TBX21 (T-box transcription factor 21)

Gene
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
30009
Gene name Gene Name - the full gene name approved by the HGNC.
T-box transcription factor 21
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
TBX21
Synonyms (NCBI Gene) Gene synonyms aliases
IMD88, T-PET, T-bet, TBET, TBLYM
Disease Acronyms (UniProt) Disease acronyms from UniProt database
IMD88
Chromosome Chromosome number
17
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
17q21.32
Summary Summary of gene provided in NCBI Entrez Gene.
This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene is the human ortholog of mou
miRNA miRNA information provided by mirtarbase database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(26)
miRTarBase ID miRNA Experiments Reference
MIRT007033 hsa-miR-29b-3p Luciferase reporter assay 22772450
MIRT1415137 hsa-miR-1289 CLIP-seq
MIRT1415138 hsa-miR-3198 CLIP-seq
MIRT1415139 hsa-miR-3942-3p CLIP-seq
MIRT1415140 hsa-miR-4294 CLIP-seq
Transcription factors
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(6)
Transcription factor Regulation Reference
NFKB1 Activation 17407192
RELA Activation 17407192
SP1 Unknown 17075044
STAT1 Unknown 18414429
STAT4 Unknown 19923468
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(30)
GO ID Ontology Definition Evidence Reference
GO:0000122 Process Negative regulation of transcription by RNA polymerase II IDA 18504404
GO:0000976 Function Transcription regulatory region sequence-specific DNA binding IDA 19805038
GO:0000978 Function RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA 21873635
GO:0000981 Function DNA-binding transcription factor activity, RNA polymerase II-specific IBA 21873635
GO:0001227 Function DNA-binding transcription repressor activity, RNA polymerase II-specific IDA 18504404
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
604895 11599 ENSG00000073861
Protein
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID Q9UL17
Protein name T-box transcription factor TBX21 (T-box protein 21) (T-cell-specific T-box transcription factor T-bet) (Transcription factor TBLYM)
Protein function Lineage-defining transcription factor which initiates Th1 lineage development from naive Th precursor cells both by activating Th1 genetic programs and by repressing the opposing Th2 and Th17 genetic programs (PubMed:10761931). Activates transcr
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00907 T-box 139 → 326 T-box Domain
Tissue specificity TISSUE SPECIFICITY: T-cell specific. {ECO:0000269|PubMed:10761931}.
Sequence 
MGIVEPGCGDMLTGTEPMPGSDEGRAPGADPQHRYFYPEPGAQDADERRGGGSLGSPYPG
GALVPAPPSRFLGAYAYPPRPQAAGFPGAGESFPPPADAEGYQPGEGYAAPDPRAGLYPG
PREDYALPAGLEVSGKLRVALNNHLLWSKFNQHQTEMIITKQGRRMFPFLSFTVAGLEPT
SHYRMFVDVVLVDQHHWRYQSGKWVQCGKAEGSMPGNRLYVHPDSPNTGAHWMRQEVSFG
KLKLTNNKGASNNVTQMIVLQSLHKYQPRLHIVEVNDGEPEAACNASNTHIFTFQETQFI
AVTAYQNAEITQLKIDNNPFAKGFRENFESMYTSVDTSIPSPPGPNCQFLGGDHYSPLLP
NQYPVPSRFYPDLPGQAKDVVPQAYWLGAPRDHSYEAEFRAVSMKPAFLPSAPGPTMSYY
RGQEVLAPGAGWPVAPQYPPKMGPASWFRPMRTLPMEPGPGGSEGRGPEDQGPPLVWTEI
APIRPESSDSGLGEGDSKRRRVSPYPSSGDSSSPAGAPSPFDKEAEGQFYNYFPN
Sequence length 535
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
  KEGG  
  Th1 and Th2 cell differentiation
Th17 cell differentiation
Inflammatory bowel disease 		 
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Unknown Diseases (10)
Unknown
Disease term Disease name Evidence References Source
Asthma Asthma, Childhood asthma, Asthma, Aspirin-Induced 30929738, 15806396, 31036433, 16502481 ClinVar, GWAS
Mental depression Unipolar Depression, Major Depressive Disorder 18504423 ClinVar
Immunodeficiency immunodeficiency 88 GenCC
Hypothyroidism Hypothyroidism GWAS
Show/Hide Text Mining Associations (168)
Associations from Text Mining
Disease Name Relationship Type References
Abortion Spontaneous Stimulate 37035756
Achalasia Addisonianism Alacrimia syndrome Stimulate 37980558
Adenocarcinoma Associate 36281585
Adenocarcinoma of Lung Associate 26348446
Adenocarcinoma of Lung Inhibit 31909418
Alopecia Areata Stimulate 26551570
Alzheimer Disease Associate 36405736
Anemia Aplastic Stimulate 16434488
Anemia Aplastic Associate 37980558
Arthritis Associate 20679229