Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
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29974
|
Gene name
Gene Name - the full gene name approved by the HGNC.
|
APOBEC1 complementation factor |
Gene symbol
Gene Symbol - the official gene symbol approved by the HGNC.
|
A1CF |
Synonyms (NCBI Gene)
Gene synonyms aliases
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ACF, ACF64, ACF65, APOBEC1CF, ASP |
Chromosome
Chromosome number
|
10 |
Chromosome location
Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
|
10q11.23 |
Summary
Summary of gene provided in NCBI Entrez Gene.
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Mammalian apolipoprotein B mRNA undergoes site-specific C to U deamination, which is mediated by a multi-component enzyme complex containing a minimal core composed of APOBEC-1 and a complementation factor encoded by this gene. The gene product has three |
UniProt ID |
Q9NQ94
|
Protein name |
APOBEC1 complementation factor (APOBEC1-stimulating protein) |
Protein function |
Essential component of the apolipoprotein B mRNA editing enzyme complex which is responsible for the postranscriptional editing of a CAA codon for Gln to a UAA codon for stop in APOB mRNA. Binds to APOB mRNA and is probably responsible for docki |
PDB |
2CPD
|
Family and domains |
Pfam
Accession |
ID |
Position in sequence |
Description |
Type |
PF00076
|
RRM_1 |
58 → 127 |
RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) |
Domain |
PF00076
|
RRM_1 |
138 → 203 |
RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) |
Domain |
PF00076
|
RRM_1 |
233 → 297 |
RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) |
Domain |
PF14709
|
DND1_DSRM |
445 → 523 |
|
Domain |
|
Tissue specificity |
TISSUE SPECIFICITY: Widely expressed with highest levels in brain, liver, pancreas, colon and spleen. {ECO:0000269|PubMed:10669759}. |
Sequence |
|
Sequence length |
594 |
Interactions |
View interactions
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