Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
301
Gene name Gene Name - the full gene name approved by the HGNC.
Annexin A1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
ANXA1
Synonyms (NCBI Gene) Gene synonyms aliases
ANX1, LPC1
Chromosome Chromosome number
9
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
9q21.13
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a membrane-localized protein that binds phospholipids. This protein inhibits phospholipase A2 and has anti-inflammatory activity. Loss of function or expression of this gene has been detected in multiple tumors. [provided by RefSeq, Dec
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT000709 hsa-miR-196a-5p real time qRT-PCR, Luciferase reporter assay, Western blot 18663355
MIRT000709 hsa-miR-196a-5p Luciferase reporter assay 18663355
MIRT018638 hsa-miR-335-5p Microarray 18185580
MIRT000709 hsa-miR-196a-5p Reporter assay;Other 18663355
MIRT028650 hsa-miR-30a-5p Proteomics 18668040
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0001533 Component Cornified envelope IDA 10908733
GO:0001780 Process Neutrophil homeostasis IMP 21957127
GO:0001891 Component Phagocytic cup IEA
GO:0002250 Process Adaptive immune response IEA
GO:0002548 Process Monocyte chemotaxis IDA 15187149
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
151690 533 ENSG00000135046
Protein
UniProt ID P04083
Protein name Annexin A1 (Annexin I) (Annexin-1) (Calpactin II) (Calpactin-2) (Chromobindin-9) (Lipocortin I) (Phospholipase A2 inhibitory protein) (p35) [Cleaved into: Annexin Ac2-26]
Protein function Plays important roles in the innate immune response as effector of glucocorticoid-mediated responses and regulator of the inflammatory process. Has anti-inflammatory activity (PubMed:8425544). Plays a role in glucocorticoid-mediated down-regulat
PDB 1AIN , 1BO9 , 1QLS , 5VFW
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00191 Annexin 46 111 Annexin Family
PF00191 Annexin 118 183 Annexin Family
PF00191 Annexin 201 267 Annexin Family
PF00191 Annexin 277 342 Annexin Family
Tissue specificity TISSUE SPECIFICITY: Detected in resting neutrophils (PubMed:10772777). Detected in peripheral blood T-cells (PubMed:17008549). Detected in extracellular vesicles in blood serum from patients with inflammatory bowel disease, but not in serum from healthy d
Sequence
Sequence length 346
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    G alpha (q) signalling events
G alpha (i) signalling events
Formyl peptide receptors bind formyl peptides and many other ligands
Interleukin-4 and Interleukin-13 signaling
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Carcinoma Carcinoma, Squamous cell carcinoma, Carcinoma, Spindle-Cell, Undifferentiated carcinoma rs121912654, rs555607708, rs786202962, rs1564055259 12376462, 16316942, 15274141
Esophagus neoplasm Squamous cell carcinoma of esophagus rs28934578, rs121918714, rs1567556006, rs1575166666 21517111
Hypertension Hypertensive disease rs13306026 22228705
Kidney disease Kidney Diseases rs74315342, rs749740335, rs757649673, rs112417755, rs35138315 20484890
Unknown
Disease term Disease name Evidence References Source
Alzheimer disease Alzheimer disease GWAS
Associations from Text Mining
Disease Name Relationship Type References
Acute Coronary Syndrome Associate 28329022
Adenocarcinoma Associate 30249885
Adenocarcinoma Follicular Associate 35923625
Adenocarcinoma of Lung Associate 1533045, 23036202
Adenoma Associate 35923625
Adenoma Pleomorphic Associate 24205396
Alzheimer Disease Associate 29763932
Anemia Sickle Cell Associate 27802331
Anti Neutrophil Cytoplasmic Antibody Associated Vasculitis Associate 31142442
Anxiety Associate 28969474