HLA-DOA (major histocompatibility complex, class II, DO alpha)

Gene

• Entrez ID: 3111
• Gene name: Major histocompatibility complex, class II, DO alpha
• Gene symbol: HLA-DOA
• Synonyms (NCBI Gene): HLA-DNA, HLA-DZA, HLADZ
• Chromosome: 6
• Chromosome location: 6p21.32
• Summary: HLA-DOA belongs to the HLA class II alpha chain paralogues. HLA-DOA forms a heterodimer with HLA-DOB. The heterodimer, HLA-DO, is found in lysosomes in B cells and regulates HLA-DM-mediated peptide loading on MHC class II molecules. In comparison with cla

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT491507	hsa-miR-6732-5p	PAR-CLIP	23592263
MIRT491505	hsa-miR-3928-3p	PAR-CLIP	23592263
MIRT491503	hsa-miR-3184-5p	PAR-CLIP	23592263
MIRT491504	hsa-miR-423-5p	PAR-CLIP	23592263
MIRT491502	hsa-miR-1914-3p	PAR-CLIP	23592263
MIRT491501	hsa-miR-5194	PAR-CLIP	23592263
MIRT491499	hsa-miR-6738-5p	PAR-CLIP	23592263
MIRT491500	hsa-miR-7160-5p	PAR-CLIP	23592263
MIRT491498	hsa-miR-7704	PAR-CLIP	23592263
MIRT491496	hsa-miR-3915	PAR-CLIP	23592263
MIRT491497	hsa-miR-6734-5p	PAR-CLIP	23592263
MIRT448019	hsa-miR-4511	PAR-CLIP	22100165
MIRT448018	hsa-miR-146a-3p	PAR-CLIP	22100165
MIRT448017	hsa-miR-301a-5p	PAR-CLIP	22100165
MIRT448016	hsa-miR-301b-5p	PAR-CLIP	22100165
MIRT448015	hsa-miR-3921	PAR-CLIP	22100165
MIRT448014	hsa-miR-4653-5p	PAR-CLIP	22100165
MIRT450608	hsa-miR-130b-5p	PAR-CLIP	22100165
MIRT448012	hsa-miR-4251	PAR-CLIP	22100165
MIRT448013	hsa-miR-4329	PAR-CLIP	22100165
MIRT448011	hsa-miR-6761-5p	PAR-CLIP	22100165
MIRT448010	hsa-miR-6859-3p	PAR-CLIP	22100165
MIRT448009	hsa-miR-6846-3p	PAR-CLIP	22100165
MIRT448008	hsa-miR-1253	PAR-CLIP	22100165
MIRT448007	hsa-miR-6770-5p	PAR-CLIP	22100165
MIRT448006	hsa-miR-3191-5p	PAR-CLIP	22100165
MIRT448005	hsa-miR-4768-5p	PAR-CLIP	22100165
MIRT448004	hsa-miR-6833-3p	PAR-CLIP	22100165
MIRT448002	hsa-miR-6809-3p	PAR-CLIP	22100165
MIRT448019	hsa-miR-4511	PAR-CLIP	22100165
MIRT448018	hsa-miR-146a-3p	PAR-CLIP	22100165
MIRT448017	hsa-miR-301a-5p	PAR-CLIP	22100165
MIRT448016	hsa-miR-301b-5p	PAR-CLIP	22100165
MIRT448015	hsa-miR-3921	PAR-CLIP	22100165
MIRT448014	hsa-miR-4653-5p	PAR-CLIP	22100165
MIRT448012	hsa-miR-4251	PAR-CLIP	22100165
MIRT448013	hsa-miR-4329	PAR-CLIP	22100165
MIRT448011	hsa-miR-6761-5p	PAR-CLIP	22100165
MIRT448010	hsa-miR-6859-3p	PAR-CLIP	22100165
MIRT448009	hsa-miR-6846-3p	PAR-CLIP	22100165
MIRT448008	hsa-miR-1253	PAR-CLIP	22100165
MIRT448007	hsa-miR-6770-5p	PAR-CLIP	22100165
MIRT448006	hsa-miR-3191-5p	PAR-CLIP	22100165
MIRT448005	hsa-miR-4768-5p	PAR-CLIP	22100165
MIRT448004	hsa-miR-6833-3p	PAR-CLIP	22100165
MIRT448002	hsa-miR-6809-3p	PAR-CLIP	22100165
MIRT491507	hsa-miR-6732-5p	PAR-CLIP	23592263
MIRT491505	hsa-miR-3928-3p	PAR-CLIP	23592263
MIRT491503	hsa-miR-3184-5p	PAR-CLIP	23592263
MIRT491504	hsa-miR-423-5p	PAR-CLIP	23592263
MIRT491502	hsa-miR-1914-3p	PAR-CLIP	23592263
MIRT491501	hsa-miR-5194	PAR-CLIP	23592263
MIRT491499	hsa-miR-6738-5p	PAR-CLIP	23592263
MIRT491500	hsa-miR-7160-5p	PAR-CLIP	23592263
MIRT491498	hsa-miR-7704	PAR-CLIP	23592263
MIRT491496	hsa-miR-3915	PAR-CLIP	23592263
MIRT491497	hsa-miR-6734-5p	PAR-CLIP	23592263
MIRT448019	hsa-miR-4511	PAR-CLIP	22100165
MIRT448018	hsa-miR-146a-3p	PAR-CLIP	22100165
MIRT448017	hsa-miR-301a-5p	PAR-CLIP	22100165
MIRT448016	hsa-miR-301b-5p	PAR-CLIP	22100165
MIRT448015	hsa-miR-3921	PAR-CLIP	22100165
MIRT448014	hsa-miR-4653-5p	PAR-CLIP	22100165
MIRT450608	hsa-miR-130b-5p	PAR-CLIP	22100165
MIRT448012	hsa-miR-4251	PAR-CLIP	22100165
MIRT448013	hsa-miR-4329	PAR-CLIP	22100165
MIRT448011	hsa-miR-6761-5p	PAR-CLIP	22100165
MIRT448010	hsa-miR-6859-3p	PAR-CLIP	22100165
MIRT448009	hsa-miR-6846-3p	PAR-CLIP	22100165
MIRT448008	hsa-miR-1253	PAR-CLIP	22100165
MIRT448007	hsa-miR-6770-5p	PAR-CLIP	22100165
MIRT448006	hsa-miR-3191-5p	PAR-CLIP	22100165
MIRT448005	hsa-miR-4768-5p	PAR-CLIP	22100165
MIRT448004	hsa-miR-6833-3p	PAR-CLIP	22100165
MIRT448002	hsa-miR-6809-3p	PAR-CLIP	22100165
MIRT448019	hsa-miR-4511	PAR-CLIP	22100165
MIRT448018	hsa-miR-146a-3p	PAR-CLIP	22100165
MIRT448017	hsa-miR-301a-5p	PAR-CLIP	22100165
MIRT448016	hsa-miR-301b-5p	PAR-CLIP	22100165
MIRT448015	hsa-miR-3921	PAR-CLIP	22100165
MIRT448014	hsa-miR-4653-5p	PAR-CLIP	22100165
MIRT448012	hsa-miR-4251	PAR-CLIP	22100165
MIRT448013	hsa-miR-4329	PAR-CLIP	22100165
MIRT448011	hsa-miR-6761-5p	PAR-CLIP	22100165
MIRT448010	hsa-miR-6859-3p	PAR-CLIP	22100165
MIRT448009	hsa-miR-6846-3p	PAR-CLIP	22100165
MIRT448008	hsa-miR-1253	PAR-CLIP	22100165
MIRT448007	hsa-miR-6770-5p	PAR-CLIP	22100165
MIRT448006	hsa-miR-3191-5p	PAR-CLIP	22100165
MIRT448005	hsa-miR-4768-5p	PAR-CLIP	22100165
MIRT448004	hsa-miR-6833-3p	PAR-CLIP	22100165
MIRT448002	hsa-miR-6809-3p	PAR-CLIP	22100165
MIRT1048296	hsa-miR-1202	CLIP-seq
MIRT1048297	hsa-miR-122	CLIP-seq
MIRT1048298	hsa-miR-1272	CLIP-seq
MIRT1048299	hsa-miR-1273f	CLIP-seq
MIRT1048300	hsa-miR-135a	CLIP-seq
MIRT1048301	hsa-miR-135b	CLIP-seq
MIRT1048302	hsa-miR-143	CLIP-seq
MIRT1048303	hsa-miR-1827	CLIP-seq
MIRT1048304	hsa-miR-1972	CLIP-seq
MIRT1048305	hsa-miR-2114	CLIP-seq
MIRT1048306	hsa-miR-24	CLIP-seq
MIRT1048307	hsa-miR-3130-3p	CLIP-seq
MIRT1048308	hsa-miR-3135b	CLIP-seq
MIRT1048309	hsa-miR-3152-5p	CLIP-seq
MIRT1048310	hsa-miR-3180-5p	CLIP-seq
MIRT1048311	hsa-miR-3194-5p	CLIP-seq
MIRT1048312	hsa-miR-3202	CLIP-seq
MIRT1048313	hsa-miR-325	CLIP-seq
MIRT1048314	hsa-miR-3545-3p	CLIP-seq
MIRT1048315	hsa-miR-3591-5p	CLIP-seq
MIRT1048316	hsa-miR-3614-3p	CLIP-seq
MIRT1048317	hsa-miR-3652	CLIP-seq
MIRT1048318	hsa-miR-3664-3p	CLIP-seq
MIRT1048319	hsa-miR-3667-3p	CLIP-seq
MIRT1048320	hsa-miR-3668	CLIP-seq
MIRT1048321	hsa-miR-3674	CLIP-seq
MIRT1048322	hsa-miR-3689d	CLIP-seq
MIRT1048323	hsa-miR-384	CLIP-seq
MIRT1048324	hsa-miR-3926	CLIP-seq
MIRT1048325	hsa-miR-3929	CLIP-seq
MIRT1048326	hsa-miR-3972	CLIP-seq
MIRT1048327	hsa-miR-4252	CLIP-seq
MIRT1048328	hsa-miR-4284	CLIP-seq
MIRT1048329	hsa-miR-4297	CLIP-seq
MIRT1048330	hsa-miR-4299	CLIP-seq
MIRT1048331	hsa-miR-4324	CLIP-seq
MIRT1048332	hsa-miR-4419b	CLIP-seq
MIRT1048333	hsa-miR-4430	CLIP-seq
MIRT1048334	hsa-miR-4431	CLIP-seq
MIRT1048335	hsa-miR-4433	CLIP-seq
MIRT1048336	hsa-miR-4446-3p	CLIP-seq
MIRT1048337	hsa-miR-4459	CLIP-seq
MIRT1048338	hsa-miR-4473	CLIP-seq
MIRT1048339	hsa-miR-4478	CLIP-seq
MIRT1048340	hsa-miR-4492	CLIP-seq
MIRT1048341	hsa-miR-4498	CLIP-seq
MIRT1048342	hsa-miR-4505	CLIP-seq
MIRT1048343	hsa-miR-4529-5p	CLIP-seq
MIRT1048344	hsa-miR-4649-3p	CLIP-seq
MIRT1048345	hsa-miR-4671-3p	CLIP-seq
MIRT1048346	hsa-miR-4680-5p	CLIP-seq
MIRT1048347	hsa-miR-4695-5p	CLIP-seq
MIRT1048348	hsa-miR-4708-5p	CLIP-seq
MIRT1048349	hsa-miR-4722-5p	CLIP-seq
MIRT1048350	hsa-miR-4726-3p	CLIP-seq
MIRT1048351	hsa-miR-4732-5p	CLIP-seq
MIRT1048352	hsa-miR-4733-3p	CLIP-seq
MIRT1048353	hsa-miR-4747-5p	CLIP-seq
MIRT1048354	hsa-miR-4768-3p	CLIP-seq
MIRT1048355	hsa-miR-4770	CLIP-seq
MIRT1048356	hsa-miR-4774-3p	CLIP-seq
MIRT1048357	hsa-miR-4786-5p	CLIP-seq
MIRT1048358	hsa-miR-4790-3p	CLIP-seq
MIRT1048359	hsa-miR-4793-5p	CLIP-seq
MIRT1048360	hsa-miR-4797-5p	CLIP-seq
MIRT1048361	hsa-miR-485-5p	CLIP-seq
MIRT1048362	hsa-miR-508-5p	CLIP-seq
MIRT1048363	hsa-miR-510	CLIP-seq
MIRT1048364	hsa-miR-512-3p	CLIP-seq
MIRT1048365	hsa-miR-512-5p	CLIP-seq
MIRT1048366	hsa-miR-520f	CLIP-seq
MIRT1048367	hsa-miR-542-3p	CLIP-seq
MIRT1048368	hsa-miR-548s	CLIP-seq
MIRT1048369	hsa-miR-554	CLIP-seq
MIRT1048370	hsa-miR-561	CLIP-seq
MIRT1048371	hsa-miR-615-5p	CLIP-seq
MIRT1048372	hsa-miR-645	CLIP-seq
MIRT1048373	hsa-miR-665	CLIP-seq
MIRT1048374	hsa-miR-759	CLIP-seq
MIRT1048375	hsa-miR-762	CLIP-seq
MIRT1048376	hsa-miR-766	CLIP-seq
MIRT1048377	hsa-miR-767-5p	CLIP-seq
MIRT1048378	hsa-miR-769-5p	CLIP-seq
MIRT1048379	hsa-miR-940	CLIP-seq
MIRT1549532	hsa-miR-1910	CLIP-seq
MIRT1549533	hsa-miR-4421	CLIP-seq
MIRT1549534	hsa-miR-4757-5p	CLIP-seq
MIRT2010991	hsa-miR-1184	CLIP-seq
MIRT1048299	hsa-miR-1273f	CLIP-seq
MIRT2010992	hsa-miR-1343	CLIP-seq
MIRT2010993	hsa-miR-145	CLIP-seq
MIRT1048306	hsa-miR-24	CLIP-seq
MIRT2010994	hsa-miR-3122	CLIP-seq
MIRT1048310	hsa-miR-3180-5p	CLIP-seq
MIRT1048314	hsa-miR-3545-3p	CLIP-seq
MIRT1048317	hsa-miR-3652	CLIP-seq
MIRT2010995	hsa-miR-3689a-3p	CLIP-seq
MIRT2010996	hsa-miR-3689c	CLIP-seq
MIRT2010997	hsa-miR-378g	CLIP-seq
MIRT2010998	hsa-miR-3913-5p	CLIP-seq
MIRT1048328	hsa-miR-4284	CLIP-seq
MIRT2010999	hsa-miR-4418	CLIP-seq
MIRT1048333	hsa-miR-4430	CLIP-seq
MIRT2011000	hsa-miR-4437	CLIP-seq
MIRT1048342	hsa-miR-4505	CLIP-seq
MIRT2011001	hsa-miR-4674	CLIP-seq
MIRT1048346	hsa-miR-4680-5p	CLIP-seq
MIRT2011002	hsa-miR-4712-5p	CLIP-seq
MIRT1048353	hsa-miR-4747-5p	CLIP-seq
MIRT2011003	hsa-miR-509-3-5p	CLIP-seq
MIRT2011004	hsa-miR-509-5p	CLIP-seq
MIRT1048368	hsa-miR-548s	CLIP-seq
MIRT2011005	hsa-miR-770-5p	CLIP-seq
MIRT2010991	hsa-miR-1184	CLIP-seq
MIRT1048297	hsa-miR-122	CLIP-seq
MIRT2243257	hsa-miR-1228	CLIP-seq
MIRT1048299	hsa-miR-1273f	CLIP-seq
MIRT2010992	hsa-miR-1343	CLIP-seq
MIRT1048300	hsa-miR-135a	CLIP-seq
MIRT1048301	hsa-miR-135b	CLIP-seq
MIRT2243258	hsa-miR-142-3p	CLIP-seq
MIRT1048302	hsa-miR-143	CLIP-seq
MIRT2010993	hsa-miR-145	CLIP-seq
MIRT1048303	hsa-miR-1827	CLIP-seq
MIRT1048305	hsa-miR-2114	CLIP-seq
MIRT1048306	hsa-miR-24	CLIP-seq
MIRT2243259	hsa-miR-296-3p	CLIP-seq
MIRT1048308	hsa-miR-3135b	CLIP-seq
MIRT2243260	hsa-miR-3160-3p	CLIP-seq
MIRT1048314	hsa-miR-3545-3p	CLIP-seq
MIRT1048317	hsa-miR-3652	CLIP-seq
MIRT1048318	hsa-miR-3664-3p	CLIP-seq
MIRT2243261	hsa-miR-3664-5p	CLIP-seq
MIRT2243262	hsa-miR-3677-5p	CLIP-seq
MIRT2243263	hsa-miR-3682-3p	CLIP-seq
MIRT2010995	hsa-miR-3689a-3p	CLIP-seq
MIRT2010996	hsa-miR-3689c	CLIP-seq
MIRT1048322	hsa-miR-3689d	CLIP-seq
MIRT2010997	hsa-miR-378g	CLIP-seq
MIRT1048325	hsa-miR-3929	CLIP-seq
MIRT2243264	hsa-miR-4280	CLIP-seq
MIRT1048328	hsa-miR-4284	CLIP-seq
MIRT2010999	hsa-miR-4418	CLIP-seq
MIRT1048332	hsa-miR-4419b	CLIP-seq
MIRT1048333	hsa-miR-4430	CLIP-seq
MIRT1048335	hsa-miR-4433	CLIP-seq
MIRT2011000	hsa-miR-4437	CLIP-seq
MIRT1048337	hsa-miR-4459	CLIP-seq
MIRT1048339	hsa-miR-4478	CLIP-seq
MIRT2243265	hsa-miR-4487	CLIP-seq
MIRT2243266	hsa-miR-4639-3p	CLIP-seq
MIRT1048344	hsa-miR-4649-3p	CLIP-seq
MIRT2243267	hsa-miR-4652-3p	CLIP-seq
MIRT2011001	hsa-miR-4674	CLIP-seq
MIRT1048346	hsa-miR-4680-5p	CLIP-seq
MIRT1048347	hsa-miR-4695-5p	CLIP-seq
MIRT1048348	hsa-miR-4708-5p	CLIP-seq
MIRT2011002	hsa-miR-4712-5p	CLIP-seq
MIRT1048349	hsa-miR-4722-5p	CLIP-seq
MIRT2243268	hsa-miR-4728-5p	CLIP-seq
MIRT1048354	hsa-miR-4768-3p	CLIP-seq
MIRT1048355	hsa-miR-4770	CLIP-seq
MIRT1048361	hsa-miR-485-5p	CLIP-seq
MIRT2011003	hsa-miR-509-3-5p	CLIP-seq
MIRT2011004	hsa-miR-509-5p	CLIP-seq
MIRT1048363	hsa-miR-510	CLIP-seq
MIRT1048365	hsa-miR-512-5p	CLIP-seq
MIRT2243269	hsa-miR-558	CLIP-seq
MIRT2243270	hsa-miR-598	CLIP-seq
MIRT1048372	hsa-miR-645	CLIP-seq
MIRT2011005	hsa-miR-770-5p	CLIP-seq
MIRT2243271	hsa-miR-935	CLIP-seq
MIRT1048379	hsa-miR-940	CLIP-seq
MIRT2010991	hsa-miR-1184	CLIP-seq
MIRT1048306	hsa-miR-24	CLIP-seq
MIRT1048310	hsa-miR-3180-5p	CLIP-seq
MIRT1048314	hsa-miR-3545-3p	CLIP-seq
MIRT1048328	hsa-miR-4284	CLIP-seq
MIRT2010999	hsa-miR-4418	CLIP-seq
MIRT1048346	hsa-miR-4680-5p	CLIP-seq
MIRT2011003	hsa-miR-509-3-5p	CLIP-seq
MIRT2011004	hsa-miR-509-5p	CLIP-seq
MIRT2451234	hsa-miR-1182	CLIP-seq
MIRT1048297	hsa-miR-122	CLIP-seq
MIRT1048308	hsa-miR-3135b	CLIP-seq
MIRT1048317	hsa-miR-3652	CLIP-seq
MIRT2243261	hsa-miR-3664-5p	CLIP-seq
MIRT1048325	hsa-miR-3929	CLIP-seq
MIRT1048332	hsa-miR-4419b	CLIP-seq
MIRT1048333	hsa-miR-4430	CLIP-seq
MIRT1048339	hsa-miR-4478	CLIP-seq
MIRT2243266	hsa-miR-4639-3p	CLIP-seq
MIRT1048372	hsa-miR-645	CLIP-seq
MIRT1048297	hsa-miR-122	CLIP-seq
MIRT1048298	hsa-miR-1272	CLIP-seq
MIRT2546435	hsa-miR-2277-3p	CLIP-seq
MIRT1048306	hsa-miR-24	CLIP-seq
MIRT1048308	hsa-miR-3135b	CLIP-seq
MIRT1048317	hsa-miR-3652	CLIP-seq
MIRT2546436	hsa-miR-3662	CLIP-seq
MIRT1048324	hsa-miR-3926	CLIP-seq
MIRT1048325	hsa-miR-3929	CLIP-seq
MIRT1048328	hsa-miR-4284	CLIP-seq
MIRT1048332	hsa-miR-4419b	CLIP-seq
MIRT1048333	hsa-miR-4430	CLIP-seq
MIRT1048339	hsa-miR-4478	CLIP-seq
MIRT1048343	hsa-miR-4529-5p	CLIP-seq
MIRT2546437	hsa-miR-4638-5p	CLIP-seq
MIRT2546438	hsa-miR-4684-5p	CLIP-seq
MIRT1048359	hsa-miR-4793-5p	CLIP-seq
MIRT2546439	hsa-miR-548c-3p	CLIP-seq
MIRT1048368	hsa-miR-548s	CLIP-seq
MIRT1048372	hsa-miR-645	CLIP-seq
MIRT1048297	hsa-miR-122	CLIP-seq
MIRT1048298	hsa-miR-1272	CLIP-seq
MIRT2546435	hsa-miR-2277-3p	CLIP-seq
MIRT1048308	hsa-miR-3135b	CLIP-seq
MIRT1048317	hsa-miR-3652	CLIP-seq
MIRT2546436	hsa-miR-3662	CLIP-seq
MIRT1048325	hsa-miR-3929	CLIP-seq
MIRT1048332	hsa-miR-4419b	CLIP-seq
MIRT1048333	hsa-miR-4430	CLIP-seq
MIRT1048339	hsa-miR-4478	CLIP-seq
MIRT2546437	hsa-miR-4638-5p	CLIP-seq
MIRT2546438	hsa-miR-4684-5p	CLIP-seq
MIRT2546439	hsa-miR-548c-3p	CLIP-seq
MIRT1048372	hsa-miR-645	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
CIITA	Activation	11823510
RFX5	Unknown	11258423
RFXANK	Unknown	11258423
RFXAP	Unknown	11258423

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0002250	Process	Adaptive immune response	IEA
GO:0002376	Process	Immune system process	IEA
GO:0002503	Process	Peptide antigen assembly with MHC class II protein complex	IBA
GO:0002504	Process	Antigen processing and presentation of peptide or polysaccharide antigen via MHC class II	IEA
GO:0002587	Process	Negative regulation of antigen processing and presentation of peptide antigen via MHC class II	IDA	22733780
GO:0005515	Function	Protein binding	IPI	25416956
GO:0005764	Component	Lysosome	IEA
GO:0005765	Component	Lysosomal membrane	IBA
GO:0005765	Component	Lysosomal membrane	IEA
GO:0005765	Component	Lysosomal membrane	TAS
GO:0005768	Component	Endosome	IEA
GO:0005886	Component	Plasma membrane	TAS	3000765
GO:0006955	Process	Immune response	IEA
GO:0010008	Component	Endosome membrane	IEA
GO:0016020	Component	Membrane	IEA
GO:0019882	Process	Antigen processing and presentation	IEA
GO:0019882	Process	Antigen processing and presentation	IEA
GO:0019886	Process	Antigen processing and presentation of exogenous peptide antigen via MHC class II	IBA
GO:0019886	Process	Antigen processing and presentation of exogenous peptide antigen via MHC class II	IEA
GO:0023026	Function	MHC class II protein complex binding	IBA
GO:0023026	Function	MHC class II protein complex binding	IDA	22733780
GO:0031902	Component	Late endosome membrane	IBA
GO:0032395	Function	MHC class II receptor activity	TAS	3000765
GO:0042605	Function	Peptide antigen binding	IBA
GO:0042613	Component	MHC class II protein complex	IBA
GO:0042613	Component	MHC class II protein complex	IDA	22733780
GO:0042613	Component	MHC class II protein complex	IEA
GO:0045580	Process	Regulation of T cell differentiation	IEA
GO:0050778	Process	Positive regulation of immune response	IBA
GO:0050870	Process	Positive regulation of T cell activation	IBA

Other IDs

• MIM: 142930
• HGNC: 4936
• e!Ensembl: ENSG00000204252

Protein

• UniProt ID: P06340
• Protein name: HLA class II histocompatibility antigen, DO alpha chain (MHC DN-alpha) (MHC DZ alpha) (MHC class II antigen DOA)
• Protein function: Important modulator in the HLA class II restricted antigen presentation pathway by interaction with the HLA-DM molecule in B-cells. Modifies peptide exchange activity of HLA-DM.
• PDB: 4I0P
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00993	MHC_II_alpha	29 → 109	Class II histocompatibility antigen, alpha domain	Domain
  PF07654	C1-set	115 → 196	Immunoglobulin C1-set domain	Domain

• Sequence:

  MALRAGLVLGFHTLMTLLSPQEAGATKADHMGSYGPAFYQSYGASGQFTHEFDEEQLFSV
  DLKKSEAVWRLPEFGDFARFDPQGGLAGIAAIKAHLDILVERSNRSRAINVPPRVTVLPK
  SRVELGQPNILICIVDNIFPPVINITWLRNGQTVTEGVAQTSFYSQPDHLFRKFHYLPFV
  PSAEDVYDCQVEHWGLDAPLLRHWELQVPIPPPDAMETLVCALGLAIGLVGFLVGTVLII
  MGTYVSSVPR

• Sequence length: 250

Pathways

KEGG:

Phagosome
Cell adhesion molecules
Antigen processing and presentation
Hematopoietic cell lineage
Th1 and Th2 cell differentiation
Th17 cell differentiation
Intestinal immune network for IgA production
Type I diabetes mellitus
Leishmaniasis
Toxoplasmosis
Staphylococcus aureus infection
Tuberculosis
Influenza A
Human T-cell leukemia virus 1 infection
Herpes simplex virus 1 infection
Epstein-Barr virus infection
Asthma
Autoimmune thyroid disease
Inflammatory bowel disease
Systemic lupus erythematosus
Rheumatoid arthritis
Allograft rejection
Graft-versus-host disease
Viral myocarditis

Reactome:

MHC class II antigen presentation