ANXA3 (annexin A3)

Gene
Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
306
Gene name Gene Name - the full gene name approved by the HGNC.
Annexin A3
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
ANXA3
Synonyms (NCBI Gene) Gene synonyms aliases
ANX3
Chromosome Chromosome number
4
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
4q21.21
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a member of the annexin family. Members of this calcium-dependent phospholipid-binding protein family play a role in the regulation of cellular growth and in signal transduction pathways. This protein functions in the inhibition of pho
miRNA miRNA information provided by mirtarbase database.
Gene miRNA Gene ontology Other IDs Protein Associated diseases
Show/Hide all(4)
miRTarBase ID miRNA Experiments Reference
MIRT030154 hsa-miR-26b-5p Microarray 19088304
MIRT786503 hsa-miR-1305 CLIP-seq
MIRT786504 hsa-miR-374c CLIP-seq
MIRT786505 hsa-miR-655 CLIP-seq
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene miRNA Gene ontology Other IDs Protein Associated diseases
Show/Hide all(24)
GO ID Ontology Definition Evidence Reference
GO:0001786 Function Phosphatidylserine binding IBA
GO:0004859 Function Phospholipase inhibitor activity IEA
GO:0005509 Function Calcium ion binding IEA
GO:0005544 Function Calcium-dependent phospholipid binding IBA
GO:0005544 Function Calcium-dependent phospholipid binding IDA 2138016, 2138632
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene miRNA Gene ontology Other IDs Protein Associated diseases
MIM HGNC e!Ensembl
106490 541 ENSG00000138772
Protein
Gene miRNA Gene ontology Other IDs Protein Associated diseases
UniProt ID P12429
Protein name Annexin A3 (35-alpha calcimedin) (Annexin III) (Annexin-3) (Inositol 1,2-cyclic phosphate 2-phosphohydrolase) (Lipocortin III) (Placental anticoagulant protein III) (PAP-III)
Protein function Inhibitor of phospholipase A2, also possesses anti-coagulant properties. Also cleaves the cyclic bond of inositol 1,2-cyclic phosphate to form inositol 1-phosphate.
PDB 1AII , 1AXN
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00191 Annexin 22 → 87 Annexin Family
PF00191 Annexin 94 → 159 Annexin Family
PF00191 Annexin 177 → 243 Annexin Family
PF00191 Annexin 253 → 318 Annexin Family
Sequence
Sequence length 323
Interactions View interactions
<
Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Gene miRNA Gene ontology Other IDs Protein Associated diseases
Show/Hide Unknown Diseases (2)
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Disease merge term Disease name Evidence References Source
Dementia Dementia N/A N/A GWAS
Rheumatoid arthritis Rheumatoid arthritis N/A N/A GWAS
Show/Hide Text Mining Associations (59)
Associations from Text Mining Disease associations identified through Pubtator
Disease Name Relationship Type References
Adenoma Stimulate 27661117
Alzheimer Disease Associate 40471493
Arthritis Rheumatoid Associate 23577190, 35789606
Atrial Fibrillation Associate 36952494
Autoimmune Diseases Stimulate 22771791
Bone Neoplasms Associate 31524248
Breast Neoplasms Associate 28497041, 30003741, 31128000
Carcinogenesis Associate 24815437, 27894078
Carcinoma Hepatocellular Associate 26095609, 33191179
Carcinoma Renal Cell Associate 20167856, 37464398