Gene Gene information from NCBI Gene database.
Entrez ID 3066
Gene name Histone deacetylase 2
Gene symbol HDAC2
Synonyms (NCBI Gene)
HD2KDAC2RPD3YAF1
Chromosome 6
Chromosome location 6q21
Summary This gene product belongs to the histone deacetylase family. Histone deacetylases act via the formation of large multiprotein complexes, and are responsible for the deacetylation of lysine residues at the N-terminal regions of core histones (H2A, H2B, H3
miRNA miRNA information provided by mirtarbase database.
526
miRTarBase ID miRNA Experiments Reference
MIRT007307 hsa-miR-145-5p Luciferase reporter assay 23499894
MIRT023724 hsa-miR-1-3p Proteomics 18668040
MIRT045549 hsa-miR-149-5p CLASH 23622248
MIRT437990 hsa-let-7f-5p qRT-PCR 24405266
MIRT437990 hsa-let-7f-5p qRT-PCR 24405266
Transcription factors Transcription factors information provided by TRRUST V2 database.
4
Transcription factor Regulation Reference
MYC Activation 20697349
MYCN Activation 20697349
RFX5 Unknown 16464847
YY1 Unknown 11532945
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
114
GO ID Ontology Definition Evidence Reference
GO:0000118 Component Histone deacetylase complex IDA 9651585
GO:0000122 Process Negative regulation of transcription by RNA polymerase II IMP 19041327, 19276356
GO:0000122 Process Negative regulation of transcription by RNA polymerase II NAS 9651585, 22865885
GO:0000781 Component Chromosome, telomeric region IDA 25150861
GO:0000785 Component Chromatin HDA 16217013
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
605164 4853 ENSG00000196591
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q92769
Protein name Histone deacetylase 2 (HD2) (EC 3.5.1.98) (Protein deacylase HDAC2) (EC 3.5.1.-)
Protein function Histone deacetylase that catalyzes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4) (PubMed:28497810). Histone deacetylation gives a tag for epigenetic repression and plays an important role
PDB 3MAX , 4LXZ , 4LY1 , 5IWG , 5IX0 , 6G3O , 6WBW , 6WBZ , 6WHN , 6WHO , 6WHQ , 6WHZ , 6WI3 , 6XDM , 6XEB , 6XEC , 7JS8 , 7KBG , 7KBH , 7LTG , 7LTK , 7LTL , 7MOS , 7MOT , 7MOX , 7MOY , 7MOZ , 7ZZO , 7ZZP , 7ZZR , 7ZZS , 7ZZT , 7ZZU , 7ZZW , 8A0B , 8BPA , 8BPB , 8BPC , 8C60 , 9DTQ
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00850 Hist_deacetyl 29 320 Histone deacetylase domain Domain
Tissue specificity TISSUE SPECIFICITY: Widely expressed; lower levels in brain and lung.
Sequence
MAYSQGGGKKKVCYYYDGDIGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKA
TAEEMTKYHSDEYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVA
GAVKLNRQQTDMAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHH
GDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNFPMRDGIDDESYGQ
IFKPIISKVMEMYQPSAVVLQCGADSLSGDRLGCFNLTVKGHAKCVEVVKTFNLPLLMLG
GGGYTIRNVARCWTYETAVA
LDCEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTPEYM
EKIKQRLFENLRMLPHAPGVQMQAIPEDAVHEDSGDEDGEDPDKRISIRASDKRIACDEE
FSDSEDEGEGGRRNVADHKKGAKKARIEEDKKETEDKKTDVKEEDKSKDNSGEKTDTKGT
KSEQLSNP
Sequence length 488
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  ATP-dependent chromatin remodeling
Polycomb repressive complex
Cell cycle
Longevity regulating pathway - multiple species
Notch signaling pathway
TGF-beta signaling pathway
Neutrophil extracellular trap formation
Thyroid hormone signaling pathway
Huntington disease
Amphetamine addiction
Alcoholism
Human papillomavirus infection
Epstein-Barr virus infection
Pathways in cancer
Transcriptional misregulation in cancer
Viral carcinogenesis
MicroRNAs in cancer
Chronic myeloid leukemia
  Constitutive Signaling by NOTCH1 PEST Domain Mutants
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
HDACs deacetylate histones
Notch-HLH transcription pathway
SUMOylation of chromatin organization proteins
Regulation of TP53 Activity through Acetylation
RNA Polymerase I Transcription Initiation
Regulation of PTEN gene transcription
Regulation of MECP2 expression and activity
EGR2 and SOX10-mediated initiation of Schwann cell myelination
Factors involved in megakaryocyte development and platelet production
Associated diseases Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
10
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
Familial pancreatic carcinoma Benign rs200805519 RCV005902935
HDAC2-related disorder Likely benign; Uncertain significance rs1252367140, rs367736850, rs2482611700, rs1312623763 RCV003929580
RCV003929532
RCV003949411
RCV003949176
Lung cancer Benign rs200805519 RCV005902938
Ovarian cancer Benign rs200805519 RCV005902934
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References
Achondrogenesis type 2 Associate 27884646
Adenocarcinoma Associate 19057998
Adenocarcinoma of Lung Associate 25333250, 27356570
AIDS Associated Nephropathy Associate 21315782
Alcoholism Associate 21447001
Alzheimer Disease Associate 25219501
Amyotrophic Lateral Sclerosis Associate 27982123, 37328865
Anemia Diamond Blackfan Associate 34036344
Asthma Associate 20538962, 24030221, 33510050, 37312162
Asthma Inhibit 31391381