Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways
Entrez ID	3117
Gene name	Major histocompatibility complex, class II, DQ alpha 1
Gene symbol	HLA-DQA1
Synonyms (NCBI Gene)	CELIAC1DQ-A1DQA1HLA-DQAHLA-DQA1*HLA-DQB1
Chromosome	6
Chromosome location	6p21.32
Summary	HLA-DQA1 belongs to the HLA class II alpha chain paralogues. The class II molecule is a heterodimer consisting of an alpha (DQA) and a beta chain (DQB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides der

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miRTarBase ID	miRNA	Experiments	Reference
MIRT023357	hsa-miR-122-5p	Microarray	17612493
MIRT723077	hsa-miR-4645-5p	HITS-CLIP	19536157
MIRT723076	hsa-miR-4673	HITS-CLIP	19536157
MIRT723075	hsa-miR-6798-3p	HITS-CLIP	19536157
MIRT723077	hsa-miR-4645-5p	HITS-CLIP	19536157
MIRT723076	hsa-miR-4673	HITS-CLIP	19536157
MIRT723075	hsa-miR-6798-3p	HITS-CLIP	19536157
MIRT2243280	hsa-miR-1270	CLIP-seq
MIRT2243281	hsa-miR-137	CLIP-seq
MIRT2243282	hsa-miR-2115	CLIP-seq
MIRT2243283	hsa-miR-3189-3p	CLIP-seq
MIRT2243284	hsa-miR-3977	CLIP-seq
MIRT2243285	hsa-miR-432	CLIP-seq
MIRT2243286	hsa-miR-4531	CLIP-seq
MIRT2243287	hsa-miR-4683	CLIP-seq
MIRT2243288	hsa-miR-502-5p	CLIP-seq
MIRT2243289	hsa-miR-516a-3p	CLIP-seq
MIRT2243290	hsa-miR-620	CLIP-seq

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Transcription factor	Regulation	Reference
ILF3	Unknown	7651394
RFX5	Unknown	11258423
RFXANK	Unknown	11258423
RFXAP	Unknown	11258423

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GO ID	Ontology	Definition	Evidence	Reference
GO:0000139	Component	Golgi membrane	TAS
GO:0002250	Process	Adaptive immune response	IEA
GO:0002376	Process	Immune system process	IEA
GO:0002503	Process	Peptide antigen assembly with MHC class II protein complex	IBA
GO:0002504	Process	Antigen processing and presentation of peptide or polysaccharide antigen via MHC class II	IEA
GO:0005515	Function	Protein binding	IPI	14769912, 17629515, 29997244, 33961781
GO:0005764	Component	Lysosome	IEA
GO:0005765	Component	Lysosomal membrane	IBA
GO:0005765	Component	Lysosomal membrane	IEA
GO:0005765	Component	Lysosomal membrane	TAS
GO:0005768	Component	Endosome	IEA
GO:0005783	Component	Endoplasmic reticulum	IEA
GO:0005789	Component	Endoplasmic reticulum membrane	IEA
GO:0005794	Component	Golgi apparatus	IEA
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	NAS	3584986, 6415485
GO:0005886	Component	Plasma membrane	TAS
GO:0006955	Process	Immune response	IEA
GO:0006955	Process	Immune response	NAS	3584986, 6415485
GO:0010008	Component	Endosome membrane	IEA
GO:0012507	Component	ER to Golgi transport vesicle membrane	TAS
GO:0016020	Component	Membrane	HDA	19946888
GO:0016020	Component	Membrane	IEA
GO:0019882	Process	Antigen processing and presentation	IEA
GO:0019886	Process	Antigen processing and presentation of exogenous peptide antigen via MHC class II	IBA
GO:0023026	Function	MHC class II protein complex binding	IBA
GO:0030658	Component	Transport vesicle membrane	TAS
GO:0030666	Component	Endocytic vesicle membrane	TAS
GO:0030669	Component	Clathrin-coated endocytic vesicle membrane	TAS
GO:0031902	Component	Late endosome membrane	IBA
GO:0032395	Function	MHC class II receptor activity	NAS	3584986, 6415485
GO:0032395	Function	MHC class II receptor activity	TAS	2300572
GO:0032588	Component	Trans-Golgi network membrane	TAS
GO:0042605	Function	Peptide antigen binding	IBA
GO:0042605	Function	Peptide antigen binding	ISS	20356827
GO:0042613	Component	MHC class II protein complex	IBA
GO:0042613	Component	MHC class II protein complex	IEA
GO:0042613	Component	MHC class II protein complex	ISS	20356827
GO:0050778	Process	Positive regulation of immune response	IBA
GO:0050870	Process	Positive regulation of T cell activation	IBA
GO:0098553	Component	Lumenal side of endoplasmic reticulum membrane	TAS

MIM	HGNC	e!Ensembl
146880	4942	ENSG00000196735

P01909

Protein name

HLA class II histocompatibility antigen, DQ alpha 1 chain (DC-1 alpha chain) (DC-alpha) (HLA-DCA) (MHC class II DQA1)

Protein function

Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptides of 10-30 residues. T

PDB

1JK8 , 1S9V , 1UVQ , 2NNA , 4GG6 , 4OZF , 4OZG , 4OZH , 4OZI , 5KSA , 5KSB , 5KSU , 5KSV , 6MFF , 6MFG , 6U3M , 6U3N , 6XP6 , 7SG0 , 7SG1 , 7SG2 , 8VSP , 8W83 , 8W84 , 8W85 , 8W86

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00993	MHC_II_alpha	29 → 108	Class II histocompatibility antigen, alpha domain	Domain
PF07654	C1-set	114 → 195	Immunoglobulin C1-set domain	Domain

Sequence

MILNKALMLGALALTTVMSPCGGEDIVADHVASYGVNLYQSYGPSGQYTHEFDGDEQFYV
DLGRKETVWCLPVLRQFRFDPQFALTNIAVLKHNLNSLIKRSNSTAATNEVPEVTVFSKS
PVTLGQPNILICLVDNIFPPVVNITWLSNGHSVTEGVSETSFLSKSDHSFFKISYLTLLP
SAEESYDCKVEHWGLDKPLLKHWEPEIPAPMSELTETVVCALGLSVGLVGIVVGTVFIIR
GLRSVGASRHQGPL

Sequence length

254

Interactions

View interactions

	KEGG		Reactome
	Phagosome Cell adhesion molecules Antigen processing and presentation Hematopoietic cell lineage Th1 and Th2 cell differentiation Th17 cell differentiation Intestinal immune network for IgA production Type I diabetes mellitus Leishmaniasis Toxoplasmosis Staphylococcus aureus infection Tuberculosis Influenza A Human T-cell leukemia virus 1 infection Herpes simplex virus 1 infection Epstein-Barr virus infection Asthma Autoimmune thyroid disease Inflammatory bowel disease Systemic lupus erythematosus Rheumatoid arthritis Allograft rejection Graft-versus-host disease Viral myocarditis		Downstream TCR signaling Phosphorylation of CD3 and TCR zeta chains Translocation of ZAP-70 to Immunological synapse Generation of second messenger molecules MHC class II antigen presentation PD-1 signaling Interferon gamma signaling

HLA-DQA1 (major histocompatibility complex, class II, DQ alpha 1)