Gene Gene information from NCBI Gene database.
Entrez ID 30837
Gene name Suppressor of cytokine signaling 7
Gene symbol SOCS7
Synonyms (NCBI Gene)
NAP4NCKAP4
Chromosome 17
Chromosome location 17q12
miRNA miRNA information provided by mirtarbase database.
1170
miRTarBase ID miRNA Experiments Reference
MIRT007248 hsa-miR-145-5p Luciferase reporter assay 23392170
MIRT040011 hsa-miR-615-3p CLASH 23622248
MIRT614745 hsa-miR-8485 HITS-CLIP 23824327
MIRT614744 hsa-miR-4643 HITS-CLIP 23824327
MIRT614743 hsa-miR-1197 HITS-CLIP 23824327
Transcription factors Transcription factors information provided by TRRUST V2 database.
1
Transcription factor Regulation Reference
PPARG Unknown 20357037
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
21
GO ID Ontology Definition Evidence Reference
GO:0005515 Function Protein binding IPI 17803907, 20598684, 32296183, 33961781
GO:0005634 Component Nucleus IEA
GO:0005737 Component Cytoplasm IDA 17803907
GO:0005737 Component Cytoplasm IEA
GO:0005829 Component Cytosol IDA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
608788 29846 ENSG00000274211
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
O14512
Protein name Suppressor of cytokine signaling 7 (SOCS-7) (Nck, Ash and phospholipase C gamma-binding protein) (Nck-associated protein 4) (NAP-4)
Protein function Substrate-recognition component of a cullin-5-RING E3 ubiquitin-protein ligase complex (ECS complex, also named CRL5 complex), which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as DAB1 and IRS1 (Pu
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00017 SH2 400 474 SH2 domain Domain
PF07525 SOCS_box 515 550 SOCS box Domain
Tissue specificity TISSUE SPECIFICITY: Expressed in brain and leukocytes (PubMed:9344857). Also in fetal lung fibroblasts and fetal brain (PubMed:9344857). {ECO:0000269|PubMed:9344857}.
Sequence
MVFRNVGRPPEEEDVEAAPEPGPSELLCPRHRCALDPKALPPGLALERTWGPAAGLEAQL
AALGLGQPAGPGVKTVGGGCCPCPCPPQPPPPQPQPPAAAPQAGEDPTETSDALLVLEGL
ESEAESLETNSCSEEELSSPGRGGGGGGRLLLQPPGPELPPVPFPLQDLVPLGRLSRGEQ
QQQQQQQPPPPPPPPGPLRPLAGPSRKGSFKIRLSRLFRTKSCNGGSGGGDGTGKRPSGE
LAASAASLTDMGGSAGRELDAGRKPKLTRTQSAFSPVSFSPLFTGETVSLVDVDISQRGL
TSPHPPTPPPPPRRSLSLLDDISGTLPTSVLVAPMGSSLQSFPLPPPPPPHAPDAFPRIA
PIRAAESLHSQPPQHLQCPLYRPDSSSFAASLRELEKCGWYWGPMNWEDAEMKLKGKPDG
SFLVRDSSDPRYILSLSFRSQGITHHTRMEHYRGTFSLWCHPKFEDRCQSVVEF
IKRAIM
HSKNGKFLYFLRSRVPGLPPTPVQLLYPVSRFSNVKSLQHLCRFRIRQLVRIDHIPDLPL
PKPLISYIRK
FYYYDPQEEVYLSLKEAQLISKQKQEVEPST
Sequence length 581
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG 
  JAK-STAT signaling pathway
Prolactin signaling pathway