TAX1BP3 (Tax1 binding protein 3)

Gene

• Entrez ID: 30851
• Gene name: Tax1 binding protein 3
• Gene symbol: TAX1BP3
• Synonyms (NCBI Gene): TIP-1, TIP1
• Chromosome: 17
• Chromosome location: 17p13.2
• Summary: This gene encodes a small, highly conserved protein with a single PDZ domain. PDZ (PSD-95/Discs large/ZO-1 homologous) domains promote protein-protein interactions that affect cell signaling, adhesion, protein scaffolding, and receptor and ion transporter

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT022204	hsa-miR-124-3p	Microarray	18668037
MIRT028783	hsa-miR-26b-5p	Microarray	19088304
MIRT049449	hsa-miR-92a-3p	CLASH	23622248
MIRT043024	hsa-miR-324-5p	CLASH	23622248
MIRT696718	hsa-miR-4494	HITS-CLIP	23313552
MIRT696717	hsa-miR-922	HITS-CLIP	23313552
MIRT696716	hsa-miR-1199-5p	HITS-CLIP	23313552
MIRT696715	hsa-miR-6751-3p	HITS-CLIP	23313552
MIRT696714	hsa-miR-2114-3p	HITS-CLIP	23313552
MIRT696713	hsa-miR-6823-3p	HITS-CLIP	23313552
MIRT696712	hsa-miR-4771	HITS-CLIP	23313552
MIRT696711	hsa-miR-6811-3p	HITS-CLIP	23313552
MIRT696710	hsa-miR-492	HITS-CLIP	23313552
MIRT696709	hsa-miR-5587-5p	HITS-CLIP	23313552
MIRT696718	hsa-miR-4494	HITS-CLIP	23313552
MIRT696717	hsa-miR-922	HITS-CLIP	23313552
MIRT696716	hsa-miR-1199-5p	HITS-CLIP	23313552
MIRT696715	hsa-miR-6751-3p	HITS-CLIP	23313552
MIRT696714	hsa-miR-2114-3p	HITS-CLIP	23313552
MIRT696713	hsa-miR-6823-3p	HITS-CLIP	23313552
MIRT696712	hsa-miR-4771	HITS-CLIP	23313552
MIRT696711	hsa-miR-6811-3p	HITS-CLIP	23313552
MIRT696710	hsa-miR-492	HITS-CLIP	23313552
MIRT696709	hsa-miR-5587-5p	HITS-CLIP	23313552
MIRT1411800	hsa-miR-1275	CLIP-seq
MIRT1411801	hsa-miR-140-5p	CLIP-seq
MIRT1411802	hsa-miR-150	CLIP-seq
MIRT1411803	hsa-miR-2115	CLIP-seq
MIRT1411804	hsa-miR-3140-3p	CLIP-seq
MIRT1411805	hsa-miR-3149	CLIP-seq
MIRT1411806	hsa-miR-3180-5p	CLIP-seq
MIRT1411807	hsa-miR-34a	CLIP-seq
MIRT1411808	hsa-miR-34c-5p	CLIP-seq
MIRT1411809	hsa-miR-3692	CLIP-seq
MIRT1411810	hsa-miR-3945	CLIP-seq
MIRT1411811	hsa-miR-3973	CLIP-seq
MIRT1411812	hsa-miR-4253	CLIP-seq
MIRT1411813	hsa-miR-4260	CLIP-seq
MIRT1411814	hsa-miR-4283	CLIP-seq
MIRT1411815	hsa-miR-4325	CLIP-seq
MIRT1411816	hsa-miR-4488	CLIP-seq
MIRT1411817	hsa-miR-449a	CLIP-seq
MIRT1411818	hsa-miR-449b	CLIP-seq
MIRT1411819	hsa-miR-4663	CLIP-seq
MIRT1411820	hsa-miR-4665-5p	CLIP-seq
MIRT1411821	hsa-miR-4697-5p	CLIP-seq
MIRT1411822	hsa-miR-515-5p	CLIP-seq
MIRT1411823	hsa-miR-520a-5p	CLIP-seq
MIRT1411824	hsa-miR-525-5p	CLIP-seq
MIRT1411825	hsa-miR-548a-5p	CLIP-seq
MIRT1411826	hsa-miR-548ab	CLIP-seq
MIRT1411827	hsa-miR-548ac	CLIP-seq
MIRT1411828	hsa-miR-548ae	CLIP-seq
MIRT1411829	hsa-miR-548aj	CLIP-seq
MIRT1411830	hsa-miR-548ak	CLIP-seq
MIRT1411831	hsa-miR-548am	CLIP-seq
MIRT1411832	hsa-miR-548b-5p	CLIP-seq
MIRT1411833	hsa-miR-548c-5p	CLIP-seq
MIRT1411834	hsa-miR-548d-3p	CLIP-seq
MIRT1411835	hsa-miR-548d-5p	CLIP-seq
MIRT1411836	hsa-miR-548h	CLIP-seq
MIRT1411837	hsa-miR-548i	CLIP-seq
MIRT1411838	hsa-miR-548j	CLIP-seq
MIRT1411839	hsa-miR-548n	CLIP-seq
MIRT1411840	hsa-miR-548w	CLIP-seq
MIRT1411841	hsa-miR-548x	CLIP-seq
MIRT1411842	hsa-miR-548y	CLIP-seq
MIRT1411843	hsa-miR-548z	CLIP-seq
MIRT1411844	hsa-miR-559	CLIP-seq
MIRT1411845	hsa-miR-628-5p	CLIP-seq
MIRT1411846	hsa-miR-15a	CLIP-seq
MIRT1411847	hsa-miR-15b	CLIP-seq
MIRT1411848	hsa-miR-16	CLIP-seq
MIRT1411849	hsa-miR-195	CLIP-seq
MIRT1411850	hsa-miR-214	CLIP-seq
MIRT1411804	hsa-miR-3140-3p	CLIP-seq
MIRT1411851	hsa-miR-338-3p	CLIP-seq
MIRT1411852	hsa-miR-3619-5p	CLIP-seq
MIRT1411853	hsa-miR-3926	CLIP-seq
MIRT1411854	hsa-miR-424	CLIP-seq
MIRT1411813	hsa-miR-4260	CLIP-seq
MIRT1411855	hsa-miR-4310	CLIP-seq
MIRT1411856	hsa-miR-4530	CLIP-seq
MIRT1411857	hsa-miR-4691-5p	CLIP-seq
MIRT1411858	hsa-miR-497	CLIP-seq
MIRT1411859	hsa-miR-548s	CLIP-seq
MIRT1411860	hsa-miR-663b	CLIP-seq
MIRT1411861	hsa-miR-761	CLIP-seq
MIRT1411862	hsa-miR-766	CLIP-seq
MIRT2123677	hsa-miR-1252	CLIP-seq
MIRT2123678	hsa-miR-146b-3p	CLIP-seq
MIRT2123679	hsa-miR-185	CLIP-seq
MIRT2123680	hsa-miR-1972	CLIP-seq
MIRT2123681	hsa-miR-198	CLIP-seq
MIRT2123682	hsa-miR-22	CLIP-seq
MIRT2123683	hsa-miR-3150a-5p	CLIP-seq
MIRT2123684	hsa-miR-3150b-5p	CLIP-seq
MIRT2123685	hsa-miR-3173-5p	CLIP-seq
MIRT2123686	hsa-miR-3911	CLIP-seq
MIRT2123687	hsa-miR-4306	CLIP-seq
MIRT2123688	hsa-miR-4463	CLIP-seq
MIRT2123689	hsa-miR-4476	CLIP-seq
MIRT2123690	hsa-miR-4493	CLIP-seq
MIRT2123691	hsa-miR-4533	CLIP-seq
MIRT2123692	hsa-miR-4644	CLIP-seq
MIRT2123693	hsa-miR-4645-5p	CLIP-seq
MIRT2123694	hsa-miR-4673	CLIP-seq
MIRT2123695	hsa-miR-4731-5p	CLIP-seq
MIRT2123696	hsa-miR-4746-5p	CLIP-seq
MIRT2123697	hsa-miR-4747-5p	CLIP-seq
MIRT2123698	hsa-miR-4753-5p	CLIP-seq
MIRT2123699	hsa-miR-4755-3p	CLIP-seq
MIRT2123700	hsa-miR-4768-3p	CLIP-seq
MIRT2123701	hsa-miR-4792	CLIP-seq
MIRT2123702	hsa-miR-4794	CLIP-seq
MIRT2123703	hsa-miR-510	CLIP-seq
MIRT2123704	hsa-miR-512-5p	CLIP-seq
MIRT2123705	hsa-miR-558	CLIP-seq
MIRT2123706	hsa-miR-665	CLIP-seq
MIRT2123707	hsa-miR-874	CLIP-seq
MIRT2123708	hsa-miR-892b	CLIP-seq
MIRT2123709	hsa-miR-938	CLIP-seq
MIRT2345734	hsa-miR-1183	CLIP-seq
MIRT1411803	hsa-miR-2115	CLIP-seq
MIRT1411850	hsa-miR-214	CLIP-seq
MIRT2345735	hsa-miR-298	CLIP-seq
MIRT2345736	hsa-miR-3160-3p	CLIP-seq
MIRT1411806	hsa-miR-3180-5p	CLIP-seq
MIRT1411852	hsa-miR-3619-5p	CLIP-seq
MIRT1411810	hsa-miR-3945	CLIP-seq
MIRT1411811	hsa-miR-3973	CLIP-seq
MIRT1411812	hsa-miR-4253	CLIP-seq
MIRT2345737	hsa-miR-4291	CLIP-seq
MIRT2345738	hsa-miR-4303	CLIP-seq
MIRT1411815	hsa-miR-4325	CLIP-seq
MIRT2345739	hsa-miR-4433	CLIP-seq
MIRT2345740	hsa-miR-4487	CLIP-seq
MIRT2345741	hsa-miR-4514	CLIP-seq
MIRT1411819	hsa-miR-4663	CLIP-seq
MIRT2345742	hsa-miR-4692	CLIP-seq
MIRT2345743	hsa-miR-4693-5p	CLIP-seq
MIRT2345744	hsa-miR-4722-5p	CLIP-seq
MIRT2123695	hsa-miR-4731-5p	CLIP-seq
MIRT2345745	hsa-miR-4786-3p	CLIP-seq
MIRT2345746	hsa-miR-4795-5p	CLIP-seq
MIRT2345747	hsa-miR-4797-5p	CLIP-seq
MIRT1411823	hsa-miR-520a-5p	CLIP-seq
MIRT1411824	hsa-miR-525-5p	CLIP-seq
MIRT1411825	hsa-miR-548a-5p	CLIP-seq
MIRT1411826	hsa-miR-548ab	CLIP-seq
MIRT1411830	hsa-miR-548ak	CLIP-seq
MIRT1411832	hsa-miR-548b-5p	CLIP-seq
MIRT1411833	hsa-miR-548c-5p	CLIP-seq
MIRT1411835	hsa-miR-548d-5p	CLIP-seq
MIRT1411836	hsa-miR-548h	CLIP-seq
MIRT1411837	hsa-miR-548i	CLIP-seq
MIRT1411838	hsa-miR-548j	CLIP-seq
MIRT1411840	hsa-miR-548w	CLIP-seq
MIRT1411842	hsa-miR-548y	CLIP-seq
MIRT2123705	hsa-miR-558	CLIP-seq
MIRT1411844	hsa-miR-559	CLIP-seq
MIRT2345748	hsa-miR-574-5p	CLIP-seq
MIRT1411845	hsa-miR-628-5p	CLIP-seq
MIRT2345749	hsa-miR-759	CLIP-seq
MIRT1411861	hsa-miR-761	CLIP-seq
MIRT2345750	hsa-miR-940	CLIP-seq
MIRT2345734	hsa-miR-1183	CLIP-seq
MIRT2638708	hsa-miR-1200	CLIP-seq
MIRT2638709	hsa-miR-1224-3p	CLIP-seq
MIRT2638710	hsa-miR-1285	CLIP-seq
MIRT2123678	hsa-miR-146b-3p	CLIP-seq
MIRT1411803	hsa-miR-2115	CLIP-seq
MIRT2123682	hsa-miR-22	CLIP-seq
MIRT2638711	hsa-miR-3065-3p	CLIP-seq
MIRT2638712	hsa-miR-3150a-3p	CLIP-seq
MIRT2123683	hsa-miR-3150a-5p	CLIP-seq
MIRT2123684	hsa-miR-3150b-5p	CLIP-seq
MIRT2123685	hsa-miR-3173-5p	CLIP-seq
MIRT2638713	hsa-miR-3175	CLIP-seq
MIRT1411806	hsa-miR-3180-5p	CLIP-seq
MIRT2638714	hsa-miR-3187-5p	CLIP-seq
MIRT2638715	hsa-miR-323-5p	CLIP-seq
MIRT2638716	hsa-miR-3653	CLIP-seq
MIRT2638717	hsa-miR-378g	CLIP-seq
MIRT2638718	hsa-miR-4292	CLIP-seq
MIRT2638719	hsa-miR-4324	CLIP-seq
MIRT1411815	hsa-miR-4325	CLIP-seq
MIRT2345739	hsa-miR-4433	CLIP-seq
MIRT2638720	hsa-miR-4470	CLIP-seq
MIRT2638721	hsa-miR-4481	CLIP-seq
MIRT2638722	hsa-miR-4486	CLIP-seq
MIRT2345741	hsa-miR-4514	CLIP-seq
MIRT1411819	hsa-miR-4663	CLIP-seq
MIRT2638723	hsa-miR-4667-5p	CLIP-seq
MIRT2345742	hsa-miR-4692	CLIP-seq
MIRT2638724	hsa-miR-4693-3p	CLIP-seq
MIRT2345743	hsa-miR-4693-5p	CLIP-seq
MIRT2638725	hsa-miR-4700-5p	CLIP-seq
MIRT2345744	hsa-miR-4722-5p	CLIP-seq
MIRT2638726	hsa-miR-4745-5p	CLIP-seq
MIRT2123701	hsa-miR-4792	CLIP-seq
MIRT2345747	hsa-miR-4797-5p	CLIP-seq
MIRT2638727	hsa-miR-4799-5p	CLIP-seq
MIRT1411823	hsa-miR-520a-5p	CLIP-seq
MIRT1411824	hsa-miR-525-5p	CLIP-seq
MIRT2638728	hsa-miR-544b	CLIP-seq
MIRT2123705	hsa-miR-558	CLIP-seq
MIRT2638729	hsa-miR-605	CLIP-seq
MIRT2638730	hsa-miR-612	CLIP-seq
MIRT1411845	hsa-miR-628-5p	CLIP-seq
MIRT2123707	hsa-miR-874	CLIP-seq
MIRT2638731	hsa-miR-876-3p	CLIP-seq
MIRT2638732	hsa-miR-939	CLIP-seq
MIRT2345750	hsa-miR-940	CLIP-seq
MIRT2345734	hsa-miR-1183	CLIP-seq
MIRT2638708	hsa-miR-1200	CLIP-seq
MIRT2638709	hsa-miR-1224-3p	CLIP-seq
MIRT2638710	hsa-miR-1285	CLIP-seq
MIRT2123678	hsa-miR-146b-3p	CLIP-seq
MIRT1411803	hsa-miR-2115	CLIP-seq
MIRT2123682	hsa-miR-22	CLIP-seq
MIRT2638711	hsa-miR-3065-3p	CLIP-seq
MIRT2638712	hsa-miR-3150a-3p	CLIP-seq
MIRT2123683	hsa-miR-3150a-5p	CLIP-seq
MIRT2123684	hsa-miR-3150b-5p	CLIP-seq
MIRT2123685	hsa-miR-3173-5p	CLIP-seq
MIRT2638713	hsa-miR-3175	CLIP-seq
MIRT1411806	hsa-miR-3180-5p	CLIP-seq
MIRT2638714	hsa-miR-3187-5p	CLIP-seq
MIRT2638715	hsa-miR-323-5p	CLIP-seq
MIRT2638716	hsa-miR-3653	CLIP-seq
MIRT2638717	hsa-miR-378g	CLIP-seq
MIRT2638718	hsa-miR-4292	CLIP-seq
MIRT2638719	hsa-miR-4324	CLIP-seq
MIRT1411815	hsa-miR-4325	CLIP-seq
MIRT2345739	hsa-miR-4433	CLIP-seq
MIRT2123688	hsa-miR-4463	CLIP-seq
MIRT2638720	hsa-miR-4470	CLIP-seq
MIRT2638721	hsa-miR-4481	CLIP-seq
MIRT2638722	hsa-miR-4486	CLIP-seq
MIRT2345741	hsa-miR-4514	CLIP-seq
MIRT2123693	hsa-miR-4645-5p	CLIP-seq
MIRT1411819	hsa-miR-4663	CLIP-seq
MIRT2638723	hsa-miR-4667-5p	CLIP-seq
MIRT2123694	hsa-miR-4673	CLIP-seq
MIRT2345742	hsa-miR-4692	CLIP-seq
MIRT2638724	hsa-miR-4693-3p	CLIP-seq
MIRT2345743	hsa-miR-4693-5p	CLIP-seq
MIRT2638725	hsa-miR-4700-5p	CLIP-seq
MIRT2345744	hsa-miR-4722-5p	CLIP-seq
MIRT2638726	hsa-miR-4745-5p	CLIP-seq
MIRT2123701	hsa-miR-4792	CLIP-seq
MIRT2123702	hsa-miR-4794	CLIP-seq
MIRT2345747	hsa-miR-4797-5p	CLIP-seq
MIRT2638727	hsa-miR-4799-5p	CLIP-seq
MIRT2123703	hsa-miR-510	CLIP-seq
MIRT2123704	hsa-miR-512-5p	CLIP-seq
MIRT1411823	hsa-miR-520a-5p	CLIP-seq
MIRT1411824	hsa-miR-525-5p	CLIP-seq
MIRT2638728	hsa-miR-544b	CLIP-seq
MIRT2123705	hsa-miR-558	CLIP-seq
MIRT2638729	hsa-miR-605	CLIP-seq
MIRT2638730	hsa-miR-612	CLIP-seq
MIRT1411845	hsa-miR-628-5p	CLIP-seq
MIRT2123707	hsa-miR-874	CLIP-seq
MIRT2638731	hsa-miR-876-3p	CLIP-seq
MIRT2123708	hsa-miR-892b	CLIP-seq
MIRT2123709	hsa-miR-938	CLIP-seq
MIRT2638732	hsa-miR-939	CLIP-seq
MIRT2345750	hsa-miR-940	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001650	Component	Fibrillar center	IDA
GO:0005515	Function	Protein binding	IPI	10940294, 11163757, 15492812, 16855024, 20211142, 21139582, 25416956, 33961781
GO:0005634	Component	Nucleus	IEA
GO:0005737	Component	Cytoplasm	IEA
GO:0005737	Component	Cytoplasm	NAS	10940294
GO:0005829	Component	Cytosol	TAS
GO:0005886	Component	Plasma membrane	IEA
GO:0007266	Process	Rho protein signal transduction	IDA	10940294
GO:0008013	Function	Beta-catenin binding	IEA
GO:0008285	Process	Negative regulation of cell population proliferation	IEA
GO:0015629	Component	Actin cytoskeleton	IDA
GO:0016020	Component	Membrane	IEA
GO:0016055	Process	Wnt signaling pathway	IEA
GO:0030178	Process	Negative regulation of Wnt signaling pathway	IEA
GO:0030178	Process	Negative regulation of Wnt signaling pathway	ISS
GO:0032489	Process	Regulation of Cdc42 protein signal transduction	IDA	21139582
GO:0070062	Component	Extracellular exosome	HDA	19056867
GO:2000009	Process	Negative regulation of protein localization to cell surface	IDA	16855024

Other IDs

• MIM: 616484
• HGNC: 30684
• e!Ensembl: ENSG00000213977

Protein

• UniProt ID: O14907
• Protein name: Tax1-binding protein 3 (Glutaminase-interacting protein 3) (Tax interaction protein 1) (TIP-1) (Tax-interacting protein 1)
• Protein function: May regulate a number of protein-protein interactions by competing for PDZ domain binding sites. Binds CTNNB1 and may thereby act as an inhibitor of the Wnt signaling pathway. Competes with LIN7A for KCNJ4 binding, and thereby promotes KCNJ4 int
• PDB: 2KG2, 2L4S, 2L4T, 2VZ5, 3GJ9, 3SFJ, 4E3B, 4NNL, 4NNM
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00595	PDZ	17 → 110	PDZ domain	Domain

• Tissue specificity: TISSUE SPECIFICITY: Ubiquitous. Detected in brain, heart, kidney, lung, small intestine and skeletal muscle. Detected in various cell lines including HeLa. Weakly expressed in peripheral blood leukocytes. {ECO:0000269|PubMed:10940294, ECO:0000269|PubMed:1
• Sequence:

  MSYIPGQPVTAVVQRVEIHKLRQGENLILGFSIGGGIDQDPSQNPFSEDKTDKGIYVTRV
  SEGGPAEIAGLQIGDKIMQVNGWDMTMVTHDQARKRLTKRSEEVVRLLVTRQSLQKAVQQ
  SMLS

• Sequence length: 124

Pathways

Reactome:

RHO GTPases Activate Rhotekin and Rhophilins

Associated diseases

Unknown Evidence from ClinVar (non-pathogenic) or external databases: GenCC, Orphanet, ClinGen, HPO, DisGeNET, CTD, GWAS Catalog
Phenotype Name	References (PMID)	Source
FAMILIAL DILATED CARDIOMYOPATHY	—	Disgenet
LIVER CIRRHOSIS, EXPERIMENTAL	25380136	CTD
NEPHROPATHIC CYSTINOSIS	—	Disgenet