Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	29967
Gene name	LDL receptor related protein 12
Gene symbol	LRP12
Synonyms (NCBI Gene)	ALS28MIG13AST7
Chromosome	8
Chromosome location	8q22.3
Summary	This gene encodes a member of the low-density lipoprotein receptor related protein family. The product of this gene is a transmembrane protein that is differentially expressed in many cancer cells. Alternate splicing results in multiple transcript variant

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Show/Hide all (179)

miRTarBase ID	miRNA	Experiments	Reference
MIRT040084	hsa-miR-615-3p	CLASH	23622248
MIRT566890	hsa-miR-302c-3p	PAR-CLIP	20371350
MIRT566889	hsa-miR-520f-3p	PAR-CLIP	20371350
MIRT566888	hsa-miR-17-5p	PAR-CLIP	20371350
MIRT566887	hsa-miR-93-5p	PAR-CLIP	20371350
MIRT566886	hsa-miR-526b-3p	PAR-CLIP	20371350
MIRT566885	hsa-miR-519d-3p	PAR-CLIP	20371350
MIRT566884	hsa-miR-106b-5p	PAR-CLIP	20371350
MIRT566883	hsa-miR-106a-5p	PAR-CLIP	20371350
MIRT566882	hsa-miR-20a-5p	PAR-CLIP	20371350
MIRT566881	hsa-miR-20b-5p	PAR-CLIP	20371350
MIRT566880	hsa-miR-3609	PAR-CLIP	20371350
MIRT566879	hsa-miR-548ah-5p	PAR-CLIP	20371350
MIRT566878	hsa-miR-4796-3p	PAR-CLIP	20371350
MIRT566877	hsa-miR-5692a	PAR-CLIP	20371350
MIRT566876	hsa-miR-548p	PAR-CLIP	20371350
MIRT566875	hsa-miR-512-3p	PAR-CLIP	20371350
MIRT566874	hsa-miR-636	PAR-CLIP	20371350
MIRT566873	hsa-miR-633	PAR-CLIP	20371350
MIRT566872	hsa-miR-4473	PAR-CLIP	20371350
MIRT321819	hsa-miR-5011-5p	PAR-CLIP	20371350
MIRT566871	hsa-miR-3688-3p	PAR-CLIP	20371350
MIRT566870	hsa-miR-5093	PAR-CLIP	20371350
MIRT566890	hsa-miR-302c-3p	PAR-CLIP	20371350
MIRT566889	hsa-miR-520f-3p	PAR-CLIP	20371350
MIRT566888	hsa-miR-17-5p	PAR-CLIP	20371350
MIRT566887	hsa-miR-93-5p	PAR-CLIP	20371350
MIRT566886	hsa-miR-526b-3p	PAR-CLIP	20371350
MIRT566885	hsa-miR-519d-3p	PAR-CLIP	20371350
MIRT566884	hsa-miR-106b-5p	PAR-CLIP	20371350
MIRT566883	hsa-miR-106a-5p	PAR-CLIP	20371350
MIRT566882	hsa-miR-20a-5p	PAR-CLIP	20371350
MIRT566881	hsa-miR-20b-5p	PAR-CLIP	20371350
MIRT566880	hsa-miR-3609	PAR-CLIP	20371350
MIRT566879	hsa-miR-548ah-5p	PAR-CLIP	20371350
MIRT566878	hsa-miR-4796-3p	PAR-CLIP	20371350
MIRT566877	hsa-miR-5692a	PAR-CLIP	20371350
MIRT566876	hsa-miR-548p	PAR-CLIP	20371350
MIRT566875	hsa-miR-512-3p	PAR-CLIP	20371350
MIRT566874	hsa-miR-636	PAR-CLIP	20371350
MIRT566873	hsa-miR-633	PAR-CLIP	20371350
MIRT566872	hsa-miR-4473	PAR-CLIP	20371350
MIRT321819	hsa-miR-5011-5p	PAR-CLIP	20371350
MIRT566871	hsa-miR-3688-3p	PAR-CLIP	20371350
MIRT566870	hsa-miR-5093	PAR-CLIP	20371350
MIRT1117819	hsa-miR-377	CLIP-seq
MIRT1117820	hsa-miR-450b-5p	CLIP-seq
MIRT1117821	hsa-miR-507	CLIP-seq
MIRT1117822	hsa-miR-557	CLIP-seq
MIRT1117823	hsa-miR-629	CLIP-seq
MIRT1117824	hsa-miR-300	CLIP-seq
MIRT1117825	hsa-miR-381	CLIP-seq
MIRT1117826	hsa-miR-4287	CLIP-seq
MIRT1117827	hsa-miR-4469	CLIP-seq
MIRT1117828	hsa-miR-4501	CLIP-seq
MIRT1117829	hsa-miR-4666-3p	CLIP-seq
MIRT1117830	hsa-miR-4685-3p	CLIP-seq
MIRT1117831	hsa-miR-568	CLIP-seq
MIRT1117832	hsa-miR-643	CLIP-seq
MIRT2033326	hsa-miR-137	CLIP-seq
MIRT2033327	hsa-miR-4775	CLIP-seq
MIRT2562939	hsa-miR-10a	CLIP-seq
MIRT2562940	hsa-miR-10b	CLIP-seq
MIRT2562941	hsa-miR-1182	CLIP-seq
MIRT2562942	hsa-miR-125a-3p	CLIP-seq
MIRT2562943	hsa-miR-1297	CLIP-seq
MIRT2562944	hsa-miR-130a	CLIP-seq
MIRT2562945	hsa-miR-130b	CLIP-seq
MIRT2562946	hsa-miR-19a	CLIP-seq
MIRT2562947	hsa-miR-19b	CLIP-seq
MIRT2562948	hsa-miR-2054	CLIP-seq
MIRT2562949	hsa-miR-2277-3p	CLIP-seq
MIRT2562950	hsa-miR-26a	CLIP-seq
MIRT2562951	hsa-miR-26b	CLIP-seq
MIRT2562952	hsa-miR-301a	CLIP-seq
MIRT2562953	hsa-miR-301b	CLIP-seq
MIRT2562954	hsa-miR-3147	CLIP-seq
MIRT2562955	hsa-miR-3153	CLIP-seq
MIRT2562956	hsa-miR-3162-5p	CLIP-seq
MIRT2562957	hsa-miR-323-3p	CLIP-seq
MIRT2562958	hsa-miR-323b-3p	CLIP-seq
MIRT2562959	hsa-miR-330-3p	CLIP-seq
MIRT2562960	hsa-miR-3591-5p	CLIP-seq
MIRT2562961	hsa-miR-361-3p	CLIP-seq
MIRT2562962	hsa-miR-3617	CLIP-seq
MIRT2562963	hsa-miR-3646	CLIP-seq
MIRT2562964	hsa-miR-3665	CLIP-seq
MIRT2562965	hsa-miR-3666	CLIP-seq
MIRT1117819	hsa-miR-377	CLIP-seq
MIRT2562966	hsa-miR-382	CLIP-seq
MIRT2562967	hsa-miR-3940-5p	CLIP-seq
MIRT2562968	hsa-miR-4280	CLIP-seq
MIRT2562969	hsa-miR-4295	CLIP-seq
MIRT2562970	hsa-miR-4310	CLIP-seq
MIRT2562971	hsa-miR-4425	CLIP-seq
MIRT2562972	hsa-miR-4427	CLIP-seq
MIRT2562973	hsa-miR-4465	CLIP-seq
MIRT2562974	hsa-miR-4507	CLIP-seq
MIRT1117820	hsa-miR-450b-5p	CLIP-seq
MIRT2562975	hsa-miR-4525	CLIP-seq
MIRT2562976	hsa-miR-454	CLIP-seq
MIRT2562977	hsa-miR-4645-3p	CLIP-seq
MIRT2562978	hsa-miR-4671-3p	CLIP-seq
MIRT2562979	hsa-miR-4680-3p	CLIP-seq
MIRT2562980	hsa-miR-4693-3p	CLIP-seq
MIRT2562981	hsa-miR-4731-3p	CLIP-seq
MIRT2562982	hsa-miR-4742-3p	CLIP-seq
MIRT2033327	hsa-miR-4775	CLIP-seq
MIRT2562983	hsa-miR-4781-3p	CLIP-seq
MIRT2562984	hsa-miR-4786-5p	CLIP-seq
MIRT2562985	hsa-miR-4801	CLIP-seq
MIRT2562986	hsa-miR-496	CLIP-seq
MIRT2562987	hsa-miR-498	CLIP-seq
MIRT1117821	hsa-miR-507	CLIP-seq
MIRT2562988	hsa-miR-545	CLIP-seq
MIRT2562989	hsa-miR-548c-3p	CLIP-seq
MIRT1117822	hsa-miR-557	CLIP-seq
MIRT2562990	hsa-miR-570	CLIP-seq
MIRT2562991	hsa-miR-590-3p	CLIP-seq
MIRT2562992	hsa-miR-605	CLIP-seq
MIRT1117823	hsa-miR-629	CLIP-seq
MIRT2562993	hsa-miR-634	CLIP-seq
MIRT2562994	hsa-miR-641	CLIP-seq
MIRT1117832	hsa-miR-643	CLIP-seq
MIRT2562995	hsa-miR-769-5p	CLIP-seq
MIRT2562939	hsa-miR-10a	CLIP-seq
MIRT2562940	hsa-miR-10b	CLIP-seq
MIRT2562941	hsa-miR-1182	CLIP-seq
MIRT2562943	hsa-miR-1297	CLIP-seq
MIRT2562944	hsa-miR-130a	CLIP-seq
MIRT2562945	hsa-miR-130b	CLIP-seq
MIRT2684152	hsa-miR-181a	CLIP-seq
MIRT2684153	hsa-miR-181b	CLIP-seq
MIRT2684154	hsa-miR-181c	CLIP-seq
MIRT2684155	hsa-miR-181d	CLIP-seq
MIRT2562946	hsa-miR-19a	CLIP-seq
MIRT2562947	hsa-miR-19b	CLIP-seq
MIRT2562948	hsa-miR-2054	CLIP-seq
MIRT2562949	hsa-miR-2277-3p	CLIP-seq
MIRT2562950	hsa-miR-26a	CLIP-seq
MIRT2562951	hsa-miR-26b	CLIP-seq
MIRT2562952	hsa-miR-301a	CLIP-seq
MIRT2562953	hsa-miR-301b	CLIP-seq
MIRT2562955	hsa-miR-3153	CLIP-seq
MIRT2562956	hsa-miR-3162-5p	CLIP-seq
MIRT2562957	hsa-miR-323-3p	CLIP-seq
MIRT2562958	hsa-miR-323b-3p	CLIP-seq
MIRT2562959	hsa-miR-330-3p	CLIP-seq
MIRT2562960	hsa-miR-3591-5p	CLIP-seq
MIRT2562961	hsa-miR-361-3p	CLIP-seq
MIRT2562962	hsa-miR-3617	CLIP-seq
MIRT2562963	hsa-miR-3646	CLIP-seq
MIRT2684156	hsa-miR-3662	CLIP-seq
MIRT2562965	hsa-miR-3666	CLIP-seq
MIRT2562966	hsa-miR-382	CLIP-seq
MIRT2684157	hsa-miR-3973	CLIP-seq
MIRT2684158	hsa-miR-4262	CLIP-seq
MIRT2684159	hsa-miR-4291	CLIP-seq
MIRT2562969	hsa-miR-4295	CLIP-seq
MIRT2562970	hsa-miR-4310	CLIP-seq
MIRT2562973	hsa-miR-4465	CLIP-seq
MIRT2562976	hsa-miR-454	CLIP-seq
MIRT2562978	hsa-miR-4671-3p	CLIP-seq
MIRT2562981	hsa-miR-4731-3p	CLIP-seq
MIRT2562982	hsa-miR-4742-3p	CLIP-seq
MIRT2033327	hsa-miR-4775	CLIP-seq
MIRT2562984	hsa-miR-4786-5p	CLIP-seq
MIRT2562985	hsa-miR-4801	CLIP-seq
MIRT2562987	hsa-miR-498	CLIP-seq
MIRT2562988	hsa-miR-545	CLIP-seq
MIRT2562989	hsa-miR-548c-3p	CLIP-seq
MIRT2684160	hsa-miR-548k	CLIP-seq
MIRT2562990	hsa-miR-570	CLIP-seq
MIRT2562991	hsa-miR-590-3p	CLIP-seq
MIRT2562992	hsa-miR-605	CLIP-seq
MIRT2562993	hsa-miR-634	CLIP-seq
MIRT2562994	hsa-miR-641	CLIP-seq
MIRT1117832	hsa-miR-643	CLIP-seq
MIRT2562995	hsa-miR-769-5p	CLIP-seq

Show/Hide all (22)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001764	Process	Neuron migration	IDA	26639854
GO:0001764	Process	Neuron migration	IEA
GO:0001764	Process	Neuron migration	IEA
GO:0005041	Function	Low-density lipoprotein particle receptor activity	NAS	12809483
GO:0005178	Function	Integrin binding	IEA
GO:0005515	Function	Protein binding	IPI	12809483
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IDA	12809483
GO:0005905	Component	Clathrin-coated pit	IEA
GO:0006897	Process	Endocytosis	IEA
GO:0006897	Process	Endocytosis	NAS	12809483
GO:0007155	Process	Cell adhesion	IEA
GO:0007165	Process	Signal transduction	NAS	12809483
GO:0016020	Component	Membrane	IEA
GO:0016020	Component	Membrane	NAS	9927190
GO:0016477	Process	Cell migration	IEA
GO:0031175	Process	Neuron projection development	IDA	26639854
GO:0031175	Process	Neuron projection development	IEA
GO:0031175	Process	Neuron projection development	IEA
GO:0033622	Process	Integrin activation	IEA
GO:0040008	Process	Regulation of growth	NAS	9927190
GO:0097021	Process	Lymphocyte migration into lymphoid organs	IEA

MIM	HGNC	e!Ensembl
618299	31708	ENSG00000147650

Q9Y561

Protein name

Low-density lipoprotein receptor-related protein 12 (LDLR-related protein 12) (LRP-12) (Suppressor of tumorigenicity 7 protein)

Protein function

Probable receptor, which may be involved in the internalization of lipophilic molecules and/or signal transduction. May act as a tumor suppressor.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00431	CUB	47 → 156	CUB domain	Domain
PF00057	Ldl_recept_a	164 → 200	Low-density lipoprotein receptor domain class A	Repeat
PF00057	Ldl_recept_a	213 → 254	Low-density lipoprotein receptor domain class A	Repeat
PF00431	CUB	259 → 369	CUB domain	Domain
PF00057	Ldl_recept_a	411 → 448	Low-density lipoprotein receptor domain class A	Repeat
PF00057	Ldl_recept_a	450 → 485	Low-density lipoprotein receptor domain class A	Repeat

Tissue specificity

TISSUE SPECIFICITY: Widely expressed in heart, skeletal muscle, brain, lung, placenta and pancreas, but not in tissues consisting of a large number of epithelial cells, such as liver and kidney. Expressed at very low levels in a number of tumor-derived ce

Sequence

MACRWSTKESPRWRSALLLLFLAGVYGNGALAEHSENVHISGVSTACGETPEQIRAPSGI
ITSPGWPSEYPAKINCSWFIRANPGEIITISFQDFDIQGSRRCNLDWLTIETYKNIESYR
ACGSTIPPPYISSQDHIWIRFHSDDNISRKGFRLAYFSGKSEEPNCACDQFRCGNGKCIP
EAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYNQFQCLSRFTKVYTCLPESLKCD
GNIDCLDLGDEIDCDVPTCGQWLKYFYGTFNSPNYPDFYPPGSNCTWLIDTGDHRKVILR
FTDFKLDGTGYGDYVKIYDGLEENPHKLLRVLTAFDSHAPLTVVSSSGQIRVHFCADKVN
AARGFNATYQVDGFCLPWEIPCGGNWGCYTEQQRCDGYWHCPNGRDETNCTMCQKEEFPC
SRNGVCYPRSDRCNYQNHCPNGSDEKNCFFCQPGNFHCKNNRCVFESWVCDSQDDCGDGS
DEENCPVIVPTRVITAAVIGSLICGLLLVIALGCTCKLYSLRMFERRSFETQLSRVEAEL
LRREAPPSYGQLIAQGLIPPVEDFPVCSPNQASVLENLRLAVRSQLGFTSVRLPMAGRSS
NIWNRIFNFARSRHSGSLALVSADGDEVVPSQSTSREPERNHTHRSLFSVESDDTDTENE
RRDMAGASGGVAAPLPQKVPPTTAVEATVGACASSSTQSTRGGHADNGRDVTSVEPPSVS
PARHQLTSALSRMTQGLRWVRFTLGRSSSLSQNQSPLRQLDNGVSGREDDDDVEMLIPIS
DGSSDFDVNDCSRPLLDLASDQGQGLRQPYNATNPGVRPSNRDGPCERCGIVHTAQIPDT
CLEVTLKNETSDDEALLLC

Sequence length

859

Interactions

View interactions

	Reactome
			Retinoid metabolism and transport

Show/Hide Unknown Diseases (4)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Amyotrophic lateral sclerosis 28	Conflicting classifications of pathogenicity	rs142053596	RCV005392762
Hereditary breast ovarian cancer syndrome	Uncertain significance	rs2140832143	RCV001374564
LRP12-related disorder	Benign	rs78131914	RCV003954205
Oculopharyngodistal myopathy 1	Conflicting classifications of pathogenicity	rs142053596	RCV005392762

Show/Hide Text Mining Associations (19)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Amyotrophic Lateral Sclerosis	Associate	37339631
Burkitt Lymphoma	Associate	25226156
Cardiovascular Abnormalities	Associate	34047774
Deglutition Disorders	Associate	34047774
Distal Myopathies	Associate	34047774
Dysarthria	Associate	34047774
Glaucoma Open Angle	Associate	25414181
Lymphoma	Associate	25226156
Lymphoma B Cell	Associate	25226156
Muscle Neoplasms	Associate	34047774
Muscle Weakness	Associate	34047774
Muscular Dystrophy Oculopharyngeal	Associate	34047774
Neoplasms	Associate	29143255
Oculopharyngodistal Myopathy	Associate	33239111, 33693509, 34047774, 35148830, 36476314, 37339631, 37864208
Phyllodes Tumor	Associate	36271373
Pneumonia Aspiration	Associate	34047774
Ptosis Hereditary Congenital 2	Associate	34047774
Stomach Neoplasms	Associate	36430456
Synovitis	Associate	29968759

LRP12 (LDL receptor related protein 12)