BICRA (BRD4 interacting chromatin remodeling complex associated protein)

Gene Gene information from NCBI Gene database.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID 29998
Gene name BRD4 interacting chromatin remodeling complex associated protein
Gene symbol BICRA
Synonyms (NCBI Gene)
CSS12GLTSCR1SMARCK1
Chromosome 19
Chromosome location 19q13.33
miRNA miRNA information provided by mirtarbase database.
14
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all (14)
miRTarBase ID miRNA Experiments Reference
MIRT567456 hsa-miR-582-5p PAR-CLIP 20371350
MIRT082594 hsa-miR-3923 PAR-CLIP 20371350
MIRT082589 hsa-miR-200a-5p PAR-CLIP 20371350
MIRT082588 hsa-miR-200b-5p PAR-CLIP 20371350
MIRT082590 hsa-miR-600 PAR-CLIP 20371350
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
16
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all (16)
GO ID Ontology Definition Evidence Reference
GO:0000785 Component Chromatin NAS 29374058
GO:0005515 Function Protein binding IPI 17474147, 21555454, 29374058, 35044719
GO:0005634 Component Nucleus IEA
GO:0005634 Component Nucleus IMP 21555454
GO:0006338 Process Chromatin remodeling NAS 29374058
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
605690 4332 ENSG00000063169
Protein Protein information from UniProt database.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q9NZM4
Protein name BRD4-interacting chromatin-remodeling complex-associated protein (Glioma tumor suppressor candidate region gene 1 protein)
Protein function Component of SWI/SNF chromatin remodeling subcomplex GBAF that carries out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner (PubMed:29374058). May play a role
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF15249 GLTSCR1 1091 → 1192 Conserved region of unknown function on GLTSCR protein Family
Tissue specificity TISSUE SPECIFICITY: Expressed at moderate levels in heart, brain, placenta, skeletal muscle, and pancreas, and at lower levels in lung, liver and kidney. {ECO:0000269|PubMed:10708517}.
Sequence 
MDDEDGRCLLDVICDPQALNDFLHGSEKLDSDDLLDNPGEAQSAFYEGPGLHVQEASGNH
LNPEPNQPAPSVDLDFLEDDILGSPATGGGGGGSGGADQPCDILQQSLQEANITEQTLEA
EAELDLGPFQLPTLQPADGGAGPTGAGGAAAVAAGPQALFPGSTDLLGLQGPPTVLTHQA
LVPPQDVVNKALSVQPFLQPVGLGNVTLQPIPGLQGLPNGSPGGATAATLGLAPIQVVGQ
PVMALNTPTSQLLAKQVPVSGYLASAAGPSEPVTLASAGVSPQGAGLVIQKNLSAAVATT
LNGNSVFGGAGAASAPTGTPSGQPLAVAPGLGSSPLVPAPNVILHRTPTPIQPKPAGVLP
PKLYQLTPKPFAPAGATLTIQGEPGALPQQPKAPQNLTFMAAGKAGQNVVLSGFPAPALQ
ANVFKQPPATTTGAAPPQPPGALSKPMSVHLLNQGSSIVIPAQHMLPGQNQFLLPGAPAV
QLPQQLSALPANVGGQILAAAAPHTGGQLIANPILTNQNLAGPLSLGPVLAPHSGAHSAH
ILSAAPIQVGQPALFQMPVSLAAGSLPTQSQPAPAGPAATTVLQGVTLPPSAVAMLNTPD
GLVQPATPAAATGEAAPVLTVQPAPQAPPAVSTPLPLGLQQPQAQQPPQAPTPQAAAPPQ
ATTPQPSPGLASSPEKIVLGQPPSATPTAILTQDSLQMFLPQERSQQPLSAEGPHLSVPA
SVIVSAPPPAQDPAPATPVAKGAGLGPQAPDSQASPAPAPQIPAAAPLKGPGPSSSPSLP
HQAPLGDSPHLPSPHPTRPPSRPPSRPQSVSRPPSEPPLHPCPPPQAPPTLPGIFVIQNQ
LGVPPPASNPAPTAPGPPQPPLRPQSQPPEGPLPPAPHLPPSSTSSAVASSSETSSRLPA
PTPSDFQLQFPPSQGPHKSPTPPPTLHLVPEPAAPPPPPPRTFQMVTTPFPALPQPKALL
ERFHQVPSGIILQNKAGGAPAAPQTSTSLGPLTSPAASVLVSGQAPSGTPTAPSHAPAPA
PMAATGLPPLLPAENKAFASNLPTLNVAKAASSGPGKPSGLQYESKLSGLKKPPTLQPSK
EACFLEHLHKHQGSVLHPDYKTAFPSFEDALHRLLPYHVYQGALPSPSDYHKVDEEFETV
STQLLKRTQAMLNKYRLLLLEESRRVSPSAEMVMIDRMFIQEEKTTLALDKQLAKEKPDE
YVSSSRSLGLPIAASSEGHRLPGHGPLSSSAPGASTQPPPHLPTKLVIRHGGAGGSPSVT
WARASSSLSSSSSSSSAASSLDADEDGPMPSRNRPPIKTYEARSRIGLKLKIKQEAGLSK
VVHNTALDPVHQPPPPPATLKVAEPPPRPPPPPPPTGQMNGTVDHPPPAAPERKPLGTAP
HCPRLPLRKTYRENVGGPGAPEGTPAGRARGGSPAPLPAKVDEATSGLIRELAAVEDELY
QRMLKGPPPEPAASAAQGTGDPDWEAPGLPPAKRRKSESPDVDQASFSSDSPQDDTLTEH
LQSAIDSILNLQQAPGRTPAPSYPHAASAGTPASPPPLHRPEAYPPSSHNGGLGARTLTR
Sequence length 1560
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
  KEGG 
  ATP-dependent chromatin remodeling  
Associated diseases Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
67
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Causal Diseases (3)
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
BICRA-related disorder Likely pathogenic rs2514138366 RCV003397708
Coffin-Siris syndrome 12 Pathogenic; Likely pathogenic rs1229548274, rs2123606076, rs2123584339, rs2123584685, rs1490477251, rs1375723922, rs1424525709, rs2514109185, rs2514111647, rs2514110530, rs2514111692, rs2514108449, rs2514126893, rs1973387849, rs2514109782
View all (2 more)		 RCV001431523
RCV001431525
RCV001431529
RCV001754554
RCV002249297
RCV002274300
RCV002274301
RCV002287201
RCV002463409
RCV002463467
RCV003147923
RCV003232040
RCV003232041
RCV003493344
RCV003596253
RCV004566518
RCV001431527
Intellectual disability Pathogenic rs1973345860 RCV001290424
Show/Hide Unknown Diseases (7)
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
Cervical cancer Likely benign rs367911716 RCV005922658
Developmental disorder Uncertain significance rs1599872135 RCV003127404
Hepatocellular carcinoma Benign rs2911005 RCV005922763
Malignant tumor of urinary bladder Likely benign rs201151265 RCV005931055
Show/Hide Text Mining Associations (14)
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References
Brain Neoplasms Associate 27613841
Coffin Siris syndrome Associate 34906496, 37485815
Colorectal Neoplasms Associate 35218185
Genetic Diseases Inborn Associate 37579195
Glioblastoma Inhibit 19318434
Glioblastoma Associate 19318434
Glioma Associate 15834925, 16212814, 20150366
Hypersensitivity Delayed Associate 37485815
Meningioma Associate 20150366
Neuroma Acoustic Associate 20150366