Gene Gene information from NCBI Gene database.
Entrez ID 29982
Gene name Nuclear receptor binding factor 2
Gene symbol NRBF2
Synonyms (NCBI Gene)
COPRCOPR1COPR2NRBF-2
Chromosome 10
Chromosome location 10q21.3
miRNA miRNA information provided by mirtarbase database.
693
miRTarBase ID miRNA Experiments Reference
MIRT027700 hsa-miR-98-5p Microarray 19088304
MIRT043423 hsa-miR-331-3p CLASH 23622248
MIRT522143 hsa-miR-652-5p PAR-CLIP 20371350
MIRT522142 hsa-miR-6732-3p PAR-CLIP 20371350
MIRT522141 hsa-miR-345-3p PAR-CLIP 20371350
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
13
GO ID Ontology Definition Evidence Reference
GO:0005515 Function Protein binding IPI 20562859, 24785657, 24849286, 25416956, 28514442, 32296183, 32707033, 33961781
GO:0005634 Component Nucleus IEA
GO:0005654 Component Nucleoplasm TAS
GO:0005737 Component Cytoplasm IDA
GO:0005737 Component Cytoplasm IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
616477 19692 ENSG00000148572
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q96F24
Protein name Nuclear receptor-binding factor 2 (NRBF-2) (Comodulator of PPAR and RXR)
Protein function May modulate transcriptional activation by target nuclear receptors. Can act as transcriptional activator (in vitro). ; Involved in starvation-induced autophagy probably by its association with PI3K comple
PDB 4ZEY
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF17169 NRBF2_MIT 4 86 MIT domain of nuclear receptor-binding factor 2 Domain
PF08961 NRBF2 89 284 Nuclear receptor-binding factor 2, autophagy regulator Domain
Tissue specificity TISSUE SPECIFICITY: Detected in keratinocytes, liver and placenta (PubMed:15610520). Expressed in a subset of cells in pediatric medulloblastoma (PubMed:18619852). {ECO:0000269|PubMed:15610520, ECO:0000269|PubMed:18619852}.
Sequence
Sequence length 287
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  Autophagy - animal
Alzheimer disease
Amyotrophic lateral sclerosis
Huntington disease
Spinocerebellar ataxia
Pathways of neurodegeneration - multiple diseases
  Nuclear Receptor transcription pathway
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
3
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
ATRIAL FIBRILLATION GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
SCHIZOPHRENIA GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
TYPE 2 DIABETES MELLITUS GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References Evidence Score
Breast Neoplasms Associate 26073781
★☆☆☆☆
Found in Text Mining only