ANXA1 (annexin A1)

Gene

• Entrez ID: 301
• Gene name: Annexin A1
• Gene symbol: ANXA1
• Synonyms (NCBI Gene): ANX1, LPC1
• Chromosome: 9
• Chromosome location: 9q21.13
• Summary: This gene encodes a membrane-localized protein that binds phospholipids. This protein inhibits phospholipase A2 and has anti-inflammatory activity. Loss of function or expression of this gene has been detected in multiple tumors. [provided by RefSeq, Dec

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT000709	hsa-miR-196a-5p	real time qRT-PCR, Luciferase reporter assay, Western blot	18663355
MIRT000709	hsa-miR-196a-5p	Luciferase reporter assay	18663355
MIRT018638	hsa-miR-335-5p	Microarray	18185580
MIRT000709	hsa-miR-196a-5p	Reporter assay;Other	18663355
MIRT028650	hsa-miR-30a-5p	Proteomics	18668040
MIRT030065	hsa-miR-26b-5p	Microarray	19088304
MIRT054354	hsa-miR-221-3p	Luciferase reporter assay, QRTPCR, Western blot	23630541
MIRT000709	hsa-miR-196a-5p	Luciferase reporter assay, qRT-PCR, Western blot	25523631
MIRT737187	hsa-miR-196a-3p	qRT-PCR	31777500
MIRT786402	hsa-miR-196a	CLIP-seq
MIRT786403	hsa-miR-196b	CLIP-seq
MIRT786404	hsa-miR-3927	CLIP-seq
MIRT786405	hsa-miR-4291	CLIP-seq
MIRT786406	hsa-miR-4310	CLIP-seq
MIRT786407	hsa-miR-500a	CLIP-seq
MIRT1555950	hsa-miR-1267	CLIP-seq
MIRT786402	hsa-miR-196a	CLIP-seq
MIRT786403	hsa-miR-196b	CLIP-seq
MIRT1555951	hsa-miR-3185	CLIP-seq
MIRT786404	hsa-miR-3927	CLIP-seq
MIRT1555952	hsa-miR-4709-3p	CLIP-seq
MIRT786407	hsa-miR-500a	CLIP-seq
MIRT1555953	hsa-miR-653	CLIP-seq
MIRT2384265	hsa-miR-296-3p	CLIP-seq
MIRT2384266	hsa-miR-568	CLIP-seq
MIRT2384267	hsa-miR-584	CLIP-seq
MIRT2384268	hsa-miR-643	CLIP-seq
MIRT1555950	hsa-miR-1267	CLIP-seq
MIRT786402	hsa-miR-196a	CLIP-seq
MIRT786403	hsa-miR-196b	CLIP-seq
MIRT2426342	hsa-miR-2110	CLIP-seq
MIRT2426343	hsa-miR-221	CLIP-seq
MIRT2426344	hsa-miR-222	CLIP-seq
MIRT2426345	hsa-miR-28-3p	CLIP-seq
MIRT2384265	hsa-miR-296-3p	CLIP-seq
MIRT2426346	hsa-miR-3150a-3p	CLIP-seq
MIRT2426347	hsa-miR-3163	CLIP-seq
MIRT1555951	hsa-miR-3185	CLIP-seq
MIRT2426348	hsa-miR-3662	CLIP-seq
MIRT2426349	hsa-miR-3675-3p	CLIP-seq
MIRT2426350	hsa-miR-369-3p	CLIP-seq
MIRT2426351	hsa-miR-374a	CLIP-seq
MIRT2426352	hsa-miR-374b	CLIP-seq
MIRT2426353	hsa-miR-376c	CLIP-seq
MIRT786404	hsa-miR-3927	CLIP-seq
MIRT2426354	hsa-miR-4260	CLIP-seq
MIRT2426355	hsa-miR-4271	CLIP-seq
MIRT786405	hsa-miR-4291	CLIP-seq
MIRT786406	hsa-miR-4310	CLIP-seq
MIRT2426356	hsa-miR-4484	CLIP-seq
MIRT2426357	hsa-miR-4668-5p	CLIP-seq
MIRT2426358	hsa-miR-4694-3p	CLIP-seq
MIRT1555952	hsa-miR-4709-3p	CLIP-seq
MIRT2426359	hsa-miR-4725-3p	CLIP-seq
MIRT2426360	hsa-miR-4773	CLIP-seq
MIRT2426361	hsa-miR-4789-5p	CLIP-seq
MIRT2426362	hsa-miR-4797-5p	CLIP-seq
MIRT786407	hsa-miR-500a	CLIP-seq
MIRT2426363	hsa-miR-548an	CLIP-seq
MIRT2426364	hsa-miR-548c-3p	CLIP-seq
MIRT2384266	hsa-miR-568	CLIP-seq
MIRT2426365	hsa-miR-570	CLIP-seq
MIRT2384267	hsa-miR-584	CLIP-seq
MIRT2384268	hsa-miR-643	CLIP-seq
MIRT1555953	hsa-miR-653	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001533	Component	Cornified envelope	IDA	10908733
GO:0001533	Component	Cornified envelope	IEA
GO:0001780	Process	Neutrophil homeostasis	IEA
GO:0001780	Process	Neutrophil homeostasis	IMP	21957127
GO:0001786	Function	Phosphatidylserine binding	IBA
GO:0001891	Component	Phagocytic cup	IEA
GO:0002250	Process	Adaptive immune response	IEA
GO:0002376	Process	Immune system process	IEA
GO:0002548	Process	Monocyte chemotaxis	IDA	15187149
GO:0002685	Process	Regulation of leukocyte migration	IEA
GO:0002685	Process	Regulation of leukocyte migration	ISS
GO:0004859	Function	Phospholipase inhibitor activity	IEA
GO:0005102	Function	Signaling receptor binding	TAS	10882119
GO:0005509	Function	Calcium ion binding	EXP	11078886
GO:0005509	Function	Calcium ion binding	IEA
GO:0005509	Function	Calcium ion binding	ISS
GO:0005509	Function	Calcium ion binding	TAS	2967291
GO:0005515	Function	Protein binding	IPI	20029029, 21383699, 24189400, 31980649, 32296183, 32814053, 34237247
GO:0005543	Function	Phospholipid binding	TAS	2967291
GO:0005544	Function	Calcium-dependent phospholipid binding	IBA
GO:0005544	Function	Calcium-dependent phospholipid binding	IDA	2138016
GO:0005544	Function	Calcium-dependent phospholipid binding	IEA
GO:0005576	Component	Extracellular region	IEA
GO:0005576	Component	Extracellular region	TAS
GO:0005615	Component	Extracellular space	HDA	22664934, 23580065
GO:0005615	Component	Extracellular space	IDA	17008549, 19625660, 25664854
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IDA	10772777, 22056994
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IDA	10772777, 17008549, 19625660, 22056994
GO:0005737	Component	Cytoplasm	IEA
GO:0005737	Component	Cytoplasm	TAS	16130169
GO:0005768	Component	Endosome	IDA	18767904
GO:0005768	Component	Endosome	IEA
GO:0005769	Component	Early endosome	IEA
GO:0005829	Component	Cytosol	IDA
GO:0005884	Component	Actin filament	IDA	22773844
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IDA	10772777
GO:0005886	Component	Plasma membrane	IEA
GO:0005912	Component	Adherens junction	HDA	25468996
GO:0005925	Component	Focal adhesion	HDA	21423176
GO:0005929	Component	Cilium	IEA
GO:0006909	Process	Phagocytosis	IBA
GO:0006909	Process	Phagocytosis	IEA
GO:0006909	Process	Phagocytosis	ISS
GO:0006954	Process	Inflammatory response	IEA
GO:0006954	Process	Inflammatory response	ISS
GO:0006954	Process	Inflammatory response	TAS	10882119
GO:0007165	Process	Signal transduction	IBA
GO:0007165	Process	Signal transduction	IEA
GO:0007165	Process	Signal transduction	TAS	16130169
GO:0007166	Process	Cell surface receptor signaling pathway	TAS	10882119
GO:0007187	Process	G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	IDA	25664854
GO:0007187	Process	G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	IMP	15187149
GO:0008289	Function	Lipid binding	EXP	8756690
GO:0008360	Process	Regulation of cell shape	IDA	15187149
GO:0009986	Component	Cell surface	IDA	22056994
GO:0010008	Component	Endosome membrane	IEA
GO:0012506	Component	Vesicle membrane	IBA
GO:0014839	Process	Myoblast migration involved in skeletal muscle regeneration	IEA
GO:0016020	Component	Membrane	IEA
GO:0016323	Component	Basolateral plasma membrane	IEA
GO:0016324	Component	Apical plasma membrane	IEA
GO:0016324	Component	Apical plasma membrane	ISS
GO:0016328	Component	Lateral plasma membrane	IEA
GO:0016328	Component	Lateral plasma membrane	ISS
GO:0018149	Process	Peptide cross-linking	IDA	10908733
GO:0019834	Function	Phospholipase A2 inhibitor activity	IDA	2936963, 3013422
GO:0019834	Function	Phospholipase A2 inhibitor activity	IEA
GO:0030036	Process	Actin cytoskeleton organization	IDA	15187149
GO:0030216	Process	Keratinocyte differentiation	IDA	10908733
GO:0030659	Component	Cytoplasmic vesicle membrane	IEA
GO:0031012	Component	Extracellular matrix	HDA	25037231, 28344315, 28675934
GO:0031340	Process	Positive regulation of vesicle fusion	IDA	2138016
GO:0031340	Process	Positive regulation of vesicle fusion	IEA
GO:0031410	Component	Cytoplasmic vesicle	IEA
GO:0031514	Component	Motile cilium	IEA
GO:0031514	Component	Motile cilium	ISS
GO:0031901	Component	Early endosome membrane	ISS
GO:0031982	Component	Vesicle	HDA	19190083
GO:0032652	Process	Regulation of interleukin-1 production	IEA
GO:0032652	Process	Regulation of interleukin-1 production	ISS
GO:0032717	Process	Negative regulation of interleukin-8 production	IMP	22056994
GO:0032743	Process	Positive regulation of interleukin-2 production	IDA	17008549
GO:0033031	Process	Positive regulation of neutrophil apoptotic process	IEA
GO:0035924	Process	Cellular response to vascular endothelial growth factor stimulus	IDA	22773844
GO:0042102	Process	Positive regulation of T cell proliferation	IDA	17008549
GO:0042119	Process	Neutrophil activation	IDA	22879591
GO:0042127	Process	Regulation of cell population proliferation	IEA
GO:0042383	Component	Sarcolemma	IEA
GO:0042995	Component	Cell projection	IEA
GO:0043066	Process	Negative regulation of apoptotic process	TAS	16130169
GO:0045087	Process	Innate immune response	IEA
GO:0045627	Process	Positive regulation of T-helper 1 cell differentiation	IDA	17008549
GO:0045629	Process	Negative regulation of T-helper 2 cell differentiation	IDA	17008549
GO:0045920	Process	Negative regulation of exocytosis	IMP	19625660
GO:0046632	Process	Alpha-beta T cell differentiation	IEA
GO:0046632	Process	Alpha-beta T cell differentiation	ISS
GO:0046872	Function	Metal ion binding	IEA
GO:0046883	Process	Regulation of hormone secretion	IMP	19625660
GO:0048306	Function	Calcium-dependent protein binding	IEA
GO:0048306	Function	Calcium-dependent protein binding	IPI	15226301
GO:0050482	Process	Arachidonate secretion	IEA
GO:0050727	Process	Regulation of inflammatory response	IEA
GO:0050727	Process	Regulation of inflammatory response	ISS
GO:0051051	Process	Negative regulation of transport	IEA
GO:0051240	Process	Positive regulation of multicellular organismal process	IEA
GO:0070062	Component	Extracellular exosome	HDA	19056867, 19199708, 21362503, 23533145
GO:0070062	Component	Extracellular exosome	IDA	25664854
GO:0070062	Component	Extracellular exosome	IEA
GO:0071385	Process	Cellular response to glucocorticoid stimulus	IBA
GO:0071385	Process	Cellular response to glucocorticoid stimulus	IDA	2936963
GO:0071385	Process	Cellular response to glucocorticoid stimulus	IEA
GO:0071621	Process	Granulocyte chemotaxis	IDA	15187149
GO:0090050	Process	Positive regulation of cell migration involved in sprouting angiogenesis	IDA	22773844
GO:0090303	Process	Positive regulation of wound healing	IDA	25664854
GO:0097350	Process	Neutrophil clearance	IMP	21957127
GO:0098609	Process	Cell-cell adhesion	IEA
GO:0098641	Function	Cadherin binding involved in cell-cell adhesion	HDA	25468996
GO:1900087	Process	Positive regulation of G1/S transition of mitotic cell cycle	IEA

Other IDs

• MIM: 151690
• HGNC: 533
• e!Ensembl: ENSG00000135046

Protein

• UniProt ID: P04083
• Protein name: Annexin A1 (Annexin I) (Annexin-1) (Calpactin II) (Calpactin-2) (Chromobindin-9) (Lipocortin I) (Phospholipase A2 inhibitory protein) (p35) [Cleaved into: Annexin Ac2-26]
• Protein function: Plays important roles in the innate immune response as effector of glucocorticoid-mediated responses and regulator of the inflammatory process. Has anti-inflammatory activity (PubMed:8425544). Plays a role in glucocorticoid-mediated down-regulat
• PDB: 1AIN, 1BO9, 1QLS, 5VFW
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00191	Annexin	46 → 111	Annexin	Family
  PF00191	Annexin	118 → 183	Annexin	Family
  PF00191	Annexin	201 → 267	Annexin	Family
  PF00191	Annexin	277 → 342	Annexin	Family

• Tissue specificity: TISSUE SPECIFICITY: Detected in resting neutrophils (PubMed:10772777). Detected in peripheral blood T-cells (PubMed:17008549). Detected in extracellular vesicles in blood serum from patients with inflammatory bowel disease, but not in serum from healthy d
• Sequence:

  MAMVSEFLKQAWFIENEEQEYVQTVKSSKGGPGSAVSPYPTFNPSSDVAALHKAIMVKGV
  DEATIIDILTKRNNAQRQQIKAAYLQETGKPLDETLKKALTGHLEEVVLALLKTPAQFDA
  DELRAAMKGLGTDEDTLIEILASRTNKEIRDINRVYREELKRDLAKDITSDTSGDFRNAL
  LSLAKGDRSEDFGVNEDLADSDARALYEAGERRKGTDVNVFNTILTTRSYPQLRRVFQKY
  TKYSKHDMNKVLDLELKGDIEKCLTAIVKCATSKPAFFAEKLHQAMKGVGTRHKALIRIM
  VSRSEIDMNDIKAFYQKMYGISLCQAILDETKGDYEKILVALCGGN

• Sequence length: 346

Pathways

Reactome:

G alpha (q) signalling events
G alpha (i) signalling events
Formyl peptide receptors bind formyl peptides and many other ligands
Interleukin-4 and Interleukin-13 signaling

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
ALZHEIMER DISEASE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ANXA1-related disorder	Uncertain significance; Likely benign; Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
BIPOLAR DISORDER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
BRAIN ISCHEMIA	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CARCINOMA	—	CTD	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CARCINOMA, SQUAMOUS CELL	—	CTD	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CRANIOFACIAL ABNORMALITIES	—	CTD, Disgenet CTD, Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ESOPHAGEAL SQUAMOUS CELL CARCINOMA	—	CTD	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
HYPERTENSION	—	CTD	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
HYPERTENSIVE DISEASE	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
KIDNEY DISEASES	—	CTD, Disgenet CTD, Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LIVER CIRRHOSIS, EXPERIMENTAL	—	CTD	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LYMPHATIC METASTASIS	—	CTD	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MAJOR DEPRESSIVE DISORDER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MENTAL OR BEHAVIOURAL DISORDER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MOUTH NEOPLASMS	—	CTD	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PROSTATIC NEOPLASMS	—	CTD	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
STOMACH DISEASES	—	CTD, Disgenet CTD, Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Relationship Type	References	Evidence Score
Acute Coronary Syndrome	Associate	28329022	★☆☆☆☆ Found in Text Mining only
Adenocarcinoma	Associate	30249885	★☆☆☆☆ Found in Text Mining only
Adenocarcinoma Follicular	Associate	35923625	★☆☆☆☆ Found in Text Mining only
Adenocarcinoma of Lung	Associate	1533045, 23036202	★☆☆☆☆ Found in Text Mining only
Adenoma	Associate	35923625	★☆☆☆☆ Found in Text Mining only
Adenoma Pleomorphic	Associate	24205396	★☆☆☆☆ Found in Text Mining only
Alzheimer Disease	Associate	29763932	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Anemia Sickle Cell	Associate	27802331	★☆☆☆☆ Found in Text Mining only
Anti Neutrophil Cytoplasmic Antibody Associated Vasculitis	Associate	31142442	★☆☆☆☆ Found in Text Mining only
Anxiety	Associate	28969474	★☆☆☆☆ Found in Text Mining only
Astrocytoma	Stimulate	18260157, 19767728	★☆☆☆☆ Found in Text Mining only
Atherosclerosis	Associate	28329022	★☆☆☆☆ Found in Text Mining only
Behcet Syndrome	Associate	28963375	★☆☆☆☆ Found in Text Mining only
Brain Neoplasms	Associate	37906427	★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Associate	25536365, 26000884, 26137966, 26657294, 26957268, 27612479, 29333087, 35626741, 36414640, 36867680	★☆☆☆☆ Found in Text Mining only
Bronchial Diseases	Associate	29749523	★☆☆☆☆ Found in Text Mining only
Calculi	Associate	34160472	★☆☆☆☆ Found in Text Mining only
Candidiasis Oral	Associate	35563776	★☆☆☆☆ Found in Text Mining only
Carcinogenesis	Associate	16627980, 19833546, 21127395, 22385607, 22929401, 23167407, 23431236, 24282368, 24719523, 26137966, 27240147, 28355254, 30984541, 33804148	★☆☆☆☆ Found in Text Mining only
Carcinoma	Inhibit	16627980	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Carcinoma	Associate	16675446	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Carcinoma Basal Cell	Associate	29333087	★☆☆☆☆ Found in Text Mining only
Carcinoma Hepatocellular	Associate	23651211, 26431426, 29391759	★☆☆☆☆ Found in Text Mining only
Carcinoma Hepatocellular	Stimulate	37117324	★☆☆☆☆ Found in Text Mining only
Carcinoma Non Small Cell Lung	Associate	23036202, 27035116	★☆☆☆☆ Found in Text Mining only
Carcinoma Ovarian Epithelial	Associate	31882477	★☆☆☆☆ Found in Text Mining only
Carcinoma Pancreatic Ductal	Associate	23167407, 25854353, 26644413, 31926587	★☆☆☆☆ Found in Text Mining only
Carcinoma Papillary	Associate	16627980	★☆☆☆☆ Found in Text Mining only
Carcinoma Papillary Follicular	Associate	25880590, 35923625	★☆☆☆☆ Found in Text Mining only
Carcinoma Renal Cell	Associate	35974388	★☆☆☆☆ Found in Text Mining only
Carcinoma Renal Cell	Stimulate	37464398	★☆☆☆☆ Found in Text Mining only
Carcinoma Squamous Cell	Associate	23341933	★☆☆☆☆ Found in Text Mining only
Cardiovascular Diseases	Associate	25038797	★☆☆☆☆ Found in Text Mining only
Carotid Stenosis	Associate	21195640	★☆☆☆☆ Found in Text Mining only
Cell Transformation Neoplastic	Associate	29986379	★☆☆☆☆ Found in Text Mining only
Cholangiocarcinoma	Associate	35225485	★☆☆☆☆ Found in Text Mining only
Cleft Palate	Associate	35693826	★☆☆☆☆ Found in Text Mining only
Colitis Ulcerative	Associate	22723974, 37891214	★☆☆☆☆ Found in Text Mining only
Colonic Neoplasms	Associate	18541673	★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Stimulate	18071363	★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Associate	20872967, 21127395, 29091952, 32823596, 33172883, 33596760, 37986009	★☆☆☆☆ Found in Text Mining only
Congenital thrombotic disease due to Protein C deficiency	Associate	35428170	★☆☆☆☆ Found in Text Mining only
Coronary Artery Disease	Associate	28329022	★☆☆☆☆ Found in Text Mining only
COVID 19	Associate	33859163	★☆☆☆☆ Found in Text Mining only
Crohn Disease	Associate	24130820, 37891214	★☆☆☆☆ Found in Text Mining only
Death	Associate	33172883	★☆☆☆☆ Found in Text Mining only
Diabetic Nephropathies	Associate	32778679, 35991124, 36401196	★☆☆☆☆ Found in Text Mining only
Diarrhea 5 With Tufting Enteropathy Congenital	Associate	14695321	★☆☆☆☆ Found in Text Mining only
Drug Related Side Effects and Adverse Reactions	Associate	32823596	★☆☆☆☆ Found in Text Mining only
Dysferlinopathy	Associate	39350328	★☆☆☆☆ Found in Text Mining only
Endometrial Neoplasms	Associate	21305022, 34195683, 36745330	★☆☆☆☆ Found in Text Mining only
Ependymoma	Associate	19767728	★☆☆☆☆ Found in Text Mining only
Esophageal Squamous Cell Carcinoma	Associate	21517111, 24551299, 28035369, 30249885, 36963399, 38085519	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Fibromyalgia	Stimulate	35693781	★☆☆☆☆ Found in Text Mining only
Fibrosis	Associate	29440885	★☆☆☆☆ Found in Text Mining only
Fuchs' Endothelial Dystrophy	Associate	35239706	★☆☆☆☆ Found in Text Mining only
Gallbladder Neoplasms	Associate	33261560	★☆☆☆☆ Found in Text Mining only
Gastritis	Associate	23431236	★☆☆☆☆ Found in Text Mining only
Gastrointestinal Neoplasms	Associate	29091952	★☆☆☆☆ Found in Text Mining only
Glioblastoma	Associate	19767728, 27770278, 34345995, 35770335, 37434432	★☆☆☆☆ Found in Text Mining only
Glioma	Associate	23991102, 28901452, 33706561, 38049523	★☆☆☆☆ Found in Text Mining only
Granulomatosis with Polyangiitis	Associate	31142442	★☆☆☆☆ Found in Text Mining only
Head and Neck Neoplasms	Associate	14695321	★☆☆☆☆ Found in Text Mining only
Head and Neck Neoplasms	Stimulate	30157864	★☆☆☆☆ Found in Text Mining only
Hemolysis	Associate	27802331	★☆☆☆☆ Found in Text Mining only
Hepatitis C	Inhibit	25899628	★☆☆☆☆ Found in Text Mining only
HTLV I Infections	Associate	33632146	★☆☆☆☆ Found in Text Mining only
Hypersensitivity Immediate	Inhibit	34627197	★☆☆☆☆ Found in Text Mining only
Hypoxia	Associate	27834582, 33804148	★☆☆☆☆ Found in Text Mining only
Hypoxia	Stimulate	32215176	★☆☆☆☆ Found in Text Mining only
Hypoxia Brain	Stimulate	27834582	★☆☆☆☆ Found in Text Mining only
Inflammation	Associate	10824106, 18006867, 18541673, 19737943, 20178593, 20398702, 21195640, 23036202, 23431236, 24130820, 24719523, 25490767, 25856673, 26072160, 27143410, 28257834, 28329022, 29440885, 29763932, 30231941, 31461932, 33335138, 33596760, 33935041, 35563776, 36627004, 38256136	★☆☆☆☆ Found in Text Mining only
Inflammation	Inhibit	19833546, 23637767, 26000884, 27802331, 30984541, 33804148, 35129068, 35684160, 38049523, 39253088	★☆☆☆☆ Found in Text Mining only
Inflammatory Bowel Diseases	Associate	24130820	★☆☆☆☆ Found in Text Mining only
Intestinal Diseases	Associate	24719523	★☆☆☆☆ Found in Text Mining only
Kidney Neoplasms	Associate	35974388	★☆☆☆☆ Found in Text Mining only
Laryngeal Neoplasms	Associate	25490767	★☆☆☆☆ Found in Text Mining only
Leprosy	Associate	33263684	★☆☆☆☆ Found in Text Mining only
Leprosy Lepromatous	Stimulate	33263684	★☆☆☆☆ Found in Text Mining only
Leprosy Multibacillary	Stimulate	33263684	★☆☆☆☆ Found in Text Mining only
Leukemia	Associate	28569789, 31912375, 36651527	★☆☆☆☆ Found in Text Mining only
Leukemia Hairy Cell	Associate	23347903, 24903677, 31077558	★☆☆☆☆ Found in Text Mining only
Leukemia Myelogenous Chronic BCR ABL Positive	Associate	23754495	★☆☆☆☆ Found in Text Mining only
Leukemia Myeloid Acute	Associate	28569789, 37302023	★☆☆☆☆ Found in Text Mining only
Leukemia Promyelocytic Acute	Associate	28569789	★☆☆☆☆ Found in Text Mining only
Lichen Planus	Associate	35563776	★☆☆☆☆ Found in Text Mining only
Light Fixation Seizure Syndrome	Associate	33263684	★☆☆☆☆ Found in Text Mining only
Lipodystrophy	Inhibit	35684160	★☆☆☆☆ Found in Text Mining only
Liver Neoplasms	Associate	26644413	★☆☆☆☆ Found in Text Mining only
Lung Neoplasms	Stimulate	22929401, 28009433	★☆☆☆☆ Found in Text Mining only
Lung Neoplasms	Associate	33959206	★☆☆☆☆ Found in Text Mining only
Lymphatic Metastasis	Inhibit	14695321, 25854353	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Lymphatic Metastasis	Associate	22929401, 24282368	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Lymphatic Metastasis	Stimulate	35225485	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Meibomian Gland Dysfunction	Associate	29234088	★☆☆☆☆ Found in Text Mining only
Melanoma	Associate	23056502, 27612479	★☆☆☆☆ Found in Text Mining only
Mouth Diseases	Inhibit	19351789	★☆☆☆☆ Found in Text Mining only
Mouth Neoplasms	Associate	19833546, 22335413, 23786757, 29937423, 34157171	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Moyamoya Disease	Associate	39948449	★☆☆☆☆ Found in Text Mining only
Mucocutaneous Lymph Node Syndrome	Associate	35692878	★☆☆☆☆ Found in Text Mining only
Muscular Dystrophies	Stimulate	21412170	★☆☆☆☆ Found in Text Mining only
Nasopharyngeal Carcinoma	Associate	28355254, 30459351	★☆☆☆☆ Found in Text Mining only
Neoplasm Metastasis	Associate	16675446, 17406026, 20872967, 21127395, 25490767, 26137966, 27834582, 27986920, 28035369, 28355254, 30518142, 30984541, 31912375, 33804148, 36988561, 38085519	★☆☆☆☆ Found in Text Mining only
Neoplasm Metastasis	Stimulate	24282368, 30459351, 35225485	★☆☆☆☆ Found in Text Mining only
Neoplasm Metastasis	Inhibit	33959206	★☆☆☆☆ Found in Text Mining only
Neoplasm Micrometastasis	Associate	20872967	★☆☆☆☆ Found in Text Mining only
Neoplasms	Associate	16627980, 19351789, 19737943, 19767728, 20220064, 21127395, 22350791, 23651211, 23786757, 24205396, 24810927, 25038797, 25490767, 25536365, 25854353, 26072160, 26137966, 27035116, 27986920, 28009433, 30459351, 30984541, 31461932, 31882477, 31912375, 32226026, 32858191, 33335138, 33353163, 33596760, 33706561, 34944403, 35225485, 35770335, 36123610, 36651527, 36867680, 37117324, 37833989, 37986009, 38085519, 38188613, 38256136, 40004024, 40484878	★☆☆☆☆ Found in Text Mining only
Neoplasms	Inhibit	19833546, 29705927, 33959206	★☆☆☆☆ Found in Text Mining only
Neoplasms	Stimulate	27240147, 37434432, 38049523, 38203548	★☆☆☆☆ Found in Text Mining only
Neoplasms Neuroepithelial	Associate	19767728	★☆☆☆☆ Found in Text Mining only
Neoplasms Squamous Cell	Associate	33959206	★☆☆☆☆ Found in Text Mining only
Nerve Degeneration	Associate	33935041, 34345995	★☆☆☆☆ Found in Text Mining only
Neurodegenerative Diseases	Associate	33935041	★☆☆☆☆ Found in Text Mining only
Neuroinflammatory Diseases	Inhibit	33632146	★☆☆☆☆ Found in Text Mining only
Neurologic Manifestations	Associate	21195640	★☆☆☆☆ Found in Text Mining only
Neurotoxicity Syndromes	Associate	37906427	★☆☆☆☆ Found in Text Mining only
Nose Diseases	Associate	20549082	★☆☆☆☆ Found in Text Mining only
Obesity	Associate	25856673	★☆☆☆☆ Found in Text Mining only
Osteoarthritis	Associate	24480285	★☆☆☆☆ Found in Text Mining only
Osteosarcoma	Associate	33291071	★☆☆☆☆ Found in Text Mining only
Pancreatic Neoplasms	Stimulate	25038797, 35428170	★☆☆☆☆ Found in Text Mining only
Pancreatic Neoplasms	Associate	25510623, 29986379, 30518142, 33353163, 33804148, 34944403	★☆☆☆☆ Found in Text Mining only
Paraparesis Tropical Spastic	Associate	33632146	★☆☆☆☆ Found in Text Mining only
Penile Neoplasms	Associate	23341933	★☆☆☆☆ Found in Text Mining only
Peritonitis	Associate	20665809	★☆☆☆☆ Found in Text Mining only
Personality Disorders	Associate	27834582	★☆☆☆☆ Found in Text Mining only
Plaque Atherosclerotic	Associate	21195640	★☆☆☆☆ Found in Text Mining only
Precancerous Conditions	Associate	24719523	★☆☆☆☆ Found in Text Mining only
Prostatic Neoplasms	Inhibit	19351789	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Prostatic Neoplasms	Associate	21703393, 24086397, 26312765, 27834582, 30027097, 32215176, 32858191	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Prostatitis	Associate	19351789, 35693826	★☆☆☆☆ Found in Text Mining only
Proteinuria	Associate	33351137	★☆☆☆☆ Found in Text Mining only
Pulmonary Disease Chronic Obstructive	Associate	29440885, 29544524, 35129068	★☆☆☆☆ Found in Text Mining only
Rectal Neoplasms	Associate	24810927	★☆☆☆☆ Found in Text Mining only
Renal Insufficiency Chronic	Associate	39253088	★☆☆☆☆ Found in Text Mining only
Reperfusion Injury	Associate	39341981	★☆☆☆☆ Found in Text Mining only
Salivary Gland Neoplasms	Associate	39201484	★☆☆☆☆ Found in Text Mining only
Sarcoma Ewing	Associate	36988561	★☆☆☆☆ Found in Text Mining only
Sjogren's Syndrome	Associate	31366407	★☆☆☆☆ Found in Text Mining only
Squamous Cell Carcinoma of Head and Neck	Associate	14695321, 20497865, 23786757, 25490767, 30157864, 34157171	★☆☆☆☆ Found in Text Mining only
Squamous Cell Carcinoma of Head and Neck	Inhibit	19833546, 28754915	★☆☆☆☆ Found in Text Mining only
Stomach Neoplasms	Associate	20665809, 23431236, 24282368, 27941907, 28058586	★☆☆☆☆ Found in Text Mining only
Stomach Neoplasms	Inhibit	25038797	★☆☆☆☆ Found in Text Mining only
Stomach Ulcer	Associate	24719523	★☆☆☆☆ Found in Text Mining only
Stroke	Associate	34345995	★☆☆☆☆ Found in Text Mining only
Thyroid Cancer Papillary	Stimulate	16627980	★☆☆☆☆ Found in Text Mining only
Thyroid Cancer Papillary	Associate	24023790, 25880590, 34723715, 34767591	★☆☆☆☆ Found in Text Mining only
Thyroid Neoplasms	Associate	16627980, 38203548	★☆☆☆☆ Found in Text Mining only
Thyroid Nodule	Associate	24023790	★☆☆☆☆ Found in Text Mining only
Triple Negative Breast Neoplasms	Associate	31461932	★☆☆☆☆ Found in Text Mining only
Ureteral Calculi	Associate	34160472	★☆☆☆☆ Found in Text Mining only
Urethral Neoplasms	Associate	22385607	★☆☆☆☆ Found in Text Mining only
Urinary Bladder Neoplasms	Associate	25337195, 32802870, 33830879, 35090432, 37950728	★☆☆☆☆ Found in Text Mining only
Uterine Cervical Dysplasia	Associate	32768930	★☆☆☆☆ Found in Text Mining only
Uterine Cervical Neoplasms	Stimulate	26738866	★☆☆☆☆ Found in Text Mining only
Uterine Cervical Neoplasms	Associate	27240147, 32768930, 37400149	★☆☆☆☆ Found in Text Mining only
Vulvodynia	Associate	35249975	★☆☆☆☆ Found in Text Mining only