Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene SNPs miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	311
Gene name Gene Name - the full gene name approved by the HGNC.	Annexin A11
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	ANXA11
Synonyms (NCBI Gene) Gene synonyms aliases	ALS23, ANX11, CAP-50, CAP50, IBMWMA
Disease Acronyms (UniProt) Disease acronyms from UniProt database	ALS23, IBMWMA
Chromosome Chromosome number	10
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	10q22.3
Summary Summary of gene provided in NCBI Entrez Gene.	This gene encodes a member of the annexin family, a group of calcium-dependent phospholipid-binding proteins. Annexins have unique N-terminal domains and conserved C-terminal domains, which contain calcium-dependent phospholipid-binding sites. The encoded

Show/Hide all(4)

SNP ID	Visualize variation	Clinical significance	Consequence
rs142083484	C>T	Pathogenic	Missense variant, coding sequence variant
rs368751524	C>A,G	Likely-pathogenic	Coding sequence variant, missense variant
rs754594235	C>A,T	Pathogenic	Coding sequence variant, missense variant
rs1247392012	T>C	Pathogenic	Missense variant, coding sequence variant

Show/Hide all(192)

miRTarBase ID	miRNA	Experiments	Reference
MIRT003084	hsa-miR-122-5p	Luciferase reporter assay, qRT-PCR	19296470
MIRT017220	hsa-miR-335-5p	Microarray	18185580
MIRT022375	hsa-miR-124-3p	Microarray	18668037
MIRT003084	hsa-miR-122-5p	Microarray	19296470
MIRT025684	hsa-miR-7-5p	Microarray	19073608
MIRT050326	hsa-miR-25-3p	CLASH	23622248
MIRT049835	hsa-miR-92a-3p	CLASH	23622248
MIRT044728	hsa-miR-320a	CLASH	23622248
MIRT042901	hsa-miR-324-3p	CLASH	23622248
MIRT042064	hsa-miR-484	CLASH	23622248
MIRT035979	hsa-miR-1301-3p	CLASH	23622248
MIRT539198	hsa-miR-4428	PAR-CLIP	22012620
MIRT539197	hsa-miR-3173-3p	PAR-CLIP	22012620
MIRT539196	hsa-miR-6891-5p	PAR-CLIP	22012620
MIRT539195	hsa-miR-548ag	PAR-CLIP	22012620
MIRT539194	hsa-miR-548ai	PAR-CLIP	22012620
MIRT539193	hsa-miR-548ba	PAR-CLIP	22012620
MIRT539192	hsa-miR-570-5p	PAR-CLIP	22012620
MIRT539191	hsa-miR-5088-5p	PAR-CLIP	22012620
MIRT539190	hsa-miR-4446-3p	PAR-CLIP	22012620
MIRT539189	hsa-miR-3158-3p	PAR-CLIP	22012620
MIRT539188	hsa-miR-505-5p	PAR-CLIP	22012620
MIRT539187	hsa-miR-4675	PAR-CLIP	22012620
MIRT539186	hsa-miR-4741	PAR-CLIP	22012620
MIRT449623	hsa-miR-4453	PAR-CLIP	22100165
MIRT449622	hsa-miR-4538	PAR-CLIP	22100165
MIRT449621	hsa-miR-5004-5p	PAR-CLIP	22100165
MIRT449620	hsa-miR-4751	PAR-CLIP	22100165
MIRT449619	hsa-miR-5579-3p	PAR-CLIP	22100165
MIRT449618	hsa-miR-1224-5p	PAR-CLIP	22100165
MIRT539198	hsa-miR-4428	PAR-CLIP	22012620
MIRT539197	hsa-miR-3173-3p	PAR-CLIP	22012620
MIRT539196	hsa-miR-6891-5p	PAR-CLIP	22012620
MIRT539195	hsa-miR-548ag	PAR-CLIP	22012620
MIRT539194	hsa-miR-548ai	PAR-CLIP	22012620
MIRT539193	hsa-miR-548ba	PAR-CLIP	22012620
MIRT539192	hsa-miR-570-5p	PAR-CLIP	22012620
MIRT539191	hsa-miR-5088-5p	PAR-CLIP	22012620
MIRT539190	hsa-miR-4446-3p	PAR-CLIP	22012620
MIRT539189	hsa-miR-3158-3p	PAR-CLIP	22012620
MIRT539188	hsa-miR-505-5p	PAR-CLIP	22012620
MIRT539187	hsa-miR-4675	PAR-CLIP	22012620
MIRT539186	hsa-miR-4741	PAR-CLIP	22012620
MIRT449623	hsa-miR-4453	PAR-CLIP	22100165
MIRT449622	hsa-miR-4538	PAR-CLIP	22100165
MIRT449621	hsa-miR-5004-5p	PAR-CLIP	22100165
MIRT449620	hsa-miR-4751	PAR-CLIP	22100165
MIRT449619	hsa-miR-5579-3p	PAR-CLIP	22100165
MIRT449618	hsa-miR-1224-5p	PAR-CLIP	22100165
MIRT786369	hsa-miR-1264	CLIP-seq
MIRT786370	hsa-miR-1294	CLIP-seq
MIRT786371	hsa-miR-15a	CLIP-seq
MIRT786372	hsa-miR-15b	CLIP-seq
MIRT786373	hsa-miR-16	CLIP-seq
MIRT786374	hsa-miR-195	CLIP-seq
MIRT786375	hsa-miR-3126-5p	CLIP-seq
MIRT786376	hsa-miR-3691-3p	CLIP-seq
MIRT786377	hsa-miR-424	CLIP-seq
MIRT786378	hsa-miR-4316	CLIP-seq
MIRT786379	hsa-miR-4419a	CLIP-seq
MIRT786380	hsa-miR-4510	CLIP-seq
MIRT786381	hsa-miR-451b	CLIP-seq
MIRT786382	hsa-miR-4524	CLIP-seq
MIRT786383	hsa-miR-4662a-5p	CLIP-seq
MIRT786384	hsa-miR-4677-3p	CLIP-seq
MIRT786385	hsa-miR-4742-5p	CLIP-seq
MIRT786386	hsa-miR-485-5p	CLIP-seq
MIRT786387	hsa-miR-497	CLIP-seq
MIRT786388	hsa-miR-503	CLIP-seq
MIRT786389	hsa-miR-646	CLIP-seq
MIRT786390	hsa-miR-298	CLIP-seq
MIRT786391	hsa-miR-3064-5p	CLIP-seq
MIRT786392	hsa-miR-3180-5p	CLIP-seq
MIRT786393	hsa-miR-3665	CLIP-seq
MIRT786394	hsa-miR-4423-5p	CLIP-seq
MIRT786395	hsa-miR-4487	CLIP-seq
MIRT786396	hsa-miR-4694-5p	CLIP-seq
MIRT786397	hsa-miR-4736	CLIP-seq
MIRT786398	hsa-miR-520a-5p	CLIP-seq
MIRT786399	hsa-miR-525-5p	CLIP-seq
MIRT786400	hsa-miR-541	CLIP-seq
MIRT786401	hsa-miR-654-5p	CLIP-seq
MIRT1931948	hsa-miR-3691-5p	CLIP-seq
MIRT1931949	hsa-miR-4752	CLIP-seq
MIRT786370	hsa-miR-1294	CLIP-seq
MIRT786371	hsa-miR-15a	CLIP-seq
MIRT786372	hsa-miR-15b	CLIP-seq
MIRT786373	hsa-miR-16	CLIP-seq
MIRT786374	hsa-miR-195	CLIP-seq
MIRT786390	hsa-miR-298	CLIP-seq
MIRT786375	hsa-miR-3126-5p	CLIP-seq
MIRT2172406	hsa-miR-3190	CLIP-seq
MIRT786393	hsa-miR-3665	CLIP-seq
MIRT786377	hsa-miR-424	CLIP-seq
MIRT786378	hsa-miR-4316	CLIP-seq
MIRT786379	hsa-miR-4419a	CLIP-seq
MIRT786394	hsa-miR-4423-5p	CLIP-seq
MIRT2172407	hsa-miR-4433	CLIP-seq
MIRT2172408	hsa-miR-4459	CLIP-seq
MIRT786380	hsa-miR-4510	CLIP-seq
MIRT786381	hsa-miR-451b	CLIP-seq
MIRT786382	hsa-miR-4524	CLIP-seq
MIRT2172409	hsa-miR-4651	CLIP-seq
MIRT786384	hsa-miR-4677-3p	CLIP-seq
MIRT786396	hsa-miR-4694-5p	CLIP-seq
MIRT2172410	hsa-miR-4704-3p	CLIP-seq
MIRT786397	hsa-miR-4736	CLIP-seq
MIRT2172411	hsa-miR-4768-3p	CLIP-seq
MIRT2172412	hsa-miR-4779	CLIP-seq
MIRT786386	hsa-miR-485-5p	CLIP-seq
MIRT786387	hsa-miR-497	CLIP-seq
MIRT786388	hsa-miR-503	CLIP-seq
MIRT786398	hsa-miR-520a-5p	CLIP-seq
MIRT786399	hsa-miR-525-5p	CLIP-seq
MIRT786400	hsa-miR-541	CLIP-seq
MIRT2172413	hsa-miR-608	CLIP-seq
MIRT786389	hsa-miR-646	CLIP-seq
MIRT786401	hsa-miR-654-5p	CLIP-seq
MIRT2172414	hsa-miR-7	CLIP-seq
MIRT2384258	hsa-miR-1281	CLIP-seq
MIRT786371	hsa-miR-15a	CLIP-seq
MIRT786372	hsa-miR-15b	CLIP-seq
MIRT786373	hsa-miR-16	CLIP-seq
MIRT786374	hsa-miR-195	CLIP-seq
MIRT2384259	hsa-miR-204	CLIP-seq
MIRT2384260	hsa-miR-211	CLIP-seq
MIRT2384261	hsa-miR-3622a-5p	CLIP-seq
MIRT786377	hsa-miR-424	CLIP-seq
MIRT2384262	hsa-miR-4287	CLIP-seq
MIRT786381	hsa-miR-451b	CLIP-seq
MIRT786382	hsa-miR-4524	CLIP-seq
MIRT2384263	hsa-miR-4685-3p	CLIP-seq
MIRT2384264	hsa-miR-4768-5p	CLIP-seq
MIRT786387	hsa-miR-497	CLIP-seq
MIRT786388	hsa-miR-503	CLIP-seq
MIRT786389	hsa-miR-646	CLIP-seq
MIRT2475331	hsa-miR-1290	CLIP-seq
MIRT2475332	hsa-miR-1914	CLIP-seq
MIRT786390	hsa-miR-298	CLIP-seq
MIRT2475333	hsa-miR-3167	CLIP-seq
MIRT2172406	hsa-miR-3190	CLIP-seq
MIRT786393	hsa-miR-3665	CLIP-seq
MIRT2475334	hsa-miR-3688-5p	CLIP-seq
MIRT1931948	hsa-miR-3691-5p	CLIP-seq
MIRT786394	hsa-miR-4423-5p	CLIP-seq
MIRT2172407	hsa-miR-4433	CLIP-seq
MIRT2172408	hsa-miR-4459	CLIP-seq
MIRT2475335	hsa-miR-4489	CLIP-seq
MIRT2475336	hsa-miR-4508	CLIP-seq
MIRT2475337	hsa-miR-4650-5p	CLIP-seq
MIRT2172409	hsa-miR-4651	CLIP-seq
MIRT786396	hsa-miR-4694-5p	CLIP-seq
MIRT2475338	hsa-miR-4726-3p	CLIP-seq
MIRT786397	hsa-miR-4736	CLIP-seq
MIRT1931949	hsa-miR-4752	CLIP-seq
MIRT2172411	hsa-miR-4768-3p	CLIP-seq
MIRT2172412	hsa-miR-4779	CLIP-seq
MIRT786400	hsa-miR-541	CLIP-seq
MIRT2475339	hsa-miR-551a	CLIP-seq
MIRT2475340	hsa-miR-551b	CLIP-seq
MIRT2172413	hsa-miR-608	CLIP-seq
MIRT786401	hsa-miR-654-5p	CLIP-seq
MIRT2172414	hsa-miR-7	CLIP-seq
MIRT2475341	hsa-miR-876-5p	CLIP-seq
MIRT2475331	hsa-miR-1290	CLIP-seq
MIRT2475332	hsa-miR-1914	CLIP-seq
MIRT786390	hsa-miR-298	CLIP-seq
MIRT2475333	hsa-miR-3167	CLIP-seq
MIRT2172406	hsa-miR-3190	CLIP-seq
MIRT786393	hsa-miR-3665	CLIP-seq
MIRT2475334	hsa-miR-3688-5p	CLIP-seq
MIRT1931948	hsa-miR-3691-5p	CLIP-seq
MIRT786394	hsa-miR-4423-5p	CLIP-seq
MIRT2172407	hsa-miR-4433	CLIP-seq
MIRT2172408	hsa-miR-4459	CLIP-seq
MIRT2475335	hsa-miR-4489	CLIP-seq
MIRT2475336	hsa-miR-4508	CLIP-seq
MIRT2475337	hsa-miR-4650-5p	CLIP-seq
MIRT2172409	hsa-miR-4651	CLIP-seq
MIRT786396	hsa-miR-4694-5p	CLIP-seq
MIRT2475338	hsa-miR-4726-3p	CLIP-seq
MIRT786397	hsa-miR-4736	CLIP-seq
MIRT1931949	hsa-miR-4752	CLIP-seq
MIRT2172411	hsa-miR-4768-3p	CLIP-seq
MIRT2172412	hsa-miR-4779	CLIP-seq
MIRT786400	hsa-miR-541	CLIP-seq
MIRT2475339	hsa-miR-551a	CLIP-seq
MIRT2475340	hsa-miR-551b	CLIP-seq
MIRT2172413	hsa-miR-608	CLIP-seq
MIRT786401	hsa-miR-654-5p	CLIP-seq
MIRT2172414	hsa-miR-7	CLIP-seq
MIRT2475341	hsa-miR-876-5p	CLIP-seq

Show/Hide all(28)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003723	Function	RNA binding	HDA	22681889
GO:0005509	Function	Calcium ion binding	IBA	21873635
GO:0005515	Function	Protein binding	IPI	9268363, 12445460, 15197175, 18256029, 25910212, 31515488, 32296183
GO:0005544	Function	Calcium-dependent phospholipid binding	IEA
GO:0005635	Component	Nuclear envelope	IDA	12601007, 15197175
GO:0005635	Component	Nuclear envelope	NAS	12577318
GO:0005654	Component	Nucleoplasm	IDA	7508441, 12601007, 15197175
GO:0005654	Component	Nucleoplasm	NAS	12577318
GO:0005737	Component	Cytoplasm	IBA	21873635
GO:0005737	Component	Cytoplasm	IDA	7508441, 12601007, 12805373
GO:0005819	Component	Spindle	IDA	12805373, 15197175
GO:0005829	Component	Cytosol	IDA
GO:0006909	Process	Phagocytosis	IBA	21873635
GO:0006909	Process	Phagocytosis	IEP	9188810
GO:0016020	Component	Membrane	HDA	19946888
GO:0023026	Function	MHC class II protein complex binding	HDA	20458337
GO:0030496	Component	Midbody	IDA	15197175
GO:0032506	Process	Cytokinetic process	IBA	21873635
GO:0032506	Process	Cytokinetic process	IMP	15197175
GO:0042470	Component	Melanosome	IEA
GO:0042581	Component	Specific granule	IDA	9188810
GO:0042582	Component	Azurophil granule	IDA	9188810
GO:0044548	Function	S100 protein binding	IPI	12577318, 19724273
GO:0045335	Component	Phagocytic vesicle	IDA	9188810
GO:0048306	Function	Calcium-dependent protein binding	IPI	11883939, 12445460
GO:0051592	Process	Response to calcium ion	IDA	9188810, 12601007
GO:0062023	Component	Collagen-containing extracellular matrix	HDA	25037231, 28344315
GO:0070062	Component	Extracellular exosome	HDA	19056867, 20458337, 23533145

MIM	HGNC	e!Ensembl
602572	535	ENSG00000122359

Protein

UniProt ID

P50995

Protein name

Annexin A11 (56 kDa autoantigen) (Annexin XI) (Annexin-11) (Calcyclin-associated annexin 50) (CAP-50)

Protein function

Binds specifically to calcyclin in a calcium-dependent manner (By similarity). Required for midbody formation and completion of the terminal phase of cytokinesis.

PDB

9FOF , 9FOR

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00191	Annexin	204 → 269	Annexin	Family
PF00191	Annexin	276 → 341	Annexin	Family
PF00191	Annexin	359 → 425	Annexin	Family
PF00191	Annexin	435 → 500	Annexin	Family

Sequence

MSYPGYPPPPGGYPPAAPGGGPWGGAAYPPPPSMPPIGLDNVATYAGQFNQDYLSGMAAN
MSGTFGGANMPNLYPGAPGAGYPPVPPGGFGQPPSAQQPVPPYGMYPPPGGNPPSRMPSY
PPYPGAPVPGQPMPPPGQQPPGAYPGQPPVTYPGQPPVPLPGQQQPVPSYPGYPGSGTVT
PAVPPTQFGSRGTITDAPGFDPLRDAEVLRKAMKGFGTDEQAIIDCLGSRSNKQRQQILL
SFKTAYGKDLIKDLKSELSGNFEKTILALMKTPVLFDIYEIKEAIKGVGTDEACLIEILA
SRSNEHIRELNRAYKAEFKKTLEEAIRSDTSGHFQRLLISLSQGNRDESTNVDMSLAQRD
AQELYAAGENRLGTDESKFNAVLCSRSRAHLVAVFNEYQRMTGRDIEKSICREMSGDLEE
GMLAVVKCLKNTPAFFAERLNKAMRGAGTKDRTLIRIMVSRSETDLLDIRSEYKRMYGKS
LYHDISGDTSGDYRKILLKICGGND

Sequence length

505

Interactions

View interactions

	KEGG
	Amyotrophic lateral sclerosis

Show/Hide Causal Diseases (2)

Disease term	Disease name	dbSNP ID	References
Causal
Amyotrophic lateral sclerosis	Amyotrophic Lateral Sclerosis, AMYOTROPHIC LATERAL SCLEROSIS 23, Amyotrophic lateral sclerosis	rs267607084, rs312262720, rs312262752, rs121908287, rs121908288, rs29001584, rs28941475, rs121434378, rs386134173, rs386134174, rs80356730, rs80356727, rs4884357, rs80356717, rs80356733 View all (171 more)	28469040, 29845112
Coronary artery disease	Coronary Artery Disease	rs137852988, rs121918313, rs121918529, rs121918531, rs137852340, rs1555800701, rs1215189537	23202125

Show/Hide Unknown Diseases (5)

Disease term	Disease name	References	Source
Unknown
Chronic obstructive pulmonary disease	Chronic Obstructive Airway Disease	23144326	ClinVar
Mental depression	Depressive disorder		ClinVar
Sarcoidosis	Sarcoidosis	22936702, 19165924	ClinVar, GWAS
Amyotrophic Lateral Sclerosis	amyotrophic lateral sclerosis type 23, amyotrophic lateral sclerosis		GenCC
Myopathy	inclusion body myopathy and brain white matter abnormalities		GenCC

Show/Hide Text Mining Associations (21)

Disease Name	Relationship Type	References
Associations from Text Mining
Amyotrophic Lateral Sclerosis	Associate	28469040, 33610019, 35525134, 36134701, 36651622
Asthma	Associate	35606283
Colorectal Neoplasms	Associate	23579219, 31308487
Frontotemporal Dementia	Associate	40713859
Inclusion Body Myopathy With Early Onset Paget Disease And Frontotemporal Dementia	Associate	36134701, 36651622
Leukemia Myeloid Acute	Associate	35463978
Lymphatic Metastasis	Stimulate	29306955
Meningeal Neoplasms	Stimulate	27399113
Muscular Diseases	Associate	36134701, 36651622
Muscular Dystrophies	Associate	36134701, 36651622
Muscular Dystrophy Oculopharyngeal	Associate	36651622
Neoplasms	Associate	19484149
Neoplasms	Stimulate	29306955
Ovarian Neoplasms	Associate	19484149, 29306955
Ovarian Neoplasms	Stimulate	31474227
Sarcoidosis	Associate	20093723, 22952805, 23151485, 23152861, 25056970, 29416296
Status Asthmaticus	Associate	35606283
Stomach Diseases	Associate	36356476
Stomach Neoplasms	Associate	29306955
Stomach Neoplasms	Stimulate	36356476
Uveitis	Associate	29416296

ANXA11 (annexin A11)