Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	3127
Gene name	Major histocompatibility complex, class II, DR beta 5
Gene symbol	HLA-DRB5
Synonyms (NCBI Gene)	DRB5HLA-DRB5*
Chromosome	6
Chromosome location	6p21.32
Summary	HLA-DRB5 belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DRA) and a beta (DRB) chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides der

122

Show/Hide all (122)

miRTarBase ID	miRNA	Experiments	Reference
MIRT018565	hsa-miR-335-5p	Microarray	18185580
MIRT717246	hsa-miR-1250-3p	HITS-CLIP	19536157
MIRT717245	hsa-miR-136-5p	HITS-CLIP	19536157
MIRT717244	hsa-miR-589-5p	HITS-CLIP	19536157
MIRT717243	hsa-miR-4434	HITS-CLIP	19536157
MIRT717242	hsa-miR-4516	HITS-CLIP	19536157
MIRT717241	hsa-miR-5703	HITS-CLIP	19536157
MIRT717240	hsa-miR-4531	HITS-CLIP	19536157
MIRT717239	hsa-miR-4263	HITS-CLIP	19536157
MIRT717238	hsa-miR-576-5p	HITS-CLIP	19536157
MIRT618812	hsa-miR-5692a	HITS-CLIP	23824327
MIRT618811	hsa-miR-4496	HITS-CLIP	23824327
MIRT618810	hsa-miR-141-5p	HITS-CLIP	23824327
MIRT618809	hsa-miR-6832-3p	HITS-CLIP	23824327
MIRT618808	hsa-miR-627-3p	HITS-CLIP	23824327
MIRT618807	hsa-miR-623	HITS-CLIP	23824327
MIRT618806	hsa-miR-204-5p	HITS-CLIP	23824327
MIRT618805	hsa-miR-211-5p	HITS-CLIP	23824327
MIRT618804	hsa-miR-4755-5p	HITS-CLIP	23824327
MIRT618803	hsa-miR-5006-3p	HITS-CLIP	23824327
MIRT618812	hsa-miR-5692a	HITS-CLIP	23824327
MIRT618811	hsa-miR-4496	HITS-CLIP	23824327
MIRT618810	hsa-miR-141-5p	HITS-CLIP	23824327
MIRT618809	hsa-miR-6832-3p	HITS-CLIP	23824327
MIRT618808	hsa-miR-627-3p	HITS-CLIP	23824327
MIRT618807	hsa-miR-623	HITS-CLIP	23824327
MIRT618806	hsa-miR-204-5p	HITS-CLIP	23824327
MIRT618805	hsa-miR-211-5p	HITS-CLIP	23824327
MIRT618804	hsa-miR-4755-5p	HITS-CLIP	23824327
MIRT618803	hsa-miR-5006-3p	HITS-CLIP	23824327
MIRT618812	hsa-miR-5692a	HITS-CLIP	23824327
MIRT618811	hsa-miR-4496	HITS-CLIP	23824327
MIRT618810	hsa-miR-141-5p	HITS-CLIP	23824327
MIRT618809	hsa-miR-6832-3p	HITS-CLIP	23824327
MIRT618808	hsa-miR-627-3p	HITS-CLIP	23824327
MIRT618807	hsa-miR-623	HITS-CLIP	23824327
MIRT618806	hsa-miR-204-5p	HITS-CLIP	23824327
MIRT618805	hsa-miR-211-5p	HITS-CLIP	23824327
MIRT618804	hsa-miR-4755-5p	HITS-CLIP	23824327
MIRT618803	hsa-miR-5006-3p	HITS-CLIP	23824327
MIRT618812	hsa-miR-5692a	HITS-CLIP	23824327
MIRT618811	hsa-miR-4496	HITS-CLIP	23824327
MIRT618810	hsa-miR-141-5p	HITS-CLIP	23824327
MIRT618809	hsa-miR-6832-3p	HITS-CLIP	23824327
MIRT618808	hsa-miR-627-3p	HITS-CLIP	23824327
MIRT618807	hsa-miR-623	HITS-CLIP	23824327
MIRT618806	hsa-miR-204-5p	HITS-CLIP	23824327
MIRT618805	hsa-miR-211-5p	HITS-CLIP	23824327
MIRT618804	hsa-miR-4755-5p	HITS-CLIP	23824327
MIRT618803	hsa-miR-5006-3p	HITS-CLIP	23824327
MIRT717246	hsa-miR-1250-3p	HITS-CLIP	19536157
MIRT717245	hsa-miR-136-5p	HITS-CLIP	19536157
MIRT717244	hsa-miR-589-5p	HITS-CLIP	19536157
MIRT717243	hsa-miR-4434	HITS-CLIP	19536157
MIRT717242	hsa-miR-4516	HITS-CLIP	19536157
MIRT717241	hsa-miR-5703	HITS-CLIP	19536157
MIRT717240	hsa-miR-4531	HITS-CLIP	19536157
MIRT717239	hsa-miR-4263	HITS-CLIP	19536157
MIRT717238	hsa-miR-576-5p	HITS-CLIP	19536157
MIRT618812	hsa-miR-5692a	HITS-CLIP	23824327
MIRT618811	hsa-miR-4496	HITS-CLIP	23824327
MIRT618810	hsa-miR-141-5p	HITS-CLIP	23824327
MIRT618809	hsa-miR-6832-3p	HITS-CLIP	23824327
MIRT618808	hsa-miR-627-3p	HITS-CLIP	23824327
MIRT618807	hsa-miR-623	HITS-CLIP	23824327
MIRT618806	hsa-miR-204-5p	HITS-CLIP	23824327
MIRT618805	hsa-miR-211-5p	HITS-CLIP	23824327
MIRT618804	hsa-miR-4755-5p	HITS-CLIP	23824327
MIRT618803	hsa-miR-5006-3p	HITS-CLIP	23824327
MIRT618812	hsa-miR-5692a	HITS-CLIP	23824327
MIRT618811	hsa-miR-4496	HITS-CLIP	23824327
MIRT618810	hsa-miR-141-5p	HITS-CLIP	23824327
MIRT618809	hsa-miR-6832-3p	HITS-CLIP	23824327
MIRT618808	hsa-miR-627-3p	HITS-CLIP	23824327
MIRT618807	hsa-miR-623	HITS-CLIP	23824327
MIRT618806	hsa-miR-204-5p	HITS-CLIP	23824327
MIRT618805	hsa-miR-211-5p	HITS-CLIP	23824327
MIRT618804	hsa-miR-4755-5p	HITS-CLIP	23824327
MIRT618803	hsa-miR-5006-3p	HITS-CLIP	23824327
MIRT618812	hsa-miR-5692a	HITS-CLIP	23824327
MIRT618811	hsa-miR-4496	HITS-CLIP	23824327
MIRT618810	hsa-miR-141-5p	HITS-CLIP	23824327
MIRT618809	hsa-miR-6832-3p	HITS-CLIP	23824327
MIRT618808	hsa-miR-627-3p	HITS-CLIP	23824327
MIRT618807	hsa-miR-623	HITS-CLIP	23824327
MIRT618806	hsa-miR-204-5p	HITS-CLIP	23824327
MIRT618805	hsa-miR-211-5p	HITS-CLIP	23824327
MIRT618804	hsa-miR-4755-5p	HITS-CLIP	23824327
MIRT618803	hsa-miR-5006-3p	HITS-CLIP	23824327
MIRT618812	hsa-miR-5692a	HITS-CLIP	23824327
MIRT618811	hsa-miR-4496	HITS-CLIP	23824327
MIRT618810	hsa-miR-141-5p	HITS-CLIP	23824327
MIRT618809	hsa-miR-6832-3p	HITS-CLIP	23824327
MIRT618808	hsa-miR-627-3p	HITS-CLIP	23824327
MIRT618807	hsa-miR-623	HITS-CLIP	23824327
MIRT618806	hsa-miR-204-5p	HITS-CLIP	23824327
MIRT618805	hsa-miR-211-5p	HITS-CLIP	23824327
MIRT618804	hsa-miR-4755-5p	HITS-CLIP	23824327
MIRT618803	hsa-miR-5006-3p	HITS-CLIP	23824327
MIRT1048472	hsa-miR-320a	CLIP-seq
MIRT1048473	hsa-miR-320b	CLIP-seq
MIRT1048474	hsa-miR-320c	CLIP-seq
MIRT1048475	hsa-miR-320d	CLIP-seq
MIRT1048476	hsa-miR-320e	CLIP-seq
MIRT1048477	hsa-miR-3689a-3p	CLIP-seq
MIRT1048478	hsa-miR-3689c	CLIP-seq
MIRT1048479	hsa-miR-4429	CLIP-seq
MIRT1048480	hsa-miR-4728-5p	CLIP-seq
MIRT1048481	hsa-miR-4731-5p	CLIP-seq
MIRT1048482	hsa-miR-518a-5p	CLIP-seq
MIRT1048483	hsa-miR-527	CLIP-seq
MIRT2243312	hsa-miR-298	CLIP-seq
MIRT1048472	hsa-miR-320a	CLIP-seq
MIRT1048473	hsa-miR-320b	CLIP-seq
MIRT1048474	hsa-miR-320c	CLIP-seq
MIRT1048475	hsa-miR-320d	CLIP-seq
MIRT1048476	hsa-miR-320e	CLIP-seq
MIRT1048479	hsa-miR-4429	CLIP-seq
MIRT1048481	hsa-miR-4731-5p	CLIP-seq
MIRT2243313	hsa-miR-486-3p	CLIP-seq
MIRT1048482	hsa-miR-518a-5p	CLIP-seq
MIRT1048483	hsa-miR-527	CLIP-seq

Show/Hide all (4)

Transcription factor	Regulation	Reference
CIITA	Unknown	10886240
RFX5	Unknown	11258423
RFXANK	Unknown	11258423
RFXAP	Unknown	11258423

Show/Hide all (40)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000139	Component	Golgi membrane	TAS
GO:0002250	Process	Adaptive immune response	IEA
GO:0002376	Process	Immune system process	IEA
GO:0002503	Process	Peptide antigen assembly with MHC class II protein complex	IBA
GO:0002504	Process	Antigen processing and presentation of peptide or polysaccharide antigen via MHC class II	IEA
GO:0005515	Function	Protein binding	IPI	28514442, 33961781
GO:0005764	Component	Lysosome	IEA
GO:0005765	Component	Lysosomal membrane	IBA
GO:0005765	Component	Lysosomal membrane	IDA	18305173
GO:0005765	Component	Lysosomal membrane	IEA
GO:0005765	Component	Lysosomal membrane	TAS
GO:0005768	Component	Endosome	IEA
GO:0005783	Component	Endoplasmic reticulum	IEA
GO:0005789	Component	Endoplasmic reticulum membrane	IEA
GO:0005794	Component	Golgi apparatus	IEA
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS
GO:0006955	Process	Immune response	IEA
GO:0010008	Component	Endosome membrane	IEA
GO:0012507	Component	ER to Golgi transport vesicle membrane	TAS
GO:0016020	Component	Membrane	IEA
GO:0019882	Process	Antigen processing and presentation	IEA
GO:0019886	Process	Antigen processing and presentation of exogenous peptide antigen via MHC class II	IBA
GO:0023026	Function	MHC class II protein complex binding	IBA
GO:0030658	Component	Transport vesicle membrane	TAS
GO:0030666	Component	Endocytic vesicle membrane	TAS
GO:0030669	Component	Clathrin-coated endocytic vesicle membrane	TAS
GO:0031902	Component	Late endosome membrane	IBA
GO:0031902	Component	Late endosome membrane	IDA	18305173
GO:0031902	Component	Late endosome membrane	IEA
GO:0032588	Component	Trans-Golgi network membrane	TAS
GO:0042605	Function	Peptide antigen binding	IBA
GO:0042605	Function	Peptide antigen binding	ISS	20356827
GO:0042613	Component	MHC class II protein complex	IBA
GO:0042613	Component	MHC class II protein complex	IEA
GO:0042613	Component	MHC class II protein complex	ISS	20356827
GO:0050778	Process	Positive regulation of immune response	IBA
GO:0050870	Process	Positive regulation of T cell activation	IBA
GO:0070062	Component	Extracellular exosome	HDA	12519789, 20458337
GO:0098553	Component	Lumenal side of endoplasmic reticulum membrane	TAS

MIM	HGNC	e!Ensembl
604776	4953	ENSG00000198502

Q30154

Protein name

HLA class II histocompatibility antigen, DR beta 5 chain (DR beta-5) (DR2-beta-2) (Dw2) (MHC class II antigen DRB5)

Protein function

Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptides of 10-30 residues. T

PDB

1FV1 , 1H15 , 1HQR , 1ZGL

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00969	MHC_II_beta	42 → 116	Class II histocompatibility antigen, beta domain	Domain
PF07654	C1-set	128 → 209	Immunoglobulin C1-set domain	Domain

Sequence

MVCLKLPGGSYMAKLTVTLMVLSSPLALAGDTRPRFLQQDKYECHFFNGTERVRFLHRDI
YNQEEDLRFDSDVGEYRAVTELGRPDAEYWNSQKDFLEDRRAAVDTYCRHNYGVGESFTV
QRRVEPKVTVYPARTQTLQHHNLLVCSVNGFYPGSIEVRWFRNSQEEKAGVVSTGLIQNG
DWTFQTLVMLETVPRSGEVYTCQVEHPSVTSPLTVEWRAQSESAQSKMLSGVGGFVLGLL
FLGAGLFIYFKNQKGHSGLHPTGLVS

Sequence length

266

Interactions

View interactions

	KEGG		Reactome
	Phagosome Cell adhesion molecules Antigen processing and presentation Hematopoietic cell lineage Th1 and Th2 cell differentiation Th17 cell differentiation Intestinal immune network for IgA production Type I diabetes mellitus Leishmaniasis Toxoplasmosis Staphylococcus aureus infection Tuberculosis Influenza A Human T-cell leukemia virus 1 infection Herpes simplex virus 1 infection Epstein-Barr virus infection Asthma Autoimmune thyroid disease Inflammatory bowel disease Systemic lupus erythematosus Rheumatoid arthritis Allograft rejection Graft-versus-host disease Viral myocarditis		Downstream TCR signaling Phosphorylation of CD3 and TCR zeta chains Translocation of ZAP-70 to Immunological synapse Generation of second messenger molecules MHC class II antigen presentation PD-1 signaling Interferon gamma signaling

Show/Hide Unknown Diseases (7)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Chronic lymphocytic leukemia/small lymphocytic lymphoma	Benign	rs201699945, rs200591586	RCV005891014 RCV005891018
Familial pancreatic carcinoma	Benign	rs201699945	RCV005891013
Hepatocellular carcinoma	Benign	rs201699945, rs200591586	RCV005891010 RCV005891015
Lymphoma	Benign	rs200591586	RCV005891017
Malignant tumor of urinary bladder	Likely benign	rs771206465	RCV005927456
Nonpapillary renal cell carcinoma	Benign	rs201699945, rs200591586	RCV005891011 RCV005891016
Ovarian cancer	Benign	rs201699945	RCV005891012

HLA-DRB5 (major histocompatibility complex, class II, DR beta 5)