Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
30837
Gene name Gene Name - the full gene name approved by the HGNC.
Suppressor of cytokine signaling 7
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
SOCS7
Synonyms (NCBI Gene) Gene synonyms aliases
NAP4, NCKAP4
Chromosome Chromosome number
17
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
17q12
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT007248 hsa-miR-145-5p Luciferase reporter assay 23392170
MIRT040011 hsa-miR-615-3p CLASH 23622248
MIRT614745 hsa-miR-8485 HITS-CLIP 23824327
MIRT614744 hsa-miR-4643 HITS-CLIP 23824327
MIRT614743 hsa-miR-1197 HITS-CLIP 23824327
Transcription factors
Transcription factor Regulation Reference
PPARG Unknown 20357037
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0005515 Function Protein binding IPI 20598684, 32296183
GO:0005634 Component Nucleus IEA
GO:0005829 Component Cytosol IDA
GO:0005886 Component Plasma membrane IEA
GO:0005942 Component Phosphatidylinositol 3-kinase complex IBA 21873635
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
608788 29846 ENSG00000274211
Protein
UniProt ID O14512
Protein name Suppressor of cytokine signaling 7 (SOCS-7) (Nck, Ash and phospholipase C gamma-binding protein) (Nck-associated protein 4) (NAP-4)
Protein function Substrate-recognition component of a cullin-5-RING E3 ubiquitin-protein ligase complex (ECS complex, also named CRL5 complex), which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as DAB1 and IRS1 (Pu
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00017 SH2 400 474 SH2 domain Domain
PF07525 SOCS_box 515 550 SOCS box Domain
Tissue specificity TISSUE SPECIFICITY: Expressed in brain and leukocytes (PubMed:9344857). Also in fetal lung fibroblasts and fetal brain (PubMed:9344857). {ECO:0000269|PubMed:9344857}.
Sequence
MVFRNVGRPPEEEDVEAAPEPGPSELLCPRHRCALDPKALPPGLALERTWGPAAGLEAQL
AALGLGQPAGPGVKTVGGGCCPCPCPPQPPPPQPQPPAAAPQAGEDPTETSDALLVLEGL
ESEAESLETNSCSEEELSSPGRGGGGGGRLLLQPPGPELPPVPFPLQDLVPLGRLSRGEQ
QQQQQQQPPPPPPPPGPLRPLAGPSRKGSFKIRLSRLFRTKSCNGGSGGGDGTGKRPSGE
LAASAASLTDMGGSAGRELDAGRKPKLTRTQSAFSPVSFSPLFTGETVSLVDVDISQRGL
TSPHPPTPPPPPRRSLSLLDDISGTLPTSVLVAPMGSSLQSFPLPPPPPPHAPDAFPRIA
PIRAAESLHSQPPQHLQCPLYRPDSSSFAASLRELEKCGWYWGPMNWEDAEMKLKGKPDG
SFLVRDSSDPRYILSLSFRSQGITHHTRMEHYRGTFSLWCHPKFEDRCQSVVEF
IKRAIM
HSKNGKFLYFLRSRVPGLPPTPVQLLYPVSRFSNVKSLQHLCRFRIRQLVRIDHIPDLPL
PKPLISYIRK
FYYYDPQEEVYLSLKEAQLISKQKQEVEPST
Sequence length 581
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  
  JAK-STAT signaling pathway
Prolactin signaling pathway