Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	3107
Gene name Gene Name - the full gene name approved by the HGNC.	Major histocompatibility complex, class I, C
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	HLA-C
Synonyms (NCBI Gene) Gene synonyms aliases	D6S204, HLA-JY3, HLAC, HLC-C, MHC, PSORS1
Disease Acronyms (UniProt) Disease acronyms from UniProt database	PSORS1
Chromosome Chromosome number	6
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	6p21.33
Summary Summary of gene provided in NCBI Entrez Gene.	HLA-C belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the

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miRTarBase ID	miRNA	Experiments	Reference
MIRT051644	hsa-let-7e-5p	CLASH	23622248
MIRT042611	hsa-miR-423-3p	CLASH	23622248
MIRT041720	hsa-miR-484	CLASH	23622248
MIRT487939	hsa-miR-6854-5p	PAR-CLIP	23592263
MIRT487938	hsa-miR-148a-3p	PAR-CLIP	23592263
MIRT487937	hsa-miR-148b-3p	PAR-CLIP	23592263
MIRT487936	hsa-miR-152-3p	PAR-CLIP	23592263
MIRT487935	hsa-miR-4524a-3p	PAR-CLIP	23592263
MIRT487934	hsa-miR-767-5p	PAR-CLIP	23592263
MIRT487933	hsa-miR-4660	PAR-CLIP	23592263
MIRT487931	hsa-miR-3672	PAR-CLIP	23592263
MIRT487932	hsa-miR-6864-3p	PAR-CLIP	23592263
MIRT487938	hsa-miR-148a-3p	PAR-CLIP	26701625
MIRT487937	hsa-miR-148b-3p	PAR-CLIP	26701625
MIRT487936	hsa-miR-152-3p	PAR-CLIP	26701625
MIRT487931	hsa-miR-3672	PAR-CLIP	26701625
MIRT487935	hsa-miR-4524a-3p	PAR-CLIP	26701625
MIRT487933	hsa-miR-4660	PAR-CLIP	26701625
MIRT487939	hsa-miR-6854-5p	PAR-CLIP	26701625
MIRT487932	hsa-miR-6864-3p	PAR-CLIP	26701625
MIRT487934	hsa-miR-767-5p	PAR-CLIP	26701625
MIRT487938	hsa-miR-148a-3p	RNA-seq, qRT-PCR	31578687
MIRT487939	hsa-miR-6854-5p	PAR-CLIP	23592263
MIRT487938	hsa-miR-148a-3p	PAR-CLIP	23592263
MIRT487937	hsa-miR-148b-3p	PAR-CLIP	23592263
MIRT487936	hsa-miR-152-3p	PAR-CLIP	23592263
MIRT487935	hsa-miR-4524a-3p	PAR-CLIP	23592263
MIRT487934	hsa-miR-767-5p	PAR-CLIP	23592263
MIRT487933	hsa-miR-4660	PAR-CLIP	23592263
MIRT487931	hsa-miR-3672	PAR-CLIP	23592263
MIRT487932	hsa-miR-6864-3p	PAR-CLIP	23592263
MIRT1048289	hsa-miR-1224-3p	CLIP-seq
MIRT1048290	hsa-miR-3138	CLIP-seq
MIRT1048291	hsa-miR-3151	CLIP-seq
MIRT1048292	hsa-miR-3191	CLIP-seq
MIRT1048293	hsa-miR-4323	CLIP-seq
MIRT1048294	hsa-miR-4462	CLIP-seq
MIRT1048295	hsa-miR-4758-3p	CLIP-seq
MIRT1549529	hsa-miR-3166	CLIP-seq
MIRT1549530	hsa-miR-4311	CLIP-seq
MIRT1549531	hsa-miR-4708-5p	CLIP-seq
MIRT1556533	hsa-miR-23a	CLIP-seq
MIRT1556534	hsa-miR-23b	CLIP-seq
MIRT1556535	hsa-miR-23c	CLIP-seq
MIRT1556536	hsa-miR-3146	CLIP-seq
MIRT1048289	hsa-miR-1224-3p	CLIP-seq
MIRT2010979	hsa-miR-181a	CLIP-seq
MIRT2010980	hsa-miR-181b	CLIP-seq
MIRT2010981	hsa-miR-181c	CLIP-seq
MIRT2010982	hsa-miR-181d	CLIP-seq
MIRT2010983	hsa-miR-2467-5p	CLIP-seq
MIRT2010984	hsa-miR-4262	CLIP-seq
MIRT1549530	hsa-miR-4311	CLIP-seq
MIRT1549531	hsa-miR-4708-5p	CLIP-seq
MIRT2010985	hsa-miR-593	CLIP-seq
MIRT2010986	hsa-miR-626	CLIP-seq
MIRT2010987	hsa-miR-642b	CLIP-seq
MIRT2243221	hsa-miR-103b	CLIP-seq
MIRT2243222	hsa-miR-1301	CLIP-seq
MIRT2243223	hsa-miR-146a	CLIP-seq
MIRT2243224	hsa-miR-146b-5p	CLIP-seq
MIRT2243225	hsa-miR-148a	CLIP-seq
MIRT2243226	hsa-miR-148b	CLIP-seq
MIRT2243227	hsa-miR-152	CLIP-seq
MIRT2243228	hsa-miR-1587	CLIP-seq
MIRT2243229	hsa-miR-224	CLIP-seq
MIRT2010983	hsa-miR-2467-5p	CLIP-seq
MIRT1048290	hsa-miR-3138	CLIP-seq
MIRT1048291	hsa-miR-3151	CLIP-seq
MIRT2243230	hsa-miR-3162-5p	CLIP-seq
MIRT1048292	hsa-miR-3191	CLIP-seq
MIRT2243231	hsa-miR-3616-5p	CLIP-seq
MIRT2243232	hsa-miR-3647-5p	CLIP-seq
MIRT2243233	hsa-miR-3653	CLIP-seq
MIRT2243234	hsa-miR-376a	CLIP-seq
MIRT2243235	hsa-miR-376b	CLIP-seq
MIRT2243236	hsa-miR-4417	CLIP-seq
MIRT2243237	hsa-miR-4428	CLIP-seq
MIRT1048294	hsa-miR-4462	CLIP-seq
MIRT2243238	hsa-miR-4492	CLIP-seq
MIRT2243239	hsa-miR-4498	CLIP-seq
MIRT2243240	hsa-miR-4635	CLIP-seq
MIRT2243241	hsa-miR-4651	CLIP-seq
MIRT2243242	hsa-miR-4656	CLIP-seq
MIRT2243243	hsa-miR-4675	CLIP-seq
MIRT2243244	hsa-miR-4719	CLIP-seq
MIRT2243245	hsa-miR-4741	CLIP-seq
MIRT2243246	hsa-miR-4787-5p	CLIP-seq
MIRT2243247	hsa-miR-5047	CLIP-seq
MIRT2243248	hsa-miR-541	CLIP-seq
MIRT2243249	hsa-miR-548p	CLIP-seq
MIRT2243250	hsa-miR-573	CLIP-seq
MIRT2243251	hsa-miR-580	CLIP-seq
MIRT2243252	hsa-miR-589	CLIP-seq
MIRT2243253	hsa-miR-602	CLIP-seq
MIRT2243254	hsa-miR-608	CLIP-seq
MIRT2243255	hsa-miR-654-5p	CLIP-seq
MIRT2243256	hsa-miR-762	CLIP-seq
MIRT1556533	hsa-miR-23a	CLIP-seq
MIRT1556534	hsa-miR-23b	CLIP-seq
MIRT1556535	hsa-miR-23c	CLIP-seq
MIRT2010983	hsa-miR-2467-5p	CLIP-seq
MIRT1556536	hsa-miR-3146	CLIP-seq
MIRT1048291	hsa-miR-3151	CLIP-seq
MIRT1549529	hsa-miR-3166	CLIP-seq
MIRT2389011	hsa-miR-3185	CLIP-seq
MIRT1048292	hsa-miR-3191	CLIP-seq
MIRT2389012	hsa-miR-3611	CLIP-seq
MIRT2243231	hsa-miR-3616-5p	CLIP-seq
MIRT2243232	hsa-miR-3647-5p	CLIP-seq
MIRT1549530	hsa-miR-4311	CLIP-seq
MIRT2243240	hsa-miR-4635	CLIP-seq
MIRT1549531	hsa-miR-4708-5p	CLIP-seq
MIRT2243250	hsa-miR-573	CLIP-seq
MIRT2010987	hsa-miR-642b	CLIP-seq
MIRT2429616	hsa-miR-125a-3p	CLIP-seq
MIRT2010979	hsa-miR-181a	CLIP-seq
MIRT2010980	hsa-miR-181b	CLIP-seq
MIRT2010981	hsa-miR-181c	CLIP-seq
MIRT2010982	hsa-miR-181d	CLIP-seq
MIRT2429617	hsa-miR-298	CLIP-seq
MIRT2429618	hsa-miR-3121-5p	CLIP-seq
MIRT1048290	hsa-miR-3138	CLIP-seq
MIRT1048291	hsa-miR-3151	CLIP-seq
MIRT1048292	hsa-miR-3191	CLIP-seq
MIRT2429619	hsa-miR-3678-3p	CLIP-seq
MIRT2429620	hsa-miR-3934	CLIP-seq
MIRT2010984	hsa-miR-4262	CLIP-seq
MIRT1048294	hsa-miR-4462	CLIP-seq
MIRT2243241	hsa-miR-4651	CLIP-seq
MIRT2243246	hsa-miR-4787-5p	CLIP-seq
MIRT2243253	hsa-miR-602	CLIP-seq
MIRT2243254	hsa-miR-608	CLIP-seq
MIRT2010987	hsa-miR-642b	CLIP-seq
MIRT2429621	hsa-miR-764	CLIP-seq
MIRT2435125	hsa-miR-873	CLIP-seq
MIRT2429616	hsa-miR-125a-3p	CLIP-seq
MIRT2243228	hsa-miR-1587	CLIP-seq
MIRT2010979	hsa-miR-181a	CLIP-seq
MIRT2010980	hsa-miR-181b	CLIP-seq
MIRT2010981	hsa-miR-181c	CLIP-seq
MIRT2010982	hsa-miR-181d	CLIP-seq
MIRT1556533	hsa-miR-23a	CLIP-seq
MIRT1556534	hsa-miR-23b	CLIP-seq
MIRT1556535	hsa-miR-23c	CLIP-seq
MIRT2429617	hsa-miR-298	CLIP-seq
MIRT2429618	hsa-miR-3121-5p	CLIP-seq
MIRT1048290	hsa-miR-3138	CLIP-seq
MIRT1556536	hsa-miR-3146	CLIP-seq
MIRT1048291	hsa-miR-3151	CLIP-seq
MIRT1549529	hsa-miR-3166	CLIP-seq
MIRT1048292	hsa-miR-3191	CLIP-seq
MIRT2429619	hsa-miR-3678-3p	CLIP-seq
MIRT2429620	hsa-miR-3934	CLIP-seq
MIRT2010984	hsa-miR-4262	CLIP-seq
MIRT1549530	hsa-miR-4311	CLIP-seq
MIRT2243236	hsa-miR-4417	CLIP-seq
MIRT1048294	hsa-miR-4462	CLIP-seq
MIRT2243238	hsa-miR-4492	CLIP-seq
MIRT2243239	hsa-miR-4498	CLIP-seq
MIRT2243241	hsa-miR-4651	CLIP-seq
MIRT2243242	hsa-miR-4656	CLIP-seq
MIRT2243243	hsa-miR-4675	CLIP-seq
MIRT1549531	hsa-miR-4708-5p	CLIP-seq
MIRT2243245	hsa-miR-4741	CLIP-seq
MIRT2243246	hsa-miR-4787-5p	CLIP-seq
MIRT2243248	hsa-miR-541	CLIP-seq
MIRT2010985	hsa-miR-593	CLIP-seq
MIRT2243253	hsa-miR-602	CLIP-seq
MIRT2243254	hsa-miR-608	CLIP-seq
MIRT2010986	hsa-miR-626	CLIP-seq
MIRT2010987	hsa-miR-642b	CLIP-seq
MIRT2243255	hsa-miR-654-5p	CLIP-seq
MIRT2243256	hsa-miR-762	CLIP-seq
MIRT2429621	hsa-miR-764	CLIP-seq
MIRT2435125	hsa-miR-873	CLIP-seq
MIRT2429616	hsa-miR-125a-3p	CLIP-seq
MIRT2243228	hsa-miR-1587	CLIP-seq
MIRT2010979	hsa-miR-181a	CLIP-seq
MIRT2010980	hsa-miR-181b	CLIP-seq
MIRT2010981	hsa-miR-181c	CLIP-seq
MIRT2010982	hsa-miR-181d	CLIP-seq
MIRT1556533	hsa-miR-23a	CLIP-seq
MIRT1556534	hsa-miR-23b	CLIP-seq
MIRT1556535	hsa-miR-23c	CLIP-seq
MIRT2010983	hsa-miR-2467-5p	CLIP-seq
MIRT2429617	hsa-miR-298	CLIP-seq
MIRT2429618	hsa-miR-3121-5p	CLIP-seq
MIRT1556536	hsa-miR-3146	CLIP-seq
MIRT1549529	hsa-miR-3166	CLIP-seq
MIRT2429619	hsa-miR-3678-3p	CLIP-seq
MIRT2429620	hsa-miR-3934	CLIP-seq
MIRT2010984	hsa-miR-4262	CLIP-seq
MIRT1549530	hsa-miR-4311	CLIP-seq
MIRT2243236	hsa-miR-4417	CLIP-seq
MIRT1048294	hsa-miR-4462	CLIP-seq
MIRT2243238	hsa-miR-4492	CLIP-seq
MIRT2243239	hsa-miR-4498	CLIP-seq
MIRT2243241	hsa-miR-4651	CLIP-seq
MIRT2243242	hsa-miR-4656	CLIP-seq
MIRT2243243	hsa-miR-4675	CLIP-seq
MIRT1549531	hsa-miR-4708-5p	CLIP-seq
MIRT2243245	hsa-miR-4741	CLIP-seq
MIRT2243246	hsa-miR-4787-5p	CLIP-seq
MIRT2243248	hsa-miR-541	CLIP-seq
MIRT2010985	hsa-miR-593	CLIP-seq
MIRT2243253	hsa-miR-602	CLIP-seq
MIRT2243254	hsa-miR-608	CLIP-seq
MIRT2010986	hsa-miR-626	CLIP-seq
MIRT2010987	hsa-miR-642b	CLIP-seq
MIRT2243255	hsa-miR-654-5p	CLIP-seq
MIRT2243256	hsa-miR-762	CLIP-seq
MIRT2429621	hsa-miR-764	CLIP-seq
MIRT1048289	hsa-miR-1224-3p	CLIP-seq
MIRT2429616	hsa-miR-125a-3p	CLIP-seq
MIRT2243228	hsa-miR-1587	CLIP-seq
MIRT2010979	hsa-miR-181a	CLIP-seq
MIRT2010980	hsa-miR-181b	CLIP-seq
MIRT2010981	hsa-miR-181c	CLIP-seq
MIRT2010982	hsa-miR-181d	CLIP-seq
MIRT2429617	hsa-miR-298	CLIP-seq
MIRT2429618	hsa-miR-3121-5p	CLIP-seq
MIRT2429619	hsa-miR-3678-3p	CLIP-seq
MIRT2429620	hsa-miR-3934	CLIP-seq
MIRT2010984	hsa-miR-4262	CLIP-seq
MIRT1549530	hsa-miR-4311	CLIP-seq
MIRT2243236	hsa-miR-4417	CLIP-seq
MIRT2243238	hsa-miR-4492	CLIP-seq
MIRT2243239	hsa-miR-4498	CLIP-seq
MIRT2243241	hsa-miR-4651	CLIP-seq
MIRT2243242	hsa-miR-4656	CLIP-seq
MIRT2243243	hsa-miR-4675	CLIP-seq
MIRT1549531	hsa-miR-4708-5p	CLIP-seq
MIRT2243245	hsa-miR-4741	CLIP-seq
MIRT2243246	hsa-miR-4787-5p	CLIP-seq
MIRT2243248	hsa-miR-541	CLIP-seq
MIRT2010985	hsa-miR-593	CLIP-seq
MIRT2243254	hsa-miR-608	CLIP-seq
MIRT2010986	hsa-miR-626	CLIP-seq
MIRT2010987	hsa-miR-642b	CLIP-seq
MIRT2243255	hsa-miR-654-5p	CLIP-seq
MIRT2243256	hsa-miR-762	CLIP-seq
MIRT2429621	hsa-miR-764	CLIP-seq

Transcription factors

Show/Hide all(4)

Transcription factor	Regulation	Reference
CIITA	Activation	11053628
HIVEP2	Unknown	1409593
MYC	Activation	8206526
MYCN	Unknown	8895520

Show/Hide all(29)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000139	Component	Golgi membrane	TAS
GO:0002250	Process	Adaptive immune response	IEA
GO:0002474	Process	Antigen processing and presentation of peptide antigen via MHC class I	TAS
GO:0002479	Process	Antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent	TAS
GO:0002480	Process	Antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent	TAS
GO:0002486	Process	Antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent	IDA	22031944
GO:0005515	Function	Protein binding	IPI	18322206, 18624290, 19858347, 27649529, 28546555, 28685972
GO:0005783	Component	Endoplasmic reticulum	IDA	20946353
GO:0005794	Component	Golgi apparatus	IDA	20946353
GO:0005886	Component	Plasma membrane	TAS
GO:0005887	Component	Integral component of plasma membrane	NAS	1384166, 2708822, 2787363, 2843461
GO:0006955	Process	Immune response	NAS	1384166, 2708822, 2787363, 2843461
GO:0009986	Component	Cell surface	IDA	9754572, 22031944
GO:0012507	Component	ER to Golgi transport vesicle membrane	TAS
GO:0016020	Component	Membrane	HDA	19946888
GO:0016032	Process	Viral process	IEA
GO:0030667	Component	Secretory granule membrane	TAS
GO:0030670	Component	Phagocytic vesicle membrane	TAS
GO:0031901	Component	Early endosome membrane	TAS
GO:0042605	Function	Peptide antigen binding	IDA	22031944
GO:0042612	Component	MHC class I protein complex	IDA	22031944
GO:0043312	Process	Neutrophil degranulation	TAS
GO:0046977	Function	TAP binding	IDA	8617941, 8805302
GO:0050776	Process	Regulation of immune response	TAS
GO:0055038	Component	Recycling endosome membrane	TAS
GO:0060333	Process	Interferon-gamma-mediated signaling pathway	TAS
GO:0060337	Process	Type I interferon signaling pathway	TAS
GO:0070062	Component	Extracellular exosome	HDA	20458337
GO:0071556	Component	Integral component of lumenal side of endoplasmic reticulum membrane	TAS

MIM	HGNC	e!Ensembl
142840	4933	ENSG00000204525

Protein

UniProt ID

P10321

Protein name

HLA class I histocompatibility antigen, C alpha chain (HLA-C) (HLA-Cw) (Human leukocyte antigen C)

Protein function

Antigen-presenting major histocompatibility complex class I (MHCI) molecule with an important role in reproduction and antiviral immunity (PubMed:11172028, PubMed:20104487, PubMed:20439706, PubMed:20972337, PubMed:24091323, PubMed:28649982, PubM

PDB

1EFX , 1IM9 , 1QQD , 3BZF , 4NT6 , 5VGD , 5VGE , 5W67 , 5W69 , 5W6A , 6JTO , 6PA1 , 6PAG

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00129	MHC_I	25 → 203	Class I Histocompatibility antigen, domains alpha 1 and 2	Domain
PF07654	C1-set	211 → 290	Immunoglobulin C1-set domain	Domain
PF06623	MHC_I_C	338 → 365	MHC_I C-terminus	Family

Tissue specificity

TISSUE SPECIFICITY: Ubiquitous. Highly expressed in fetal extravillous trophoblasts in the decidua basalis (at protein level). {ECO:0000269|PubMed:20972337}.

Sequence

MRVMAPRALLLLLSGGLALTETWACSHSMRYFDTAVSRPGRGEPRFISVGYVDDTQFVRF
DSDAASPRGEPRAPWVEQEGPEYWDRETQKYKRQAQADRVSLRNLRGYYNQSEDGSHTLQ
RMSGCDLGPDGRLLRGYDQSAYDGKDYIALNEDLRSWTAADTAAQITQRKLEAARAAEQL
RAYLEGTCVEWLRRYLENGKETLQRAEPPKTHVTHHPLSDHEATLRCWALGFYPAEITLT
WQRDGEDQTQDTELVETRPAGDGTFQKWAAVVVPSGQEQRYTCHMQHEGLQEPLTLSWEP
SSQPTIPIMGIVAGLAVLVVLAVLGAVVTAMMCRRKSSGGKGGSCSQAACSNSAQGSDES
LITCKA

Sequence length

366

Interactions

View interactions

	KEGG		Reactome
	Endocytosis Phagosome Cellular senescence Cell adhesion molecules Antigen processing and presentation Natural killer cell mediated cytotoxicity Type I diabetes mellitus Human cytomegalovirus infection Human papillomavirus infection Human T-cell leukemia virus 1 infection Kaposi sarcoma-associated herpesvirus infection Herpes simplex virus 1 infection Epstein-Barr virus infection Human immunodeficiency virus 1 infection Viral carcinogenesis Autoimmune thyroid disease Allograft rejection Graft-versus-host disease Viral myocarditis		ER-Phagosome pathway Endosomal/Vacuolar pathway Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell DAP12 interactions Neutrophil degranulation Interferon gamma signaling Interferon alpha/beta signaling Antigen Presentation: Folding, assembly and peptide loading of class I MHC

Show/Hide Causal Diseases (7)

Disease term	Disease name	dbSNP ID	References
Causal
Arthritis	Arthritis	rs1594890601, rs1594882933, rs184370809, rs776489319, rs1594883470
Burkitt`s lymphoma	Burkitt Lymphoma	rs28933407, rs121918683, rs121918684	25163702
Glioma	Glioma, mixed gliomas, Malignant Glioma	rs121909219, rs121909224, rs587776667, rs587776671, rs121909239, rs121909241, rs28933368, rs121913500, rs55863639, rs786201995, rs786202517, rs786201044, rs398123317, rs1057518425, rs121913499 View all (13 more)	14511464
Lymphoblastic leukemia	Precursor B-cell lymphoblastic leukemia, Precursor B-cell acute lymphoblastic leukemia	rs387906351, rs104894562, rs398122513, rs398122840, rs1057524466, rs1064796115, rs1064795660, rs1064793129, rs1064796227, rs1567887558, rs1161194345, rs1597558200, rs1406320425, rs1597566470, rs1597566699 View all (13 more)	25163702
Psoriasis	Psoriasis	rs281875215, rs587777763, rs281875213, rs281875212	19169254, 20953190
Rheumatoid arthritis	Rheumatoid Arthritis	rs587776843	21156761
Schizophrenia	Schizophrenia	rs13447324, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346 View all (12 more)	24365204, 22883433

Show/Hide Unknown Diseases (1)

Disease term	Disease name	Evidence	References	Source
Unknown
Sarcoidosis	Sarcoidosis		22952805	ClinVar

HLA-C (major histocompatibility complex, class I, C)