Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	30832
Gene name	Zinc finger protein 354C
Gene symbol	ZNF354C
Synonyms (NCBI Gene)	KID3
Chromosome	5
Chromosome location	5q35.3

Show/Hide all (34)

miRTarBase ID	miRNA	Experiments	Reference
MIRT450085	hsa-miR-548l	PAR-CLIP	22100165
MIRT450084	hsa-miR-495-3p	PAR-CLIP	22100165
MIRT450083	hsa-miR-5688	PAR-CLIP	22100165
MIRT450082	hsa-miR-7-1-3p	PAR-CLIP	22100165
MIRT450081	hsa-miR-7-2-3p	PAR-CLIP	22100165
MIRT450080	hsa-miR-455-5p	PAR-CLIP	22100165
MIRT450079	hsa-miR-3973	PAR-CLIP	22100165
MIRT450078	hsa-miR-4645-3p	PAR-CLIP	22100165
MIRT450077	hsa-miR-636	PAR-CLIP	22100165
MIRT450076	hsa-miR-1273e	PAR-CLIP	22100165
MIRT450075	hsa-miR-218-5p	PAR-CLIP	22100165
MIRT450085	hsa-miR-548l	PAR-CLIP	22100165
MIRT450084	hsa-miR-495-3p	PAR-CLIP	22100165
MIRT450083	hsa-miR-5688	PAR-CLIP	22100165
MIRT450082	hsa-miR-7-1-3p	PAR-CLIP	22100165
MIRT450081	hsa-miR-7-2-3p	PAR-CLIP	22100165
MIRT450080	hsa-miR-455-5p	PAR-CLIP	22100165
MIRT450079	hsa-miR-3973	PAR-CLIP	22100165
MIRT450078	hsa-miR-4645-3p	PAR-CLIP	22100165
MIRT450077	hsa-miR-636	PAR-CLIP	22100165
MIRT450076	hsa-miR-1273e	PAR-CLIP	22100165
MIRT450075	hsa-miR-218-5p	PAR-CLIP	22100165
MIRT1523080	hsa-miR-4698	CLIP-seq
MIRT1523081	hsa-miR-4712-3p	CLIP-seq
MIRT2158028	hsa-miR-4477a	CLIP-seq
MIRT2377606	hsa-miR-1253	CLIP-seq
MIRT2377607	hsa-miR-204	CLIP-seq
MIRT2377608	hsa-miR-211	CLIP-seq
MIRT2377609	hsa-miR-2355-5p	CLIP-seq
MIRT2377610	hsa-miR-3938	CLIP-seq
MIRT2377611	hsa-miR-4755-5p	CLIP-seq
MIRT2377612	hsa-miR-623	CLIP-seq
MIRT2464218	hsa-miR-4272	CLIP-seq
MIRT1523080	hsa-miR-4698	CLIP-seq

Show/Hide all (24)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000122	Process	Negative regulation of transcription by RNA polymerase II	IEA
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA
GO:0001227	Function	DNA-binding transcription repressor activity, RNA polymerase II-specific	IMP	33154469
GO:0001525	Process	Angiogenesis	IEA
GO:0003677	Function	DNA binding	IEA
GO:0005515	Function	Protein binding	IPI	33154469
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IDA	33154469
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005737	Component	Cytoplasm	IDA	33154469
GO:0005737	Component	Cytoplasm	IEA
GO:0006355	Process	Regulation of DNA-templated transcription	IEA
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IBA
GO:0008270	Function	Zinc ion binding	IEA
GO:0010558	Process	Negative regulation of macromolecule biosynthetic process	IEA
GO:0016020	Component	Membrane	IEA
GO:0022603	Process	Regulation of anatomical structure morphogenesis	IEA
GO:0031965	Component	Nuclear membrane	IDA	33154469
GO:0031965	Component	Nuclear membrane	IEA
GO:0031981	Component	Nuclear lumen	IEA
GO:0046872	Function	Metal ion binding	IEA
GO:1903671	Process	Negative regulation of sprouting angiogenesis	IMP	33154469

MIM	HGNC	e!Ensembl
619511	16736	ENSG00000177932

Q86Y25

Protein name

Zinc finger protein 354C (Kidney, ischemia, and developmentally-regulated protein 3) (hKID3)

Protein function

Transcriptional repressor that inhibits endothelial angiogenic sprouting (PubMed:15555547, PubMed:33154469). Suppresses osteogenic effects of RUNX2 and may be involved in osteoblastic differentiation (By similarity). Plays a role in postnatal my

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01352	KRAB	11 → 52	KRAB box	Family
PF00096	zf-C2H2	216 → 238	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	244 → 266	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	272 → 294	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	300 → 322	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	356 → 378	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	384 → 406	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	412 → 434	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	440 → 462	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	468 → 490	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	496 → 518	Zinc finger, C2H2 type	Domain

Tissue specificity

TISSUE SPECIFICITY: Expressed in kidney and skeletal muscle. Very low expression in brain and heart (PubMed:15555547). Strongly expressed in vascular cells such as umbilical vein endothelial cells, microvascular endothelial cells and aortic smooth muscle

Sequence

MAVDLLSAQEPVTFRDVAVFFSQDEWLHLDSAQRALYREVMLENYSSLVSLGIPFSMPKL
IHQLQQGEDPCMVEREVPSDTRLGFKTWLETEALPHRQDIFIEETSQGMVKKESIKDGHW
DINFEEAVEFESEIEEEQEKKPLRQMIDSHEKTISEDGNHTSLELGKSLFTNTALVTQQS
VPIERIPNMYYTFGKDFKQNFDLMKCFQIYPGGKPHICNECGKSFKQNLHLIEHQRIHTG
EKPYKCNECEKTFSHRSSLLSHQRIHTGEKPYKCNECEKAFSNSSTLIKHLRVHTGEKPY
RCRECGKAFSQCSTLTVHQRIHTGEKLYKCGECEKAFNCRAKLHRHQRIHTGEKPYKCSE
CGKGYSQFTSLAEHQRFHTGEQLYTCLECGRTFTRIVTLIEHQRIHTGQKPYQCNECEKA
FNQYSSFNEHRKIHTGEKLYTCEECGKAFGCKSNLYRHQRIHTGEKPYQCNQCGKAFSQY
SFLTEHERIHTGEKLYKCMECGKAYSYRSNLCRHKKVHTKEKLYKWKEYGKPFICSSSLT
QYQRFFKGDKAYEV

Sequence length

554

Interactions

View interactions

	Reactome
			Generic Transcription Pathway

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (3)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
BIPOLAR DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MAJOR DEPRESSIVE DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCHIZOPHRENIA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (2)

Disease Name	Relationship Type	References	Evidence Score
Associations from Text MiningDisease associations identified through Pubtator
Breast Neoplasms	Associate	27809618	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Hepatocellular	Associate	27458175	★★★★★ ★☆☆☆☆ Found in Text Mining only

ZNF354C (zinc finger protein 354C)