Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	3111
Gene name Gene Name - the full gene name approved by the HGNC.	Major histocompatibility complex, class II, DO alpha
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	HLA-DOA
Synonyms (NCBI Gene) Gene synonyms aliases	HLA-DNA, HLA-DZA, HLADZ
Chromosome Chromosome number	6
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	6p21.32
Summary Summary of gene provided in NCBI Entrez Gene.	HLA-DOA belongs to the HLA class II alpha chain paralogues. HLA-DOA forms a heterodimer with HLA-DOB. The heterodimer, HLA-DO, is found in lysosomes in B cells and regulates HLA-DM-mediated peptide loading on MHC class II molecules. In comparison with cla

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miRTarBase ID	miRNA	Experiments	Reference
MIRT491507	hsa-miR-6732-5p	PAR-CLIP	23592263
MIRT491505	hsa-miR-3928-3p	PAR-CLIP	23592263
MIRT491503	hsa-miR-3184-5p	PAR-CLIP	23592263
MIRT491504	hsa-miR-423-5p	PAR-CLIP	23592263
MIRT491502	hsa-miR-1914-3p	PAR-CLIP	23592263
MIRT491501	hsa-miR-5194	PAR-CLIP	23592263
MIRT491499	hsa-miR-6738-5p	PAR-CLIP	23592263
MIRT491500	hsa-miR-7160-5p	PAR-CLIP	23592263
MIRT491498	hsa-miR-7704	PAR-CLIP	23592263
MIRT491496	hsa-miR-3915	PAR-CLIP	23592263
MIRT491497	hsa-miR-6734-5p	PAR-CLIP	23592263
MIRT448019	hsa-miR-4511	PAR-CLIP	22100165
MIRT448018	hsa-miR-146a-3p	PAR-CLIP	22100165
MIRT448017	hsa-miR-301a-5p	PAR-CLIP	22100165
MIRT448016	hsa-miR-301b-5p	PAR-CLIP	22100165
MIRT448015	hsa-miR-3921	PAR-CLIP	22100165
MIRT448014	hsa-miR-4653-5p	PAR-CLIP	22100165
MIRT450608	hsa-miR-130b-5p	PAR-CLIP	22100165
MIRT448012	hsa-miR-4251	PAR-CLIP	22100165
MIRT448013	hsa-miR-4329	PAR-CLIP	22100165
MIRT448011	hsa-miR-6761-5p	PAR-CLIP	22100165
MIRT448010	hsa-miR-6859-3p	PAR-CLIP	22100165
MIRT448009	hsa-miR-6846-3p	PAR-CLIP	22100165
MIRT448008	hsa-miR-1253	PAR-CLIP	22100165
MIRT448007	hsa-miR-6770-5p	PAR-CLIP	22100165
MIRT448006	hsa-miR-3191-5p	PAR-CLIP	22100165
MIRT448005	hsa-miR-4768-5p	PAR-CLIP	22100165
MIRT448004	hsa-miR-6833-3p	PAR-CLIP	22100165
MIRT448002	hsa-miR-6809-3p	PAR-CLIP	22100165
MIRT448019	hsa-miR-4511	PAR-CLIP	22100165
MIRT448018	hsa-miR-146a-3p	PAR-CLIP	22100165
MIRT448017	hsa-miR-301a-5p	PAR-CLIP	22100165
MIRT448016	hsa-miR-301b-5p	PAR-CLIP	22100165
MIRT448015	hsa-miR-3921	PAR-CLIP	22100165
MIRT448014	hsa-miR-4653-5p	PAR-CLIP	22100165
MIRT448012	hsa-miR-4251	PAR-CLIP	22100165
MIRT448013	hsa-miR-4329	PAR-CLIP	22100165
MIRT448011	hsa-miR-6761-5p	PAR-CLIP	22100165
MIRT448010	hsa-miR-6859-3p	PAR-CLIP	22100165
MIRT448009	hsa-miR-6846-3p	PAR-CLIP	22100165
MIRT448008	hsa-miR-1253	PAR-CLIP	22100165
MIRT448007	hsa-miR-6770-5p	PAR-CLIP	22100165
MIRT448006	hsa-miR-3191-5p	PAR-CLIP	22100165
MIRT448005	hsa-miR-4768-5p	PAR-CLIP	22100165
MIRT448004	hsa-miR-6833-3p	PAR-CLIP	22100165
MIRT448002	hsa-miR-6809-3p	PAR-CLIP	22100165
MIRT491507	hsa-miR-6732-5p	PAR-CLIP	23592263
MIRT491505	hsa-miR-3928-3p	PAR-CLIP	23592263
MIRT491503	hsa-miR-3184-5p	PAR-CLIP	23592263
MIRT491504	hsa-miR-423-5p	PAR-CLIP	23592263
MIRT491502	hsa-miR-1914-3p	PAR-CLIP	23592263
MIRT491501	hsa-miR-5194	PAR-CLIP	23592263
MIRT491499	hsa-miR-6738-5p	PAR-CLIP	23592263
MIRT491500	hsa-miR-7160-5p	PAR-CLIP	23592263
MIRT491498	hsa-miR-7704	PAR-CLIP	23592263
MIRT491496	hsa-miR-3915	PAR-CLIP	23592263
MIRT491497	hsa-miR-6734-5p	PAR-CLIP	23592263
MIRT448019	hsa-miR-4511	PAR-CLIP	22100165
MIRT448018	hsa-miR-146a-3p	PAR-CLIP	22100165
MIRT448017	hsa-miR-301a-5p	PAR-CLIP	22100165
MIRT448016	hsa-miR-301b-5p	PAR-CLIP	22100165
MIRT448015	hsa-miR-3921	PAR-CLIP	22100165
MIRT448014	hsa-miR-4653-5p	PAR-CLIP	22100165
MIRT450608	hsa-miR-130b-5p	PAR-CLIP	22100165
MIRT448012	hsa-miR-4251	PAR-CLIP	22100165
MIRT448013	hsa-miR-4329	PAR-CLIP	22100165
MIRT448011	hsa-miR-6761-5p	PAR-CLIP	22100165
MIRT448010	hsa-miR-6859-3p	PAR-CLIP	22100165
MIRT448009	hsa-miR-6846-3p	PAR-CLIP	22100165
MIRT448008	hsa-miR-1253	PAR-CLIP	22100165
MIRT448007	hsa-miR-6770-5p	PAR-CLIP	22100165
MIRT448006	hsa-miR-3191-5p	PAR-CLIP	22100165
MIRT448005	hsa-miR-4768-5p	PAR-CLIP	22100165
MIRT448004	hsa-miR-6833-3p	PAR-CLIP	22100165
MIRT448002	hsa-miR-6809-3p	PAR-CLIP	22100165
MIRT448019	hsa-miR-4511	PAR-CLIP	22100165
MIRT448018	hsa-miR-146a-3p	PAR-CLIP	22100165
MIRT448017	hsa-miR-301a-5p	PAR-CLIP	22100165
MIRT448016	hsa-miR-301b-5p	PAR-CLIP	22100165
MIRT448015	hsa-miR-3921	PAR-CLIP	22100165
MIRT448014	hsa-miR-4653-5p	PAR-CLIP	22100165
MIRT448012	hsa-miR-4251	PAR-CLIP	22100165
MIRT448013	hsa-miR-4329	PAR-CLIP	22100165
MIRT448011	hsa-miR-6761-5p	PAR-CLIP	22100165
MIRT448010	hsa-miR-6859-3p	PAR-CLIP	22100165
MIRT448009	hsa-miR-6846-3p	PAR-CLIP	22100165
MIRT448008	hsa-miR-1253	PAR-CLIP	22100165
MIRT448007	hsa-miR-6770-5p	PAR-CLIP	22100165
MIRT448006	hsa-miR-3191-5p	PAR-CLIP	22100165
MIRT448005	hsa-miR-4768-5p	PAR-CLIP	22100165
MIRT448004	hsa-miR-6833-3p	PAR-CLIP	22100165
MIRT448002	hsa-miR-6809-3p	PAR-CLIP	22100165
MIRT1048296	hsa-miR-1202	CLIP-seq
MIRT1048297	hsa-miR-122	CLIP-seq
MIRT1048298	hsa-miR-1272	CLIP-seq
MIRT1048299	hsa-miR-1273f	CLIP-seq
MIRT1048300	hsa-miR-135a	CLIP-seq
MIRT1048301	hsa-miR-135b	CLIP-seq
MIRT1048302	hsa-miR-143	CLIP-seq
MIRT1048303	hsa-miR-1827	CLIP-seq
MIRT1048304	hsa-miR-1972	CLIP-seq
MIRT1048305	hsa-miR-2114	CLIP-seq
MIRT1048306	hsa-miR-24	CLIP-seq
MIRT1048307	hsa-miR-3130-3p	CLIP-seq
MIRT1048308	hsa-miR-3135b	CLIP-seq
MIRT1048309	hsa-miR-3152-5p	CLIP-seq
MIRT1048310	hsa-miR-3180-5p	CLIP-seq
MIRT1048311	hsa-miR-3194-5p	CLIP-seq
MIRT1048312	hsa-miR-3202	CLIP-seq
MIRT1048313	hsa-miR-325	CLIP-seq
MIRT1048314	hsa-miR-3545-3p	CLIP-seq
MIRT1048315	hsa-miR-3591-5p	CLIP-seq
MIRT1048316	hsa-miR-3614-3p	CLIP-seq
MIRT1048317	hsa-miR-3652	CLIP-seq
MIRT1048318	hsa-miR-3664-3p	CLIP-seq
MIRT1048319	hsa-miR-3667-3p	CLIP-seq
MIRT1048320	hsa-miR-3668	CLIP-seq
MIRT1048321	hsa-miR-3674	CLIP-seq
MIRT1048322	hsa-miR-3689d	CLIP-seq
MIRT1048323	hsa-miR-384	CLIP-seq
MIRT1048324	hsa-miR-3926	CLIP-seq
MIRT1048325	hsa-miR-3929	CLIP-seq
MIRT1048326	hsa-miR-3972	CLIP-seq
MIRT1048327	hsa-miR-4252	CLIP-seq
MIRT1048328	hsa-miR-4284	CLIP-seq
MIRT1048329	hsa-miR-4297	CLIP-seq
MIRT1048330	hsa-miR-4299	CLIP-seq
MIRT1048331	hsa-miR-4324	CLIP-seq
MIRT1048332	hsa-miR-4419b	CLIP-seq
MIRT1048333	hsa-miR-4430	CLIP-seq
MIRT1048334	hsa-miR-4431	CLIP-seq
MIRT1048335	hsa-miR-4433	CLIP-seq
MIRT1048336	hsa-miR-4446-3p	CLIP-seq
MIRT1048337	hsa-miR-4459	CLIP-seq
MIRT1048338	hsa-miR-4473	CLIP-seq
MIRT1048339	hsa-miR-4478	CLIP-seq
MIRT1048340	hsa-miR-4492	CLIP-seq
MIRT1048341	hsa-miR-4498	CLIP-seq
MIRT1048342	hsa-miR-4505	CLIP-seq
MIRT1048343	hsa-miR-4529-5p	CLIP-seq
MIRT1048344	hsa-miR-4649-3p	CLIP-seq
MIRT1048345	hsa-miR-4671-3p	CLIP-seq
MIRT1048346	hsa-miR-4680-5p	CLIP-seq
MIRT1048347	hsa-miR-4695-5p	CLIP-seq
MIRT1048348	hsa-miR-4708-5p	CLIP-seq
MIRT1048349	hsa-miR-4722-5p	CLIP-seq
MIRT1048350	hsa-miR-4726-3p	CLIP-seq
MIRT1048351	hsa-miR-4732-5p	CLIP-seq
MIRT1048352	hsa-miR-4733-3p	CLIP-seq
MIRT1048353	hsa-miR-4747-5p	CLIP-seq
MIRT1048354	hsa-miR-4768-3p	CLIP-seq
MIRT1048355	hsa-miR-4770	CLIP-seq
MIRT1048356	hsa-miR-4774-3p	CLIP-seq
MIRT1048357	hsa-miR-4786-5p	CLIP-seq
MIRT1048358	hsa-miR-4790-3p	CLIP-seq
MIRT1048359	hsa-miR-4793-5p	CLIP-seq
MIRT1048360	hsa-miR-4797-5p	CLIP-seq
MIRT1048361	hsa-miR-485-5p	CLIP-seq
MIRT1048362	hsa-miR-508-5p	CLIP-seq
MIRT1048363	hsa-miR-510	CLIP-seq
MIRT1048364	hsa-miR-512-3p	CLIP-seq
MIRT1048365	hsa-miR-512-5p	CLIP-seq
MIRT1048366	hsa-miR-520f	CLIP-seq
MIRT1048367	hsa-miR-542-3p	CLIP-seq
MIRT1048368	hsa-miR-548s	CLIP-seq
MIRT1048369	hsa-miR-554	CLIP-seq
MIRT1048370	hsa-miR-561	CLIP-seq
MIRT1048371	hsa-miR-615-5p	CLIP-seq
MIRT1048372	hsa-miR-645	CLIP-seq
MIRT1048373	hsa-miR-665	CLIP-seq
MIRT1048374	hsa-miR-759	CLIP-seq
MIRT1048375	hsa-miR-762	CLIP-seq
MIRT1048376	hsa-miR-766	CLIP-seq
MIRT1048377	hsa-miR-767-5p	CLIP-seq
MIRT1048378	hsa-miR-769-5p	CLIP-seq
MIRT1048379	hsa-miR-940	CLIP-seq
MIRT1549532	hsa-miR-1910	CLIP-seq
MIRT1549533	hsa-miR-4421	CLIP-seq
MIRT1549534	hsa-miR-4757-5p	CLIP-seq
MIRT2010991	hsa-miR-1184	CLIP-seq
MIRT1048299	hsa-miR-1273f	CLIP-seq
MIRT2010992	hsa-miR-1343	CLIP-seq
MIRT2010993	hsa-miR-145	CLIP-seq
MIRT1048306	hsa-miR-24	CLIP-seq
MIRT2010994	hsa-miR-3122	CLIP-seq
MIRT1048310	hsa-miR-3180-5p	CLIP-seq
MIRT1048314	hsa-miR-3545-3p	CLIP-seq
MIRT1048317	hsa-miR-3652	CLIP-seq
MIRT2010995	hsa-miR-3689a-3p	CLIP-seq
MIRT2010996	hsa-miR-3689c	CLIP-seq
MIRT2010997	hsa-miR-378g	CLIP-seq
MIRT2010998	hsa-miR-3913-5p	CLIP-seq
MIRT1048328	hsa-miR-4284	CLIP-seq
MIRT2010999	hsa-miR-4418	CLIP-seq
MIRT1048333	hsa-miR-4430	CLIP-seq
MIRT2011000	hsa-miR-4437	CLIP-seq
MIRT1048342	hsa-miR-4505	CLIP-seq
MIRT2011001	hsa-miR-4674	CLIP-seq
MIRT1048346	hsa-miR-4680-5p	CLIP-seq
MIRT2011002	hsa-miR-4712-5p	CLIP-seq
MIRT1048353	hsa-miR-4747-5p	CLIP-seq
MIRT2011003	hsa-miR-509-3-5p	CLIP-seq
MIRT2011004	hsa-miR-509-5p	CLIP-seq
MIRT1048368	hsa-miR-548s	CLIP-seq
MIRT2011005	hsa-miR-770-5p	CLIP-seq
MIRT2010991	hsa-miR-1184	CLIP-seq
MIRT1048297	hsa-miR-122	CLIP-seq
MIRT2243257	hsa-miR-1228	CLIP-seq
MIRT1048299	hsa-miR-1273f	CLIP-seq
MIRT2010992	hsa-miR-1343	CLIP-seq
MIRT1048300	hsa-miR-135a	CLIP-seq
MIRT1048301	hsa-miR-135b	CLIP-seq
MIRT2243258	hsa-miR-142-3p	CLIP-seq
MIRT1048302	hsa-miR-143	CLIP-seq
MIRT2010993	hsa-miR-145	CLIP-seq
MIRT1048303	hsa-miR-1827	CLIP-seq
MIRT1048305	hsa-miR-2114	CLIP-seq
MIRT1048306	hsa-miR-24	CLIP-seq
MIRT2243259	hsa-miR-296-3p	CLIP-seq
MIRT1048308	hsa-miR-3135b	CLIP-seq
MIRT2243260	hsa-miR-3160-3p	CLIP-seq
MIRT1048314	hsa-miR-3545-3p	CLIP-seq
MIRT1048317	hsa-miR-3652	CLIP-seq
MIRT1048318	hsa-miR-3664-3p	CLIP-seq
MIRT2243261	hsa-miR-3664-5p	CLIP-seq
MIRT2243262	hsa-miR-3677-5p	CLIP-seq
MIRT2243263	hsa-miR-3682-3p	CLIP-seq
MIRT2010995	hsa-miR-3689a-3p	CLIP-seq
MIRT2010996	hsa-miR-3689c	CLIP-seq
MIRT1048322	hsa-miR-3689d	CLIP-seq
MIRT2010997	hsa-miR-378g	CLIP-seq
MIRT1048325	hsa-miR-3929	CLIP-seq
MIRT2243264	hsa-miR-4280	CLIP-seq
MIRT1048328	hsa-miR-4284	CLIP-seq
MIRT2010999	hsa-miR-4418	CLIP-seq
MIRT1048332	hsa-miR-4419b	CLIP-seq
MIRT1048333	hsa-miR-4430	CLIP-seq
MIRT1048335	hsa-miR-4433	CLIP-seq
MIRT2011000	hsa-miR-4437	CLIP-seq
MIRT1048337	hsa-miR-4459	CLIP-seq
MIRT1048339	hsa-miR-4478	CLIP-seq
MIRT2243265	hsa-miR-4487	CLIP-seq
MIRT2243266	hsa-miR-4639-3p	CLIP-seq
MIRT1048344	hsa-miR-4649-3p	CLIP-seq
MIRT2243267	hsa-miR-4652-3p	CLIP-seq
MIRT2011001	hsa-miR-4674	CLIP-seq
MIRT1048346	hsa-miR-4680-5p	CLIP-seq
MIRT1048347	hsa-miR-4695-5p	CLIP-seq
MIRT1048348	hsa-miR-4708-5p	CLIP-seq
MIRT2011002	hsa-miR-4712-5p	CLIP-seq
MIRT1048349	hsa-miR-4722-5p	CLIP-seq
MIRT2243268	hsa-miR-4728-5p	CLIP-seq
MIRT1048354	hsa-miR-4768-3p	CLIP-seq
MIRT1048355	hsa-miR-4770	CLIP-seq
MIRT1048361	hsa-miR-485-5p	CLIP-seq
MIRT2011003	hsa-miR-509-3-5p	CLIP-seq
MIRT2011004	hsa-miR-509-5p	CLIP-seq
MIRT1048363	hsa-miR-510	CLIP-seq
MIRT1048365	hsa-miR-512-5p	CLIP-seq
MIRT2243269	hsa-miR-558	CLIP-seq
MIRT2243270	hsa-miR-598	CLIP-seq
MIRT1048372	hsa-miR-645	CLIP-seq
MIRT2011005	hsa-miR-770-5p	CLIP-seq
MIRT2243271	hsa-miR-935	CLIP-seq
MIRT1048379	hsa-miR-940	CLIP-seq
MIRT2010991	hsa-miR-1184	CLIP-seq
MIRT1048306	hsa-miR-24	CLIP-seq
MIRT1048310	hsa-miR-3180-5p	CLIP-seq
MIRT1048314	hsa-miR-3545-3p	CLIP-seq
MIRT1048328	hsa-miR-4284	CLIP-seq
MIRT2010999	hsa-miR-4418	CLIP-seq
MIRT1048346	hsa-miR-4680-5p	CLIP-seq
MIRT2011003	hsa-miR-509-3-5p	CLIP-seq
MIRT2011004	hsa-miR-509-5p	CLIP-seq
MIRT2451234	hsa-miR-1182	CLIP-seq
MIRT1048297	hsa-miR-122	CLIP-seq
MIRT1048308	hsa-miR-3135b	CLIP-seq
MIRT1048317	hsa-miR-3652	CLIP-seq
MIRT2243261	hsa-miR-3664-5p	CLIP-seq
MIRT1048325	hsa-miR-3929	CLIP-seq
MIRT1048332	hsa-miR-4419b	CLIP-seq
MIRT1048333	hsa-miR-4430	CLIP-seq
MIRT1048339	hsa-miR-4478	CLIP-seq
MIRT2243266	hsa-miR-4639-3p	CLIP-seq
MIRT1048372	hsa-miR-645	CLIP-seq
MIRT1048297	hsa-miR-122	CLIP-seq
MIRT1048298	hsa-miR-1272	CLIP-seq
MIRT2546435	hsa-miR-2277-3p	CLIP-seq
MIRT1048306	hsa-miR-24	CLIP-seq
MIRT1048308	hsa-miR-3135b	CLIP-seq
MIRT1048317	hsa-miR-3652	CLIP-seq
MIRT2546436	hsa-miR-3662	CLIP-seq
MIRT1048324	hsa-miR-3926	CLIP-seq
MIRT1048325	hsa-miR-3929	CLIP-seq
MIRT1048328	hsa-miR-4284	CLIP-seq
MIRT1048332	hsa-miR-4419b	CLIP-seq
MIRT1048333	hsa-miR-4430	CLIP-seq
MIRT1048339	hsa-miR-4478	CLIP-seq
MIRT1048343	hsa-miR-4529-5p	CLIP-seq
MIRT2546437	hsa-miR-4638-5p	CLIP-seq
MIRT2546438	hsa-miR-4684-5p	CLIP-seq
MIRT1048359	hsa-miR-4793-5p	CLIP-seq
MIRT2546439	hsa-miR-548c-3p	CLIP-seq
MIRT1048368	hsa-miR-548s	CLIP-seq
MIRT1048372	hsa-miR-645	CLIP-seq
MIRT1048297	hsa-miR-122	CLIP-seq
MIRT1048298	hsa-miR-1272	CLIP-seq
MIRT2546435	hsa-miR-2277-3p	CLIP-seq
MIRT1048308	hsa-miR-3135b	CLIP-seq
MIRT1048317	hsa-miR-3652	CLIP-seq
MIRT2546436	hsa-miR-3662	CLIP-seq
MIRT1048325	hsa-miR-3929	CLIP-seq
MIRT1048332	hsa-miR-4419b	CLIP-seq
MIRT1048333	hsa-miR-4430	CLIP-seq
MIRT1048339	hsa-miR-4478	CLIP-seq
MIRT2546437	hsa-miR-4638-5p	CLIP-seq
MIRT2546438	hsa-miR-4684-5p	CLIP-seq
MIRT2546439	hsa-miR-548c-3p	CLIP-seq
MIRT1048372	hsa-miR-645	CLIP-seq

Transcription factors

Show/Hide all(4)

Transcription factor	Regulation	Reference
CIITA	Activation	11823510
RFX5	Unknown	11258423
RFXANK	Unknown	11258423
RFXAP	Unknown	11258423

Show/Hide all(30)

GO ID	Ontology	Definition	Evidence	Reference
GO:0002250	Process	Adaptive immune response	IEA
GO:0002376	Process	Immune system process	IEA
GO:0002503	Process	Peptide antigen assembly with MHC class II protein complex	IBA
GO:0002504	Process	Antigen processing and presentation of peptide or polysaccharide antigen via MHC class II	IEA
GO:0002587	Process	Negative regulation of antigen processing and presentation of peptide antigen via MHC class II	IDA	22733780
GO:0005515	Function	Protein binding	IPI	25416956
GO:0005764	Component	Lysosome	IEA
GO:0005765	Component	Lysosomal membrane	IBA
GO:0005765	Component	Lysosomal membrane	IEA
GO:0005765	Component	Lysosomal membrane	TAS
GO:0005768	Component	Endosome	IEA
GO:0005886	Component	Plasma membrane	TAS	3000765
GO:0006955	Process	Immune response	IEA
GO:0010008	Component	Endosome membrane	IEA
GO:0016020	Component	Membrane	IEA
GO:0019882	Process	Antigen processing and presentation	IEA
GO:0019882	Process	Antigen processing and presentation	IEA
GO:0019886	Process	Antigen processing and presentation of exogenous peptide antigen via MHC class II	IBA
GO:0019886	Process	Antigen processing and presentation of exogenous peptide antigen via MHC class II	IEA
GO:0023026	Function	MHC class II protein complex binding	IBA
GO:0023026	Function	MHC class II protein complex binding	IDA	22733780
GO:0031902	Component	Late endosome membrane	IBA
GO:0032395	Function	MHC class II receptor activity	TAS	3000765
GO:0042605	Function	Peptide antigen binding	IBA
GO:0042613	Component	MHC class II protein complex	IBA
GO:0042613	Component	MHC class II protein complex	IDA	22733780
GO:0042613	Component	MHC class II protein complex	IEA
GO:0045580	Process	Regulation of T cell differentiation	IEA
GO:0050778	Process	Positive regulation of immune response	IBA
GO:0050870	Process	Positive regulation of T cell activation	IBA

MIM	HGNC	e!Ensembl
142930	4936	ENSG00000204252

Protein

UniProt ID

P06340

Protein name

HLA class II histocompatibility antigen, DO alpha chain (MHC DN-alpha) (MHC DZ alpha) (MHC class II antigen DOA)

Protein function

Important modulator in the HLA class II restricted antigen presentation pathway by interaction with the HLA-DM molecule in B-cells. Modifies peptide exchange activity of HLA-DM.

PDB

4I0P

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00993	MHC_II_alpha	29 → 109	Class II histocompatibility antigen, alpha domain	Domain
PF07654	C1-set	115 → 196	Immunoglobulin C1-set domain	Domain

Sequence

MALRAGLVLGFHTLMTLLSPQEAGATKADHMGSYGPAFYQSYGASGQFTHEFDEEQLFSV
DLKKSEAVWRLPEFGDFARFDPQGGLAGIAAIKAHLDILVERSNRSRAINVPPRVTVLPK
SRVELGQPNILICIVDNIFPPVINITWLRNGQTVTEGVAQTSFYSQPDHLFRKFHYLPFV
PSAEDVYDCQVEHWGLDAPLLRHWELQVPIPPPDAMETLVCALGLAIGLVGFLVGTVLII
MGTYVSSVPR

Sequence length

250

Interactions

View interactions

	KEGG		Reactome
	Phagosome Cell adhesion molecules Antigen processing and presentation Hematopoietic cell lineage Th1 and Th2 cell differentiation Th17 cell differentiation Intestinal immune network for IgA production Type I diabetes mellitus Leishmaniasis Toxoplasmosis Staphylococcus aureus infection Tuberculosis Influenza A Human T-cell leukemia virus 1 infection Herpes simplex virus 1 infection Epstein-Barr virus infection Asthma Autoimmune thyroid disease Inflammatory bowel disease Systemic lupus erythematosus Rheumatoid arthritis Allograft rejection Graft-versus-host disease Viral myocarditis		MHC class II antigen presentation

HLA-DOA (major histocompatibility complex, class II, DO alpha)