Gene Gene information from NCBI Gene database.
Entrez ID 30811
Gene name Hormonally up-regulated Neu-associated kinase
Gene symbol HUNK
Synonyms (NCBI Gene)
-
Chromosome 21
Chromosome location 21q22.11
miRNA miRNA information provided by mirtarbase database.
512
miRTarBase ID miRNA Experiments Reference
MIRT630687 hsa-miR-377-3p HITS-CLIP 23313552
MIRT630686 hsa-miR-342-3p HITS-CLIP 23313552
MIRT630685 hsa-miR-8485 HITS-CLIP 23313552
MIRT630684 hsa-miR-4719 HITS-CLIP 23313552
MIRT630683 hsa-miR-125a-3p HITS-CLIP 23313552
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
13
GO ID Ontology Definition Evidence Reference
GO:0000166 Function Nucleotide binding IEA
GO:0004672 Function Protein kinase activity IEA
GO:0004674 Function Protein serine/threonine kinase activity IBA
GO:0004674 Function Protein serine/threonine kinase activity IEA
GO:0004674 Function Protein serine/threonine kinase activity TAS 10662544
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
606532 13326 ENSG00000142149
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P57058
Protein name Hormonally up-regulated neu tumor-associated kinase (EC 2.7.11.1) (B19) (Serine/threonine-protein kinase MAK-V)
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00069 Pkinase 63 320 Protein kinase domain Domain
Sequence
MPAAAGDGLLGEPAAPGGGGGAEDAARPAAACEGSFLPAWVSGVPRERLRDFQHHKRVGN
YLIGSRKLGEGSFAKVREGLHVLTGEKVAIKVIDKKRAKKDTYVTKNLRREGQIQQMIRH
PNITQLLDILETENSYYLVMELCPGGNLMHKIYEKKRLEESEARRYIRQLISAVEHLHRA
GVVHRDLKIENLLLDEDNNIKLIDFGLSNCAGILGYSDPFSTQCGSPAYAAPELLARKKY
GPKIDVWSIGVNMYAMLTGTLPFTVEPFSLRALYQKMVDKEMNPLPTQLSTGAISFLRSL
LEPDPVKRPNIQQALANRWL
NENYTGKVPCNVTYPNRISLEDLSPSVVLHMTEKLGYKNS
DVINTVLSNRACHILAIYFLLNKKLERYLSGKSDIQDSLCYKTRLYQIEKYRAPKESYEA
SLDTWTRDLEFHAVQDKKPKEQEKRGDFLHRPFSKKLDKNLPSHKQPSGSLMTQIQNTKA
LLKDRKASKSSFPDKDSFGCRNIFRKTSDSNCVASSSMEFIPVPPPRTPRIVKKPEPHQP
GPGSTGIPHKEDPLMLDMVRSFESVDRDDHVEVLSPSHHYRILNSPVSLARRNSSERTLS
PGLPSGSMSPLHTPLHPTLVSFAHEDKNSPPKEEGLCCPPPVPSNGPMQPLGSPNCVKSR
GRFPMMGIGQMLRKRHQSLQPSADRPLEASLPPLQPLAPVNLAFDMADGVKTQC
Sequence length 714
Interactions View interactions
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
9
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
ASTROCYTOMA GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
CROHN'S DISEASE GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
HEARING LOSS GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
INFLAMMATORY BOWEL DISEASE GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References Evidence Score
Arthritis Rheumatoid Associate 9653169
★☆☆☆☆
Found in Text Mining only
Breast Neoplasms Associate 27045589, 31438969
★☆☆☆☆
Found in Text Mining only
Carcinogenesis Associate 31438969
★☆☆☆☆
Found in Text Mining only
Coinfection Associate 9797569
★☆☆☆☆
Found in Text Mining only
Colorectal Neoplasms Inhibit 37193711
★☆☆☆☆
Found in Text Mining only
Hydrops Fetalis Associate 8736082
★☆☆☆☆
Found in Text Mining only
Joint Diseases Associate 9653169
★☆☆☆☆
Found in Text Mining only
Liver Failure Acute Associate 17479159
★☆☆☆☆
Found in Text Mining only
Mammary Neoplasms Animal Associate 27045589
★☆☆☆☆
Found in Text Mining only
Neoplasm Metastasis Inhibit 37193711
★☆☆☆☆
Found in Text Mining only