Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	3135
Gene name Gene Name - the full gene name approved by the HGNC.	Major histocompatibility complex, class I, G
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	HLA-G
Synonyms (NCBI Gene) Gene synonyms aliases	MHC-G
Chromosome Chromosome number	6
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	6p22.1
Summary Summary of gene provided in NCBI Entrez Gene.	HLA-G belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. HLA-G is expressed on fetal derived placenta

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miRTarBase ID	miRNA	Experiments	Reference
MIRT000297	hsa-miR-148a-3p	Luciferase reporter assay	17847008
MIRT000295	hsa-miR-148b-3p	Luciferase reporter assay	17847008
MIRT000293	hsa-miR-152-3p	Luciferase reporter assay	17847008
MIRT731747	hsa-miR-152-5p	ELISA, Luciferase reporter assay, qRT-PCR	26187665
MIRT731747	hsa-miR-152-5p	ELISA, Luciferase reporter assay, qRT-PCR	26187665
MIRT000293	hsa-miR-152-3p	ELISA, Luciferase reporter assay, qRT-PCR	26627200
MIRT000293	hsa-miR-152-3p	ELISA, Luciferase reporter assay, qRT-PCR	26627200
MIRT735226	hsa-miR-744-3p	Luciferase reporter assay, Western blotting, RNA-seq, qRT-PCR, Flow cytometry	32571994
MIRT1048571	hsa-miR-1252	CLIP-seq
MIRT1048572	hsa-miR-2110	CLIP-seq
MIRT1048573	hsa-miR-3150a-3p	CLIP-seq
MIRT1048574	hsa-miR-4271	CLIP-seq
MIRT1048575	hsa-miR-4291	CLIP-seq
MIRT1048576	hsa-miR-4533	CLIP-seq
MIRT1048577	hsa-miR-4725-3p	CLIP-seq
MIRT1048578	hsa-miR-4747-5p	CLIP-seq
MIRT1048579	hsa-miR-509-3p	CLIP-seq
MIRT2011037	hsa-miR-513a-3p	CLIP-seq
MIRT2011038	hsa-miR-873	CLIP-seq
MIRT2243326	hsa-miR-1587	CLIP-seq
MIRT2243327	hsa-miR-224	CLIP-seq
MIRT2243328	hsa-miR-3616-5p	CLIP-seq
MIRT2243329	hsa-miR-3647-5p	CLIP-seq
MIRT2243330	hsa-miR-3663-5p	CLIP-seq
MIRT2243331	hsa-miR-4417	CLIP-seq
MIRT2243332	hsa-miR-4492	CLIP-seq
MIRT2243333	hsa-miR-4498	CLIP-seq
MIRT2243334	hsa-miR-4635	CLIP-seq
MIRT2243335	hsa-miR-4656	CLIP-seq
MIRT2243336	hsa-miR-4675	CLIP-seq
MIRT2243337	hsa-miR-4719	CLIP-seq
MIRT2243338	hsa-miR-4741	CLIP-seq
MIRT2243339	hsa-miR-526b	CLIP-seq
MIRT2243340	hsa-miR-541	CLIP-seq
MIRT2243341	hsa-miR-573	CLIP-seq
MIRT2243342	hsa-miR-593	CLIP-seq
MIRT2243343	hsa-miR-654-5p	CLIP-seq
MIRT2243344	hsa-miR-762	CLIP-seq

Transcription factors

Show/Hide all(8)

Transcription factor	Regulation	Reference
CIITA	Unknown	11137218
GLI3	Repression	23592762
HIVEP2	Unknown	1409593
HSF1	Unknown	11005379
IRF1	Unknown	11087747
MYC	Activation	8206526
MYCN	Unknown	8895520
SP1	Unknown	11137218

Show/Hide all(56)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000139	Component	Golgi membrane	TAS
GO:0001915	Process	Negative regulation of T cell mediated cytotoxicity	IDA	11290782
GO:0001916	Process	Positive regulation of T cell mediated cytotoxicity	IBA	21873635
GO:0002451	Process	Peripheral B cell tolerance induction	IDA	24453251
GO:0002474	Process	Antigen processing and presentation of peptide antigen via MHC class I	TAS
GO:0002476	Process	Antigen processing and presentation of endogenous peptide antigen via MHC class Ib	IBA	21873635
GO:0002476	Process	Antigen processing and presentation of endogenous peptide antigen via MHC class Ib	IDA	7584149, 8805247
GO:0002479	Process	Antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent	TAS
GO:0002480	Process	Antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent	TAS
GO:0002486	Process	Antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent	IBA	21873635
GO:0002645	Process	Positive regulation of tolerance induction	IMP	22802125
GO:0002666	Process	Positive regulation of T cell tolerance induction	IMP	20448110
GO:0002729	Process	Positive regulation of natural killer cell cytokine production	IDA	16366734, 19304799, 23184984
GO:0002767	Process	Immune response-inhibiting cell surface receptor signaling pathway	IDA	20702625
GO:0005102	Function	Signaling receptor binding	IBA	21873635
GO:0005102	Function	Signaling receptor binding	IPI	20702625, 22802125
GO:0005515	Function	Protein binding	IPI	9640257, 10190900, 11520457, 12582157, 12853576, 12874224, 16366734, 16455647, 16809620, 17056715, 19583775, 24899623
GO:0005615	Component	Extracellular space	IBA	21873635
GO:0005769	Component	Early endosome	IDA	16366734
GO:0005886	Component	Plasma membrane	IDA	11290782, 12582157
GO:0005886	Component	Plasma membrane	TAS
GO:0006955	Process	Immune response	IBA	21873635
GO:0006968	Process	Cellular defense response	TAS	9539768
GO:0009897	Component	External side of plasma membrane	IBA	21873635
GO:0012507	Component	ER to Golgi transport vesicle membrane	TAS
GO:0016020	Component	Membrane	HDA	19946888
GO:0016525	Process	Negative regulation of angiogenesis	IDA	16809620
GO:0030670	Component	Phagocytic vesicle membrane	TAS
GO:0031527	Component	Filopodium membrane	IEA
GO:0031901	Component	Early endosome membrane	TAS
GO:0032735	Process	Positive regulation of interleukin-12 production	IDA	20702625
GO:0033106	Component	Cis-Golgi network membrane	IDA	12582157
GO:0042130	Process	Negative regulation of T cell proliferation	IDA	20702625
GO:0042270	Process	Protection from natural killer cell mediated cytotoxicity	IDA	11290782
GO:0042605	Function	Peptide antigen binding	IBA	21873635
GO:0042605	Function	Peptide antigen binding	IDA	7584149, 8805247, 20122941
GO:0042610	Function	CD8 receptor binding	IDA	12853576
GO:0042612	Component	MHC class I protein complex	IEA
GO:0042802	Function	Identical protein binding	IPI	16455647, 18550825
GO:0042803	Function	Protein homodimerization activity	IDA	12874224, 22802125
GO:0045591	Process	Positive regulation of regulatory T cell differentiation	IMP	20448110
GO:0045953	Process	Negative regulation of natural killer cell mediated cytotoxicity	IDA	10190900
GO:0045953	Process	Negative regulation of natural killer cell mediated cytotoxicity	IMP	12874224
GO:0050776	Process	Regulation of immune response	TAS
GO:0050777	Process	Negative regulation of immune response	IC	22802125
GO:0051898	Process	Negative regulation of protein kinase B signaling	IDA	24453251
GO:0055038	Component	Recycling endosome membrane	TAS
GO:0060333	Process	Interferon-gamma-mediated signaling pathway	TAS
GO:0060337	Process	Type I interferon signaling pathway	TAS
GO:0060907	Process	Positive regulation of macrophage cytokine production	IDA	19304799
GO:0070207	Process	Protein homotrimerization	IDA	12874224
GO:0070317	Process	Negative regulation of G0 to G1 transition	IDA	24453251
GO:0071556	Component	Integral component of lumenal side of endoplasmic reticulum membrane	TAS
GO:2000353	Process	Positive regulation of endothelial cell apoptotic process	IDA	16809620
GO:2000774	Process	Positive regulation of cellular senescence	IDA	23184984
GO:2001199	Process	Negative regulation of dendritic cell differentiation	IDA	20702625

MIM	HGNC	e!Ensembl
142871	4964	ENSG00000204632

Protein

UniProt ID

P17693

Protein name

HLA class I histocompatibility antigen, alpha chain G (HLA G antigen) (MHC class I antigen G) [Cleaved into: Soluble HLA class I histocompatibility antigen, alpha chain G (sHLA-G)]

Protein function

[Isoform 1]: Non-classical major histocompatibility class Ib molecule involved in immune regulatory processes at the maternal-fetal interface (PubMed:19304799, PubMed:23184984, PubMed:29262349). In complex with B2M/beta-2 microglobulin binds a l

PDB

1YDP , 2D31 , 2DYP , 3BZE , 3CDG , 3CII , 3KYN , 3KYO , 6AEE , 6K60

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00129	MHC_I	25 → 203	Class I Histocompatibility antigen, domains alpha 1 and 2	Domain
PF07654	C1-set	211 → 290	Immunoglobulin C1-set domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Expressed in adult eye (PubMed:1570318). Expressed in immune cell subsets including monocytes, myeloid and plasmacytoid dendritic cells and regulatory T cells (Tr1)(at protein level) (PubMed:20448110). Secreted by follicular dendritic

Sequence

MVVMAPRTLFLLLSGALTLTETWAGSHSMRYFSAAVSRPGRGEPRFIAMGYVDDTQFVRF
DSDSACPRMEPRAPWVEQEGPEYWEEETRNTKAHAQTDRMNLQTLRGYYNQSEASSHTLQ
WMIGCDLGSDGRLLRGYEQYAYDGKDYLALNEDLRSWTAADTAAQISKRKCEAANVAEQR
RAYLEGTCVEWLHRYLENGKEMLQRADPPKTHVTHHPVFDYEATLRCWALGFYPAEIILT
WQRDGEDQTQDVELVETRPAGDGTFQKWAAVVVPSGEEQRYTCHVQHEGLPEPLMLRWKQ
SSLPTIPIMGIVAGLVVLAAVVTGAAVAAVLWRKKSSD

Sequence length

338

Interactions

View interactions

	KEGG		Reactome
	Endocytosis Phagosome Cellular senescence Cell adhesion molecules Antigen processing and presentation Natural killer cell mediated cytotoxicity Type I diabetes mellitus Human cytomegalovirus infection Human papillomavirus infection Human T-cell leukemia virus 1 infection Kaposi sarcoma-associated herpesvirus infection Herpes simplex virus 1 infection Epstein-Barr virus infection Human immunodeficiency virus 1 infection Viral carcinogenesis Autoimmune thyroid disease Allograft rejection Graft-versus-host disease Viral myocarditis		ER-Phagosome pathway Endosomal/Vacuolar pathway Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Interferon gamma signaling Interferon alpha/beta signaling Antigen Presentation: Folding, assembly and peptide loading of class I MHC

Show/Hide Unknown Diseases (1)

Disease term	Disease name	Evidence	References	Source
Unknown
Asthma	Asthma			ClinVar

HLA-G (major histocompatibility complex, class I, G)