HLA-A (major histocompatibility complex, class I, A)

Gene

• Entrez ID: 3105
• Gene name: Major histocompatibility complex, class I, A
• Gene symbol: HLA-A
• Synonyms (NCBI Gene): HLAA
• Chromosome: 6
• Chromosome location: 6p22.1
• Summary: HLA-A belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the

SNPs

SNP ID	Visualize variation	Clinical significance	Consequence
rs1061235	A>T	Risk-factor	3 prime UTR variant

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT019424	hsa-miR-148b-3p	Microarray	17612493
MIRT021411	hsa-miR-9-5p	Microarray	17612493
MIRT022132	hsa-miR-124-3p	Microarray	18668037
MIRT025003	hsa-miR-183-5p	Sequencing	20371350
MIRT040433	hsa-miR-615-3p	CLASH	23622248
MIRT454223	hsa-miR-4419a	PAR-CLIP	23592263
MIRT454221	hsa-miR-4510	PAR-CLIP	23592263
MIRT454220	hsa-miR-6127	PAR-CLIP	23592263
MIRT454219	hsa-miR-6129	PAR-CLIP	23592263
MIRT454218	hsa-miR-6130	PAR-CLIP	23592263
MIRT454217	hsa-miR-6133	PAR-CLIP	23592263
MIRT454216	hsa-miR-509-3p	PAR-CLIP	23592263
MIRT454215	hsa-miR-1249-5p	PAR-CLIP	23592263
MIRT454214	hsa-miR-6797-5p	PAR-CLIP	23592263
MIRT454213	hsa-miR-149-3p	PAR-CLIP	23592263
MIRT454212	hsa-miR-4728-5p	PAR-CLIP	23592263
MIRT454211	hsa-miR-6785-5p	PAR-CLIP	23592263
MIRT454210	hsa-miR-6883-5p	PAR-CLIP	23592263
MIRT454209	hsa-miR-3175	PAR-CLIP	23592263
MIRT454208	hsa-miR-6825-5p	PAR-CLIP	23592263
MIRT454207	hsa-miR-2110	PAR-CLIP	23592263
MIRT454206	hsa-miR-6810-5p	PAR-CLIP	23592263
MIRT454205	hsa-miR-6857-5p	PAR-CLIP	23592263
MIRT454204	hsa-miR-450a-2-3p	PAR-CLIP	23592263
MIRT401722	hsa-miR-6854-5p	PAR-CLIP	23592263
MIRT454203	hsa-miR-4756-3p	PAR-CLIP	23592263
MIRT218522	hsa-miR-148a-3p	PAR-CLIP	23592263
MIRT019424	hsa-miR-148b-3p	PAR-CLIP	23592263
MIRT218523	hsa-miR-152-3p	PAR-CLIP	23592263
MIRT218527	hsa-miR-8060	PAR-CLIP	23592263
MIRT392109	hsa-miR-4670-3p	PAR-CLIP	23592263
MIRT454202	hsa-miR-4524a-3p	PAR-CLIP	23592263
MIRT454201	hsa-miR-1273f	PAR-CLIP	23592263
MIRT454199	hsa-miR-4534	PAR-CLIP	23592263
MIRT454200	hsa-miR-8082	PAR-CLIP	23592263
MIRT218525	hsa-miR-767-5p	PAR-CLIP	23592263
MIRT454198	hsa-miR-139-3p	PAR-CLIP	23592263
MIRT454197	hsa-miR-3672	PAR-CLIP	23592263
MIRT454195	hsa-miR-6864-3p	PAR-CLIP	23592263
MIRT440499	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT440499	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT454201	hsa-miR-1273f	PAR-CLIP	26701625
MIRT454198	hsa-miR-139-3p	PAR-CLIP	26701625
MIRT218522	hsa-miR-148a-3p	PAR-CLIP	26701625
MIRT019424	hsa-miR-148b-3p	PAR-CLIP	26701625
MIRT218523	hsa-miR-152-3p	PAR-CLIP	26701625
MIRT454197	hsa-miR-3672	PAR-CLIP	26701625
MIRT454202	hsa-miR-4524a-3p	PAR-CLIP	26701625
MIRT454199	hsa-miR-4534	PAR-CLIP	26701625
MIRT392109	hsa-miR-4670-3p	PAR-CLIP	26701625
MIRT454203	hsa-miR-4756-3p	PAR-CLIP	26701625
MIRT401722	hsa-miR-6854-5p	PAR-CLIP	26701625
MIRT454195	hsa-miR-6864-3p	PAR-CLIP	26701625
MIRT218525	hsa-miR-767-5p	PAR-CLIP	26701625
MIRT218527	hsa-miR-8060	PAR-CLIP	26701625
MIRT454200	hsa-miR-8082	PAR-CLIP	26701625
MIRT454223	hsa-miR-4419a	PAR-CLIP	23592263
MIRT454221	hsa-miR-4510	PAR-CLIP	23592263
MIRT454220	hsa-miR-6127	PAR-CLIP	23592263
MIRT454219	hsa-miR-6129	PAR-CLIP	23592263
MIRT454218	hsa-miR-6130	PAR-CLIP	23592263
MIRT454217	hsa-miR-6133	PAR-CLIP	23592263
MIRT454216	hsa-miR-509-3p	PAR-CLIP	23592263
MIRT454215	hsa-miR-1249-5p	PAR-CLIP	23592263
MIRT454214	hsa-miR-6797-5p	PAR-CLIP	23592263
MIRT454213	hsa-miR-149-3p	PAR-CLIP	23592263
MIRT454212	hsa-miR-4728-5p	PAR-CLIP	23592263
MIRT454211	hsa-miR-6785-5p	PAR-CLIP	23592263
MIRT454210	hsa-miR-6883-5p	PAR-CLIP	23592263
MIRT454209	hsa-miR-3175	PAR-CLIP	23592263
MIRT454208	hsa-miR-6825-5p	PAR-CLIP	23592263
MIRT454207	hsa-miR-2110	PAR-CLIP	23592263
MIRT454206	hsa-miR-6810-5p	PAR-CLIP	23592263
MIRT454205	hsa-miR-6857-5p	PAR-CLIP	23592263
MIRT454204	hsa-miR-450a-2-3p	PAR-CLIP	23592263
MIRT401722	hsa-miR-6854-5p	PAR-CLIP	23592263
MIRT454203	hsa-miR-4756-3p	PAR-CLIP	23592263
MIRT218522	hsa-miR-148a-3p	PAR-CLIP	23592263
MIRT019424	hsa-miR-148b-3p	PAR-CLIP	23592263
MIRT218523	hsa-miR-152-3p	PAR-CLIP	23592263
MIRT218527	hsa-miR-8060	PAR-CLIP	23592263
MIRT392109	hsa-miR-4670-3p	PAR-CLIP	23592263
MIRT454202	hsa-miR-4524a-3p	PAR-CLIP	23592263
MIRT454201	hsa-miR-1273f	PAR-CLIP	23592263
MIRT454199	hsa-miR-4534	PAR-CLIP	23592263
MIRT454200	hsa-miR-8082	PAR-CLIP	23592263
MIRT218525	hsa-miR-767-5p	PAR-CLIP	23592263
MIRT454198	hsa-miR-139-3p	PAR-CLIP	23592263
MIRT454197	hsa-miR-3672	PAR-CLIP	23592263
MIRT454195	hsa-miR-6864-3p	PAR-CLIP	23592263
MIRT1048273	hsa-miR-1252	CLIP-seq
MIRT1048274	hsa-miR-148a	CLIP-seq
MIRT1048275	hsa-miR-148b	CLIP-seq
MIRT1048276	hsa-miR-152	CLIP-seq
MIRT1048277	hsa-miR-3185	CLIP-seq
MIRT1048278	hsa-miR-3202	CLIP-seq
MIRT1048279	hsa-miR-4436b-3p	CLIP-seq
MIRT1048280	hsa-miR-4533	CLIP-seq
MIRT1048281	hsa-miR-4735-5p	CLIP-seq
MIRT1048282	hsa-miR-4747-5p	CLIP-seq
MIRT1048283	hsa-miR-4775	CLIP-seq
MIRT1048284	hsa-miR-590-3p	CLIP-seq
MIRT1048285	hsa-miR-633	CLIP-seq
MIRT1048286	hsa-miR-873	CLIP-seq
MIRT1048273	hsa-miR-1252	CLIP-seq
MIRT1048277	hsa-miR-3185	CLIP-seq
MIRT1048280	hsa-miR-4533	CLIP-seq
MIRT1048282	hsa-miR-4747-5p	CLIP-seq
MIRT1048283	hsa-miR-4775	CLIP-seq
MIRT1048284	hsa-miR-590-3p	CLIP-seq
MIRT1048285	hsa-miR-633	CLIP-seq
MIRT1556518	hsa-miR-1224-3p	CLIP-seq
MIRT1556519	hsa-miR-1293	CLIP-seq
MIRT1556520	hsa-miR-3138	CLIP-seq
MIRT1556521	hsa-miR-3165	CLIP-seq
MIRT1556522	hsa-miR-3183	CLIP-seq
MIRT1556523	hsa-miR-323-5p	CLIP-seq
MIRT1556524	hsa-miR-342-5p	CLIP-seq
MIRT1556525	hsa-miR-4323	CLIP-seq
MIRT1556526	hsa-miR-4483	CLIP-seq
MIRT1556527	hsa-miR-4651	CLIP-seq
MIRT1556528	hsa-miR-4664-5p	CLIP-seq
MIRT1556529	hsa-miR-4690-3p	CLIP-seq
MIRT1556530	hsa-miR-4723-3p	CLIP-seq
MIRT1556531	hsa-miR-4758-3p	CLIP-seq
MIRT1556532	hsa-miR-608	CLIP-seq
MIRT1920049	hsa-miR-1297	CLIP-seq
MIRT1920050	hsa-miR-26a	CLIP-seq
MIRT1920051	hsa-miR-26b	CLIP-seq
MIRT1920052	hsa-miR-298	CLIP-seq
MIRT1920053	hsa-miR-3121-5p	CLIP-seq
MIRT1920054	hsa-miR-3665	CLIP-seq
MIRT1920055	hsa-miR-3678-3p	CLIP-seq
MIRT1920056	hsa-miR-4465	CLIP-seq
MIRT1920057	hsa-miR-4643	CLIP-seq
MIRT1920058	hsa-miR-642b	CLIP-seq
MIRT1920059	hsa-miR-657	CLIP-seq
MIRT1920060	hsa-miR-764	CLIP-seq
MIRT1920052	hsa-miR-298	CLIP-seq
MIRT1920053	hsa-miR-3121-5p	CLIP-seq
MIRT1920055	hsa-miR-3678-3p	CLIP-seq
MIRT1048282	hsa-miR-4747-5p	CLIP-seq
MIRT1556518	hsa-miR-1224-3p	CLIP-seq
MIRT1556519	hsa-miR-1293	CLIP-seq
MIRT1920049	hsa-miR-1297	CLIP-seq
MIRT2437592	hsa-miR-1299	CLIP-seq
MIRT1048274	hsa-miR-148a	CLIP-seq
MIRT1048275	hsa-miR-148b	CLIP-seq
MIRT1048276	hsa-miR-152	CLIP-seq
MIRT2437593	hsa-miR-224	CLIP-seq
MIRT1920050	hsa-miR-26a	CLIP-seq
MIRT1920051	hsa-miR-26b	CLIP-seq
MIRT1920052	hsa-miR-298	CLIP-seq
MIRT1920053	hsa-miR-3121-5p	CLIP-seq
MIRT1556520	hsa-miR-3138	CLIP-seq
MIRT2437594	hsa-miR-3150a-3p	CLIP-seq
MIRT2437595	hsa-miR-3152-5p	CLIP-seq
MIRT1556521	hsa-miR-3165	CLIP-seq
MIRT1556522	hsa-miR-3183	CLIP-seq
MIRT1048277	hsa-miR-3185	CLIP-seq
MIRT1048278	hsa-miR-3202	CLIP-seq
MIRT1556523	hsa-miR-323-5p	CLIP-seq
MIRT2437596	hsa-miR-326	CLIP-seq
MIRT2437597	hsa-miR-330-5p	CLIP-seq
MIRT1556524	hsa-miR-342-5p	CLIP-seq
MIRT1920054	hsa-miR-3665	CLIP-seq
MIRT1920055	hsa-miR-3678-3p	CLIP-seq
MIRT1556525	hsa-miR-4323	CLIP-seq
MIRT1048279	hsa-miR-4436b-3p	CLIP-seq
MIRT1920056	hsa-miR-4465	CLIP-seq
MIRT1556526	hsa-miR-4483	CLIP-seq
MIRT1920057	hsa-miR-4643	CLIP-seq
MIRT1556527	hsa-miR-4651	CLIP-seq
MIRT1556528	hsa-miR-4664-5p	CLIP-seq
MIRT1556529	hsa-miR-4690-3p	CLIP-seq
MIRT2437598	hsa-miR-4719	CLIP-seq
MIRT1556530	hsa-miR-4723-3p	CLIP-seq
MIRT1048282	hsa-miR-4747-5p	CLIP-seq
MIRT1556531	hsa-miR-4758-3p	CLIP-seq
MIRT1556532	hsa-miR-608	CLIP-seq
MIRT1920058	hsa-miR-642b	CLIP-seq
MIRT1920059	hsa-miR-657	CLIP-seq
MIRT1920060	hsa-miR-764	CLIP-seq
MIRT1048286	hsa-miR-873	CLIP-seq
MIRT2437599	hsa-miR-875-3p	CLIP-seq
MIRT2437600	hsa-miR-939	CLIP-seq
MIRT2451227	hsa-miR-188-3p	CLIP-seq
MIRT2451228	hsa-miR-1910	CLIP-seq
MIRT2451229	hsa-miR-3714	CLIP-seq
MIRT2451230	hsa-miR-4457	CLIP-seq
MIRT2451231	hsa-miR-455-3p	CLIP-seq
MIRT2451232	hsa-miR-4731-3p	CLIP-seq
MIRT2451233	hsa-miR-4801	CLIP-seq
MIRT1556518	hsa-miR-1224-3p	CLIP-seq
MIRT1556519	hsa-miR-1293	CLIP-seq
MIRT1920049	hsa-miR-1297	CLIP-seq
MIRT2437592	hsa-miR-1299	CLIP-seq
MIRT2451227	hsa-miR-188-3p	CLIP-seq
MIRT2451228	hsa-miR-1910	CLIP-seq
MIRT2437593	hsa-miR-224	CLIP-seq
MIRT2546413	hsa-miR-23a	CLIP-seq
MIRT2546414	hsa-miR-23b	CLIP-seq
MIRT2546415	hsa-miR-23c	CLIP-seq
MIRT1920050	hsa-miR-26a	CLIP-seq
MIRT1920051	hsa-miR-26b	CLIP-seq
MIRT1920052	hsa-miR-298	CLIP-seq
MIRT1920053	hsa-miR-3121-5p	CLIP-seq
MIRT1556520	hsa-miR-3138	CLIP-seq
MIRT2437594	hsa-miR-3150a-3p	CLIP-seq
MIRT2437595	hsa-miR-3152-5p	CLIP-seq
MIRT1556521	hsa-miR-3165	CLIP-seq
MIRT1556522	hsa-miR-3183	CLIP-seq
MIRT1048278	hsa-miR-3202	CLIP-seq
MIRT1556523	hsa-miR-323-5p	CLIP-seq
MIRT2437596	hsa-miR-326	CLIP-seq
MIRT2437597	hsa-miR-330-5p	CLIP-seq
MIRT1556524	hsa-miR-342-5p	CLIP-seq
MIRT1920054	hsa-miR-3665	CLIP-seq
MIRT1920055	hsa-miR-3678-3p	CLIP-seq
MIRT2451229	hsa-miR-3714	CLIP-seq
MIRT2546416	hsa-miR-4264	CLIP-seq
MIRT2546417	hsa-miR-4286	CLIP-seq
MIRT1556525	hsa-miR-4323	CLIP-seq
MIRT1048279	hsa-miR-4436b-3p	CLIP-seq
MIRT2451230	hsa-miR-4457	CLIP-seq
MIRT1920056	hsa-miR-4465	CLIP-seq
MIRT1556526	hsa-miR-4483	CLIP-seq
MIRT2451231	hsa-miR-455-3p	CLIP-seq
MIRT2546418	hsa-miR-4633-5p	CLIP-seq
MIRT1920057	hsa-miR-4643	CLIP-seq
MIRT1556527	hsa-miR-4651	CLIP-seq
MIRT1556528	hsa-miR-4664-5p	CLIP-seq
MIRT1556529	hsa-miR-4690-3p	CLIP-seq
MIRT2437598	hsa-miR-4719	CLIP-seq
MIRT1556530	hsa-miR-4723-3p	CLIP-seq
MIRT2451232	hsa-miR-4731-3p	CLIP-seq
MIRT1048282	hsa-miR-4747-5p	CLIP-seq
MIRT1556531	hsa-miR-4758-3p	CLIP-seq
MIRT2546419	hsa-miR-4797-3p	CLIP-seq
MIRT2451233	hsa-miR-4801	CLIP-seq
MIRT2546420	hsa-miR-532-5p	CLIP-seq
MIRT1556532	hsa-miR-608	CLIP-seq
MIRT1920058	hsa-miR-642b	CLIP-seq
MIRT1920059	hsa-miR-657	CLIP-seq
MIRT1920060	hsa-miR-764	CLIP-seq
MIRT1048286	hsa-miR-873	CLIP-seq
MIRT2437599	hsa-miR-875-3p	CLIP-seq
MIRT2437600	hsa-miR-939	CLIP-seq
MIRT1556518	hsa-miR-1224-3p	CLIP-seq
MIRT1556519	hsa-miR-1293	CLIP-seq
MIRT1920049	hsa-miR-1297	CLIP-seq
MIRT2437592	hsa-miR-1299	CLIP-seq
MIRT2451227	hsa-miR-188-3p	CLIP-seq
MIRT2451228	hsa-miR-1910	CLIP-seq
MIRT2437593	hsa-miR-224	CLIP-seq
MIRT2546413	hsa-miR-23a	CLIP-seq
MIRT2546414	hsa-miR-23b	CLIP-seq
MIRT2546415	hsa-miR-23c	CLIP-seq
MIRT1920050	hsa-miR-26a	CLIP-seq
MIRT1920051	hsa-miR-26b	CLIP-seq
MIRT1920052	hsa-miR-298	CLIP-seq
MIRT1920053	hsa-miR-3121-5p	CLIP-seq
MIRT1556520	hsa-miR-3138	CLIP-seq
MIRT2437594	hsa-miR-3150a-3p	CLIP-seq
MIRT2437595	hsa-miR-3152-5p	CLIP-seq
MIRT1556521	hsa-miR-3165	CLIP-seq
MIRT1556522	hsa-miR-3183	CLIP-seq
MIRT1048278	hsa-miR-3202	CLIP-seq
MIRT1556523	hsa-miR-323-5p	CLIP-seq
MIRT2437596	hsa-miR-326	CLIP-seq
MIRT2437597	hsa-miR-330-5p	CLIP-seq
MIRT1556524	hsa-miR-342-5p	CLIP-seq
MIRT1920054	hsa-miR-3665	CLIP-seq
MIRT1920055	hsa-miR-3678-3p	CLIP-seq
MIRT2451229	hsa-miR-3714	CLIP-seq
MIRT2546416	hsa-miR-4264	CLIP-seq
MIRT2546417	hsa-miR-4286	CLIP-seq
MIRT1556525	hsa-miR-4323	CLIP-seq
MIRT1048279	hsa-miR-4436b-3p	CLIP-seq
MIRT2451230	hsa-miR-4457	CLIP-seq
MIRT1920056	hsa-miR-4465	CLIP-seq
MIRT1556526	hsa-miR-4483	CLIP-seq
MIRT2451231	hsa-miR-455-3p	CLIP-seq
MIRT2546418	hsa-miR-4633-5p	CLIP-seq
MIRT1920057	hsa-miR-4643	CLIP-seq
MIRT1556527	hsa-miR-4651	CLIP-seq
MIRT1556528	hsa-miR-4664-5p	CLIP-seq
MIRT1556529	hsa-miR-4690-3p	CLIP-seq
MIRT2437598	hsa-miR-4719	CLIP-seq
MIRT1556530	hsa-miR-4723-3p	CLIP-seq
MIRT2451232	hsa-miR-4731-3p	CLIP-seq
MIRT1048282	hsa-miR-4747-5p	CLIP-seq
MIRT1556531	hsa-miR-4758-3p	CLIP-seq
MIRT2546419	hsa-miR-4797-3p	CLIP-seq
MIRT2451233	hsa-miR-4801	CLIP-seq
MIRT2546420	hsa-miR-532-5p	CLIP-seq
MIRT1556532	hsa-miR-608	CLIP-seq
MIRT1920058	hsa-miR-642b	CLIP-seq
MIRT1920059	hsa-miR-657	CLIP-seq
MIRT1920060	hsa-miR-764	CLIP-seq
MIRT1048286	hsa-miR-873	CLIP-seq
MIRT2437599	hsa-miR-875-3p	CLIP-seq
MIRT2437600	hsa-miR-939	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
CIITA	Activation	10329350
HIVEP2	Unknown	1409593
IRF1	Activation	19428110
MYC	Activation	8206526
MYCN	Unknown	8895520
RELA	Activation	19428110

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000139	Component	Golgi membrane	IEA
GO:0000139	Component	Golgi membrane	TAS
GO:0001913	Process	T cell mediated cytotoxicity	IDA	7504010
GO:0001916	Process	Positive regulation of T cell mediated cytotoxicity	IBA
GO:0001916	Process	Positive regulation of T cell mediated cytotoxicity	IDA	2420472, 8805302, 22031944, 25631937
GO:0002250	Process	Adaptive immune response	IEA
GO:0002376	Process	Immune system process	IEA
GO:0002419	Process	T cell mediated cytotoxicity directed against tumor cell target	IDA	1402688, 17189421, 20364150
GO:0002474	Process	Antigen processing and presentation of peptide antigen via MHC class I	IEA
GO:0002476	Process	Antigen processing and presentation of endogenous peptide antigen via MHC class Ib	IBA
GO:0002485	Process	Antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent	IMP	8630735
GO:0002486	Process	Antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent	IBA
GO:0002486	Process	Antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent	IDA	22031944
GO:0002502	Process	Peptide antigen assembly with MHC class I protein complex	IDA	36104323
GO:0002726	Process	Positive regulation of T cell cytokine production	IDA	24643698
GO:0003723	Function	RNA binding	HDA	22658674
GO:0005102	Function	Signaling receptor binding	IBA
GO:0005102	Function	Signaling receptor binding	IPI	19124746
GO:0005515	Function	Protein binding	IPI	9177355, 12414957, 20946353, 23401559, 26869717
GO:0005615	Component	Extracellular space	IBA
GO:0005783	Component	Endoplasmic reticulum	IDA	8805302, 20946353
GO:0005783	Component	Endoplasmic reticulum	IEA
GO:0005789	Component	Endoplasmic reticulum membrane	IEA
GO:0005789	Component	Endoplasmic reticulum membrane	TAS
GO:0005794	Component	Golgi apparatus	IDA	20946353
GO:0005797	Component	Golgi medial cisterna	IDA	8805302
GO:0005886	Component	Plasma membrane	IDA	2784196, 8630735
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	NAS	1431115, 2437024, 2478623, 2715640, 6609814, 8188325
GO:0005886	Component	Plasma membrane	TAS
GO:0006955	Process	Immune response	IBA
GO:0006955	Process	Immune response	IEA
GO:0006955	Process	Immune response	IMP	22321387
GO:0006955	Process	Immune response	NAS	1431115, 2437024, 2478623, 2715640, 6609814, 8188325
GO:0009897	Component	External side of plasma membrane	IBA
GO:0009986	Component	Cell surface	IDA	8805302, 8839770, 22031944
GO:0009986	Component	Cell surface	IEA
GO:0012507	Component	ER to Golgi transport vesicle membrane	IEA
GO:0012507	Component	ER to Golgi transport vesicle membrane	TAS
GO:0016020	Component	Membrane	HDA	19946888
GO:0016020	Component	Membrane	IEA
GO:0016045	Process	Detection of bacterium	IMP	22321387
GO:0019731	Process	Antibacterial humoral response	IDA	25631937
GO:0019882	Process	Antigen processing and presentation	IEA
GO:0019885	Process	Antigen processing and presentation of endogenous peptide antigen via MHC class I	IDA	1402688, 20364150, 24643698
GO:0030670	Component	Phagocytic vesicle membrane	IEA
GO:0030670	Component	Phagocytic vesicle membrane	TAS
GO:0030881	Function	Beta-2-microglobulin binding	IC	25631937
GO:0030881	Function	Beta-2-microglobulin binding	IDA	3309677, 7694806, 8805302, 8906788
GO:0030881	Function	Beta-2-microglobulin binding	IMP	23566939
GO:0031901	Component	Early endosome membrane	IEA
GO:0031901	Component	Early endosome membrane	TAS
GO:0032729	Process	Positive regulation of type II interferon production	IDA	22031944
GO:0036037	Process	CD8-positive, alpha-beta T cell activation	IDA	1402688, 2784196, 7504010, 8630735, 12138174, 17189421, 20364150
GO:0042270	Process	Protection from natural killer cell mediated cytotoxicity	IDA	18502829
GO:0042270	Process	Protection from natural killer cell mediated cytotoxicity	IDA	8839770, 18502829
GO:0042590	Process	Antigen processing and presentation of exogenous peptide antigen via MHC class I	IDA	7504010, 12138174
GO:0042605	Function	Peptide antigen binding	IBA
GO:0042605	Function	Peptide antigen binding	IDA	1402688, 7504010, 7694806, 8805302, 8839770, 8906788, 8955188, 9177355, 10435578, 17189421, 20364150, 22031944, 24643698, 25631937
GO:0042605	Function	Peptide antigen binding	IMP	23566939
GO:0042608	Function	T cell receptor binding	IDA	8906788, 8955188, 10435578
GO:0042610	Function	CD8 receptor binding	IDA	2784196
GO:0042612	Component	MHC class I protein complex	IDA	7694806, 8805302, 8906788, 22031944, 25631937
GO:0042612	Component	MHC class I protein complex	IEA
GO:0042824	Component	MHC class I peptide loading complex	IDA	21263072
GO:0045087	Process	Innate immune response	IEA
GO:0046977	Function	TAP binding	IDA	8617941, 8805302
GO:0050830	Process	Defense response to Gram-positive bacterium	IDA	25631937
GO:0050852	Process	T cell receptor signaling pathway	IDA	10435578
GO:0055038	Component	Recycling endosome membrane	IEA
GO:0055038	Component	Recycling endosome membrane	TAS
GO:0062061	Function	TAP complex binding	IDA	8630735
GO:0070062	Component	Extracellular exosome	HDA	11487543, 19199708, 20458337
GO:0070971	Component	Endoplasmic reticulum exit site	IDA	20946353
GO:0098553	Component	Lumenal side of endoplasmic reticulum membrane	IEA
GO:0098553	Component	Lumenal side of endoplasmic reticulum membrane	TAS
GO:2000566	Process	Positive regulation of CD8-positive, alpha-beta T cell proliferation	IDA	25631937
GO:2000568	Process	Positive regulation of memory T cell activation	IDA	22031944
GO:2001187	Process	Positive regulation of CD8-positive, alpha-beta T cell activation	IDA	24643698

Other IDs

• MIM: 142800
• HGNC: 4931
• e!Ensembl: ENSG00000206503

Protein

• UniProt ID: P04439
• Protein name: HLA class I histocompatibility antigen, A alpha chain (Human leukocyte antigen A) (HLA-A)
• Protein function: Antigen-presenting major histocompatibility complex class I (MHCI) molecule. In complex with B2M/beta 2 microglobulin displays primarily viral and tumor-derived peptides on antigen-presenting cells for recognition by alpha-beta T cell receptor (
• PDB: 1AKJ, 1AO7, 1AQD, 1B0G, 1B0R, 1BD2, 1DUY, 1DUZ, 1EEY, 1EEZ, 1HHG, 1HHH, 1HHI, 1HHJ, 1HHK, 1HLA, 1HSB, 1I1F, 1I1Y, 1I4F, 1I7R, 1I7T, 1I7U, 1IM3, 1JF1, 1JHT, 1LP9, 1OGA, 1P7Q, 1Q94, 1QEW, 1QR1, 1QRN, 1QSE, 1QSF, 1QVO, 1S8D, 1S9W, 1S9X, 1S9Y, 1T1W, 1T1X, 1T1Y, 1T1Z, 1T20, 1T21, 1T22, 1TMC, 1TVB, 1TVH, 1W72
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00129	MHC_I	25 → 203	Class I Histocompatibility antigen, domains alpha 1 and 2	Domain
  PF07654	C1-set	210 → 290	Immunoglobulin C1-set domain	Domain
  PF06623	MHC_I_C	337 → 364	MHC_I C-terminus	Family

• Tissue specificity: TISSUE SPECIFICITY: Ubiquitous. {ECO:0000305}.
• Sequence:

  MAVMAPRTLLLLLSGALALTQTWAGSHSMRYFFTSVSRPGRGEPRFIAVGYVDDTQFVRF
  DSDAASQRMEPRAPWIEQEGPEYWDQETRNVKAQSQTDRVDLGTLRGYYNQSEAGSHTIQ
  IMYGCDVGSDGRFLRGYRQDAYDGKDYIALNEDLRSWTAADMAAQITKRKWEAAHEAEQL
  RAYLDGTCVEWLRRYLENGKETLQRTDPPKTHMTHHPISDHEATLRCWALGFYPAEITLT
  WQRDGEDQTQDTELVETRPAGDGTFQKWAAVVVPSGEEQRYTCHVQHEGLPKPLTLRWEL
  SSQPTIPIVGIIAGLVLLGAVITGAVVAAVMWRRKSSDRKGGSYTQAASSDSAQGSDVSL
  TACKV

• Sequence length: 365

Pathways

KEGG:

Endocytosis
Phagosome
Cellular senescence
Cell adhesion molecules
Antigen processing and presentation
Natural killer cell mediated cytotoxicity
Type I diabetes mellitus
Human cytomegalovirus infection
Human papillomavirus infection
Human T-cell leukemia virus 1 infection
Kaposi sarcoma-associated herpesvirus infection
Herpes simplex virus 1 infection
Epstein-Barr virus infection
Human immunodeficiency virus 1 infection
Viral carcinogenesis
Autoimmune thyroid disease
Allograft rejection
Graft-versus-host disease
Viral myocarditis

Reactome:

ER-Phagosome pathway
Endosomal/Vacuolar pathway
Nef mediated downregulation of MHC class I complex cell surface expression
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Neutrophil degranulation
Interferon gamma signaling
E3 ubiquitin ligases ubiquitinate target proteins
Interferon alpha/beta signaling
Antigen Presentation: Folding, assembly and peptide loading of class I MHC

Associated diseases

Unknown
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
-	no classification for the single variant	rs2231004, rs1136689, rs1136690, rs9260138, rs9260139, rs9260140, rs1136691, rs1136695, rs1136700, rs1059488, rs3173420, rs1059506, rs1059517, rs1059536, rs9256983, rs1059542, rs1136741, rs1136749, rs1136754, rs1059563, rs1059564, rs2230954, rs9260179, rs9260180, rs9260181, rs1059632, rs2231095, rs1136903, rs1059846, rs3179982, rs1059896, rs3180278, rs3173429, rs1137078, rs1141891, rs1137296, rs2231119, rs1137631, rs14288, rs78306866, rs1071742, rs1136688	-
Abnormality of neuronal migration	Benign	rs199474493, rs281864764	RCV000201367 RCV000201406
Acute myeloid leukemia	-	rs1137110	RCV005931795
Adrenocortical carcinoma, hereditary	-	rs1137110	RCV005931796
Carbamazepine hypersensitivity	risk factor	rs1061235	RCV000022618
Cervical cancer	-	rs1137110	RCV005931797
Cholangiocarcinoma	-	rs1137110	RCV005931803
EBV-positive nodal T- and NK-cell lymphoma	Likely benign	rs45585732	RCV004560304
Gastric cancer	-	rs1137110	RCV005931800
Lung cancer	-	rs1137110	RCV005931804
Malignant lymphoma, large B-cell, diffuse	-	rs1137110	RCV005931798
Sarcoma	-	rs1137110	RCV005931799
Susceptibility to severe cutaneous adverse reaction	not provided	rs1554115495	RCV000509352
Thymoma	-	rs1137110	RCV005931802
Uterine carcinosarcoma	-	rs1137110	RCV005931801
Uterine corpus endometrial carcinoma	-	rs1137110	RCV005931805