Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	3126
Gene name Gene Name - the full gene name approved by the HGNC.	Major histocompatibility complex, class II, DR beta 4
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	HLA-DRB4
Synonyms (NCBI Gene) Gene synonyms aliases	DR4, DRB4, HLA-DR4B, HLA-DRB, HLA-DRB4*
Chromosome Chromosome number	6
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	6p21.3
Summary Summary of gene provided in NCBI Entrez Gene.	HLA-DRB4 belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DRA) and a beta (DRB) chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides der

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miRTarBase ID	miRNA	Experiments
MIRT1048470	hsa-miR-4699-5p	CLIP-seq
MIRT1048471	hsa-miR-4709-3p	CLIP-seq
MIRT2011024	hsa-miR-320a	CLIP-seq
MIRT2011025	hsa-miR-320b	CLIP-seq
MIRT2011026	hsa-miR-320c	CLIP-seq
MIRT2011027	hsa-miR-320d	CLIP-seq
MIRT2011028	hsa-miR-4429	CLIP-seq
MIRT2243305	hsa-miR-298	CLIP-seq
MIRT2011024	hsa-miR-320a	CLIP-seq
MIRT2011025	hsa-miR-320b	CLIP-seq
MIRT2011026	hsa-miR-320c	CLIP-seq
MIRT2011027	hsa-miR-320d	CLIP-seq
MIRT2243306	hsa-miR-320e	CLIP-seq
MIRT2011028	hsa-miR-4429	CLIP-seq
MIRT2243307	hsa-miR-4457	CLIP-seq
MIRT2243308	hsa-miR-4731-5p	CLIP-seq
MIRT2243309	hsa-miR-486-3p	CLIP-seq
MIRT2243310	hsa-miR-518a-5p	CLIP-seq
MIRT2243311	hsa-miR-527	CLIP-seq

Transcription factors

Show/Hide all(4)

Transcription factor	Regulation	Reference
CIITA	Unknown	10886240
RFX5	Unknown	11258423
RFXANK	Unknown	11258423
RFXAP	Unknown	11258423

Show/Hide all(16)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000139	Component	Golgi membrane	TAS
GO:0002250	Process	Adaptive immune response	IEA
GO:0005765	Component	Lysosomal membrane	IDA	18305173
GO:0005765	Component	Lysosomal membrane	TAS
GO:0005886	Component	Plasma membrane	TAS
GO:0012507	Component	ER to Golgi transport vesicle membrane	TAS
GO:0019886	Process	Antigen processing and presentation of exogenous peptide antigen via MHC class II	TAS
GO:0030658	Component	Transport vesicle membrane	TAS
GO:0030666	Component	Endocytic vesicle membrane	TAS
GO:0030669	Component	Clathrin-coated endocytic vesicle membrane	TAS
GO:0031902	Component	Late endosome membrane	IDA	18305173, 19117940
GO:0032588	Component	Trans-Golgi network membrane	TAS
GO:0042613	Component	MHC class II protein complex	IEA
GO:0050852	Process	T cell receptor signaling pathway	TAS
GO:0060333	Process	Interferon-gamma-mediated signaling pathway	TAS
GO:0071556	Component	Integral component of lumenal side of endoplasmic reticulum membrane	TAS

MIM	HGNC	e!Ensembl
HGNC	4952	N/A

Protein

UniProt ID

P13762

Protein name

HLA class II histocompatibility antigen, DR beta 4 chain (MHC class II antigen DRB4)

Protein function

Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptides of 10-30 residues. T

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00969	MHC_II_beta	42 → 116	Class II histocompatibility antigen, beta domain	Domain
PF07654	C1-set	128 → 209	Immunoglobulin C1-set domain	Domain

Sequence

MVCLKLPGGSCMAALTVTLTVLSSPLALAGDTQPRFLEQAKCECHFLNGTERVWNLIRYI
YNQEEYARYNSDLGEYQAVTELGRPDAEYWNSQKDLLERRRAEVDTYCRYNYGVVESFTV
QRRVQPKVTVYPSKTQPLQHHNLLVCSVNGFYPGSIEVRWFRNGQEEKAGVVSTGLIQNG
DWTFQTLVMLETVPRSGEVYTCQVEHPSMMSPLTVQWSARSESAQSKMLSGVGGFVLGLL
FLGTGLFIYFRNQKGHSGLQPTGLLS

Sequence length

266

Interactions

View interactions

	KEGG		Reactome
	Phagosome Cell adhesion molecules Antigen processing and presentation Hematopoietic cell lineage Th1 and Th2 cell differentiation Th17 cell differentiation Intestinal immune network for IgA production Type I diabetes mellitus Leishmaniasis Toxoplasmosis Staphylococcus aureus infection Tuberculosis Influenza A Human T-cell leukemia virus 1 infection Herpes simplex virus 1 infection Epstein-Barr virus infection Asthma Autoimmune thyroid disease Inflammatory bowel disease Systemic lupus erythematosus Rheumatoid arthritis Allograft rejection Graft-versus-host disease Viral myocarditis		Downstream TCR signaling Phosphorylation of CD3 and TCR zeta chains Translocation of ZAP-70 to Immunological synapse Generation of second messenger molecules MHC class II antigen presentation PD-1 signaling Interferon gamma signaling

Show/Hide Causal Diseases (1)

Disease term	Disease name	dbSNP ID	References
Causal
Multiple sclerosis	Multiple Sclerosis	rs104895219, rs483353022, rs483353023, rs483353028, rs483353029, rs483353024, rs483353030, rs3207617, rs483353031, rs483353032, rs483353033, rs483353034, rs483353035, rs483353036, rs483353039 View all (4 more)	23472185

HLA-DRB4 (major histocompatibility complex, class II, DR beta 4)