Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
308
Gene name Gene Name - the full gene name approved by the HGNC.
Annexin A5
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
ANXA5
Synonyms (NCBI Gene) Gene synonyms aliases
ANX5, CPB-I, ENX2, HEL-S-7, PP4, RPRGL3, VAC-alph
Disease Acronyms (UniProt) Disease acronyms from UniProt database
RPRGL3
Chromosome Chromosome number
4
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
4q27
Summary Summary of gene provided in NCBI Entrez Gene.
The Annexin 5 gene spans 29 kb containing 13 exons, and encodes a single transcript of approximately 1.6 kb and a protein product with a molecular weight of about 35 kDa.The protein encoded by this gene belongs to the annexin family of calcium-dependent p
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT022801 hsa-miR-124-3p Proteomics;Microarray 18668037
MIRT029721 hsa-miR-26b-5p Microarray 19088304
MIRT038248 hsa-miR-330-5p CLASH 23622248
MIRT545134 hsa-miR-4694-3p PAR-CLIP 21572407
MIRT545135 hsa-miR-224-3p PAR-CLIP 21572407
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0002576 Process Platelet degranulation TAS
GO:0004859 Function Phospholipase inhibitor activity TAS 2967495
GO:0005509 Function Calcium ion binding IBA 21873635
GO:0005515 Function Protein binding IPI 21044950, 32296183, 32814053
GO:0005543 Function Phospholipid binding TAS 2967291
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
131230 543 ENSG00000164111
Protein
UniProt ID P08758
Protein name Annexin A5 (Anchorin CII) (Annexin V) (Annexin-5) (Calphobindin I) (CPB-I) (Endonexin II) (Lipocortin V) (Placental anticoagulant protein 4) (PP4) (Placental anticoagulant protein I) (PAP-I) (Thromboplastin inhibitor) (Vascular anticoagulant-alpha) (VAC-a
Protein function This protein is an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade.
PDB 1ANW , 1ANX , 1AVH , 1AVR , 1HAK , 1HVD , 1HVE , 1HVF , 1HVG , 1SAV , 2XO2 , 2XO3 , 6K22 , 6K25 , 8GYC , 8H0J , 8H9Z
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00191 Annexin 19 84 Annexin Family
PF00191 Annexin 91 156 Annexin Family
PF00191 Annexin 174 240 Annexin Family
PF00191 Annexin 250 315 Annexin Family
Sequence
Sequence length 320
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    Platelet degranulation
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Carcinoma Squamous cell carcinoma rs121912654, rs555607708, rs786202962, rs1564055259 15274141
Gastric cancer Hereditary Diffuse Gastric Cancer rs137854571, rs63751108, rs34612342, rs121908383, rs121909144, rs121909775, rs121909219, rs121909223, rs63750871, rs80359530, rs121964873, rs121913530, rs606231203, rs121918505, rs587776802
View all (244 more)
16367923
Leukemia Leukemia, Myelocytic, Acute, Acute Myeloid Leukemia (AML-M2) rs121909646, rs121913488, rs587776834, rs752746786, rs869312821, rs767454740, rs1554564297 17330099
Lung adenocarcinoma Adenocarcinoma of lung (disorder) rs28934576, rs121913530, rs397516975, rs587776805, rs121913469, rs121913364, rs121913351, rs121913366, rs397516896, rs397516977, rs397516981, rs397517127, rs121913344, rs727504233, rs121913370
View all (5 more)
19381893
Unknown
Disease term Disease name Evidence References Source
Chronic obstructive pulmonary disease Chronic Obstructive Airway Disease 21685187 ClinVar
Diabetes Diabetes GWAS
Associations from Text Mining
Disease Name Relationship Type References
Abortion Habitual Associate 23529182, 23899942, 24335248, 27418639, 28108842
Abortion Habitual Inhibit 29497952
Abortion Spontaneous Associate 16449315, 23529182, 23899942, 24335248, 27418639, 28900802, 29497952
Acne Vulgaris Stimulate 39493760
Acute Kidney Injury Stimulate 32132597
Adenocarcinoma Stimulate 27150162
Adenocarcinoma Follicular Associate 22275472
Alzheimer Disease Associate 32301581, 33049317
Amyotrophic Lateral Sclerosis Associate 31861978
Angina Unstable Associate 24339880