Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
3066
Gene name Gene Name - the full gene name approved by the HGNC.
Histone deacetylase 2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
HDAC2
Synonyms (NCBI Gene) Gene synonyms aliases
HD2, KDAC2, RPD3, YAF1
Chromosome Chromosome number
6
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
6q21
Summary Summary of gene provided in NCBI Entrez Gene.
This gene product belongs to the histone deacetylase family. Histone deacetylases act via the formation of large multiprotein complexes, and are responsible for the deacetylation of lysine residues at the N-terminal regions of core histones (H2A, H2B, H3
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT007307 hsa-miR-145-5p Luciferase reporter assay 23499894
MIRT023724 hsa-miR-1-3p Proteomics 18668040
MIRT045549 hsa-miR-149-5p CLASH 23622248
MIRT437990 hsa-let-7f-5p qRT-PCR 24405266
MIRT437990 hsa-let-7f-5p qRT-PCR 24405266
Transcription factors
Transcription factor Regulation Reference
MYC Activation 20697349
MYCN Activation 20697349
RFX5 Unknown 16464847
YY1 Unknown 11532945
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000118 Component Histone deacetylase complex IDA 9651585
GO:0000122 Process Negative regulation of transcription by RNA polymerase II IMP 19041327, 19276356
GO:0000122 Process Negative regulation of transcription by RNA polymerase II NAS 9651585, 22865885
GO:0000781 Component Chromosome, telomeric region IDA 25150861
GO:0000785 Component Chromatin HDA 16217013
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
605164 4853 ENSG00000196591
Protein
UniProt ID Q92769
Protein name Histone deacetylase 2 (HD2) (EC 3.5.1.98) (Protein deacylase HDAC2) (EC 3.5.1.-)
Protein function Histone deacetylase that catalyzes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4) (PubMed:28497810). Histone deacetylation gives a tag for epigenetic repression and plays an important role
PDB 3MAX , 4LXZ , 4LY1 , 5IWG , 5IX0 , 6G3O , 6WBW , 6WBZ , 6WHN , 6WHO , 6WHQ , 6WHZ , 6WI3 , 6XDM , 6XEB , 6XEC , 7JS8 , 7KBG , 7KBH , 7LTG , 7LTK , 7LTL , 7MOS , 7MOT , 7MOX , 7MOY , 7MOZ , 7ZZO , 7ZZP , 7ZZR , 7ZZS , 7ZZT , 7ZZU , 7ZZW , 8A0B , 8BPA , 8BPB , 8BPC , 8C60 , 9DTQ
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00850 Hist_deacetyl 29 320 Histone deacetylase domain Domain
Tissue specificity TISSUE SPECIFICITY: Widely expressed; lower levels in brain and lung.
Sequence
MAYSQGGGKKKVCYYYDGDIGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKA
TAEEMTKYHSDEYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVA
GAVKLNRQQTDMAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHH
GDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNFPMRDGIDDESYGQ
IFKPIISKVMEMYQPSAVVLQCGADSLSGDRLGCFNLTVKGHAKCVEVVKTFNLPLLMLG
GGGYTIRNVARCWTYETAVA
LDCEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTPEYM
EKIKQRLFENLRMLPHAPGVQMQAIPEDAVHEDSGDEDGEDPDKRISIRASDKRIACDEE
FSDSEDEGEGGRRNVADHKKGAKKARIEEDKKETEDKKTDVKEEDKSKDNSGEKTDTKGT
KSEQLSNP
Sequence length 488
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  ATP-dependent chromatin remodeling
Polycomb repressive complex
Cell cycle
Longevity regulating pathway - multiple species
Notch signaling pathway
TGF-beta signaling pathway
Neutrophil extracellular trap formation
Thyroid hormone signaling pathway
Huntington disease
Amphetamine addiction
Alcoholism
Human papillomavirus infection
Epstein-Barr virus infection
Pathways in cancer
Transcriptional misregulation in cancer
Viral carcinogenesis
MicroRNAs in cancer
Chronic myeloid leukemia
  Constitutive Signaling by NOTCH1 PEST Domain Mutants
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
HDACs deacetylate histones
Notch-HLH transcription pathway
SUMOylation of chromatin organization proteins
Regulation of TP53 Activity through Acetylation
RNA Polymerase I Transcription Initiation
Regulation of PTEN gene transcription
Regulation of MECP2 expression and activity
EGR2 and SOX10-mediated initiation of Schwann cell myelination
Factors involved in megakaryocyte development and platelet production
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Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Disease merge term Disease name Evidence References Source
Diabetes Type 2 diabetes (adjusted for BMI) N/A N/A GWAS
Iritis Iritis N/A N/A GWAS
Neurodevelopmental Disorders complex neurodevelopmental disorder N/A N/A GenCC
Schizophrenia Schizophrenia N/A N/A GWAS
Associations from Text Mining Disease associations identified through Pubtator
Disease Name Relationship Type References
Achondrogenesis type 2 Associate 27884646
Adenocarcinoma Associate 19057998
Adenocarcinoma of Lung Associate 25333250, 27356570
AIDS Associated Nephropathy Associate 21315782
Alcoholism Associate 21447001
Alzheimer Disease Associate 25219501
Amyotrophic Lateral Sclerosis Associate 27982123, 37328865
Anemia Diamond Blackfan Associate 34036344
Asthma Associate 20538962, 24030221, 33510050, 37312162
Asthma Inhibit 31391381