Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
3112
Gene name Gene Name - the full gene name approved by the HGNC.
Major histocompatibility complex, class II, DO beta
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
HLA-DOB
Synonyms (NCBI Gene) Gene synonyms aliases
DOB, HLA_DOB
Chromosome Chromosome number
6
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
6p21.32
Summary Summary of gene provided in NCBI Entrez Gene.
HLA-DOB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DOA) and a beta chain (DOB), both anchored in the membrane. It is located in intracellular vesicles. DO suppresses peptide loading o
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT526746 hsa-miR-497-3p PAR-CLIP 22012620
MIRT526745 hsa-miR-7844-5p PAR-CLIP 22012620
MIRT526744 hsa-miR-513b-3p PAR-CLIP 22012620
MIRT526743 hsa-miR-4301 PAR-CLIP 22012620
MIRT526742 hsa-miR-616-3p PAR-CLIP 22012620
Transcription factors
Transcription factor Regulation Reference
CIITA Activation 11823510
CREB1 Unknown 12938212
POU2F2 Unknown 12938212
RFX1 Unknown 12938212
RFX5 Unknown 11258423
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0002250 Process Adaptive immune response IEA
GO:0002587 Process Negative regulation of antigen processing and presentation of peptide antigen via MHC class II IDA 22733780
GO:0005764 Component Lysosome IDA 8890155
GO:0005765 Component Lysosomal membrane TAS
GO:0010008 Component Endosome membrane IEA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
600629 4937 ENSG00000241106
Protein
UniProt ID P13765
Protein name HLA class II histocompatibility antigen, DO beta chain (MHC class II antigen DOB)
Protein function Important modulator in the HLA class II restricted antigen presentation pathway by interaction with the HLA-DM molecule in B-cells. Modifies peptide exchange activity of HLA-DM.
PDB 4I0P
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00969 MHC_II_beta 39 113 Class II histocompatibility antigen, beta domain Domain
PF07654 C1-set 125 206 Immunoglobulin C1-set domain Domain
Sequence
MGSGWVPWVVALLVNLTRLDSSMTQGTDSPEDFVIQAKADCYFTNGTEKVQFVVRFIFNL
EEYVRFDSDVGMFVALTKLGQPDAEQWNSRLDLLERSRQAVDGVCRHNYRLGA
PFTVGRK
VQPEVTVYPERTPLLHQHNLLHCSVTGFYPGDIKIKWFLNGQEERAGVMSTGPIRNGDWT
FQTVVMLEMTPELGHVYTCLVDHSSL
LSPVSVEWRAQSEYSWRKMLSGIAAFLLGLIFLL
VGIVIQLRAQKGYVRTQMSGNEVSRAVLLPQSC
Sequence length 273
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Phagosome
Cell adhesion molecules
Antigen processing and presentation
Hematopoietic cell lineage
Th1 and Th2 cell differentiation
Th17 cell differentiation
Intestinal immune network for IgA production
Type I diabetes mellitus
Leishmaniasis
Toxoplasmosis
Staphylococcus aureus infection
Tuberculosis
Influenza A
Human T-cell leukemia virus 1 infection
Herpes simplex virus 1 infection
Epstein-Barr virus infection
Asthma
Autoimmune thyroid disease
Inflammatory bowel disease
Systemic lupus erythematosus
Rheumatoid arthritis
Allograft rejection
Graft-versus-host disease
Viral myocarditis
  MHC class II antigen presentation
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Diabetes mellitus Diabetes Mellitus, Insulin-Dependent, Diabetes Mellitus, Non-Insulin-Dependent rs587776515, rs61730328, rs606231121, rs606231122, rs79020217, rs77625743, rs78378398, rs606231123, rs1362648752, rs104893649, rs80356624, rs80356616, rs80356625, rs80356611, rs104894237
View all (293 more)
17632545, 30054458
Lung carcinoma Carcinoma of lung rs1805076, rs121909071, rs121913530, rs112445441, rs121913529, rs121913535, rs121913297, rs121913279, rs104886003, rs397516975, rs11554290, rs121913364, rs121913351, rs121913369, rs121913355
View all (44 more)
28604730
Narcolepsy Narcolepsy rs104894574, rs387906655 19629137
Rheumatoid arthritis Rheumatoid Arthritis rs587776843 19503088, 17804836, 26272072, 21156761
Unknown
Disease term Disease name Evidence References Source
Sarcoidosis Sarcoidosis 26651848 ClinVar