Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein
Entrez ID	307
Gene name	Annexin A4
Gene symbol	ANXA4
Synonyms (NCBI Gene)	ANX4HEL-S-274P32.5PAP-IIPIG28PP4-XZAP36
Chromosome	2
Chromosome location	2p13.3
Summary	Annexin IV (ANX4) belongs to the annexin family of calcium-dependent phospholipid binding proteins. Although their functions are still not clearly defined, several members of the annexin family have been implicated in membrane-related events along exocyto

185

Show/Hide all (185)

miRTarBase ID	miRNA	Experiments	Reference
MIRT025331	hsa-miR-34a-5p	Proteomics	21566225
MIRT025331	hsa-miR-34a-5p	Proteomics	21566225
MIRT025331	hsa-miR-34a-5p	Proteomics	21566225
MIRT624732	hsa-miR-548u	HITS-CLIP	23824327
MIRT624731	hsa-miR-7161-5p	HITS-CLIP	23824327
MIRT624732	hsa-miR-548u	HITS-CLIP	23824327
MIRT624731	hsa-miR-7161-5p	HITS-CLIP	23824327
MIRT624730	hsa-miR-4760-5p	HITS-CLIP	23824327
MIRT624729	hsa-miR-8061	HITS-CLIP	23824327
MIRT624732	hsa-miR-548u	HITS-CLIP	23824327
MIRT624731	hsa-miR-7161-5p	HITS-CLIP	23824327
MIRT635253	hsa-miR-3134	HITS-CLIP	23824327
MIRT624730	hsa-miR-4760-5p	HITS-CLIP	23824327
MIRT624729	hsa-miR-8061	HITS-CLIP	23824327
MIRT624732	hsa-miR-548u	HITS-CLIP	23824327
MIRT624731	hsa-miR-7161-5p	HITS-CLIP	23824327
MIRT624730	hsa-miR-4760-5p	HITS-CLIP	23824327
MIRT624729	hsa-miR-8061	HITS-CLIP	23824327
MIRT624732	hsa-miR-548u	HITS-CLIP	23824327
MIRT624731	hsa-miR-7161-5p	HITS-CLIP	23824327
MIRT624730	hsa-miR-4760-5p	HITS-CLIP	23824327
MIRT624729	hsa-miR-8061	HITS-CLIP	23824327
MIRT635253	hsa-miR-3134	HITS-CLIP	27418678
MIRT576963	hsa-miR-4760-5p	HITS-CLIP	27418678
MIRT576961	hsa-miR-8061	HITS-CLIP	27418678
MIRT576964	hsa-miR-548u	HITS-CLIP	23824327
MIRT576962	hsa-miR-7161-5p	HITS-CLIP	23824327
MIRT576964	hsa-miR-548u	HITS-CLIP	23824327
MIRT576962	hsa-miR-7161-5p	HITS-CLIP	23824327
MIRT576963	hsa-miR-4760-5p	HITS-CLIP	23824327
MIRT576961	hsa-miR-8061	HITS-CLIP	23824327
MIRT576964	hsa-miR-548u	HITS-CLIP	23824327
MIRT576962	hsa-miR-7161-5p	HITS-CLIP	23824327
MIRT635253	hsa-miR-3134	HITS-CLIP	23824327
MIRT576963	hsa-miR-4760-5p	HITS-CLIP	23824327
MIRT576961	hsa-miR-8061	HITS-CLIP	23824327
MIRT576964	hsa-miR-548u	HITS-CLIP	23824327
MIRT576962	hsa-miR-7161-5p	HITS-CLIP	23824327
MIRT576963	hsa-miR-4760-5p	HITS-CLIP	23824327
MIRT576961	hsa-miR-8061	HITS-CLIP	23824327
MIRT576964	hsa-miR-548u	HITS-CLIP	23824327
MIRT576962	hsa-miR-7161-5p	HITS-CLIP	23824327
MIRT576963	hsa-miR-4760-5p	HITS-CLIP	23824327
MIRT576961	hsa-miR-8061	HITS-CLIP	23824327
MIRT786506	hsa-miR-105	CLIP-seq
MIRT786507	hsa-miR-1179	CLIP-seq
MIRT786508	hsa-miR-1305	CLIP-seq
MIRT786509	hsa-miR-1324	CLIP-seq
MIRT786510	hsa-miR-1827	CLIP-seq
MIRT786511	hsa-miR-3148	CLIP-seq
MIRT786512	hsa-miR-3149	CLIP-seq
MIRT786513	hsa-miR-3162-5p	CLIP-seq
MIRT786514	hsa-miR-3171	CLIP-seq
MIRT786515	hsa-miR-3185	CLIP-seq
MIRT786516	hsa-miR-3186-5p	CLIP-seq
MIRT786517	hsa-miR-3609	CLIP-seq
MIRT786518	hsa-miR-3612	CLIP-seq
MIRT786519	hsa-miR-3646	CLIP-seq
MIRT786520	hsa-miR-3671	CLIP-seq
MIRT786521	hsa-miR-369-3p	CLIP-seq
MIRT786522	hsa-miR-374c	CLIP-seq
MIRT786523	hsa-miR-3978	CLIP-seq
MIRT786524	hsa-miR-421	CLIP-seq
MIRT786525	hsa-miR-4266	CLIP-seq
MIRT786526	hsa-miR-4303	CLIP-seq
MIRT786527	hsa-miR-4661-5p	CLIP-seq
MIRT786528	hsa-miR-4668-5p	CLIP-seq
MIRT786529	hsa-miR-4695-5p	CLIP-seq
MIRT786530	hsa-miR-4779	CLIP-seq
MIRT786531	hsa-miR-4796-5p	CLIP-seq
MIRT786532	hsa-miR-548ah	CLIP-seq
MIRT786533	hsa-miR-548c-3p	CLIP-seq
MIRT786534	hsa-miR-548t	CLIP-seq
MIRT786535	hsa-miR-568	CLIP-seq
MIRT786536	hsa-miR-584	CLIP-seq
MIRT786537	hsa-miR-606	CLIP-seq
MIRT786538	hsa-miR-607	CLIP-seq
MIRT786539	hsa-miR-650	CLIP-seq
MIRT786540	hsa-miR-655	CLIP-seq
MIRT1931970	hsa-miR-1	CLIP-seq
MIRT1931971	hsa-miR-1287	CLIP-seq
MIRT1931972	hsa-miR-206	CLIP-seq
MIRT1931973	hsa-miR-208a	CLIP-seq
MIRT1931974	hsa-miR-208b	CLIP-seq
MIRT1931975	hsa-miR-320e	CLIP-seq
MIRT1931976	hsa-miR-3617	CLIP-seq
MIRT1931977	hsa-miR-3673	CLIP-seq
MIRT1931978	hsa-miR-3688-3p	CLIP-seq
MIRT786521	hsa-miR-369-3p	CLIP-seq
MIRT1931979	hsa-miR-374a	CLIP-seq
MIRT1931980	hsa-miR-374b	CLIP-seq
MIRT1931981	hsa-miR-4291	CLIP-seq
MIRT1931982	hsa-miR-4307	CLIP-seq
MIRT1931983	hsa-miR-4310	CLIP-seq
MIRT1931984	hsa-miR-4517	CLIP-seq
MIRT1931985	hsa-miR-4729	CLIP-seq
MIRT1931986	hsa-miR-499-5p	CLIP-seq
MIRT1931987	hsa-miR-613	CLIP-seq
MIRT1931988	hsa-miR-641	CLIP-seq
MIRT2172417	hsa-miR-124	CLIP-seq
MIRT2172418	hsa-miR-128	CLIP-seq
MIRT2172419	hsa-miR-132	CLIP-seq
MIRT2172420	hsa-miR-148a	CLIP-seq
MIRT2172421	hsa-miR-148b	CLIP-seq
MIRT2172422	hsa-miR-152	CLIP-seq
MIRT786510	hsa-miR-1827	CLIP-seq
MIRT2172423	hsa-miR-212	CLIP-seq
MIRT786516	hsa-miR-3186-5p	CLIP-seq
MIRT786518	hsa-miR-3612	CLIP-seq
MIRT786525	hsa-miR-4266	CLIP-seq
MIRT786529	hsa-miR-4695-5p	CLIP-seq
MIRT1931985	hsa-miR-4729	CLIP-seq
MIRT2172424	hsa-miR-4773	CLIP-seq
MIRT786530	hsa-miR-4779	CLIP-seq
MIRT2172425	hsa-miR-488	CLIP-seq
MIRT2172426	hsa-miR-506	CLIP-seq
MIRT2172427	hsa-miR-548an	CLIP-seq
MIRT786539	hsa-miR-650	CLIP-seq
MIRT786506	hsa-miR-105	CLIP-seq
MIRT786507	hsa-miR-1179	CLIP-seq
MIRT786510	hsa-miR-1827	CLIP-seq
MIRT786513	hsa-miR-3162-5p	CLIP-seq
MIRT786515	hsa-miR-3185	CLIP-seq
MIRT786516	hsa-miR-3186-5p	CLIP-seq
MIRT786518	hsa-miR-3612	CLIP-seq
MIRT786519	hsa-miR-3646	CLIP-seq
MIRT2475350	hsa-miR-3662	CLIP-seq
MIRT786520	hsa-miR-3671	CLIP-seq
MIRT2475351	hsa-miR-3973	CLIP-seq
MIRT786523	hsa-miR-3978	CLIP-seq
MIRT2475352	hsa-miR-4251	CLIP-seq
MIRT786525	hsa-miR-4266	CLIP-seq
MIRT2475353	hsa-miR-4274	CLIP-seq
MIRT2475354	hsa-miR-4280	CLIP-seq
MIRT786526	hsa-miR-4303	CLIP-seq
MIRT2475355	hsa-miR-4329	CLIP-seq
MIRT2475356	hsa-miR-4519	CLIP-seq
MIRT786527	hsa-miR-4661-5p	CLIP-seq
MIRT2475357	hsa-miR-4670-3p	CLIP-seq
MIRT786529	hsa-miR-4695-5p	CLIP-seq
MIRT786530	hsa-miR-4779	CLIP-seq
MIRT786531	hsa-miR-4796-5p	CLIP-seq
MIRT2475358	hsa-miR-520g	CLIP-seq
MIRT2475359	hsa-miR-520h	CLIP-seq
MIRT786533	hsa-miR-548c-3p	CLIP-seq
MIRT786537	hsa-miR-606	CLIP-seq
MIRT786538	hsa-miR-607	CLIP-seq
MIRT786539	hsa-miR-650	CLIP-seq
MIRT786506	hsa-miR-105	CLIP-seq
MIRT786507	hsa-miR-1179	CLIP-seq
MIRT786510	hsa-miR-1827	CLIP-seq
MIRT786511	hsa-miR-3148	CLIP-seq
MIRT786513	hsa-miR-3162-5p	CLIP-seq
MIRT786515	hsa-miR-3185	CLIP-seq
MIRT786516	hsa-miR-3186-5p	CLIP-seq
MIRT786517	hsa-miR-3609	CLIP-seq
MIRT786518	hsa-miR-3612	CLIP-seq
MIRT786519	hsa-miR-3646	CLIP-seq
MIRT2475350	hsa-miR-3662	CLIP-seq
MIRT786520	hsa-miR-3671	CLIP-seq
MIRT2475351	hsa-miR-3973	CLIP-seq
MIRT786523	hsa-miR-3978	CLIP-seq
MIRT2475352	hsa-miR-4251	CLIP-seq
MIRT786525	hsa-miR-4266	CLIP-seq
MIRT2475353	hsa-miR-4274	CLIP-seq
MIRT2475354	hsa-miR-4280	CLIP-seq
MIRT786526	hsa-miR-4303	CLIP-seq
MIRT2475355	hsa-miR-4329	CLIP-seq
MIRT2675074	hsa-miR-4421	CLIP-seq
MIRT2475356	hsa-miR-4519	CLIP-seq
MIRT786527	hsa-miR-4661-5p	CLIP-seq
MIRT786528	hsa-miR-4668-5p	CLIP-seq
MIRT2475357	hsa-miR-4670-3p	CLIP-seq
MIRT786529	hsa-miR-4695-5p	CLIP-seq
MIRT786530	hsa-miR-4779	CLIP-seq
MIRT786531	hsa-miR-4796-5p	CLIP-seq
MIRT2475358	hsa-miR-520g	CLIP-seq
MIRT2475359	hsa-miR-520h	CLIP-seq
MIRT786532	hsa-miR-548ah	CLIP-seq
MIRT786533	hsa-miR-548c-3p	CLIP-seq
MIRT786534	hsa-miR-548t	CLIP-seq
MIRT2675075	hsa-miR-580	CLIP-seq
MIRT786537	hsa-miR-606	CLIP-seq
MIRT786538	hsa-miR-607	CLIP-seq
MIRT786539	hsa-miR-650	CLIP-seq

Show/Hide all (38)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000122	Process	Negative regulation of transcription by RNA polymerase II	IDA	20237821
GO:0001786	Function	Phosphatidylserine binding	IBA
GO:0004859	Function	Phospholipase inhibitor activity	NAS	2970257
GO:0005509	Function	Calcium ion binding	IDA	20237821
GO:0005509	Function	Calcium ion binding	IEA
GO:0005515	Function	Protein binding	IPI	21044950, 25416956, 32296183, 32814053
GO:0005544	Function	Calcium-dependent phospholipid binding	IBA
GO:0005544	Function	Calcium-dependent phospholipid binding	IDA	2138016
GO:0005544	Function	Calcium-dependent phospholipid binding	IEA
GO:0005544	Function	Calcium-dependent phospholipid binding	NAS	2970257
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IDA	16687573, 20237821
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IDA	20237821
GO:0005737	Component	Cytoplasm	TAS	16130169
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IDA	16687573
GO:0007165	Process	Signal transduction	TAS	16130169
GO:0007219	Process	Notch signaling pathway	IEA
GO:0009986	Component	Cell surface	IDA	22056994
GO:0010804	Process	Negative regulation of tumor necrosis factor-mediated signaling pathway	IMP	20237821
GO:0012506	Component	Vesicle membrane	IBA
GO:0012506	Component	Vesicle membrane	IDA	16687573
GO:0016020	Component	Membrane	IEA
GO:0030855	Process	Epithelial cell differentiation	IEP	21492153
GO:0031012	Component	Extracellular matrix	HDA	25037231, 28675934
GO:0031410	Component	Cytoplasmic vesicle	IEA
GO:0031965	Component	Nuclear membrane	IDA	16687573
GO:0032717	Process	Negative regulation of interleukin-8 production	IMP	22056994
GO:0042589	Component	Zymogen granule membrane	IEA
GO:0042802	Function	Identical protein binding	IPI	16687573
GO:0043066	Process	Negative regulation of apoptotic process	TAS	16130169
GO:0043124	Process	Negative regulation of canonical NF-kappaB signal transduction	IDA	20237821
GO:0048306	Function	Calcium-dependent protein binding	IPI	15226301, 20237821
GO:0048471	Component	Perinuclear region of cytoplasm	IDA	16687573
GO:0051059	Function	NF-kappaB binding	IPI	20237821
GO:0070062	Component	Extracellular exosome	HDA	19056867, 19199708, 20458337, 23533145
GO:0140416	Function	Transcription regulator inhibitor activity	IDA	20237821

MIM	HGNC	e!Ensembl
106491	542	ENSG00000196975

P09525

Protein name

Annexin A4 (35-beta calcimedin) (Annexin IV) (Annexin-4) (Carbohydrate-binding protein p33/p41) (Chromobindin-4) (Endonexin I) (Lipocortin IV) (P32.5) (PP4-X) (Placental anticoagulant protein II) (PAP-II) (Protein II)

Protein function

Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis.

PDB

2ZOC

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00191	Annexin	18 → 83	Annexin	Family
PF00191	Annexin	90 → 155	Annexin	Family
PF00191	Annexin	173 → 239	Annexin	Family
PF00191	Annexin	249 → 314	Annexin	Family

Sequence

MATKGGTVKAASGFNAMEDAQTLRKAMKGLGTDEDAIISVLAYRNTAQRQEIRTAYKSTI
GRDLIDDLKSELSGNFEQVIVGMMTPTVLYDVQELRRAMKGAGTDEGCLIEILASRTPEE
IRRISQTYQQQYGRSLEDDIRSDTSFMFQRVLVSLSAGGRDEGNYLDDALVRQDAQDLYE
AGEKKWGTDEVKFLTVLCSRNRNHLLHVFDEYKRISQKDIEQSIKSETSGSFEDALLAIV
KCMRNKSAYFAEKLYKSMKGLGTDDNTLIRVMVSRAEIDMLDIRAHFKRLYGKSLYSFIK
GDTSGDYRKVLLVLCGGDD

Sequence length

319

Interactions

View interactions

ANXA4 (annexin A4)