Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene SNPs miRNA Transcription factors Gene ontology Other IDs Protein Pathways
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	3105
Gene name Gene Name - the full gene name approved by the HGNC.	Major histocompatibility complex, class I, A
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	HLA-A
Synonyms (NCBI Gene) Gene synonyms aliases	HLAA
Chromosome Chromosome number	6
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	6p22.1
Summary Summary of gene provided in NCBI Entrez Gene.	HLA-A belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the

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SNP ID	Visualize variation	Clinical significance	Consequence
rs1061235	A>T	Risk-factor	3 prime UTR variant

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miRTarBase ID	miRNA	Experiments	Reference
MIRT019424	hsa-miR-148b-3p	Microarray	17612493
MIRT021411	hsa-miR-9-5p	Microarray	17612493
MIRT022132	hsa-miR-124-3p	Microarray	18668037
MIRT025003	hsa-miR-183-5p	Sequencing	20371350
MIRT040433	hsa-miR-615-3p	CLASH	23622248
MIRT454223	hsa-miR-4419a	PAR-CLIP	23592263
MIRT454221	hsa-miR-4510	PAR-CLIP	23592263
MIRT454220	hsa-miR-6127	PAR-CLIP	23592263
MIRT454219	hsa-miR-6129	PAR-CLIP	23592263
MIRT454218	hsa-miR-6130	PAR-CLIP	23592263
MIRT454217	hsa-miR-6133	PAR-CLIP	23592263
MIRT454216	hsa-miR-509-3p	PAR-CLIP	23592263
MIRT454215	hsa-miR-1249-5p	PAR-CLIP	23592263
MIRT454214	hsa-miR-6797-5p	PAR-CLIP	23592263
MIRT454213	hsa-miR-149-3p	PAR-CLIP	23592263
MIRT454212	hsa-miR-4728-5p	PAR-CLIP	23592263
MIRT454211	hsa-miR-6785-5p	PAR-CLIP	23592263
MIRT454210	hsa-miR-6883-5p	PAR-CLIP	23592263
MIRT454209	hsa-miR-3175	PAR-CLIP	23592263
MIRT454208	hsa-miR-6825-5p	PAR-CLIP	23592263
MIRT454207	hsa-miR-2110	PAR-CLIP	23592263
MIRT454206	hsa-miR-6810-5p	PAR-CLIP	23592263
MIRT454205	hsa-miR-6857-5p	PAR-CLIP	23592263
MIRT454204	hsa-miR-450a-2-3p	PAR-CLIP	23592263
MIRT401722	hsa-miR-6854-5p	PAR-CLIP	23592263
MIRT454203	hsa-miR-4756-3p	PAR-CLIP	23592263
MIRT218522	hsa-miR-148a-3p	PAR-CLIP	23592263
MIRT019424	hsa-miR-148b-3p	PAR-CLIP	23592263
MIRT218523	hsa-miR-152-3p	PAR-CLIP	23592263
MIRT218527	hsa-miR-8060	PAR-CLIP	23592263
MIRT392109	hsa-miR-4670-3p	PAR-CLIP	23592263
MIRT454202	hsa-miR-4524a-3p	PAR-CLIP	23592263
MIRT454201	hsa-miR-1273f	PAR-CLIP	23592263
MIRT454199	hsa-miR-4534	PAR-CLIP	23592263
MIRT454200	hsa-miR-8082	PAR-CLIP	23592263
MIRT218525	hsa-miR-767-5p	PAR-CLIP	23592263
MIRT454198	hsa-miR-139-3p	PAR-CLIP	23592263
MIRT454197	hsa-miR-3672	PAR-CLIP	23592263
MIRT454195	hsa-miR-6864-3p	PAR-CLIP	23592263
MIRT440499	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT440499	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT454201	hsa-miR-1273f	PAR-CLIP	26701625
MIRT454198	hsa-miR-139-3p	PAR-CLIP	26701625
MIRT218522	hsa-miR-148a-3p	PAR-CLIP	26701625
MIRT019424	hsa-miR-148b-3p	PAR-CLIP	26701625
MIRT218523	hsa-miR-152-3p	PAR-CLIP	26701625
MIRT454197	hsa-miR-3672	PAR-CLIP	26701625
MIRT454202	hsa-miR-4524a-3p	PAR-CLIP	26701625
MIRT454199	hsa-miR-4534	PAR-CLIP	26701625
MIRT392109	hsa-miR-4670-3p	PAR-CLIP	26701625
MIRT454203	hsa-miR-4756-3p	PAR-CLIP	26701625
MIRT401722	hsa-miR-6854-5p	PAR-CLIP	26701625
MIRT454195	hsa-miR-6864-3p	PAR-CLIP	26701625
MIRT218525	hsa-miR-767-5p	PAR-CLIP	26701625
MIRT218527	hsa-miR-8060	PAR-CLIP	26701625
MIRT454200	hsa-miR-8082	PAR-CLIP	26701625
MIRT454223	hsa-miR-4419a	PAR-CLIP	23592263
MIRT454221	hsa-miR-4510	PAR-CLIP	23592263
MIRT454220	hsa-miR-6127	PAR-CLIP	23592263
MIRT454219	hsa-miR-6129	PAR-CLIP	23592263
MIRT454218	hsa-miR-6130	PAR-CLIP	23592263
MIRT454217	hsa-miR-6133	PAR-CLIP	23592263
MIRT454216	hsa-miR-509-3p	PAR-CLIP	23592263
MIRT454215	hsa-miR-1249-5p	PAR-CLIP	23592263
MIRT454214	hsa-miR-6797-5p	PAR-CLIP	23592263
MIRT454213	hsa-miR-149-3p	PAR-CLIP	23592263
MIRT454212	hsa-miR-4728-5p	PAR-CLIP	23592263
MIRT454211	hsa-miR-6785-5p	PAR-CLIP	23592263
MIRT454210	hsa-miR-6883-5p	PAR-CLIP	23592263
MIRT454209	hsa-miR-3175	PAR-CLIP	23592263
MIRT454208	hsa-miR-6825-5p	PAR-CLIP	23592263
MIRT454207	hsa-miR-2110	PAR-CLIP	23592263
MIRT454206	hsa-miR-6810-5p	PAR-CLIP	23592263
MIRT454205	hsa-miR-6857-5p	PAR-CLIP	23592263
MIRT454204	hsa-miR-450a-2-3p	PAR-CLIP	23592263
MIRT401722	hsa-miR-6854-5p	PAR-CLIP	23592263
MIRT454203	hsa-miR-4756-3p	PAR-CLIP	23592263
MIRT218522	hsa-miR-148a-3p	PAR-CLIP	23592263
MIRT019424	hsa-miR-148b-3p	PAR-CLIP	23592263
MIRT218523	hsa-miR-152-3p	PAR-CLIP	23592263
MIRT218527	hsa-miR-8060	PAR-CLIP	23592263
MIRT392109	hsa-miR-4670-3p	PAR-CLIP	23592263
MIRT454202	hsa-miR-4524a-3p	PAR-CLIP	23592263
MIRT454201	hsa-miR-1273f	PAR-CLIP	23592263
MIRT454199	hsa-miR-4534	PAR-CLIP	23592263
MIRT454200	hsa-miR-8082	PAR-CLIP	23592263
MIRT218525	hsa-miR-767-5p	PAR-CLIP	23592263
MIRT454198	hsa-miR-139-3p	PAR-CLIP	23592263
MIRT454197	hsa-miR-3672	PAR-CLIP	23592263
MIRT454195	hsa-miR-6864-3p	PAR-CLIP	23592263
MIRT1048273	hsa-miR-1252	CLIP-seq
MIRT1048274	hsa-miR-148a	CLIP-seq
MIRT1048275	hsa-miR-148b	CLIP-seq
MIRT1048276	hsa-miR-152	CLIP-seq
MIRT1048277	hsa-miR-3185	CLIP-seq
MIRT1048278	hsa-miR-3202	CLIP-seq
MIRT1048279	hsa-miR-4436b-3p	CLIP-seq
MIRT1048280	hsa-miR-4533	CLIP-seq
MIRT1048281	hsa-miR-4735-5p	CLIP-seq
MIRT1048282	hsa-miR-4747-5p	CLIP-seq
MIRT1048283	hsa-miR-4775	CLIP-seq
MIRT1048284	hsa-miR-590-3p	CLIP-seq
MIRT1048285	hsa-miR-633	CLIP-seq
MIRT1048286	hsa-miR-873	CLIP-seq
MIRT1048273	hsa-miR-1252	CLIP-seq
MIRT1048277	hsa-miR-3185	CLIP-seq
MIRT1048280	hsa-miR-4533	CLIP-seq
MIRT1048282	hsa-miR-4747-5p	CLIP-seq
MIRT1048283	hsa-miR-4775	CLIP-seq
MIRT1048284	hsa-miR-590-3p	CLIP-seq
MIRT1048285	hsa-miR-633	CLIP-seq
MIRT1556518	hsa-miR-1224-3p	CLIP-seq
MIRT1556519	hsa-miR-1293	CLIP-seq
MIRT1556520	hsa-miR-3138	CLIP-seq
MIRT1556521	hsa-miR-3165	CLIP-seq
MIRT1556522	hsa-miR-3183	CLIP-seq
MIRT1556523	hsa-miR-323-5p	CLIP-seq
MIRT1556524	hsa-miR-342-5p	CLIP-seq
MIRT1556525	hsa-miR-4323	CLIP-seq
MIRT1556526	hsa-miR-4483	CLIP-seq
MIRT1556527	hsa-miR-4651	CLIP-seq
MIRT1556528	hsa-miR-4664-5p	CLIP-seq
MIRT1556529	hsa-miR-4690-3p	CLIP-seq
MIRT1556530	hsa-miR-4723-3p	CLIP-seq
MIRT1556531	hsa-miR-4758-3p	CLIP-seq
MIRT1556532	hsa-miR-608	CLIP-seq
MIRT1920049	hsa-miR-1297	CLIP-seq
MIRT1920050	hsa-miR-26a	CLIP-seq
MIRT1920051	hsa-miR-26b	CLIP-seq
MIRT1920052	hsa-miR-298	CLIP-seq
MIRT1920053	hsa-miR-3121-5p	CLIP-seq
MIRT1920054	hsa-miR-3665	CLIP-seq
MIRT1920055	hsa-miR-3678-3p	CLIP-seq
MIRT1920056	hsa-miR-4465	CLIP-seq
MIRT1920057	hsa-miR-4643	CLIP-seq
MIRT1920058	hsa-miR-642b	CLIP-seq
MIRT1920059	hsa-miR-657	CLIP-seq
MIRT1920060	hsa-miR-764	CLIP-seq
MIRT1920052	hsa-miR-298	CLIP-seq
MIRT1920053	hsa-miR-3121-5p	CLIP-seq
MIRT1920055	hsa-miR-3678-3p	CLIP-seq
MIRT1048282	hsa-miR-4747-5p	CLIP-seq
MIRT1556518	hsa-miR-1224-3p	CLIP-seq
MIRT1556519	hsa-miR-1293	CLIP-seq
MIRT1920049	hsa-miR-1297	CLIP-seq
MIRT2437592	hsa-miR-1299	CLIP-seq
MIRT1048274	hsa-miR-148a	CLIP-seq
MIRT1048275	hsa-miR-148b	CLIP-seq
MIRT1048276	hsa-miR-152	CLIP-seq
MIRT2437593	hsa-miR-224	CLIP-seq
MIRT1920050	hsa-miR-26a	CLIP-seq
MIRT1920051	hsa-miR-26b	CLIP-seq
MIRT1920052	hsa-miR-298	CLIP-seq
MIRT1920053	hsa-miR-3121-5p	CLIP-seq
MIRT1556520	hsa-miR-3138	CLIP-seq
MIRT2437594	hsa-miR-3150a-3p	CLIP-seq
MIRT2437595	hsa-miR-3152-5p	CLIP-seq
MIRT1556521	hsa-miR-3165	CLIP-seq
MIRT1556522	hsa-miR-3183	CLIP-seq
MIRT1048277	hsa-miR-3185	CLIP-seq
MIRT1048278	hsa-miR-3202	CLIP-seq
MIRT1556523	hsa-miR-323-5p	CLIP-seq
MIRT2437596	hsa-miR-326	CLIP-seq
MIRT2437597	hsa-miR-330-5p	CLIP-seq
MIRT1556524	hsa-miR-342-5p	CLIP-seq
MIRT1920054	hsa-miR-3665	CLIP-seq
MIRT1920055	hsa-miR-3678-3p	CLIP-seq
MIRT1556525	hsa-miR-4323	CLIP-seq
MIRT1048279	hsa-miR-4436b-3p	CLIP-seq
MIRT1920056	hsa-miR-4465	CLIP-seq
MIRT1556526	hsa-miR-4483	CLIP-seq
MIRT1920057	hsa-miR-4643	CLIP-seq
MIRT1556527	hsa-miR-4651	CLIP-seq
MIRT1556528	hsa-miR-4664-5p	CLIP-seq
MIRT1556529	hsa-miR-4690-3p	CLIP-seq
MIRT2437598	hsa-miR-4719	CLIP-seq
MIRT1556530	hsa-miR-4723-3p	CLIP-seq
MIRT1048282	hsa-miR-4747-5p	CLIP-seq
MIRT1556531	hsa-miR-4758-3p	CLIP-seq
MIRT1556532	hsa-miR-608	CLIP-seq
MIRT1920058	hsa-miR-642b	CLIP-seq
MIRT1920059	hsa-miR-657	CLIP-seq
MIRT1920060	hsa-miR-764	CLIP-seq
MIRT1048286	hsa-miR-873	CLIP-seq
MIRT2437599	hsa-miR-875-3p	CLIP-seq
MIRT2437600	hsa-miR-939	CLIP-seq
MIRT2451227	hsa-miR-188-3p	CLIP-seq
MIRT2451228	hsa-miR-1910	CLIP-seq
MIRT2451229	hsa-miR-3714	CLIP-seq
MIRT2451230	hsa-miR-4457	CLIP-seq
MIRT2451231	hsa-miR-455-3p	CLIP-seq
MIRT2451232	hsa-miR-4731-3p	CLIP-seq
MIRT2451233	hsa-miR-4801	CLIP-seq
MIRT1556518	hsa-miR-1224-3p	CLIP-seq
MIRT1556519	hsa-miR-1293	CLIP-seq
MIRT1920049	hsa-miR-1297	CLIP-seq
MIRT2437592	hsa-miR-1299	CLIP-seq
MIRT2451227	hsa-miR-188-3p	CLIP-seq
MIRT2451228	hsa-miR-1910	CLIP-seq
MIRT2437593	hsa-miR-224	CLIP-seq
MIRT2546413	hsa-miR-23a	CLIP-seq
MIRT2546414	hsa-miR-23b	CLIP-seq
MIRT2546415	hsa-miR-23c	CLIP-seq
MIRT1920050	hsa-miR-26a	CLIP-seq
MIRT1920051	hsa-miR-26b	CLIP-seq
MIRT1920052	hsa-miR-298	CLIP-seq
MIRT1920053	hsa-miR-3121-5p	CLIP-seq
MIRT1556520	hsa-miR-3138	CLIP-seq
MIRT2437594	hsa-miR-3150a-3p	CLIP-seq
MIRT2437595	hsa-miR-3152-5p	CLIP-seq
MIRT1556521	hsa-miR-3165	CLIP-seq
MIRT1556522	hsa-miR-3183	CLIP-seq
MIRT1048278	hsa-miR-3202	CLIP-seq
MIRT1556523	hsa-miR-323-5p	CLIP-seq
MIRT2437596	hsa-miR-326	CLIP-seq
MIRT2437597	hsa-miR-330-5p	CLIP-seq
MIRT1556524	hsa-miR-342-5p	CLIP-seq
MIRT1920054	hsa-miR-3665	CLIP-seq
MIRT1920055	hsa-miR-3678-3p	CLIP-seq
MIRT2451229	hsa-miR-3714	CLIP-seq
MIRT2546416	hsa-miR-4264	CLIP-seq
MIRT2546417	hsa-miR-4286	CLIP-seq
MIRT1556525	hsa-miR-4323	CLIP-seq
MIRT1048279	hsa-miR-4436b-3p	CLIP-seq
MIRT2451230	hsa-miR-4457	CLIP-seq
MIRT1920056	hsa-miR-4465	CLIP-seq
MIRT1556526	hsa-miR-4483	CLIP-seq
MIRT2451231	hsa-miR-455-3p	CLIP-seq
MIRT2546418	hsa-miR-4633-5p	CLIP-seq
MIRT1920057	hsa-miR-4643	CLIP-seq
MIRT1556527	hsa-miR-4651	CLIP-seq
MIRT1556528	hsa-miR-4664-5p	CLIP-seq
MIRT1556529	hsa-miR-4690-3p	CLIP-seq
MIRT2437598	hsa-miR-4719	CLIP-seq
MIRT1556530	hsa-miR-4723-3p	CLIP-seq
MIRT2451232	hsa-miR-4731-3p	CLIP-seq
MIRT1048282	hsa-miR-4747-5p	CLIP-seq
MIRT1556531	hsa-miR-4758-3p	CLIP-seq
MIRT2546419	hsa-miR-4797-3p	CLIP-seq
MIRT2451233	hsa-miR-4801	CLIP-seq
MIRT2546420	hsa-miR-532-5p	CLIP-seq
MIRT1556532	hsa-miR-608	CLIP-seq
MIRT1920058	hsa-miR-642b	CLIP-seq
MIRT1920059	hsa-miR-657	CLIP-seq
MIRT1920060	hsa-miR-764	CLIP-seq
MIRT1048286	hsa-miR-873	CLIP-seq
MIRT2437599	hsa-miR-875-3p	CLIP-seq
MIRT2437600	hsa-miR-939	CLIP-seq
MIRT1556518	hsa-miR-1224-3p	CLIP-seq
MIRT1556519	hsa-miR-1293	CLIP-seq
MIRT1920049	hsa-miR-1297	CLIP-seq
MIRT2437592	hsa-miR-1299	CLIP-seq
MIRT2451227	hsa-miR-188-3p	CLIP-seq
MIRT2451228	hsa-miR-1910	CLIP-seq
MIRT2437593	hsa-miR-224	CLIP-seq
MIRT2546413	hsa-miR-23a	CLIP-seq
MIRT2546414	hsa-miR-23b	CLIP-seq
MIRT2546415	hsa-miR-23c	CLIP-seq
MIRT1920050	hsa-miR-26a	CLIP-seq
MIRT1920051	hsa-miR-26b	CLIP-seq
MIRT1920052	hsa-miR-298	CLIP-seq
MIRT1920053	hsa-miR-3121-5p	CLIP-seq
MIRT1556520	hsa-miR-3138	CLIP-seq
MIRT2437594	hsa-miR-3150a-3p	CLIP-seq
MIRT2437595	hsa-miR-3152-5p	CLIP-seq
MIRT1556521	hsa-miR-3165	CLIP-seq
MIRT1556522	hsa-miR-3183	CLIP-seq
MIRT1048278	hsa-miR-3202	CLIP-seq
MIRT1556523	hsa-miR-323-5p	CLIP-seq
MIRT2437596	hsa-miR-326	CLIP-seq
MIRT2437597	hsa-miR-330-5p	CLIP-seq
MIRT1556524	hsa-miR-342-5p	CLIP-seq
MIRT1920054	hsa-miR-3665	CLIP-seq
MIRT1920055	hsa-miR-3678-3p	CLIP-seq
MIRT2451229	hsa-miR-3714	CLIP-seq
MIRT2546416	hsa-miR-4264	CLIP-seq
MIRT2546417	hsa-miR-4286	CLIP-seq
MIRT1556525	hsa-miR-4323	CLIP-seq
MIRT1048279	hsa-miR-4436b-3p	CLIP-seq
MIRT2451230	hsa-miR-4457	CLIP-seq
MIRT1920056	hsa-miR-4465	CLIP-seq
MIRT1556526	hsa-miR-4483	CLIP-seq
MIRT2451231	hsa-miR-455-3p	CLIP-seq
MIRT2546418	hsa-miR-4633-5p	CLIP-seq
MIRT1920057	hsa-miR-4643	CLIP-seq
MIRT1556527	hsa-miR-4651	CLIP-seq
MIRT1556528	hsa-miR-4664-5p	CLIP-seq
MIRT1556529	hsa-miR-4690-3p	CLIP-seq
MIRT2437598	hsa-miR-4719	CLIP-seq
MIRT1556530	hsa-miR-4723-3p	CLIP-seq
MIRT2451232	hsa-miR-4731-3p	CLIP-seq
MIRT1048282	hsa-miR-4747-5p	CLIP-seq
MIRT1556531	hsa-miR-4758-3p	CLIP-seq
MIRT2546419	hsa-miR-4797-3p	CLIP-seq
MIRT2451233	hsa-miR-4801	CLIP-seq
MIRT2546420	hsa-miR-532-5p	CLIP-seq
MIRT1556532	hsa-miR-608	CLIP-seq
MIRT1920058	hsa-miR-642b	CLIP-seq
MIRT1920059	hsa-miR-657	CLIP-seq
MIRT1920060	hsa-miR-764	CLIP-seq
MIRT1048286	hsa-miR-873	CLIP-seq
MIRT2437599	hsa-miR-875-3p	CLIP-seq
MIRT2437600	hsa-miR-939	CLIP-seq

Transcription factors

Show/Hide all(6)

Transcription factor	Regulation	Reference
CIITA	Activation	10329350
HIVEP2	Unknown	1409593
IRF1	Activation	19428110
MYC	Activation	8206526
MYCN	Unknown	8895520
RELA	Activation	19428110

Show/Hide all(79)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000139	Component	Golgi membrane	IEA
GO:0000139	Component	Golgi membrane	TAS
GO:0001913	Process	T cell mediated cytotoxicity	IDA	7504010
GO:0001916	Process	Positive regulation of T cell mediated cytotoxicity	IBA
GO:0001916	Process	Positive regulation of T cell mediated cytotoxicity	IDA	2420472, 8805302, 22031944, 25631937
GO:0002250	Process	Adaptive immune response	IEA
GO:0002376	Process	Immune system process	IEA
GO:0002419	Process	T cell mediated cytotoxicity directed against tumor cell target	IDA	1402688, 17189421, 20364150
GO:0002474	Process	Antigen processing and presentation of peptide antigen via MHC class I	IEA
GO:0002476	Process	Antigen processing and presentation of endogenous peptide antigen via MHC class Ib	IBA
GO:0002485	Process	Antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent	IMP	8630735
GO:0002486	Process	Antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent	IBA
GO:0002486	Process	Antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent	IDA	22031944
GO:0002502	Process	Peptide antigen assembly with MHC class I protein complex	IDA	36104323
GO:0002726	Process	Positive regulation of T cell cytokine production	IDA	24643698
GO:0003723	Function	RNA binding	HDA	22658674
GO:0005102	Function	Signaling receptor binding	IBA
GO:0005102	Function	Signaling receptor binding	IPI	19124746
GO:0005515	Function	Protein binding	IPI	9177355, 12414957, 20946353, 23401559, 26869717
GO:0005615	Component	Extracellular space	IBA
GO:0005783	Component	Endoplasmic reticulum	IDA	8805302, 20946353
GO:0005783	Component	Endoplasmic reticulum	IEA
GO:0005789	Component	Endoplasmic reticulum membrane	IEA
GO:0005789	Component	Endoplasmic reticulum membrane	TAS
GO:0005794	Component	Golgi apparatus	IDA	20946353
GO:0005797	Component	Golgi medial cisterna	IDA	8805302
GO:0005886	Component	Plasma membrane	IDA	2784196, 8630735
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	NAS	1431115, 2437024, 2478623, 2715640, 6609814, 8188325
GO:0005886	Component	Plasma membrane	TAS
GO:0006955	Process	Immune response	IBA
GO:0006955	Process	Immune response	IEA
GO:0006955	Process	Immune response	IMP	22321387
GO:0006955	Process	Immune response	NAS	1431115, 2437024, 2478623, 2715640, 6609814, 8188325
GO:0009897	Component	External side of plasma membrane	IBA
GO:0009986	Component	Cell surface	IDA	8805302, 8839770, 22031944
GO:0009986	Component	Cell surface	IEA
GO:0012507	Component	ER to Golgi transport vesicle membrane	IEA
GO:0012507	Component	ER to Golgi transport vesicle membrane	TAS
GO:0016020	Component	Membrane	HDA	19946888
GO:0016020	Component	Membrane	IEA
GO:0016045	Process	Detection of bacterium	IMP	22321387
GO:0019731	Process	Antibacterial humoral response	IDA	25631937
GO:0019882	Process	Antigen processing and presentation	IEA
GO:0019885	Process	Antigen processing and presentation of endogenous peptide antigen via MHC class I	IDA	1402688, 20364150, 24643698
GO:0030670	Component	Phagocytic vesicle membrane	IEA
GO:0030670	Component	Phagocytic vesicle membrane	TAS
GO:0030881	Function	Beta-2-microglobulin binding	IC	25631937
GO:0030881	Function	Beta-2-microglobulin binding	IDA	3309677, 7694806, 8805302, 8906788
GO:0030881	Function	Beta-2-microglobulin binding	IMP	23566939
GO:0031901	Component	Early endosome membrane	IEA
GO:0031901	Component	Early endosome membrane	TAS
GO:0032729	Process	Positive regulation of type II interferon production	IDA	22031944
GO:0036037	Process	CD8-positive, alpha-beta T cell activation	IDA	1402688, 2784196, 7504010, 8630735, 12138174, 17189421, 20364150
GO:0042270	Process	Protection from natural killer cell mediated cytotoxicity	IDA	18502829
GO:0042270	Process	Protection from natural killer cell mediated cytotoxicity	IDA	8839770, 18502829
GO:0042590	Process	Antigen processing and presentation of exogenous peptide antigen via MHC class I	IDA	7504010, 12138174
GO:0042605	Function	Peptide antigen binding	IBA
GO:0042605	Function	Peptide antigen binding	IDA	1402688, 7504010, 7694806, 8805302, 8839770, 8906788, 8955188, 9177355, 10435578, 17189421, 20364150, 22031944, 24643698, 25631937
GO:0042605	Function	Peptide antigen binding	IMP	23566939
GO:0042608	Function	T cell receptor binding	IDA	8906788, 8955188, 10435578
GO:0042610	Function	CD8 receptor binding	IDA	2784196
GO:0042612	Component	MHC class I protein complex	IDA	7694806, 8805302, 8906788, 22031944, 25631937
GO:0042612	Component	MHC class I protein complex	IEA
GO:0042824	Component	MHC class I peptide loading complex	IDA	21263072
GO:0045087	Process	Innate immune response	IEA
GO:0046977	Function	TAP binding	IDA	8617941, 8805302
GO:0050830	Process	Defense response to Gram-positive bacterium	IDA	25631937
GO:0050852	Process	T cell receptor signaling pathway	IDA	10435578
GO:0055038	Component	Recycling endosome membrane	IEA
GO:0055038	Component	Recycling endosome membrane	TAS
GO:0062061	Function	TAP complex binding	IDA	8630735
GO:0070062	Component	Extracellular exosome	HDA	11487543, 19199708, 20458337
GO:0070971	Component	Endoplasmic reticulum exit site	IDA	20946353
GO:0098553	Component	Lumenal side of endoplasmic reticulum membrane	IEA
GO:0098553	Component	Lumenal side of endoplasmic reticulum membrane	TAS
GO:2000566	Process	Positive regulation of CD8-positive, alpha-beta T cell proliferation	IDA	25631937
GO:2000568	Process	Positive regulation of memory T cell activation	IDA	22031944
GO:2001187	Process	Positive regulation of CD8-positive, alpha-beta T cell activation	IDA	24643698

MIM	HGNC	e!Ensembl
142800	4931	ENSG00000206503

Protein

UniProt ID

P04439

Protein name

HLA class I histocompatibility antigen, A alpha chain (Human leukocyte antigen A) (HLA-A)

Protein function

Antigen-presenting major histocompatibility complex class I (MHCI) molecule. In complex with B2M/beta 2 microglobulin displays primarily viral and tumor-derived peptides on antigen-presenting cells for recognition by alpha-beta T cell receptor (

PDB

1AKJ , 1AO7 , 1AQD , 1B0G , 1B0R , 1BD2 , 1DUY , 1DUZ , 1EEY , 1EEZ , 1HHG , 1HHH , 1HHI , 1HHJ , 1HHK , 1HLA , 1HSB , 1I1F , 1I1Y , 1I4F , 1I7R , 1I7T , 1I7U , 1IM3 , 1JF1 , 1JHT , 1LP9 , 1OGA , 1P7Q , 1Q94 , 1QEW , 1QR1 , 1QRN , 1QSE , 1QSF , 1QVO , 1S8D , 1S9W , 1S9X , 1S9Y , 1T1W , 1T1X , 1T1Y , 1T1Z , 1T20 , 1T21 , 1T22 , 1TMC , 1TVB , 1TVH , 1W72

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00129	MHC_I	25 → 203	Class I Histocompatibility antigen, domains alpha 1 and 2	Domain
PF07654	C1-set	210 → 290	Immunoglobulin C1-set domain	Domain
PF06623	MHC_I_C	337 → 364	MHC_I C-terminus	Family

Tissue specificity

TISSUE SPECIFICITY: Ubiquitous. {ECO:0000305}.

Sequence

MAVMAPRTLLLLLSGALALTQTWAGSHSMRYFFTSVSRPGRGEPRFIAVGYVDDTQFVRF
DSDAASQRMEPRAPWIEQEGPEYWDQETRNVKAQSQTDRVDLGTLRGYYNQSEAGSHTIQ
IMYGCDVGSDGRFLRGYRQDAYDGKDYIALNEDLRSWTAADMAAQITKRKWEAAHEAEQL
RAYLDGTCVEWLRRYLENGKETLQRTDPPKTHMTHHPISDHEATLRCWALGFYPAEITLT
WQRDGEDQTQDTELVETRPAGDGTFQKWAAVVVPSGEEQRYTCHVQHEGLPKPLTLRWEL
SSQPTIPIVGIIAGLVLLGAVITGAVVAAVMWRRKSSDRKGGSYTQAASSDSAQGSDVSL
TACKV

Sequence length

365

Interactions

View interactions

	KEGG		Reactome
	Endocytosis Phagosome Cellular senescence Cell adhesion molecules Antigen processing and presentation Natural killer cell mediated cytotoxicity Type I diabetes mellitus Human cytomegalovirus infection Human papillomavirus infection Human T-cell leukemia virus 1 infection Kaposi sarcoma-associated herpesvirus infection Herpes simplex virus 1 infection Epstein-Barr virus infection Human immunodeficiency virus 1 infection Viral carcinogenesis Autoimmune thyroid disease Allograft rejection Graft-versus-host disease Viral myocarditis		ER-Phagosome pathway Endosomal/Vacuolar pathway Nef mediated downregulation of MHC class I complex cell surface expression Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Neutrophil degranulation Interferon gamma signaling E3 ubiquitin ligases ubiquitinate target proteins Interferon alpha/beta signaling Antigen Presentation: Folding, assembly and peptide loading of class I MHC

HLA-A (major histocompatibility complex, class I, A)