Gene Gene information from NCBI Gene database.
Entrez ID 29966
Gene name Striatin 3
Gene symbol STRN3
Synonyms (NCBI Gene)
PPP2R6BS/G2NASG2NA
Chromosome 14
Chromosome location 14q12
miRNA miRNA information provided by mirtarbase database.
465
miRTarBase ID miRNA Experiments Reference
MIRT045977 hsa-miR-125b-5p CLASH 23622248
MIRT541029 hsa-miR-548at-3p HITS-CLIP 21572407
MIRT541028 hsa-miR-548ay-3p HITS-CLIP 21572407
MIRT190769 hsa-miR-5003-3p HITS-CLIP 21572407
MIRT541027 hsa-miR-767-5p HITS-CLIP 21572407
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
42
GO ID Ontology Definition Evidence Reference
GO:0000122 Process Negative regulation of transcription by RNA polymerase II IDA 11570823
GO:0005515 Function Protein binding IPI 18782753, 19156129, 24255178, 24366813, 26496610, 28514442, 30595372, 30622739, 32296183, 32814053, 33633399, 33961781, 34524948, 35271311
GO:0005516 Function Calmodulin binding IEA
GO:0005516 Function Calmodulin binding NAS 10748158
GO:0005634 Component Nucleus IDA 18434427
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
614766 15720 ENSG00000196792
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q13033
Protein name Striatin-3 (Cell cycle autoantigen SG2NA) (S/G2 antigen)
Protein function Calmodulin-binding scaffolding protein which is the center of the striatin-interacting phosphatase and kinase (STRIPAK) complexes (PubMed:18782753, PubMed:30622739, PubMed:33633399). STRIPAK complexes have critical roles in protein (de)phosphory
PDB 4N6J , 6AKL , 6IUR , 7K36
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF08232 Striatin 64 194 Striatin family Family
PF00400 WD40 470 508 WD domain, G-beta repeat Repeat
PF00400 WD40 523 561 WD domain, G-beta repeat Repeat
PF00400 WD40 577 614 WD domain, G-beta repeat Repeat
PF00400 WD40 713 751 WD domain, G-beta repeat Repeat
PF00400 WD40 755 796 WD domain, G-beta repeat Repeat
Sequence
MDELAGGGGGGPGMAAPPRQQQGPGGNLGLSPGGNGAAGGGGPPASEGAGPAAGPELSRP
QQYTIPGILHYIQHEWARFEMERAHWEVERAELQARIAFLQGERKGQENLKKDLVRRIKM
LEYALKQERAKYHKLKYGTELNQGDLKMPTFESEETKDTEAPTAPQNSQLTWKQGRQLLR
QYLQEVGYTDTILD
VRSQRVRSLLGLSNSEPNGSVETKNLEQILNGGESPKQKGQEIKRS
SGDVLETFNFLENADDSDEDEENDMIEGIPEGKDKHRMNKHKIGNEGLAADLTDDPDTEE
ALKEFDFLVTAEDGEGAGEARSSGDGTEWDKDDLSPTAEVWDVDQGLISKLKEQYKKERK
GKKGVKRANRTKLYDMIADLGDDELPHIPSGIINQSRSASTRMTDHEGARAEEAEPITFP
SGGGKSFIMGSDDVLLSVLGLGDLADLTVTNDADYSYDLPANKDAFRKTWNPKYTLRSHF
DGVRALAFHPVEPVLVTASEDHTLKLWN
LQKTVPAKKSASLDVEPIYTFRAHIGPVLSLA
ISSNGEQCFSGGIDATIQWWN
MPSPSVDPYDTYEPNVLAGTLVGHTDAVWGLAYSGIKNQ
LLSCSADGTVRLWN
PQEKLPCICTYNGDKKHGIPTSVDFIGCDPAHMVTSFNTGSAVIYD
LETSQSLVILSSQVDSGLQSNNHINRVVSHPTLPVTITAHEDRHIKFFDNKTGKMIHSMV
AHLDAVTSLAVDPNGIYLMSGSHDCSIRLWN
LDSKTCVQEITAHRKKLDESIYDVAFHSS
KAYIASAGADALAKVF
V
Sequence length 797
Interactions View interactions
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
4
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
Adrenocortical carcinoma, hereditary Likely benign ClinVar
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Clear cell carcinoma of kidney Likely benign ClinVar
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
COLORECTAL CANCER GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Thyroid cancer, nonmedullary, 1 Uncertain significance ClinVar
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References Evidence Score
Carcinoma Hepatocellular Associate 31335995
★☆☆☆☆
Found in Text Mining only
Influenza Human Associate 36602306
★☆☆☆☆
Found in Text Mining only
Neoplasms Associate 38215077
★☆☆☆☆
Found in Text Mining only
Vitiligo Associate 23678272
★☆☆☆☆
Found in Text Mining only