HGF (hepatocyte growth factor)

Gene
Gene SNPs miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
3082
Gene name Gene Name - the full gene name approved by the HGNC.
Hepatocyte growth factor
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
HGF
Synonyms (NCBI Gene) Gene synonyms aliases
DFNB39, F-TCF, HGFB, HPTA, SF
Chromosome Chromosome number
7
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
7q21.11
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a protein that binds to the hepatocyte growth factor receptor to regulate cell growth, cell motility and morphogenesis in numerous cell and tissue types. Alternative splicing results in multiple transcript variants, at least one of which
SNPs SNP information provided by dbSNP.
Gene SNPs miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(5)
SNP ID Visualize variation Clinical significance Consequence
rs137853235 C>T Pathogenic Synonymous variant, intron variant, coding sequence variant
rs145494248 C>G,T Benign, conflicting-interpretations-of-pathogenicity Genic downstream transcript variant, coding sequence variant, missense variant
rs145598174 A>G Likely-benign, conflicting-interpretations-of-pathogenicity Synonymous variant, coding sequence variant
rs148714837 C>T Benign-likely-benign, likely-benign, conflicting-interpretations-of-pathogenicity Synonymous variant, genic downstream transcript variant, coding sequence variant
rs367800414 A>G Conflicting-interpretations-of-pathogenicity Synonymous variant, genic downstream transcript variant, coding sequence variant
miRNA miRNA information provided by mirtarbase database.
Gene SNPs miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(58)
miRTarBase ID miRNA Experiments Reference
MIRT054477 hsa-miR-199a-3p Luciferase reporter assay, QRTPCR, Western blot 23657814
MIRT054645 hsa-miR-26a-5p ELISA, Immunohistochemistry, Luciferase reporter assay, qRT-PCR, Western blot 28393839
MIRT054645 hsa-miR-26a-5p ELISA, Immunohistochemistry, Luciferase reporter assay, qRT-PCR, Western blot 28393839
MIRT054645 hsa-miR-26a-5p ELISA, Luciferase reporter assay, qRT-PCR 28386375
MIRT732936 hsa-miR-144-3p RNA-seq 33804111
Transcription factors
Gene SNPs miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(6)
Transcription factor Regulation Reference
NFIC Unknown 10860846
SP1 Activation 9223667
SP3 Activation 9223667
STAT3 Activation 12168776
STAT3 Unknown 23954444
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene SNPs miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(50)
GO ID Ontology Definition Evidence Reference
GO:0000278 Process Mitotic cell cycle NAS 2531289
GO:0000902 Process Cell morphogenesis IEA
GO:0001837 Process Epithelial to mesenchymal transition TAS 14679171
GO:0001889 Process Liver development IEA
GO:0004175 Function Endopeptidase activity IBA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene SNPs miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
142409 4893 ENSG00000019991
Protein
Gene SNPs miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID P14210
Protein name Hepatocyte growth factor (Hepatopoietin-A) (Scatter factor) (SF) [Cleaved into: Hepatocyte growth factor alpha chain; Hepatocyte growth factor beta chain]
Protein function Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types (PubMed:20624990). Activating ligand for the receptor tyrosine kinase MET by b
PDB 1BHT , 1GMN , 1GMO , 1GP9 , 1NK1 , 1SHY , 1SI5 , 2HGF , 2QJ2 , 3HMS , 3HMT , 3HN4 , 3MKP , 3SP8 , 4D3C , 4K3J , 4O3T , 4O3U , 5COE , 5CP9 , 5CS1 , 5CS3 , 5CS5 , 5CS9 , 5CSQ , 5CT1 , 5CT2 , 5CT3 , 7MO7 , 7MO8 , 7MO9 , 7MOA , 7MOB , 7OCL , 7OCM
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00024 PAN_1 40 → 124 PAN domain Domain
PF00051 Kringle 128 → 206 Kringle domain Domain
PF00051 Kringle 211 → 288 Kringle domain Domain
PF00051 Kringle 305 → 383 Kringle domain Domain
PF00051 Kringle 391 → 469 Kringle domain Domain
PF00089 Trypsin 495 → 716 Trypsin Domain
Sequence
Sequence length 728
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene SNPs miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
  KEGG   Reactome
  EGFR tyrosine kinase inhibitor resistance
MAPK signaling pathway
Ras signaling pathway
Rap1 signaling pathway
Calcium signaling pathway
PI3K-Akt signaling pathway
Focal adhesion
Malaria
Pathways in cancer
Proteoglycans in cancer
Chemical carcinogenesis - reactive oxygen species
Renal cell carcinoma
Melanoma
Non-small cell lung cancer
Hepatocellular carcinoma
Gastric cancer 		  Platelet degranulation
PIP3 activates AKT signaling
Constitutive Signaling by Aberrant PI3K in Cancer
RAF/MAP kinase cascade
Interleukin-4 and Interleukin-13 signaling
MET Receptor Activation
Negative regulation of MET activity
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
MET activates RAS signaling
MET activates PI3K/AKT signaling
MET activates PTPN11
MET activates PTK2 signaling
MET interacts with TNS proteins
MET activates RAP1 and RAC1
MET receptor recycling
MET activates STAT3
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Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Gene SNPs miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Causal Diseases (1)
Causal Diseases caused by PATHOGENIC or LIKELY PATHOGENIC variants from ClinVar only
Disease merge term Disease name dbSNP ID References
Deafness Autosomal recessive nonsyndromic hearing loss 39 rs137853235, rs1788701297 N/A
Show/Hide Unknown Diseases (5)
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Disease merge term Disease name Evidence References Source
Gout Gout N/A N/A GWAS
Multiple myeloma Multiple myeloma N/A N/A GWAS
Nonsyndromic Deafness Nonsyndromic Hearing Loss, Mixed N/A N/A ClinVar
Oligodendroglioma Oligodendroglioma N/A N/A GWAS
Show/Hide Text Mining Associations (315)
Associations from Text Mining Disease associations identified through Pubtator
Disease Name Relationship Type References
Acquired ichthyosis Associate 36303457
Acro Osteolysis Associate 35145077
Acute Disease Associate 38045696
Acute Kidney Injury Inhibit 16501492
Acute Kidney Injury Associate 21618526, 26327776
Acute Lung Injury Stimulate 18065658
Acute Lung Injury Associate 26674641
Adenocarcinoma Associate 7573364
Adenocarcinoma of Lung Associate 11290563, 17459054, 20150826, 26919104, 35635202
Adenocarcinoma of Lung Stimulate 19817696