Associate 24376296, 25772690, 34445093