Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	3125
Gene name Gene Name - the full gene name approved by the HGNC.	Major histocompatibility complex, class II, DR beta 3
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	HLA-DRB3
Synonyms (NCBI Gene) Gene synonyms aliases	DRB3, HLA-DPB1, HLA-DR1B, HLA-DR3B, HLA-DRB3*
Chromosome Chromosome number	6
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	6p21.3
Summary Summary of gene provided in NCBI Entrez Gene.	HLA-DRB3 belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DRA) and a beta (DRB) chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides der

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miRTarBase ID	miRNA	Experiments
MIRT1048461	hsa-miR-320a	CLIP-seq
MIRT1048462	hsa-miR-320b	CLIP-seq
MIRT1048463	hsa-miR-320c	CLIP-seq
MIRT1048464	hsa-miR-320d	CLIP-seq
MIRT1048465	hsa-miR-320e	CLIP-seq
MIRT1048466	hsa-miR-4429	CLIP-seq
MIRT1048467	hsa-miR-4793-5p	CLIP-seq
MIRT1048468	hsa-miR-518a-5p	CLIP-seq
MIRT1048469	hsa-miR-527	CLIP-seq
MIRT2011021	hsa-miR-298	CLIP-seq
MIRT1048461	hsa-miR-320a	CLIP-seq
MIRT1048462	hsa-miR-320b	CLIP-seq
MIRT1048463	hsa-miR-320c	CLIP-seq
MIRT1048464	hsa-miR-320d	CLIP-seq
MIRT1048465	hsa-miR-320e	CLIP-seq
MIRT1048466	hsa-miR-4429	CLIP-seq
MIRT2011022	hsa-miR-4731-5p	CLIP-seq
MIRT2011023	hsa-miR-486-3p	CLIP-seq
MIRT1048468	hsa-miR-518a-5p	CLIP-seq
MIRT1048469	hsa-miR-527	CLIP-seq
MIRT2011021	hsa-miR-298	CLIP-seq
MIRT1048461	hsa-miR-320a	CLIP-seq
MIRT1048462	hsa-miR-320b	CLIP-seq
MIRT1048463	hsa-miR-320c	CLIP-seq
MIRT1048464	hsa-miR-320d	CLIP-seq
MIRT1048465	hsa-miR-320e	CLIP-seq
MIRT1048466	hsa-miR-4429	CLIP-seq
MIRT2243304	hsa-miR-4699-5p	CLIP-seq
MIRT2011022	hsa-miR-4731-5p	CLIP-seq
MIRT2011023	hsa-miR-486-3p	CLIP-seq
MIRT1048468	hsa-miR-518a-5p	CLIP-seq
MIRT1048469	hsa-miR-527	CLIP-seq

Transcription factors

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Transcription factor	Regulation	Reference
CIITA	Unknown	10886240
RFX5	Unknown	11258423
RFXANK	Unknown	11258423
RFXAP	Unknown	11258423

Show/Hide all(50)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000139	Component	Golgi membrane	TAS
GO:0002250	Process	Adaptive immune response	IEA
GO:0002376	Process	Immune system process	IEA
GO:0002469	Process	Myeloid dendritic cell antigen processing and presentation	IDA	19531622, 30282837
GO:0002503	Process	Peptide antigen assembly with MHC class II protein complex	IBA
GO:0002504	Process	Antigen processing and presentation of peptide or polysaccharide antigen via MHC class II	IEA
GO:0002842	Process	Positive regulation of T cell mediated immune response to tumor cell	IDA	30282837
GO:0005515	Function	Protein binding	IPI	32814053
GO:0005764	Component	Lysosome	IEA
GO:0005765	Component	Lysosomal membrane	IBA
GO:0005765	Component	Lysosomal membrane	IDA	18305173
GO:0005765	Component	Lysosomal membrane	IEA
GO:0005765	Component	Lysosomal membrane	TAS
GO:0005768	Component	Endosome	IEA
GO:0005783	Component	Endoplasmic reticulum	IEA
GO:0005789	Component	Endoplasmic reticulum membrane	IEA
GO:0005886	Component	Plasma membrane	IDA	19531622
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	NAS	6414998
GO:0005886	Component	Plasma membrane	TAS
GO:0006955	Process	Immune response	IEA
GO:0007165	Process	Signal transduction	NAS	8775462
GO:0012507	Component	ER to Golgi transport vesicle membrane	TAS
GO:0016020	Component	Membrane	HDA	19946888
GO:0016020	Component	Membrane	IEA
GO:0019882	Process	Antigen processing and presentation	IEA
GO:0019886	Process	Antigen processing and presentation of exogenous peptide antigen via MHC class II	IBA
GO:0019886	Process	Antigen processing and presentation of exogenous peptide antigen via MHC class II	IDA	19531622, 32341563
GO:0023026	Function	MHC class II protein complex binding	IBA
GO:0030658	Component	Transport vesicle membrane	TAS
GO:0030666	Component	Endocytic vesicle membrane	TAS
GO:0030669	Component	Clathrin-coated endocytic vesicle membrane	TAS
GO:0031410	Component	Cytoplasmic vesicle	IEA
GO:0031902	Component	Late endosome membrane	IBA
GO:0031902	Component	Late endosome membrane	IDA	18305173
GO:0031902	Component	Late endosome membrane	IEA
GO:0032395	Function	MHC class II receptor activity	NAS	6414998
GO:0032588	Component	Trans-Golgi network membrane	TAS
GO:0042605	Function	Peptide antigen binding	IBA
GO:0042605	Function	Peptide antigen binding	IDA	17583734, 18697946
GO:0042605	Function	Peptide antigen binding	ISS	20356827
GO:0042613	Component	MHC class II protein complex	IBA
GO:0042613	Component	MHC class II protein complex	IEA
GO:0042613	Component	MHC class II protein complex	ISS	20356827
GO:0050778	Process	Positive regulation of immune response	IBA
GO:0050852	Process	T cell receptor signaling pathway	IDA	32341563
GO:0050870	Process	Positive regulation of T cell activation	IBA
GO:0098553	Component	Lumenal side of endoplasmic reticulum membrane	TAS
GO:0120281	Component	Autolysosome membrane	IEA
GO:2000516	Process	Positive regulation of CD4-positive, alpha-beta T cell activation	IDA	19531622

MIM	HGNC	e!Ensembl
612735	4951	HGNC

Protein

UniProt ID

P79483

Protein name

HLA class II histocompatibility antigen, DR beta 3 chain (MHC class II antigen DRB3)

Protein function

A beta chain of antigen-presenting major histocompatibility complex class II (MHCII) molecule. In complex with the alpha chain HLA-DRA, displays antigenic peptides on professional antigen presenting cells (APCs) for recognition by alpha-beta T c

PDB

2Q6W , 3C5J , 4H1L

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00969	MHC_II_beta	42 → 116	Class II histocompatibility antigen, beta domain	Domain
PF07654	C1-set	128 → 209	Immunoglobulin C1-set domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Expressed in professional APCs: monocyte/macrophages, dendritic cells and B cells (at protein level). {ECO:0000269|PubMed:19531622, ECO:0000269|PubMed:19830726}.

Sequence

MVCLKLPGGSSLAALTVTLMVLSSRLAFAGDTRPRFLELRKSECHFFNGTERVRYLDRYF
HNQEEFLRFDSDVGEYRAVTELGRPVAESWNSQKDLLEQKRGRVDNYCRHNYGVGESFTV
QRRVHPQVTVYPAKTQPLQHHNLLVCSVSGFYPGSIEVRWFRNGQEEKAGVVSTGLIQNG
DWTFQTLVMLETVPRSGEVYTCQVEHPSVTSALTVEWRARSESAQSKMLSGVGGFVLGLL
FLGAGLFIYFRNQKGHSGLQPTGFLS

Sequence length

266

Interactions

View interactions

	KEGG		Reactome
	Phagosome Cell adhesion molecules Antigen processing and presentation Hematopoietic cell lineage Th1 and Th2 cell differentiation Th17 cell differentiation Intestinal immune network for IgA production Type I diabetes mellitus Leishmaniasis Toxoplasmosis Staphylococcus aureus infection Tuberculosis Influenza A Human T-cell leukemia virus 1 infection Herpes simplex virus 1 infection Epstein-Barr virus infection Asthma Autoimmune thyroid disease Inflammatory bowel disease Systemic lupus erythematosus Rheumatoid arthritis Allograft rejection Graft-versus-host disease Viral myocarditis		Downstream TCR signaling Phosphorylation of CD3 and TCR zeta chains Translocation of ZAP-70 to Immunological synapse Generation of second messenger molecules MHC class II antigen presentation PD-1 signaling Interferon gamma signaling

HLA-DRB3 (major histocompatibility complex, class II, DR beta 3)