Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
29974
Gene name Gene Name - the full gene name approved by the HGNC.
APOBEC1 complementation factor
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
A1CF
Synonyms (NCBI Gene) Gene synonyms aliases
ACF, ACF64, ACF65, APOBEC1CF, ASP
Chromosome Chromosome number
10
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
10q11.23
Summary Summary of gene provided in NCBI Entrez Gene.
Mammalian apolipoprotein B mRNA undergoes site-specific C to U deamination, which is mediated by a multi-component enzyme complex containing a minimal core composed of APOBEC-1 and a complementation factor encoded by this gene. The gene product has three
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT709873 hsa-miR-4742-3p HITS-CLIP 19536157
MIRT709872 hsa-miR-4778-3p HITS-CLIP 19536157
MIRT709871 hsa-miR-4635 HITS-CLIP 19536157
MIRT709870 hsa-miR-4999-5p HITS-CLIP 19536157
MIRT709869 hsa-miR-630 HITS-CLIP 19536157
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0003676 Function Nucleic acid binding IEA
GO:0003723 Function RNA binding IEA
GO:0003723 Function RNA binding TAS 10669759
GO:0003725 Function Double-stranded RNA binding IDA 11871661
GO:0003727 Function Single-stranded RNA binding IDA 11871661
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
618199 24086 ENSG00000148584
Protein
UniProt ID Q9NQ94
Protein name APOBEC1 complementation factor (APOBEC1-stimulating protein)
Protein function Essential component of the apolipoprotein B mRNA editing enzyme complex which is responsible for the postranscriptional editing of a CAA codon for Gln to a UAA codon for stop in APOB mRNA. Binds to APOB mRNA and is probably responsible for docki
PDB 2CPD
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00076 RRM_1 58 127 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Domain
PF00076 RRM_1 138 203 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Domain
PF00076 RRM_1 233 297 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Domain
PF14709 DND1_DSRM 445 523 Domain
Tissue specificity TISSUE SPECIFICITY: Widely expressed with highest levels in brain, liver, pancreas, colon and spleen. {ECO:0000269|PubMed:10669759}.
Sequence
MESNHKSGDGLSGTQKEAALRALVQRTGYSLVQENGQRKYGGPPPGWDAAPPERGCEIFI
GKLPRDLFEDELIPLCEKIGKIYEMRMMMDFNGNNRGYAFVTFSNKVEAKNAIKQLNNYE
IRNGRLL
GVCASVDNCRLFVGGIPKTKKREEILSEMKKVTEGVVDVIVYPSAADKTKNRG
FAFVEYESHRAAAMARRKLLPGR
IQLWGHGIAVDWAEPEVEVDEDTMSSVKILYVRNLML
STSEEMIEKEFNNIKPGAVERVKKIRDYAFVHFSNREDAVEAMKALNGKVLDGSPIE
VTL
AKPVDKDSYVRYTRGTGGRGTMLQGEYTYSLGQVYDPTTTYLGAPVFYAPQTYAAIPSLH
FPATKGHLSNRAIIRAPSVREIYMNVPVGAAGVRGLGGRGYLAYTGLGRGYQVKGDKRED
KLYDILPGMELTPMNPVTLKPQGIKLAPQILEEICQKNNWGQPVYQLHSAIGQDQRQLFL
YKITIPALASQNPAIHPFTPPKLSAFVDEAKTYAAEYTLQTLG
IPTDGGDGTMATAAAAA
TAFPGYAVPNATAPVSAAQLKQAVTLGQDLAAYTTYEVYPTFAVTARGDGYGTF
Sequence length 594
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    mRNA Editing: C to U Conversion
Formation of the Editosome
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Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Disease merge term Disease name Evidence References Source
Colorectal Cancer Colorectal cancer N/A N/A GWAS
Diabetes Type 2 diabetes N/A N/A GWAS
Gout Gout N/A N/A GWAS
Tremor Essential tremor N/A N/A GWAS
Associations from Text Mining Disease associations identified through Pubtator
Disease Name Relationship Type References
Adenocarcinoma of Lung Associate 37120564
Breast Neoplasms Associate 28639893
Gout Associate 28252667, 28679452
Hypertension Associate 35023146
Hyperuricemia Associate 35023146