Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
302
Gene name Gene Name - the full gene name approved by the HGNC.
Annexin A2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
ANXA2
Synonyms (NCBI Gene) Gene synonyms aliases
ANX2, ANX2L4, CAL1H, HEL-S-270, LIP2, LPC2, LPC2D, P36, PAP-IV
Chromosome Chromosome number
15
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
15q22.2
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a member of the annexin family. Members of this calcium-dependent phospholipid-binding protein family play a role in the regulation of cellular growth and in signal transduction pathways. This protein functions as an autocrine factor whi
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT001388 hsa-miR-1-3p pSILAC 18668040
MIRT020897 hsa-miR-155-5p Proteomics 18668040
MIRT001388 hsa-miR-1-3p Proteomics;Microarray 18668037
MIRT001388 hsa-miR-1-3p Proteomics 18668040
MIRT045844 hsa-miR-132-3p CLASH 23622248
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0001525 Process Angiogenesis IEP 11866539
GO:0001765 Process Membrane raft assembly IMP 23861394
GO:0001786 Function Phosphatidylserine binding IBA 21873635
GO:0001921 Process Positive regulation of receptor recycling IDA 22848640
GO:0002020 Function Protease binding IBA 21873635
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
151740 537 ENSG00000182718
Protein
UniProt ID P07355
Protein name Annexin A2 (Annexin II) (Annexin-2) (Calpactin I heavy chain) (Calpactin-1 heavy chain) (Chromobindin-8) (Lipocortin II) (Placental anticoagulant protein IV) (PAP-IV) (Protein I) (p36)
Protein function Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. Inhibits PCSK9-enhanced LDLR degradation,
PDB 1W7B , 1XJL , 2HYU , 2HYV , 2HYW , 4DRW , 4FTG , 4HRH , 5LPU , 5LPX , 5LQ0 , 5LQ2 , 5N7D , 5N7F , 5N7G , 6TWQ , 6TWU , 6TWX , 6TWY , 7DTO , 7EQ7 , 7NMI , 7P70 , 7P71 , 7P72 , 7P73 , 7P74 , 7PC3 , 7PC4 , 7PC5 , 7PC7 , 7PC8 , 7PC9 , 7PCB , 7QQL , 7QQM , 7QQN , 7ZVN , 7ZVX , 8AEL
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00191 Annexin 37 102 Annexin Family
PF00191 Annexin 109 174 Annexin Family
PF00191 Annexin 193 259 Annexin Family
PF00191 Annexin 269 334 Annexin Family
Sequence
Sequence length 339
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Salmonella infection   Neutrophil degranulation
Dissolution of Fibrin Clot
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Carcinoma Squamous cell carcinoma rs121912654, rs555607708, rs786202962, rs1564055259 15274141
Leukemia Leukemia, Myelocytic, Acute, Acute Myeloid Leukemia (AML-M2) rs121909646, rs121913488, rs587776834, rs752746786, rs869312821, rs767454740, rs1554564297 17330099
Lung cancer Malignant neoplasm of lung rs121913530, rs121913529, rs878855122, rs1057519784, rs770315135 20682992
Osteoporosis Osteoporosis, Age-Related, Osteoporosis, Osteoporosis, Senile, Post-Traumatic Osteoporosis rs72658152, rs72667023, rs587776916, rs72656370, rs768615287 18924182
Unknown
Disease term Disease name Evidence References Source
Diabetes Diabetes GWAS
Associations from Text Mining
Disease Name Relationship Type References
Adenocarcinoma Associate 17054434, 28178129
Adenocarcinoma Follicular Associate 17695432
Adenocarcinoma of Lung Associate 11504947, 31865638
Adenoma Inhibit 25880590
Adenomyosis Associate 31183557
Alopecia Areata Associate 29323127
Anemia Sickle Cell Associate 15784727
Antiphospholipid Syndrome Associate 16493010, 18759277, 22288586
Aortic Aneurysm Abdominal Associate 22226179
Aortic Valve Stenosis Inhibit 31856737