MR1 (major histocompatibility complex, class I-related)
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Gene
Gene information from NCBI Gene database.
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| Entrez ID | 3140 |
| Gene name | Major histocompatibility complex, class I-related |
| Gene symbol | MR1 |
| Synonyms (NCBI Gene) |
HLALS
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| Chromosome | 1 |
| Chromosome location | 1q25.3 |
| Summary | MAIT (mucosal-associated invariant T-cells) lymphocytes represent a small population of T-cells primarily found in the gut. The protein encoded by this gene is an antigen-presenting molecule that presents metabolites of microbial vitamin B to MAITs. This |
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miRNA
miRNA information provided by mirtarbase database.
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Gene ontology (GO)
Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
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Other IDs
Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
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Protein
Protein information from UniProt database.
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UniProt ID
Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
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Q95460 | |||||||||||||||
| Protein name | Major histocompatibility complex class I-related protein 1 (MHC class I-related protein 1) (Class I histocompatibility antigen-like protein) | |||||||||||||||
| Protein function | Antigen-presenting molecule specialized in displaying microbial pyrimidine-based metabolites to alpha-beta T cell receptors (TCR) on innate-type mucosal-associated invariant T (MAIT) cells (PubMed:19416870, PubMed:23457030, PubMed:22692454, PubM | |||||||||||||||
| PDB | 4GUP , 4L4T , 4L4V , 4LCW , 4NQC , 4NQD , 4NQE , 4PJ5 , 4PJ7 , 4PJ8 , 4PJ9 , 4PJA , 4PJB , 4PJC , 4PJD , 4PJE , 4PJF , 4PJG , 4PJH , 4PJI , 4PJX , 5D5M , 5D7I , 5D7J , 5D7L , 5U16 , 5U17 , 5U1R , 5U2V , 5U6Q , 5U72 , 6MWR , 6PUC , 6PUD , 6PUE , 6PUF , 6PUG , 6PUH , 6PUI , 6PUJ , 6PUK , 6PUL , 6PUM , 6PVC , 6PVD , 6W9U , 6W9V , 6XQP , 7LLI , 7LLJ , 7RNO | |||||||||||||||
| Family and domains |
Pfam
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| Tissue specificity | TISSUE SPECIFICITY: Ubiquitous (PubMed:7624800, PubMed:9780177). Low expression is detected in peripheral blood B cells, T cells, monocytes and in bronchial epithelial cells (at protein level) (PubMed:27043408). Expressed in plasmablasts or plasma B cells | |||||||||||||||
| Sequence |
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| Sequence length | 341 | |||||||||||||||
| Interactions | View interactions | |||||||||||||||
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Associated diseases
Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
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Evidence Score:
★☆☆☆☆ Gene-disease association found in Text Mining only
★★☆☆☆ Found in Text Mining and Unknown/Other Associations
★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources
★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
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