Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	309
Gene name Gene Name - the full gene name approved by the HGNC.	Annexin A6
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	ANXA6
Synonyms (NCBI Gene) Gene synonyms aliases	ANX6, CBP68, CPB-II, p68, p70
Chromosome Chromosome number	5
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	5q33.1
Summary Summary of gene provided in NCBI Entrez Gene.	Annexin VI belongs to a family of calcium-dependent membrane and phospholipid binding proteins. Several members of the annexin family have been implicated in membrane-related events along exocytotic and endocytotic pathways. The annexin VI gene is approxi

Show/Hide all(155)

miRTarBase ID	miRNA	Experiments	Reference
MIRT022347	hsa-miR-124-3p	Microarray	18668037
MIRT043164	hsa-miR-324-5p	CLASH	23622248
MIRT037148	hsa-miR-877-3p	CLASH	23622248
MIRT786577	hsa-miR-138	CLIP-seq
MIRT786578	hsa-miR-3155	CLIP-seq
MIRT786579	hsa-miR-3187-3p	CLIP-seq
MIRT786580	hsa-miR-3907	CLIP-seq
MIRT786581	hsa-miR-4435	CLIP-seq
MIRT786582	hsa-miR-4467	CLIP-seq
MIRT786583	hsa-miR-4529-5p	CLIP-seq
MIRT786584	hsa-miR-4701-5p	CLIP-seq
MIRT786585	hsa-miR-548q	CLIP-seq
MIRT786586	hsa-miR-548s	CLIP-seq
MIRT786587	hsa-miR-588	CLIP-seq
MIRT786588	hsa-miR-135a	CLIP-seq
MIRT786589	hsa-miR-135b	CLIP-seq
MIRT786590	hsa-miR-1538	CLIP-seq
MIRT786591	hsa-miR-1913	CLIP-seq
MIRT786592	hsa-miR-3127-3p	CLIP-seq
MIRT786593	hsa-miR-3157-5p	CLIP-seq
MIRT786594	hsa-miR-324-3p	CLIP-seq
MIRT786595	hsa-miR-3667-3p	CLIP-seq
MIRT786596	hsa-miR-3685	CLIP-seq
MIRT786597	hsa-miR-384	CLIP-seq
MIRT786598	hsa-miR-4257	CLIP-seq
MIRT786599	hsa-miR-4300	CLIP-seq
MIRT786600	hsa-miR-4481	CLIP-seq
MIRT786601	hsa-miR-4520a-3p	CLIP-seq
MIRT786602	hsa-miR-4699-5p	CLIP-seq
MIRT786603	hsa-miR-4745-3p	CLIP-seq
MIRT786604	hsa-miR-4745-5p	CLIP-seq
MIRT786605	hsa-miR-4749-3p	CLIP-seq
MIRT786606	hsa-miR-544b	CLIP-seq
MIRT786607	hsa-miR-920	CLIP-seq
MIRT786590	hsa-miR-1538	CLIP-seq
MIRT1932021	hsa-miR-296-5p	CLIP-seq
MIRT1932022	hsa-miR-3137	CLIP-seq
MIRT1932023	hsa-miR-3153	CLIP-seq
MIRT1932024	hsa-miR-3154	CLIP-seq
MIRT1932025	hsa-miR-320e	CLIP-seq
MIRT1932026	hsa-miR-3610	CLIP-seq
MIRT786598	hsa-miR-4257	CLIP-seq
MIRT1932027	hsa-miR-4293	CLIP-seq
MIRT786599	hsa-miR-4300	CLIP-seq
MIRT786600	hsa-miR-4481	CLIP-seq
MIRT1932028	hsa-miR-451b	CLIP-seq
MIRT1932029	hsa-miR-4646-5p	CLIP-seq
MIRT1932030	hsa-miR-4668-5p	CLIP-seq
MIRT1932031	hsa-miR-4731-5p	CLIP-seq
MIRT786603	hsa-miR-4745-3p	CLIP-seq
MIRT786604	hsa-miR-4745-5p	CLIP-seq
MIRT1932032	hsa-miR-4786-3p	CLIP-seq
MIRT1932033	hsa-miR-485-5p	CLIP-seq
MIRT786606	hsa-miR-544b	CLIP-seq
MIRT1932034	hsa-miR-548t	CLIP-seq
MIRT1932035	hsa-miR-671-5p	CLIP-seq
MIRT786607	hsa-miR-920	CLIP-seq
MIRT2172432	hsa-miR-1270	CLIP-seq
MIRT2172433	hsa-miR-1273f	CLIP-seq
MIRT2172434	hsa-miR-4683	CLIP-seq
MIRT2172435	hsa-miR-620	CLIP-seq
MIRT2172436	hsa-miR-1265	CLIP-seq
MIRT786598	hsa-miR-4257	CLIP-seq
MIRT2172437	hsa-miR-4272	CLIP-seq
MIRT2172438	hsa-miR-4307	CLIP-seq
MIRT2435397	hsa-miR-103b	CLIP-seq
MIRT2435398	hsa-miR-2467-3p	CLIP-seq
MIRT1932022	hsa-miR-3137	CLIP-seq
MIRT2435399	hsa-miR-3651	CLIP-seq
MIRT2435400	hsa-miR-4436b-3p	CLIP-seq
MIRT2435401	hsa-miR-4685-5p	CLIP-seq
MIRT1932033	hsa-miR-485-5p	CLIP-seq
MIRT2435397	hsa-miR-103b	CLIP-seq
MIRT2172436	hsa-miR-1265	CLIP-seq
MIRT2475360	hsa-miR-1324	CLIP-seq
MIRT786588	hsa-miR-135a	CLIP-seq
MIRT786589	hsa-miR-135b	CLIP-seq
MIRT786590	hsa-miR-1538	CLIP-seq
MIRT2435398	hsa-miR-2467-3p	CLIP-seq
MIRT1932021	hsa-miR-296-5p	CLIP-seq
MIRT2475361	hsa-miR-3117-5p	CLIP-seq
MIRT1932022	hsa-miR-3137	CLIP-seq
MIRT1932023	hsa-miR-3153	CLIP-seq
MIRT786593	hsa-miR-3157-5p	CLIP-seq
MIRT1932025	hsa-miR-320e	CLIP-seq
MIRT1932026	hsa-miR-3610	CLIP-seq
MIRT2475362	hsa-miR-3612	CLIP-seq
MIRT2435399	hsa-miR-3651	CLIP-seq
MIRT2475363	hsa-miR-3660	CLIP-seq
MIRT786598	hsa-miR-4257	CLIP-seq
MIRT1932027	hsa-miR-4293	CLIP-seq
MIRT786599	hsa-miR-4300	CLIP-seq
MIRT2172438	hsa-miR-4307	CLIP-seq
MIRT2435400	hsa-miR-4436b-3p	CLIP-seq
MIRT786600	hsa-miR-4481	CLIP-seq
MIRT1932028	hsa-miR-451b	CLIP-seq
MIRT786601	hsa-miR-4520a-3p	CLIP-seq
MIRT2475364	hsa-miR-4526	CLIP-seq
MIRT1932029	hsa-miR-4646-5p	CLIP-seq
MIRT1932030	hsa-miR-4668-5p	CLIP-seq
MIRT2435401	hsa-miR-4685-5p	CLIP-seq
MIRT1932031	hsa-miR-4731-5p	CLIP-seq
MIRT786603	hsa-miR-4745-3p	CLIP-seq
MIRT786604	hsa-miR-4745-5p	CLIP-seq
MIRT1932033	hsa-miR-485-5p	CLIP-seq
MIRT786606	hsa-miR-544b	CLIP-seq
MIRT2475365	hsa-miR-650	CLIP-seq
MIRT2475366	hsa-miR-651	CLIP-seq
MIRT786607	hsa-miR-920	CLIP-seq
MIRT2435397	hsa-miR-103b	CLIP-seq
MIRT2172436	hsa-miR-1265	CLIP-seq
MIRT2475360	hsa-miR-1324	CLIP-seq
MIRT786588	hsa-miR-135a	CLIP-seq
MIRT786589	hsa-miR-135b	CLIP-seq
MIRT786590	hsa-miR-1538	CLIP-seq
MIRT2435398	hsa-miR-2467-3p	CLIP-seq
MIRT1932021	hsa-miR-296-5p	CLIP-seq
MIRT2475361	hsa-miR-3117-5p	CLIP-seq
MIRT786592	hsa-miR-3127-3p	CLIP-seq
MIRT1932022	hsa-miR-3137	CLIP-seq
MIRT1932023	hsa-miR-3153	CLIP-seq
MIRT786593	hsa-miR-3157-5p	CLIP-seq
MIRT1932025	hsa-miR-320e	CLIP-seq
MIRT1932026	hsa-miR-3610	CLIP-seq
MIRT2475362	hsa-miR-3612	CLIP-seq
MIRT2435399	hsa-miR-3651	CLIP-seq
MIRT2475363	hsa-miR-3660	CLIP-seq
MIRT786595	hsa-miR-3667-3p	CLIP-seq
MIRT786596	hsa-miR-3685	CLIP-seq
MIRT786597	hsa-miR-384	CLIP-seq
MIRT786598	hsa-miR-4257	CLIP-seq
MIRT1932027	hsa-miR-4293	CLIP-seq
MIRT786599	hsa-miR-4300	CLIP-seq
MIRT2172438	hsa-miR-4307	CLIP-seq
MIRT2435400	hsa-miR-4436b-3p	CLIP-seq
MIRT2675076	hsa-miR-4474-5p	CLIP-seq
MIRT786600	hsa-miR-4481	CLIP-seq
MIRT1932028	hsa-miR-451b	CLIP-seq
MIRT786601	hsa-miR-4520a-3p	CLIP-seq
MIRT2475364	hsa-miR-4526	CLIP-seq
MIRT1932029	hsa-miR-4646-5p	CLIP-seq
MIRT1932030	hsa-miR-4668-5p	CLIP-seq
MIRT2435401	hsa-miR-4685-5p	CLIP-seq
MIRT786602	hsa-miR-4699-5p	CLIP-seq
MIRT1932031	hsa-miR-4731-5p	CLIP-seq
MIRT786603	hsa-miR-4745-3p	CLIP-seq
MIRT786604	hsa-miR-4745-5p	CLIP-seq
MIRT786605	hsa-miR-4749-3p	CLIP-seq
MIRT1932033	hsa-miR-485-5p	CLIP-seq
MIRT2675077	hsa-miR-516b	CLIP-seq
MIRT786606	hsa-miR-544b	CLIP-seq
MIRT2675078	hsa-miR-593	CLIP-seq
MIRT2475365	hsa-miR-650	CLIP-seq
MIRT2475366	hsa-miR-651	CLIP-seq
MIRT786607	hsa-miR-920	CLIP-seq

Show/Hide all(36)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001786	Function	Phosphatidylserine binding	IBA
GO:0005509	Function	Calcium ion binding	IEA
GO:0005515	Function	Protein binding	IPI	15576473, 29636414, 32296183, 35063084
GO:0005525	Function	GTP binding	IMP	16605264
GO:0005544	Function	Calcium-dependent phospholipid binding	IBA
GO:0005544	Function	Calcium-dependent phospholipid binding	IDA	2138016
GO:0005544	Function	Calcium-dependent phospholipid binding	IEA
GO:0005634	Component	Nucleus	IBA
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IEA
GO:0005739	Component	Mitochondrion	IEA
GO:0005765	Component	Lysosomal membrane	IDA	23360953
GO:0005886	Component	Plasma membrane	IBA
GO:0005925	Component	Focal adhesion	HDA	21423176
GO:0006816	Process	Calcium ion transport	IBA
GO:0006816	Process	Calcium ion transport	IEA
GO:0006937	Process	Regulation of muscle contraction	IEA
GO:0008289	Function	Lipid binding	IMP	16605264
GO:0012506	Component	Vesicle membrane	IBA
GO:0015276	Function	Ligand-gated monoatomic ion channel activity	IMP	16605264
GO:0015485	Function	Cholesterol binding	IDA	23360953
GO:0016020	Component	Membrane	HDA	19946888
GO:0031012	Component	Extracellular matrix	HDA	28327460
GO:0031012	Component	Extracellular matrix	HDA	25037231, 28344315, 28675934
GO:0031902	Component	Late endosome membrane	IDA	23360953
GO:0034220	Process	Monoatomic ion transmembrane transport	IMP	16605264
GO:0042470	Component	Melanosome	IEA
GO:0042802	Function	Identical protein binding	IPI	16605264
GO:0048306	Function	Calcium-dependent protein binding	IPI	15226301
GO:0048471	Component	Perinuclear region of cytoplasm	IEA
GO:0051283	Process	Negative regulation of sequestering of calcium ion	IBA
GO:0051560	Process	Mitochondrial calcium ion homeostasis	IBA
GO:0051560	Process	Mitochondrial calcium ion homeostasis	IEA
GO:0070062	Component	Extracellular exosome	HDA	19056867, 20458337, 21362503, 23533145
GO:0097190	Process	Apoptotic signaling pathway	IBA
GO:0097190	Process	Apoptotic signaling pathway	IEA

MIM	HGNC	e!Ensembl
114070	544	ENSG00000197043

Protein

UniProt ID

P08133

Protein name

Annexin A6 (67 kDa calelectrin) (Annexin VI) (Annexin-6) (Calphobindin-II) (CPB-II) (Chromobindin-20) (Lipocortin VI) (Protein III) (p68) (p70)

Protein function

May associate with CD21. May regulate the release of Ca(2+) from intracellular stores.

PDB

1M9I

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00191	Annexin	24 → 89	Annexin	Family
PF00191	Annexin	96 → 161	Annexin	Family
PF00191	Annexin	179 → 245	Annexin	Family
PF00191	Annexin	255 → 320	Annexin	Family
PF00191	Annexin	367 → 432	Annexin	Family
PF00191	Annexin	439 → 504	Annexin	Family
PF00191	Annexin	524 → 593	Annexin	Family
PF00191	Annexin	603 → 668	Annexin	Family

Sequence

MAKPAQGAKYRGSIHDFPGFDPNQDAEALYTAMKGFGSDKEAILDIITSRSNRQRQEVCQ
SYKSLYGKDLIADLKYELTGKFERLIVGLMRPPAYCDAKEIKDAISGIGTDEKCLIEILA
SRTNEQMHQLVAAYKDAYERDLEADIIGDTSGHFQKMLVVLLQGTREEDDVVSEDLVQQD
VQDLYEAGELKWGTDEAQFIYILGNRSKQHLRLVFDEYLKTTGKPIEASIRGELSGDFEK
LMLAVVKCIRSTPEYFAERLFKAMKGLGTRDNTLIRIMVSRSELDMLDIREIFRTKYEKS
LYSMIKNDTSGEYKKTLLKLSGGDDDAAGQFFPEAAQVAYQMWELSAVARVELKGTVRPA
NDFNPDADAKALRKAMKGLGTDEDTIIDIITHRSNVQRQQIRQTFKSHFGRDLMTDLKSE
ISGDLARLILGLMMPPAHYDAKQLKKAMEGAGTDEKALIEILATRTNAEIRAINEAYKED
YHKSLEDALSSDTSGHFRRILISLATGHREEGGENLDQAREDAQVAAEILEIADTPSGDK
TSLETRFMTILCTRSYPHLRRVFQEFIKMTNYDVEHTIKKEMSGDVRDAFVAIVQSVKNK
PLFFADKLYKSMKGAGTDEKTLTRIMVSRSEIDLLNIRREFIEKYDKSLHQAIEGDTSGD
FLKALLALCGGED

Sequence length

673

Interactions

View interactions

Show/Hide Unknown Diseases (2)

Disease merge term	Disease name	Evidence	References	Source
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Psoriasis	Psoriasis	N/A	N/A	GWAS
Systemic lupus erythematosus	Systemic lupus erythematosus	N/A	N/A	GWAS

Show/Hide Text Mining Associations (28)

Disease Name	Relationship Type	References
Associations from Text Mining Disease associations identified through Pubtator
Adenoma	Associate	31784980
Breast Neoplasms	Associate	21185831
Breast Neoplasms	Inhibit	24354805
Cardiomyopathy Dilated	Associate	27711126
Dermatitis Atopic	Associate	25574825
Hypoxia	Stimulate	36230969
Inflammation	Associate	27046189
Leukemia Lymphocytic Chronic B Cell	Associate	16113842
Lupus Erythematosus Systemic	Associate	2466842
Lymphoma Follicular	Associate	34791836
Neoplasm Invasiveness	Stimulate	16417404
Neoplasm Metastasis	Associate	24354805
Neoplasms	Stimulate	16417404
Neoplasms	Associate	21119665, 24354805, 34238922, 37229937
Neoplasms	Inhibit	30590459, 36230969
Neoplasms Squamous Cell	Associate	21119665
Osteosarcoma	Associate	40616392
Ovarian Neoplasms	Associate	31474227
Polycystic Ovary Syndrome	Associate	27046189, 27846214
Polymyositis	Associate	2308937
Psoriasis	Associate	25574825
Renal Insufficiency Chronic	Associate	32046176
Sarcopenia	Associate	34371826
Scleroderma Systemic	Associate	32977850
Triple Negative Breast Neoplasms	Associate	30590459, 34238922, 36230969
Urinary Bladder Neoplasms	Associate	32420368, 33184436, 36761744
Uterine Cervical Dysplasia	Associate	21119665
Uterine Diseases	Stimulate	26586929

ANXA6 (annexin A6)