H3-3B (H3.3 histone B)

Gene

• Entrez ID: 3021
• Gene name: H3.3 histone B
• Gene symbol: H3-3B
• Synonyms (NCBI Gene): BRYLIB2, H3-3A, H3.3B, H3F3B
• Disease Acronyms (UniProt): BRYLIB2
• Chromosome: 17
• Chromosome location: 17q25.1
• Summary: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000183	Process	RDNA heterochromatin assembly	TAS
GO:0000228	Component	Nuclear chromosome	IDA	14718166
GO:0000781	Component	Chromosome, telomeric region	IDA	20110566
GO:0000786	Component	Nucleosome	IDA	19633671, 21636898, 25615412
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA	19633671
GO:0000979	Function	RNA polymerase II core promoter sequence-specific DNA binding	IDA	19633671
GO:0001649	Process	Osteoblast differentiation	IEA
GO:0001740	Component	Barr body	IEA
GO:0005515	Function	Protein binding	IPI	19494831, 19834512, 20110566, 20211137, 20448663, 20651253, 20953165, 23075851, 23142979, 24183680, 24209620, 24590075, 24981860, 25416956, 26167883, 26439302, 32296183
GO:0005576	Component	Extracellular region	TAS
GO:0005634	Component	Nucleus	HDA	21630459
GO:0005634	Component	Nucleus	IBA	21873635
GO:0005634	Component	Nucleus	IDA	21636898
GO:0005654	Component	Nucleoplasm	TAS
GO:0006334	Process	Nucleosome assembly	IDA	21636898
GO:0006334	Process	Nucleosome assembly	IMP	25615412
GO:0006336	Process	DNA replication-independent nucleosome assembly	IDA	14718166
GO:0006997	Process	Nucleus organization	IEA
GO:0007286	Process	Spermatid development	IEA
GO:0007338	Process	Single fertilization	IEA
GO:0007566	Process	Embryo implantation	IEA
GO:0007596	Process	Blood coagulation	TAS
GO:0008283	Process	Cell population proliferation	IEA
GO:0008584	Process	Male gonad development	IEA
GO:0030307	Process	Positive regulation of cell growth	IMP	21274551
GO:0031492	Function	Nucleosomal DNA binding	IDA	19633671
GO:0031508	Process	Pericentric heterochromatin assembly	IEA
GO:0031509	Process	Subtelomeric heterochromatin assembly	IEA
GO:0032200	Process	Telomere organization	TAS	17675446
GO:0032991	Component	Protein-containing complex	IDA	14718166
GO:0035264	Process	Multicellular organism growth	IEA
GO:0042692	Process	Muscle cell differentiation	IEA
GO:0044267	Process	Cellular protein metabolic process	TAS
GO:0045652	Process	Regulation of megakaryocyte differentiation	TAS
GO:0045814	Process	Negative regulation of gene expression, epigenetic	TAS
GO:0046982	Function	Protein heterodimerization activity	IEA
GO:0048477	Process	Oogenesis	IEA
GO:0060964	Process	Regulation of gene silencing by miRNA	TAS
GO:0070062	Component	Extracellular exosome	HDA	20458337
GO:0090230	Process	Regulation of centromere complex assembly	IEA
GO:1902340	Process	Negative regulation of chromosome condensation	IEA

Other IDs

• MIM: 601058
• HGNC: 4765
• e!Ensembl: ENSG00000132475

Pathways

KEGG:

Neutrophil extracellular trap formation
Alcoholism
Shigellosis
Transcriptional misregulation in cancer
Systemic lupus erythematosus

Reactome:

Formation of the beta-catenin:TCF transactivating complex
PRC2 methylates histones and DNA
Condensation of Prophase Chromosomes
Oxidative Stress Induced Senescence
Senescence-Associated Secretory Phenotype (SASP)
SIRT1 negatively regulates rRNA expression
NoRC negatively regulates rRNA expression
B-WICH complex positively regulates rRNA expression
Transcriptional regulation by small RNAs
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
RNA Polymerase I Promoter Opening
RNA Polymerase I Promoter Escape
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
Estrogen-dependent gene expression
Amyloid fiber formation
Factors involved in megakaryocyte development and platelet production