Gene Gene information from NCBI Gene database.
Entrez ID 302
Gene name Annexin A2
Gene symbol ANXA2
Synonyms (NCBI Gene)
ANX2ANX2L4CAL1HHEL-S-270LIP2LPC2LPC2DP36PAP-IV
Chromosome 15
Chromosome location 15q22.2
Summary This gene encodes a member of the annexin family. Members of this calcium-dependent phospholipid-binding protein family play a role in the regulation of cellular growth and in signal transduction pathways. This protein functions as an autocrine factor whi
miRNA miRNA information provided by mirtarbase database.
686
miRTarBase ID miRNA Experiments Reference
MIRT001388 hsa-miR-1-3p pSILAC 18668040
MIRT020897 hsa-miR-155-5p Proteomics 18668040
MIRT001388 hsa-miR-1-3p Proteomics;Microarray 18668037
MIRT001388 hsa-miR-1-3p Proteomics 18668040
MIRT045844 hsa-miR-132-3p CLASH 23622248
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
109
GO ID Ontology Definition Evidence Reference
GO:0001525 Process Angiogenesis IEA
GO:0001525 Process Angiogenesis IEP 11866539
GO:0001533 Component Cornified envelope IEA
GO:0001765 Process Membrane raft assembly IMP 23861394
GO:0001786 Function Phosphatidylserine binding IBA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
151740 537 ENSG00000182718
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P07355
Protein name Annexin A2 (Annexin II) (Annexin-2) (Calpactin I heavy chain) (Calpactin-1 heavy chain) (Chromobindin-8) (Lipocortin II) (Placental anticoagulant protein IV) (PAP-IV) (Protein I) (p36)
Protein function Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. Inhibits PCSK9-enhanced LDLR degradation,
PDB 1W7B , 1XJL , 2HYU , 2HYV , 2HYW , 4DRW , 4FTG , 4HRH , 5LPU , 5LPX , 5LQ0 , 5LQ2 , 5N7D , 5N7F , 5N7G , 6TWQ , 6TWU , 6TWX , 6TWY , 7DTO , 7EQ7 , 7NMI , 7P70 , 7P71 , 7P72 , 7P73 , 7P74 , 7PC3 , 7PC4 , 7PC5 , 7PC7 , 7PC8 , 7PC9 , 7PCB , 7QQL , 7QQM , 7QQN , 7ZVN , 7ZVX , 8AEL
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00191 Annexin 37 102 Annexin Family
PF00191 Annexin 109 174 Annexin Family
PF00191 Annexin 193 259 Annexin Family
PF00191 Annexin 269 334 Annexin Family
Sequence
Sequence length 339
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  Salmonella infection   Neutrophil degranulation
Dissolution of Fibrin Clot
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation