HLA-DRB5 (major histocompatibility complex, class II, DR beta 5)

Gene

• Entrez ID: 3127
• Gene name: Major histocompatibility complex, class II, DR beta 5
• Gene symbol: HLA-DRB5
• Synonyms (NCBI Gene): DRB5, HLA-DRB5*
• Chromosome: 6
• Chromosome location: 6p21.32
• Summary: HLA-DRB5 belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DRA) and a beta (DRB) chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides der

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT018565	hsa-miR-335-5p	Microarray	18185580
MIRT717246	hsa-miR-1250-3p	HITS-CLIP	19536157
MIRT717245	hsa-miR-136-5p	HITS-CLIP	19536157
MIRT717244	hsa-miR-589-5p	HITS-CLIP	19536157
MIRT717243	hsa-miR-4434	HITS-CLIP	19536157
MIRT717242	hsa-miR-4516	HITS-CLIP	19536157
MIRT717241	hsa-miR-5703	HITS-CLIP	19536157
MIRT717240	hsa-miR-4531	HITS-CLIP	19536157
MIRT717239	hsa-miR-4263	HITS-CLIP	19536157
MIRT717238	hsa-miR-576-5p	HITS-CLIP	19536157
MIRT618812	hsa-miR-5692a	HITS-CLIP	23824327
MIRT618811	hsa-miR-4496	HITS-CLIP	23824327
MIRT618810	hsa-miR-141-5p	HITS-CLIP	23824327
MIRT618809	hsa-miR-6832-3p	HITS-CLIP	23824327
MIRT618808	hsa-miR-627-3p	HITS-CLIP	23824327
MIRT618807	hsa-miR-623	HITS-CLIP	23824327
MIRT618806	hsa-miR-204-5p	HITS-CLIP	23824327
MIRT618805	hsa-miR-211-5p	HITS-CLIP	23824327
MIRT618804	hsa-miR-4755-5p	HITS-CLIP	23824327
MIRT618803	hsa-miR-5006-3p	HITS-CLIP	23824327
MIRT618812	hsa-miR-5692a	HITS-CLIP	23824327
MIRT618811	hsa-miR-4496	HITS-CLIP	23824327
MIRT618810	hsa-miR-141-5p	HITS-CLIP	23824327
MIRT618809	hsa-miR-6832-3p	HITS-CLIP	23824327
MIRT618808	hsa-miR-627-3p	HITS-CLIP	23824327
MIRT618807	hsa-miR-623	HITS-CLIP	23824327
MIRT618806	hsa-miR-204-5p	HITS-CLIP	23824327
MIRT618805	hsa-miR-211-5p	HITS-CLIP	23824327
MIRT618804	hsa-miR-4755-5p	HITS-CLIP	23824327
MIRT618803	hsa-miR-5006-3p	HITS-CLIP	23824327
MIRT618812	hsa-miR-5692a	HITS-CLIP	23824327
MIRT618811	hsa-miR-4496	HITS-CLIP	23824327
MIRT618810	hsa-miR-141-5p	HITS-CLIP	23824327
MIRT618809	hsa-miR-6832-3p	HITS-CLIP	23824327
MIRT618808	hsa-miR-627-3p	HITS-CLIP	23824327
MIRT618807	hsa-miR-623	HITS-CLIP	23824327
MIRT618806	hsa-miR-204-5p	HITS-CLIP	23824327
MIRT618805	hsa-miR-211-5p	HITS-CLIP	23824327
MIRT618804	hsa-miR-4755-5p	HITS-CLIP	23824327
MIRT618803	hsa-miR-5006-3p	HITS-CLIP	23824327
MIRT618812	hsa-miR-5692a	HITS-CLIP	23824327
MIRT618811	hsa-miR-4496	HITS-CLIP	23824327
MIRT618810	hsa-miR-141-5p	HITS-CLIP	23824327
MIRT618809	hsa-miR-6832-3p	HITS-CLIP	23824327
MIRT618808	hsa-miR-627-3p	HITS-CLIP	23824327
MIRT618807	hsa-miR-623	HITS-CLIP	23824327
MIRT618806	hsa-miR-204-5p	HITS-CLIP	23824327
MIRT618805	hsa-miR-211-5p	HITS-CLIP	23824327
MIRT618804	hsa-miR-4755-5p	HITS-CLIP	23824327
MIRT618803	hsa-miR-5006-3p	HITS-CLIP	23824327
MIRT717246	hsa-miR-1250-3p	HITS-CLIP	19536157
MIRT717245	hsa-miR-136-5p	HITS-CLIP	19536157
MIRT717244	hsa-miR-589-5p	HITS-CLIP	19536157
MIRT717243	hsa-miR-4434	HITS-CLIP	19536157
MIRT717242	hsa-miR-4516	HITS-CLIP	19536157
MIRT717241	hsa-miR-5703	HITS-CLIP	19536157
MIRT717240	hsa-miR-4531	HITS-CLIP	19536157
MIRT717239	hsa-miR-4263	HITS-CLIP	19536157
MIRT717238	hsa-miR-576-5p	HITS-CLIP	19536157
MIRT618812	hsa-miR-5692a	HITS-CLIP	23824327
MIRT618811	hsa-miR-4496	HITS-CLIP	23824327
MIRT618810	hsa-miR-141-5p	HITS-CLIP	23824327
MIRT618809	hsa-miR-6832-3p	HITS-CLIP	23824327
MIRT618808	hsa-miR-627-3p	HITS-CLIP	23824327
MIRT618807	hsa-miR-623	HITS-CLIP	23824327
MIRT618806	hsa-miR-204-5p	HITS-CLIP	23824327
MIRT618805	hsa-miR-211-5p	HITS-CLIP	23824327
MIRT618804	hsa-miR-4755-5p	HITS-CLIP	23824327
MIRT618803	hsa-miR-5006-3p	HITS-CLIP	23824327
MIRT618812	hsa-miR-5692a	HITS-CLIP	23824327
MIRT618811	hsa-miR-4496	HITS-CLIP	23824327
MIRT618810	hsa-miR-141-5p	HITS-CLIP	23824327
MIRT618809	hsa-miR-6832-3p	HITS-CLIP	23824327
MIRT618808	hsa-miR-627-3p	HITS-CLIP	23824327
MIRT618807	hsa-miR-623	HITS-CLIP	23824327
MIRT618806	hsa-miR-204-5p	HITS-CLIP	23824327
MIRT618805	hsa-miR-211-5p	HITS-CLIP	23824327
MIRT618804	hsa-miR-4755-5p	HITS-CLIP	23824327
MIRT618803	hsa-miR-5006-3p	HITS-CLIP	23824327
MIRT618812	hsa-miR-5692a	HITS-CLIP	23824327
MIRT618811	hsa-miR-4496	HITS-CLIP	23824327
MIRT618810	hsa-miR-141-5p	HITS-CLIP	23824327
MIRT618809	hsa-miR-6832-3p	HITS-CLIP	23824327
MIRT618808	hsa-miR-627-3p	HITS-CLIP	23824327
MIRT618807	hsa-miR-623	HITS-CLIP	23824327
MIRT618806	hsa-miR-204-5p	HITS-CLIP	23824327
MIRT618805	hsa-miR-211-5p	HITS-CLIP	23824327
MIRT618804	hsa-miR-4755-5p	HITS-CLIP	23824327
MIRT618803	hsa-miR-5006-3p	HITS-CLIP	23824327
MIRT618812	hsa-miR-5692a	HITS-CLIP	23824327
MIRT618811	hsa-miR-4496	HITS-CLIP	23824327
MIRT618810	hsa-miR-141-5p	HITS-CLIP	23824327
MIRT618809	hsa-miR-6832-3p	HITS-CLIP	23824327
MIRT618808	hsa-miR-627-3p	HITS-CLIP	23824327
MIRT618807	hsa-miR-623	HITS-CLIP	23824327
MIRT618806	hsa-miR-204-5p	HITS-CLIP	23824327
MIRT618805	hsa-miR-211-5p	HITS-CLIP	23824327
MIRT618804	hsa-miR-4755-5p	HITS-CLIP	23824327
MIRT618803	hsa-miR-5006-3p	HITS-CLIP	23824327
MIRT1048472	hsa-miR-320a	CLIP-seq
MIRT1048473	hsa-miR-320b	CLIP-seq
MIRT1048474	hsa-miR-320c	CLIP-seq
MIRT1048475	hsa-miR-320d	CLIP-seq
MIRT1048476	hsa-miR-320e	CLIP-seq
MIRT1048477	hsa-miR-3689a-3p	CLIP-seq
MIRT1048478	hsa-miR-3689c	CLIP-seq
MIRT1048479	hsa-miR-4429	CLIP-seq
MIRT1048480	hsa-miR-4728-5p	CLIP-seq
MIRT1048481	hsa-miR-4731-5p	CLIP-seq
MIRT1048482	hsa-miR-518a-5p	CLIP-seq
MIRT1048483	hsa-miR-527	CLIP-seq
MIRT2243312	hsa-miR-298	CLIP-seq
MIRT1048472	hsa-miR-320a	CLIP-seq
MIRT1048473	hsa-miR-320b	CLIP-seq
MIRT1048474	hsa-miR-320c	CLIP-seq
MIRT1048475	hsa-miR-320d	CLIP-seq
MIRT1048476	hsa-miR-320e	CLIP-seq
MIRT1048479	hsa-miR-4429	CLIP-seq
MIRT1048481	hsa-miR-4731-5p	CLIP-seq
MIRT2243313	hsa-miR-486-3p	CLIP-seq
MIRT1048482	hsa-miR-518a-5p	CLIP-seq
MIRT1048483	hsa-miR-527	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
CIITA	Unknown	10886240
RFX5	Unknown	11258423
RFXANK	Unknown	11258423
RFXAP	Unknown	11258423

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000139	Component	Golgi membrane	TAS
GO:0002250	Process	Adaptive immune response	IEA
GO:0005765	Component	Lysosomal membrane	IDA	18305173
GO:0005765	Component	Lysosomal membrane	TAS
GO:0005886	Component	Plasma membrane	TAS
GO:0012507	Component	ER to Golgi transport vesicle membrane	TAS
GO:0019886	Process	Antigen processing and presentation of exogenous peptide antigen via MHC class II	TAS
GO:0030658	Component	Transport vesicle membrane	TAS
GO:0030666	Component	Endocytic vesicle membrane	TAS
GO:0030669	Component	Clathrin-coated endocytic vesicle membrane	TAS
GO:0031902	Component	Late endosome membrane	IDA	18305173
GO:0032588	Component	Trans-Golgi network membrane	TAS
GO:0042605	Function	Peptide antigen binding	ISS	20356827
GO:0042613	Component	MHC class II protein complex	ISS	20356827
GO:0050852	Process	T cell receptor signaling pathway	TAS
GO:0060333	Process	Interferon-gamma-mediated signaling pathway	TAS
GO:0070062	Component	Extracellular exosome	HDA	12519789, 20458337
GO:0071556	Component	Integral component of lumenal side of endoplasmic reticulum membrane	TAS

Other IDs

• MIM: 604776
• HGNC: 4953
• e!Ensembl: ENSG00000198502

Protein

• UniProt ID: Q30154
• Protein name: HLA class II histocompatibility antigen, DR beta 5 chain (DR beta-5) (DR2-beta-2) (Dw2) (MHC class II antigen DRB5)
• Protein function: Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptides of 10-30 residues. T
• PDB: 1FV1, 1H15, 1HQR, 1ZGL
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00969	MHC_II_beta	42 → 116	Class II histocompatibility antigen, beta domain	Domain
  PF07654	C1-set	128 → 209	Immunoglobulin C1-set domain	Domain

• Sequence:

  MVCLKLPGGSYMAKLTVTLMVLSSPLALAGDTRPRFLQQDKYECHFFNGTERVRFLHRDI
  YNQEEDLRFDSDVGEYRAVTELGRPDAEYWNSQKDFLEDRRAAVDTYCRHNYGVGESFTV
  QRRVEPKVTVYPARTQTLQHHNLLVCSVNGFYPGSIEVRWFRNSQEEKAGVVSTGLIQNG
  DWTFQTLVMLETVPRSGEVYTCQVEHPSVTSPLTVEWRAQSESAQSKMLSGVGGFVLGLL
  FLGAGLFIYFKNQKGHSGLHPTGLVS

• Sequence length: 266

Pathways

KEGG:

Phagosome
Cell adhesion molecules
Antigen processing and presentation
Hematopoietic cell lineage
Th1 and Th2 cell differentiation
Th17 cell differentiation
Intestinal immune network for IgA production
Type I diabetes mellitus
Leishmaniasis
Toxoplasmosis
Staphylococcus aureus infection
Tuberculosis
Influenza A
Human T-cell leukemia virus 1 infection
Herpes simplex virus 1 infection
Epstein-Barr virus infection
Asthma
Autoimmune thyroid disease
Inflammatory bowel disease
Systemic lupus erythematosus
Rheumatoid arthritis
Allograft rejection
Graft-versus-host disease
Viral myocarditis

Reactome:

Downstream TCR signaling
Phosphorylation of CD3 and TCR zeta chains
Translocation of ZAP-70 to Immunological synapse
Generation of second messenger molecules
MHC class II antigen presentation
PD-1 signaling
Interferon gamma signaling

Associated diseases

Causal
Disease term	Disease name	dbSNP ID	References
Alzheimer disease	Familial Alzheimer Disease (FAD), Alzheimer Disease, Late Onset, Alzheimer Disease, Early Onset, Alzheimer`s Disease, Alzheimer`s Disease, Focal Onset	rs63750215, rs28936379, rs63749851, rs63749884, rs28936380, rs63750048, rs63750579, rs63750264, rs63749964, rs63750671, rs281865161, rs63750066, rs63750399, rs63750734, rs63751039, rs63750973, rs63749810, rs63750643, rs193922916, rs63750306, rs63750590, rs63750526, rs63751235, rs661, rs63751037, rs63749885, rs63750231, rs63751229, rs63751272, rs63751223, rs63750391, rs63751163, rs281875357, rs63751141, rs63750082, rs121917807, rs63751399, rs63750265, rs63751144, rs63750886, rs63751068, rs121917808, rs63749891, rs63750083, rs63749824, rs63750577, rs267606983, rs63750218, rs63751287, rs63750900, rs63751475, rs63750450, rs63749805, rs63751278, rs63751106, rs63750004, rs63749806, rs63751024, rs63750248, rs63750779, rs63751139, rs63750219, rs63750298, rs63750687, rs63750851, rs1553268799, rs1561901881, rs1561905293, rs866101707, rs1566638673, rs63750009, rs1566656702, rs1566657804, rs1567885728, rs1568339995, rs1566630791, rs1555358260, rs63750964, rs1594998354, rs63751316	27713094
Diabetes mellitus	Diabetes Mellitus, Non-Insulin-Dependent	rs587776515, rs61730328, rs606231121, rs606231122, rs79020217, rs77625743, rs78378398, rs606231123, rs1362648752, rs104893649, rs80356624, rs80356616, rs80356625, rs80356611, rs104894237, rs80356613, rs387906407, rs151344623, rs28938469, rs28936371, rs137852672, rs80356637, rs80356642, rs80356653, rs137852673, rs137852674, rs80356634, rs80356651, rs193929360, rs137853334, rs137853335, rs137853336, rs1600731198, rs137853338, rs121964882, rs121964883, rs387906511, rs121964884, rs121964885, rs2147483647, rs387906512, rs121964887, rs121964888, rs121964889, rs121964890, rs121964891, rs28934878, rs74315383, rs121964893, rs886037620, rs886037621, rs121434593, rs121913150, rs587776825, rs137853236, rs2135842335, rs137853237, rs137853238, rs2135818776, rs1566092470, rs1463923467, rs137853243, rs137853244, rs2135839114, rs137853245, rs2135847417, rs121918407, rs104894005, rs104894006, rs80356655, rs104894008, rs104894009, rs104894010, rs104894011, rs80356654, rs104894016, rs193929376, rs193929374, rs193929375, rs193929373, rs80356669, rs80356664, rs193929366, rs1048095, rs193929355, rs193929356, rs1259467443, rs104893642, rs387906777, rs193922396, rs193922400, rs193922401, rs137852676, rs193922407, rs193922638, rs193922257, rs193922258, rs193922259, rs193922260, rs193922261, rs193922262, rs193922263, rs193922264, rs193922265, rs193922268, rs193921338, rs193922269, rs193922272, rs193922273, rs193922275, rs193922278, rs193922279, rs193922280, rs193922281, rs193922282, rs193922283, rs193922284, rs193922286, rs193922287, rs193922289, rs193922291, rs193922295, rs193922297, rs193922300, rs193922302, rs193922303, rs193922308, rs193922313, rs193922314, rs144723656, rs193922315, rs193922316, rs193922317, rs148311934, rs193922319, rs193922320, rs193922326, rs193922329, rs193922330, rs193922331, rs193922335, rs193922336, rs193922338, rs193922340, rs193922341, rs193922471, rs193922475, rs193922476, rs193922479, rs80356663, rs193922355, rs193922356, rs193922576, rs193922578, rs193922582, rs193922588, rs193922592, rs193922594, rs193922596, rs386134267, rs193922598, rs193922599, rs193922600, rs193922604, rs193922605, rs397514580, rs397515519, rs267601516, rs587780343, rs587780345, rs587780346, rs587780347, rs587780357, rs148954387, rs587783672, rs587783669, rs786204676, rs794727236, rs151344624, rs794727775, rs794727839, rs199946797, rs869320673, rs796065047, rs759072800, rs797045595, rs797045209, rs797045207, rs797045213, rs863225280, rs149703259, rs864321656, rs139964066, rs777870079, rs878853246, rs769268803, rs886039380, rs886041392, rs886041391, rs886042610, rs143064649, rs1057516192, rs746480424, rs1057516281, rs576684889, rs754728827, rs1057520291, rs1057520779, rs893256143, rs1057520504, rs1057524790, rs1057524902, rs1057524904, rs1057524905, rs764232985, rs1064793998, rs1064794268, rs769086289, rs369429452, rs1085307913, rs1131691416, rs765432081, rs1131692182, rs748749585, rs1554335441, rs762263694, rs1312678560, rs767565869, rs1375656631, rs1554335391, rs1360415315, rs1554335616, rs1554335752, rs1554909277, rs769518471, rs757171524, rs768951263, rs762703502, rs1555212248, rs1555212359, rs1555813319, rs1555816654, rs371977235, rs1415041911, rs1554334894, rs1260178539, rs1554335421, rs1555211904, rs779184183, rs1554335564, rs200670692, rs1400535021, rs1554334872, rs1555212749, rs1553876668, rs1553878211, rs954727530, rs1554924035, rs372307320, rs925231098, rs1554913069, rs1554933565, rs766431403, rs746714109, rs751279984, rs770664202, rs1008906426, rs758844607, rs1554924540, rs1566092307, rs753998395, rs1565885935, rs1167124132, rs1376796469, rs556436603, rs1562715657, rs1486280029, rs1564869850, rs755259997, rs769569410, rs1172328722, rs1286294151, rs1375557127, rs1568731279, rs1562715426, rs556581174, rs1564865302, rs1565886545, rs1568724014, rs1392795567, rs781260712, rs1562719705, rs1382448285, rs1564977373, rs750586210, rs1598842892, rs1583592247, rs780612692, rs1593060859, rs1476637197, rs751279776, rs1593060890, rs1191912908, rs1167675604, rs1583601110, rs1593058932, rs778611627, rs753296261	28869590
Parkinson disease	Parkinson Disease	rs33939927, rs35801418, rs34805604, rs35870237, rs34995376, rs74315355, rs28940284, rs74315356, rs74315357, rs28940285, rs730880302, rs750664040, rs74315359, rs74315360, rs45539432, rs119451946, rs80356771, rs74500255, rs75822236, rs1141814, rs78973108, rs121908681, rs121908686, rs121908687, rs137853054, rs137853055, rs137853056, rs137853057, rs137853058, rs137853059, rs34424986, rs137853060, rs397518439, rs28938172, rs74315351, rs74315353, rs137853051, rs118192098, rs121918104, rs1589451049, rs104893877, rs104893878, rs188286943, rs387906863, rs387906864, rs774631197, rs199935023, rs397514694, rs398122403, rs398122404, rs398122405, rs104886460, rs409652, rs431905511, rs63751392, rs756677845, rs864309527, rs864309650, rs750014782, rs1554391082, rs864622011, rs869312810, rs869312809, rs869312811, rs369100678, rs879253853, rs869320761, rs747506979, rs879255630, rs886039854, rs191486604, rs781442277, rs1060499619, rs751037529, rs55777503, rs768091663, rs34208370, rs1553122929, rs772786691, rs754809877, rs1555907463, rs1557561340, rs781600849, rs141263564, rs1557901552, rs777160388, rs756783990, rs867929413, rs1237637353, rs1005937012, rs755000580, rs747427602, rs1578089802, rs771586218, rs748142049, rs1582953433, rs746646126, rs771529549, rs121918106	27713094
Schizophrenia	Schizophrenia	rs13447324, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346, rs863223347, rs863223351, rs863223352, rs61734270, rs797045205, rs869312829, rs869312830, rs770913157, rs869312832, rs869312831, rs781720548, rs1262969313	28540026

Unknown
Disease term	Disease name	Evidence	References	Source
Asthma	Asthma		30929738	ClinVar