HCRTR2 (hypocretin receptor 2)

Gene
Gene Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
3062
Gene name Gene Name - the full gene name approved by the HGNC.
Hypocretin receptor 2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
HCRTR2
Synonyms (NCBI Gene) Gene synonyms aliases
ORXR2, OX2R, OXR2
Chromosome Chromosome number
6
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
6p12.1
Summary Summary of gene provided in NCBI Entrez Gene.
The protein encoded by this gene is a G-protein coupled receptor involved in the regulation of feeding behavior. The encoded protein binds the hypothalamic neuropeptides orexin A and orexin B. A related gene (HCRTR1) encodes a G-protein coupled receptor t
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(31)
GO ID Ontology Definition Evidence Reference
GO:0004930 Function G protein-coupled receptor activity IEA
GO:0005515 Function Protein binding IPI 32814053
GO:0005654 Component Nucleoplasm IDA
GO:0005886 Component Plasma membrane IBA
GO:0005886 Component Plasma membrane IDA 26950369
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
602393 4849 ENSG00000137252
Protein
Gene Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID O43614
Protein name Orexin receptor type 2 (Ox-2-R) (Ox2-R) (Ox2R) (Hypocretin receptor type 2)
Protein function Nonselective, high-affinity receptor for both orexin-A and orexin-B neuropeptides (PubMed:26950369, PubMed:9491897). Triggers an increase in cytoplasmic Ca(2+) levels in response to orexin-A binding (PubMed:26950369, PubMed:9491897). {ECO:000026
PDB 4S0V , 5WQC , 5WS3 , 6TPG , 6TPJ , 6TPN , 7L1U , 7L1V , 7SQO , 7SR8 , 7XRR
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00001 7tm_1 71 → 364 7 transmembrane receptor (rhodopsin family) Family
PF03827 Orexin_rec2 387 → 444 Orexin receptor type 2 Family
Sequence
Sequence length 444
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene Gene ontology Other IDs Protein Pathways Associated diseases
  KEGG   Reactome
  Neuroactive ligand-receptor interaction
Hormone signaling 		  Orexin and neuropeptides FF and QRFP bind to their respective receptors
G alpha (q) signalling events
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Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Gene Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Unknown Diseases (1)
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Disease merge term Disease name Evidence References Source
Urolithiasis Urolithiasis N/A N/A GWAS
Show/Hide Text Mining Associations (16)
Associations from Text Mining Disease associations identified through Pubtator
Disease Name Relationship Type References
Anorexia Associate 28487995
Carcinoma Endometrioid Associate 23482607
Cluster Headache Associate 29318394, 30652302
Depressive Disorder Associate 28487995
Endometrial Neoplasms Associate 23482607
Glioblastoma Associate 33470396
Goiter Associate 26289589
Mental Disorders Associate 36901420
Myotonic Dystrophy Associate 18195268
Narcolepsy Associate 22028875, 29220370