Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene SNPs miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	3065
Gene name	Histone deacetylase 1
Gene symbol	HDAC1
Synonyms (NCBI Gene)	GON-10HD1KDAC1RPD3RPD3L1
Chromosome	1
Chromosome location	1p35.2-p35.1
Summary	Histone acetylation and deacetylation, catalyzed by multisubunit complexes, play a key role in the regulation of eukaryotic gene expression. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family and is a component of the his

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SNP ID	Visualize variation	Clinical significance	Consequence
rs797044931	A>G	Likely-pathogenic	Missense variant, coding sequence variant, 5 prime UTR variant

177

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miRTarBase ID	miRNA	Experiments	Reference
MIRT003760	hsa-miR-449a	BPH-1 and LNCaP)"	19252524
MIRT003760	hsa-miR-449a	BPH-1 and LNCaP)"	19252524
MIRT003760	hsa-miR-449a	BPH-1 and LNCaP)"	19252524
MIRT003760	hsa-miR-449a	Immunoblot	20948989
MIRT006353	hsa-miR-449b-5p	Luciferase reporter assayWestern blot	21418558
MIRT003760	hsa-miR-449a	Luciferase reporter assayWestern blot	21418558
MIRT006353	hsa-miR-449b-5p	Luciferase reporter assayWestern blot	21418558
MIRT006353	hsa-miR-449b-5p	Luciferase reporter assayWestern blot	21418558
MIRT003760	hsa-miR-449a	Reporter assay;Other	19252524
MIRT025557	hsa-miR-34a-5p	Reporter assay;Proteomics	21566225
MIRT030619	hsa-miR-24-3p	Sequencing	20371350
MIRT049948	hsa-miR-30a-5p	CLASH	23622248
MIRT049098	hsa-miR-92a-3p	CLASH	23622248
MIRT039704	hsa-miR-615-3p	CLASH	23622248
MIRT039285	hsa-miR-671-5p	CLASH	23622248
MIRT053053	hsa-miR-874-3p	FlowLuciferase reporter assayqRT-PCRWestern blot	23558898
MIRT053589	hsa-miR-520h	FlowLuciferase reporter assayqRT-PCRWestern blot	24316511
MIRT025557	hsa-miR-34a-5p	Luciferase reporter assayqRT-PCRWestern blot	23836017
MIRT025557	hsa-miR-34a-5p	Luciferase reporter assayqRT-PCRWestern blot	23836017
MIRT025557	hsa-miR-34a-5p	Luciferase reporter assayqRT-PCRWestern blot	23836017
MIRT025557	hsa-miR-34a-5p	Luciferase reporter assayqRT-PCRWestern blot	23836017
MIRT025557	hsa-miR-34a-5p	ImmunofluorescenceMicroarrayqRT-PCRWestern blot	26035691
MIRT003760	hsa-miR-449a	Luciferase reporter assay	25405810
MIRT025557	hsa-miR-34a-5p	FlowLuciferase reporter assayqRT-PCRWestern blot	28123637
MIRT025557	hsa-miR-34a-5p	FlowLuciferase reporter assayqRT-PCRWestern blot	28123637
MIRT053053	hsa-miR-874-3p	Western blottingqRT-PCRFlow cytometry	33732332
MIRT735834	hsa-miR-520d-5p	Luciferase reporter assayWestern blottingqRT-PCR	32950972
MIRT737513	hsa-miR-125a-3p	Luciferase reporter assayWestern blottingImmunoprecipitaion (IP)Immunohistochemistry (IHC)qRT-PCR	33790607
MIRT756075	hsa-miR-570-3p	Luciferase reporter assayWestern blottingqRT-PCR	36120375
MIRT1042275	hsa-miR-1256	CLIP-seq
MIRT1042276	hsa-miR-1304	CLIP-seq
MIRT1042277	hsa-miR-153	CLIP-seq
MIRT1042278	hsa-miR-2110	CLIP-seq
MIRT1042279	hsa-miR-24	CLIP-seq
MIRT1042280	hsa-miR-298	CLIP-seq
MIRT1042281	hsa-miR-3150a-3p	CLIP-seq
MIRT1042282	hsa-miR-3158-5p	CLIP-seq
MIRT1042283	hsa-miR-3184	CLIP-seq
MIRT1042284	hsa-miR-3613-3p	CLIP-seq
MIRT1042285	hsa-miR-3614-5p	CLIP-seq
MIRT1042286	hsa-miR-371-5p	CLIP-seq
MIRT1042287	hsa-miR-371b-5p	CLIP-seq
MIRT1042288	hsa-miR-423-5p	CLIP-seq
MIRT1042289	hsa-miR-4266	CLIP-seq
MIRT1042290	hsa-miR-4269	CLIP-seq
MIRT1042291	hsa-miR-4271	CLIP-seq
MIRT1042292	hsa-miR-4284	CLIP-seq
MIRT1042293	hsa-miR-4433	CLIP-seq
MIRT1042294	hsa-miR-4459	CLIP-seq
MIRT1042295	hsa-miR-448	CLIP-seq
MIRT1042296	hsa-miR-4496	CLIP-seq
MIRT1042297	hsa-miR-4642	CLIP-seq
MIRT1042298	hsa-miR-4690-5p	CLIP-seq
MIRT1042299	hsa-miR-4725-3p	CLIP-seq
MIRT1042300	hsa-miR-4747-5p	CLIP-seq
MIRT1042301	hsa-miR-4768-3p	CLIP-seq
MIRT1042302	hsa-miR-511	CLIP-seq
MIRT1042303	hsa-miR-548l	CLIP-seq
MIRT1042304	hsa-miR-548n	CLIP-seq
MIRT1042305	hsa-miR-548t	CLIP-seq
MIRT1042306	hsa-miR-584	CLIP-seq
MIRT2008914	hsa-miR-3145-3p	CLIP-seq
MIRT2008915	hsa-miR-4292	CLIP-seq
MIRT2008916	hsa-miR-4308	CLIP-seq
MIRT2008917	hsa-miR-4450	CLIP-seq
MIRT2008918	hsa-miR-4652-3p	CLIP-seq
MIRT2008919	hsa-miR-4667-5p	CLIP-seq
MIRT2008920	hsa-miR-4700-5p	CLIP-seq
MIRT1042275	hsa-miR-1256	CLIP-seq
MIRT1042277	hsa-miR-153	CLIP-seq
MIRT1042285	hsa-miR-3614-5p	CLIP-seq
MIRT1042293	hsa-miR-4433	CLIP-seq
MIRT1042294	hsa-miR-4459	CLIP-seq
MIRT1042295	hsa-miR-448	CLIP-seq
MIRT1042297	hsa-miR-4642	CLIP-seq
MIRT1042301	hsa-miR-4768-3p	CLIP-seq
MIRT1042302	hsa-miR-511	CLIP-seq
MIRT1042303	hsa-miR-548l	CLIP-seq
MIRT1042304	hsa-miR-548n	CLIP-seq
MIRT1042305	hsa-miR-548t	CLIP-seq
MIRT1042306	hsa-miR-584	CLIP-seq
MIRT2544977	hsa-miR-125a-5p	CLIP-seq
MIRT2544978	hsa-miR-125b	CLIP-seq
MIRT2544979	hsa-miR-1293	CLIP-seq
MIRT1042276	hsa-miR-1304	CLIP-seq
MIRT2544980	hsa-miR-146b-3p	CLIP-seq
MIRT2544981	hsa-miR-22	CLIP-seq
MIRT1042279	hsa-miR-24	CLIP-seq
MIRT2544982	hsa-miR-2682	CLIP-seq
MIRT2544983	hsa-miR-31	CLIP-seq
MIRT2008914	hsa-miR-3145-3p	CLIP-seq
MIRT2544984	hsa-miR-3173-5p	CLIP-seq
MIRT2544985	hsa-miR-34a	CLIP-seq
MIRT2544986	hsa-miR-34c-5p	CLIP-seq
MIRT1042285	hsa-miR-3614-5p	CLIP-seq
MIRT2544987	hsa-miR-3616-3p	CLIP-seq
MIRT2544988	hsa-miR-3653	CLIP-seq
MIRT2544989	hsa-miR-3658	CLIP-seq
MIRT2544990	hsa-miR-3670	CLIP-seq
MIRT2544991	hsa-miR-3688-5p	CLIP-seq
MIRT2544992	hsa-miR-3690	CLIP-seq
MIRT2544993	hsa-miR-3973	CLIP-seq
MIRT2544994	hsa-miR-4254	CLIP-seq
MIRT1042292	hsa-miR-4284	CLIP-seq
MIRT2008915	hsa-miR-4292	CLIP-seq
MIRT2008916	hsa-miR-4308	CLIP-seq
MIRT2544995	hsa-miR-4319	CLIP-seq
MIRT2544996	hsa-miR-4436b-3p	CLIP-seq
MIRT2008917	hsa-miR-4450	CLIP-seq
MIRT2544997	hsa-miR-4483	CLIP-seq
MIRT2544998	hsa-miR-449b	CLIP-seq
MIRT2544999	hsa-miR-449c	CLIP-seq
MIRT2545000	hsa-miR-4506	CLIP-seq
MIRT2545001	hsa-miR-4508	CLIP-seq
MIRT2545002	hsa-miR-4511	CLIP-seq
MIRT2545003	hsa-miR-4514	CLIP-seq
MIRT2008918	hsa-miR-4652-3p	CLIP-seq
MIRT2008919	hsa-miR-4667-5p	CLIP-seq
MIRT2545004	hsa-miR-4681	CLIP-seq
MIRT2545005	hsa-miR-4692	CLIP-seq
MIRT2008920	hsa-miR-4700-5p	CLIP-seq
MIRT1042300	hsa-miR-4747-5p	CLIP-seq
MIRT2545006	hsa-miR-4761-5p	CLIP-seq
MIRT2545007	hsa-miR-520g	CLIP-seq
MIRT2545008	hsa-miR-548b-3p	CLIP-seq
MIRT2545009	hsa-miR-578	CLIP-seq
MIRT1042306	hsa-miR-584	CLIP-seq
MIRT2545010	hsa-miR-7	CLIP-seq
MIRT2545011	hsa-miR-874	CLIP-seq
MIRT2544977	hsa-miR-125a-5p	CLIP-seq
MIRT2544978	hsa-miR-125b	CLIP-seq
MIRT2544979	hsa-miR-1293	CLIP-seq
MIRT1042276	hsa-miR-1304	CLIP-seq
MIRT2544980	hsa-miR-146b-3p	CLIP-seq
MIRT2544981	hsa-miR-22	CLIP-seq
MIRT1042279	hsa-miR-24	CLIP-seq
MIRT2544982	hsa-miR-2682	CLIP-seq
MIRT2544983	hsa-miR-31	CLIP-seq
MIRT2008914	hsa-miR-3145-3p	CLIP-seq
MIRT2544984	hsa-miR-3173-5p	CLIP-seq
MIRT2544985	hsa-miR-34a	CLIP-seq
MIRT2544986	hsa-miR-34c-5p	CLIP-seq
MIRT1042285	hsa-miR-3614-5p	CLIP-seq
MIRT2544987	hsa-miR-3616-3p	CLIP-seq
MIRT2544988	hsa-miR-3653	CLIP-seq
MIRT2544989	hsa-miR-3658	CLIP-seq
MIRT2544990	hsa-miR-3670	CLIP-seq
MIRT2544991	hsa-miR-3688-5p	CLIP-seq
MIRT2544992	hsa-miR-3690	CLIP-seq
MIRT2544993	hsa-miR-3973	CLIP-seq
MIRT2544994	hsa-miR-4254	CLIP-seq
MIRT1042292	hsa-miR-4284	CLIP-seq
MIRT2008915	hsa-miR-4292	CLIP-seq
MIRT2008916	hsa-miR-4308	CLIP-seq
MIRT2544995	hsa-miR-4319	CLIP-seq
MIRT2544996	hsa-miR-4436b-3p	CLIP-seq
MIRT2008917	hsa-miR-4450	CLIP-seq
MIRT2544997	hsa-miR-4483	CLIP-seq
MIRT2544998	hsa-miR-449b	CLIP-seq
MIRT2544999	hsa-miR-449c	CLIP-seq
MIRT2545000	hsa-miR-4506	CLIP-seq
MIRT2545001	hsa-miR-4508	CLIP-seq
MIRT2545002	hsa-miR-4511	CLIP-seq
MIRT2545003	hsa-miR-4514	CLIP-seq
MIRT2008918	hsa-miR-4652-3p	CLIP-seq
MIRT2008919	hsa-miR-4667-5p	CLIP-seq
MIRT2545004	hsa-miR-4681	CLIP-seq
MIRT2545005	hsa-miR-4692	CLIP-seq
MIRT2008920	hsa-miR-4700-5p	CLIP-seq
MIRT1042300	hsa-miR-4747-5p	CLIP-seq
MIRT2545006	hsa-miR-4761-5p	CLIP-seq
MIRT2545007	hsa-miR-520g	CLIP-seq
MIRT2545008	hsa-miR-548b-3p	CLIP-seq
MIRT2545009	hsa-miR-578	CLIP-seq
MIRT1042306	hsa-miR-584	CLIP-seq
MIRT2545010	hsa-miR-7	CLIP-seq
MIRT2545011	hsa-miR-874	CLIP-seq

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Transcription factor	Regulation	Reference
DNMT1	Unknown	24475290
EZH2	Repression	20132185
FLI1	Unknown	24058639
MTA1	Unknown	23791785
NFKB1	Unknown	23027620
RELA	Unknown	23027620
RFX1	Unknown	16464847
SATB1	Unknown	15713622
YY1	Unknown	11532945

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GO ID	Ontology	Definition	Evidence	Reference
GO:0000118	Component	Histone deacetylase complex	IDA	9651585
GO:0000118	Component	Histone deacetylase complex	IEA
GO:0000118	Component	Histone deacetylase complex	TAS	12711221
GO:0000122	Process	Negative regulation of transcription by RNA polymerase II	IDA	18854353, 30599067
GO:0000122	Process	Negative regulation of transcription by RNA polymerase II	IEA
GO:0000122	Process	Negative regulation of transcription by RNA polymerase II	IGI	18936100, 23770133
GO:0000122	Process	Negative regulation of transcription by RNA polymerase II	IMP	18850004
GO:0000122	Process	Negative regulation of transcription by RNA polymerase II	NAS	9651585, 22865885
GO:0000785	Component	Chromatin	HDA	16217013
GO:0000785	Component	Chromatin	IDA	16731528, 22926524, 23629966, 23770133
GO:0000785	Component	Chromatin	IEA
GO:0000792	Component	Heterochromatin	IEA
GO:0000976	Function	Transcription cis-regulatory region binding	IEA
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IGI	18974119
GO:0000979	Function	RNA polymerase II core promoter sequence-specific DNA binding	IDA	19057576
GO:0001046	Function	Core promoter sequence-specific DNA binding	IDA	23629966
GO:0001222	Function	Transcription corepressor binding	IPI	10898795
GO:0002039	Function	P53 binding	IPI	23629966
GO:0003677	Function	DNA binding	IEA
GO:0003682	Function	Chromatin binding	IEA
GO:0003714	Function	Transcription corepressor activity	IDA	15919722, 30599067
GO:0003714	Function	Transcription corepressor activity	IEA
GO:0004407	Function	Histone deacetylase activity	IBA
GO:0004407	Function	Histone deacetylase activity	IDA	12590135, 16762839, 28497810
GO:0004407	Function	Histone deacetylase activity	IEA
GO:0004407	Function	Histone deacetylase activity	IMP	17996965, 19182791
GO:0004407	Function	Histone deacetylase activity	TAS	12711221
GO:0005515	Function	Protein binding	IDA	17150957
GO:0005515	Function	Protein binding	IPI	9150135, 9468139, 9468140, 9651585, 10220385, 10779361, 10846170, 11006275, 11013263, 11259576, 11553631, 11559788, 11641274, 11739383, 11863372, 11931769, 12176973, 12192000, 12202768, 12482978, 12529400, 12670868, 12711603, 12730668, 12847090, 14752048, 15140878, 15273251, 1529870
GO:0005634	Component	Nucleus	IDA	9651585, 10846170, 18347167, 18936100, 20523938, 28977666, 33283408
GO:0005634	Component	Nucleus	IEA
GO:0005634	Component	Nucleus	NAS	28554894
GO:0005654	Component	Nucleoplasm	IDA	22720776, 22926524
GO:0005654	Component	Nucleoplasm	TAS
GO:0005667	Component	Transcription regulator complex	IEA
GO:0005737	Component	Cytoplasm	IEA
GO:0005737	Component	Cytoplasm	TAS	12711221
GO:0005829	Component	Cytosol	IDA	18326024
GO:0006325	Process	Chromatin organization	IEA
GO:0006325	Process	Chromatin organization	TAS	12711221
GO:0006338	Process	Chromatin remodeling	HDA	16217013
GO:0006338	Process	Chromatin remodeling	IC	16762839, 17827154
GO:0006338	Process	Chromatin remodeling	IDA	9790534
GO:0006346	Process	DNA methylation-dependent constitutive heterochromatin formation	IGI	23770133
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IGI	19057576
GO:0006476	Process	Protein deacetylation	IDA	23629966
GO:0007492	Process	Endoderm development	IEA
GO:0007623	Process	Circadian rhythm	IEA
GO:0008284	Process	Positive regulation of cell population proliferation	IEA
GO:0008284	Process	Positive regulation of cell population proliferation	IMP	18347167
GO:0009913	Process	Epidermal cell differentiation	IEA
GO:0009913	Process	Epidermal cell differentiation	ISS
GO:0010628	Process	Positive regulation of gene expression	ISS
GO:0010629	Process	Negative regulation of gene expression	IMP	16581785
GO:0010832	Process	Negative regulation of myotube differentiation	IMP	10983972
GO:0016581	Component	NuRD complex	IBA
GO:0016581	Component	NuRD complex	IDA	17827154, 19644445, 22926524, 33283408
GO:0016581	Component	NuRD complex	IEA
GO:0016581	Component	NuRD complex	NAS	16428440
GO:0016787	Function	Hydrolase activity	IEA
GO:0016811	Function	Hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	IEA
GO:0017053	Component	Transcription repressor complex	IEA
GO:0019899	Function	Enzyme binding	IPI	11062478, 11136718, 11641274
GO:0021766	Process	Hippocampus development	IEA
GO:0030182	Process	Neuron differentiation	IEA
GO:0030336	Process	Negative regulation of cell migration	NAS	22984288
GO:0030512	Process	Negative regulation of transforming growth factor beta receptor signaling pathway	NAS	22984288
GO:0031492	Function	Nucleosomal DNA binding	HDA	16217013
GO:0031507	Process	Heterochromatin formation	IBA
GO:0031507	Process	Heterochromatin formation	IEA
GO:0032922	Process	Circadian regulation of gene expression	IEA
GO:0032922	Process	Circadian regulation of gene expression	ISS
GO:0032991	Component	Protein-containing complex	HDA	16217013
GO:0032991	Component	Protein-containing complex	IDA	28046085
GO:0032991	Component	Protein-containing complex	IEA
GO:0033148	Process	Positive regulation of intracellular estrogen receptor signaling pathway	IEA
GO:0033148	Process	Positive regulation of intracellular estrogen receptor signaling pathway	IMP	18316616
GO:0033558	Function	Protein lysine deacetylase activity	IDA	16285960, 17172643, 23629966
GO:0033558	Function	Protein lysine deacetylase activity	IEA
GO:0033558	Function	Protein lysine deacetylase activity	IMP	19182791
GO:0033558	Function	Protein lysine deacetylase activity	TAS
GO:0035851	Function	Krueppel-associated box domain binding	IEA
GO:0036120	Process	Cellular response to platelet-derived growth factor stimulus	ISS
GO:0042475	Process	Odontogenesis of dentin-containing tooth	IEA
GO:0042475	Process	Odontogenesis of dentin-containing tooth	ISS
GO:0042659	Process	Regulation of cell fate specification	NAS	22560079
GO:0042733	Process	Embryonic digit morphogenesis	IEA
GO:0042733	Process	Embryonic digit morphogenesis	ISS
GO:0042826	Function	Histone deacetylase binding	IPI	12590135, 28046085
GO:0043025	Component	Neuronal cell body	IEA
GO:0043066	Process	Negative regulation of apoptotic process	IEA
GO:0043066	Process	Negative regulation of apoptotic process	ISS
GO:0043066	Process	Negative regulation of apoptotic process	TAS	10777477
GO:0043124	Process	Negative regulation of canonical NF-kappaB signal transduction	IEA
GO:0043922	Process	Host-mediated suppression of viral transcription	IMP	16540471
GO:0045814	Process	Negative regulation of gene expression, epigenetic	IMP	19057576
GO:0045892	Process	Negative regulation of DNA-templated transcription	IEA
GO:0045892	Process	Negative regulation of DNA-templated transcription	IMP	18247378, 18974119
GO:0045892	Process	Negative regulation of DNA-templated transcription	ISS
GO:0045892	Process	Negative regulation of DNA-templated transcription	NAS	22560079
GO:0045893	Process	Positive regulation of DNA-templated transcription	IDA	16762839
GO:0045893	Process	Positive regulation of DNA-templated transcription	NAS	19927129
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IDA	16762839
GO:0046872	Function	Metal ion binding	IEA
GO:0048511	Process	Rhythmic process	IEA
GO:0048661	Process	Positive regulation of smooth muscle cell proliferation	ISS
GO:0048709	Process	Oligodendrocyte differentiation	IEA
GO:0048714	Process	Positive regulation of oligodendrocyte differentiation	IEA
GO:0051059	Function	NF-kappaB binding	IEA
GO:0051059	Function	NF-kappaB binding	IPI	17785205
GO:0060766	Process	Negative regulation of androgen receptor signaling pathway	IDA	15919722
GO:0060789	Process	Hair follicle placode formation	IEA
GO:0060789	Process	Hair follicle placode formation	ISS
GO:0061029	Process	Eyelid development in camera-type eye	IEA
GO:0061029	Process	Eyelid development in camera-type eye	ISS
GO:0061198	Process	Fungiform papilla formation	IEA
GO:0061198	Process	Fungiform papilla formation	ISS
GO:0061629	Function	RNA polymerase II-specific DNA-binding transcription factor binding	IEA
GO:0061629	Function	RNA polymerase II-specific DNA-binding transcription factor binding	IPI	18850004, 18936100, 22926524
GO:0070822	Component	Sin3-type complex	IDA	17827154
GO:0070822	Component	Sin3-type complex	IEA
GO:0070822	Component	Sin3-type complex	NAS	28554894
GO:0070888	Function	E-box binding	IEA
GO:0090090	Process	Negative regulation of canonical Wnt signaling pathway	IEA
GO:0090090	Process	Negative regulation of canonical Wnt signaling pathway	IGI	18936100
GO:0140297	Function	DNA-binding transcription factor binding	IEA
GO:0140297	Function	DNA-binding transcription factor binding	IPI	15509593, 16731528, 18974119, 20590529
GO:0140297	Function	DNA-binding transcription factor binding	TAS	12711221
GO:0141221	Function	Histone deacetylase activity, hydrolytic mechanism	IEA
GO:0160008	Function	Protein decrotonylase activity	IEA
GO:0160009	Function	Histone decrotonylase activity	IDA	28497810
GO:0160009	Function	Histone decrotonylase activity	IEA
GO:0160216	Function	Protein lysine delactylase activity	IDA	35044827
GO:0160216	Function	Protein lysine delactylase activity	IEA
GO:1902455	Process	Negative regulation of stem cell population maintenance	NAS	28554894
GO:1902459	Process	Positive regulation of stem cell population maintenance	NAS	28554894
GO:1990841	Function	Promoter-specific chromatin binding	IEA
GO:2000736	Process	Regulation of stem cell differentiation	NAS	22560079
GO:2001243	Process	Negative regulation of intrinsic apoptotic signaling pathway	IEA

MIM	HGNC	e!Ensembl
601241	4852	ENSG00000116478

Q13547

Protein name

Histone deacetylase 1 (HD1) (EC 3.5.1.98) (Protein deacetylase HDAC1) (EC 3.5.1.-) (Protein deacylase HDAC1) (EC 3.5.1.-)

Protein function

Histone deacetylase that catalyzes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4) (PubMed:16762839, PubMed:17704056, PubMed:28497810). Histone deacetylation gives a tag for epigenetic repre

PDB

4BKX , 5ICN , 6Z2J , 6Z2K , 7AO8 , 7AO9 , 7AOA , 7SME , 8VOJ , 8VPQ , 8VRT

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00850	Hist_deacetyl	28 → 319	Histone deacetylase domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Ubiquitous, with higher levels in heart, pancreas and testis, and lower levels in kidney and brain.

Sequence

MAQTQGTRRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKAN
AEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVAS
AVKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHG
DGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEAI
FKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAKCVEFVKSFNLPMLMLGG
GGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTNEYLE
KIKQRLFENLRMLPHAPGVQMQAIPEDAIPEESGDEDEDDPDKRISICSSDKRIACEEEF
SDSEEEGEGGRKNSSNFKKAKRVKTEDEKEKDPEEKKEVTEEEKTKEEKPEAKGVKEEVK
LA

Sequence length

482

Interactions

View interactions

	KEGG		Reactome
	ATP-dependent chromatin remodeling Polycomb repressive complex Cell cycle Longevity regulating pathway - multiple species Notch signaling pathway TGF-beta signaling pathway Neutrophil extracellular trap formation Thyroid hormone signaling pathway Huntington disease Amphetamine addiction Alcoholism Human papillomavirus infection Epstein-Barr virus infection Pathways in cancer Transcriptional misregulation in cancer Viral carcinogenesis MicroRNAs in cancer Chronic myeloid leukemia		G0 and Early G1 Formation of the beta-catenin:TCF transactivating complex Downregulation of SMAD2/3:SMAD4 transcriptional activity SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants HDACs deacetylate histones Notch-HLH transcription pathway Deactivation of the beta-catenin transactivating complex SUMOylation of chromatin organization proteins Repression of WNT target genes Regulation of TP53 Activity through Acetylation RNA Polymerase I Transcription Initiation RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function Regulation of PTEN gene transcription Estrogen-dependent gene expression Loss of MECP2 binding ability to 5mC-DNA Regulation of MECP2 expression and activity Factors involved in megakaryocyte development and platelet production

Show/Hide Unknown Diseases (1)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
HDAC1-related disorder	Likely benign; Benign	rs145425494, rs146340055, rs116148674	RCV003903845 RCV003960775 RCV003910537

Show/Hide Text Mining Associations (139)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Acute Lung Injury	Associate	31754335
Adenocarcinoma of Lung	Associate	24830600
Adenomatous Polyps	Associate	26423403
Anemia Diamond Blackfan	Associate	34036344
Aortic Aneurysm Abdominal	Associate	31001930
Arthritis Rheumatoid	Associate	20609223, 20959025, 34353082
Asthma	Associate	24307847, 29956778
Astrocytoma	Associate	21143702
Atherosclerosis	Associate	33757583
Autoimmune Diseases	Associate	30463877
Bipolar Disorder	Associate	27959513
Breast Neoplasms	Associate	19383825, 21655924, 21737614, 23627572, 24376786, 26764010, 26862729, 28349825, 28534825, 32686908, 33885658, 35053185, 37505141, 37649051, 38206773
Burkitt Lymphoma	Associate	40021103
Calcinosis Cutis	Associate	25071017
Carcinogenesis	Associate	11749695, 25791281
Carcinoma Ductal Breast	Associate	22455563, 23421821
Carcinoma Hepatocellular	Associate	22496786, 26352599, 26575952, 27507654, 32191631, 32557953, 32807131, 34245919, 34319031, 34691238, 37923899, 38127054
Carcinoma Hepatocellular	Stimulate	27342975
Carcinoma Intraductal Noninfiltrating	Inhibit	19383825
Carcinoma Non Small Cell Lung	Associate	22965008, 23110995, 26794658, 33786615, 37291119
Carcinoma Pancreatic Ductal	Associate	29374219, 34049503, 37996815
Carcinoma Papillary	Associate	23873102
Carcinoma Renal Cell	Associate	27506904, 30463940, 30951404
Carcinoma Squamous Cell	Associate	33671013, 35756488
Cardiomyopathy Hypertrophic	Associate	36883446
Cholangiocarcinoma	Associate	29436659, 32116234
Colonic Neoplasms	Associate	12847090
Colorectal Neoplasms	Associate	17720775, 19198625, 23708667, 24518414, 24948597, 32592383, 33576217, 36982429, 38062013
Colorectal Neoplasms	Stimulate	26423403, 28424407
Coronary Artery Disease	Associate	30857550
Coronavirus Infections	Associate	39201509
COVID 19	Associate	33691446
Crohn Disease	Associate	36175163
Death	Stimulate	26352599
Death	Associate	28545442
Demyelinating Diseases	Associate	20930523
Depressive Disorder	Associate	27959513
Dermatitis Atopic	Associate	37330465, 38250727
Diabetes Mellitus	Associate	34233433, 36529747
Diabetic Foot	Associate	33096729
Disorders of Excessive Somnolence	Stimulate	34667186
DNA Virus Infections	Associate	29140459
Drug Related Side Effects and Adverse Reactions	Associate	25899338
Drug Related Side Effects and Adverse Reactions	Inhibit	33994851
Endometriosis	Associate	22344732, 23690335, 35321026, 35980861
Epilepsy Familial Mesial Temporal Lobe	Stimulate	33258018
Esophageal Neoplasms	Associate	26898709, 27086779
Friedreich Ataxia	Associate	24933366
Gastrointestinal Neoplasms	Associate	28424407
Genetic Diseases Inborn	Associate	30463877
Glioblastoma	Associate	18708058, 30654849, 32328646, 34494550, 35417530
Glioma	Associate	18708058, 21143702, 24176859, 25791281, 26521947, 32328646, 34494550, 35545840, 36810892, 37528157
Glioma	Stimulate	30654849
Gout	Associate	30728075
Hematologic Diseases	Stimulate	36293392
Hepatoblastoma	Associate	27635950, 34245919, 35507738
Hereditary Breast and Ovarian Cancer Syndrome	Associate	34459501
Hereditary leiomyomatosis and renal cell cancer	Stimulate	29481474
Hirschsprung Disease	Associate	37061531
Hodgkin Disease	Associate	29481474
Huntington Disease	Associate	24933366
Hypertension	Associate	34667186
Hypoxia	Stimulate	27506904, 34667186
Hypoxia	Associate	35840042
Inflammation	Associate	30918008, 33757583, 34353082, 35794630
Influenza Human	Associate	36070294
Latent Autoimmune Diabetes in Adults	Associate	26839444
Leiomyoma	Associate	31761932
Leiomyosarcoma	Associate	36497061
Leukemia	Associate	21359182, 26655717, 34073721
Leukemia Biphenotypic Acute	Associate	26655717
Leukemia Lymphocytic Chronic B Cell	Associate	16409301, 28480959, 36287107, 38579402
Leukemia Myeloid Acute	Associate	21359182, 26858310, 28030834, 31411110, 36424383
Liposarcoma	Associate	22328974
Lung Neoplasms	Associate	19596925, 25970771, 29108454, 30612578, 34203519
Lung Neoplasms	Stimulate	24441677
Lupus Erythematosus Systemic	Associate	21976679
Lupus Erythematosus Systemic	Stimulate	37661113
Lymphatic Metastasis	Associate	22455563
Lymphoma Large B Cell Diffuse	Associate	25605023
Lymphoma Mantle Cell	Associate	20427703
Lymphoma Non Hodgkin	Associate	37649051
Lymphoma T Cell Cutaneous	Associate	28288848
Malignant mesenchymal tumor	Associate	22037263
Melanoma	Associate	24850177, 25071017
Melioidosis	Associate	28628607
Multiple Myeloma	Associate	25482492, 27738323
Multiple Myeloma	Stimulate	34738621
Multiple Sclerosis	Associate	30463275, 32241259, 36282535
Myoepithelioma	Associate	25223915
Nasopharyngeal Carcinoma	Associate	35689852
Neoplasm Metastasis	Associate	19182791, 29917299
Neoplasm Metastasis	Inhibit	28984297
Neoplasms	Associate	12665570, 16309230, 16638127, 17470557, 17923479, 18212746, 18430739, 19860841, 21143702, 22029821, 22037263, 22158273, 22180294, 22496786, 23312906 View all (29 more)
Neoplasms	Inhibit	19182791, 21798853, 24475290, 34494550
Neoplasms Squamous Cell	Associate	35756488
Neoplastic Cells Circulating	Associate	11749695
Nerve Degeneration	Associate	20930523
Neuroblastoma	Associate	23706636, 35821006, 36130928, 37488358, 38063204
Nevus Pigmented	Associate	17578512
Oculodigitoesophagoduodenal syndrome	Associate	29855565
Osteosarcoma	Associate	28984297, 31337976
Ovarian Diseases	Associate	22344732
Ovarian Neoplasms	Associate	24249678, 24475290
Pancreatic Neoplasms	Associate	15647279, 20484017, 25275504, 26502922, 29374219, 29917299, 37996815
Peritoneal Fibrosis	Associate	29855565
Precancerous Conditions	Associate	30872677
Precursor T Cell Lymphoblastic Leukemia Lymphoma	Stimulate	20636436
Prostatic Neoplasms	Associate	17079440, 18212746, 22531786, 22797919, 23737958, 24294372, 32397189
Prostatitis	Associate	21622623
Pulmonary Disease Chronic Obstructive	Associate	35975032
Respiratory Distress Syndrome	Associate	34556700
Retinitis Pigmentosa	Associate	22848708
Rett Syndrome	Associate	37408271
Rhabdoid Tumor	Stimulate	23764045
Sarcoma	Associate	22037263
Schizophrenia	Associate	17961987
Scleroderma Systemic	Associate	35663995
Sepsis	Associate	28628607
Sleep Apnea Obstructive	Associate	34667186
Spondylitis Ankylosing	Associate	35794630
Squamous Cell Carcinoma of Head and Neck	Associate	23558898, 27349552, 31938073, 33649777
Status Asthmaticus	Associate	24307847
Status Asthmaticus	Stimulate	33626953
Stomach Neoplasms	Stimulate	11749695, 34232196
Stomach Neoplasms	Inhibit	24668547
Stomach Neoplasms	Associate	26675260, 28424407, 39201509
Thyroid Cancer Papillary	Associate	31591432
Thyroid Diseases	Associate	23873102
Thyroid Neoplasms	Associate	30669676
Thyroiditis	Associate	23873102
Uremia	Associate	27018948
Urethral Neoplasms	Associate	27250763, 35624179
Urinary Bladder Neoplasms	Associate	36140796
Uterine Cervical Dysplasia	Associate	22029821
Uterine Cervical Neoplasms	Associate	24606473, 32319591, 33671013, 34151839, 38244809
Uveal melanoma	Associate	35332245
Varicose Veins	Associate	36293392
Vitamin D Deficiency	Associate	38250727

HDAC1 (histone deacetylase 1)