Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
29982
Gene name Gene Name - the full gene name approved by the HGNC.
Nuclear receptor binding factor 2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
NRBF2
Synonyms (NCBI Gene) Gene synonyms aliases
COPR, COPR1, COPR2, NRBF-2
Chromosome Chromosome number
10
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
10q21.3
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT027700 hsa-miR-98-5p Microarray 19088304
MIRT043423 hsa-miR-331-3p CLASH 23622248
MIRT522143 hsa-miR-652-5p PAR-CLIP 20371350
MIRT522142 hsa-miR-6732-3p PAR-CLIP 20371350
MIRT522141 hsa-miR-345-3p PAR-CLIP 20371350
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0005515 Function Protein binding IPI 20562859, 24785657, 24849286, 25416956, 28514442, 32296183
GO:0005654 Component Nucleoplasm TAS
GO:0005737 Component Cytoplasm IDA
GO:0005776 Component Autophagosome IEA
GO:0006367 Process Transcription initiation from RNA polymerase II promoter TAS
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
616477 19692 ENSG00000148572
Protein
UniProt ID Q96F24
Protein name Nuclear receptor-binding factor 2 (NRBF-2) (Comodulator of PPAR and RXR)
Protein function May modulate transcriptional activation by target nuclear receptors. Can act as transcriptional activator (in vitro). ; Involved in starvation-induced autophagy probably by its association with PI3K comple
PDB 4ZEY
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF17169 NRBF2_MIT 4 86 MIT domain of nuclear receptor-binding factor 2 Domain
PF08961 NRBF2 89 284 Nuclear receptor-binding factor 2, autophagy regulator Domain
Tissue specificity TISSUE SPECIFICITY: Detected in keratinocytes, liver and placenta (PubMed:15610520). Expressed in a subset of cells in pediatric medulloblastoma (PubMed:18619852). {ECO:0000269|PubMed:15610520, ECO:0000269|PubMed:18619852}.
Sequence
Sequence length 287
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Autophagy - animal
Alzheimer disease
Amyotrophic lateral sclerosis
Huntington disease
Spinocerebellar ataxia
Pathways of neurodegeneration - multiple diseases
  Nuclear Receptor transcription pathway
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Arthritis Juvenile arthritis rs1594890601, rs1594882933, rs184370809, rs776489319, rs1594883470 22354554
Unknown
Disease term Disease name Evidence References Source
Schizophrenia Schizophrenia GWAS
Diabetes Diabetes GWAS
Associations from Text Mining
Disease Name Relationship Type References
Breast Neoplasms Associate 26073781