Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	29907
Gene name	Sorting nexin 15
Gene symbol	SNX15
Synonyms (NCBI Gene)	HSAF001435
Chromosome	11
Chromosome location	11q13.1
Summary	This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. Overexpression of this gene results in a decrease in the

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miRTarBase ID	miRNA	Experiments	Reference
MIRT001477	hsa-miR-16-5p	Proteomics	18668040
MIRT1377053	hsa-miR-1268	CLIP-seq
MIRT1377054	hsa-miR-1268b	CLIP-seq
MIRT1377055	hsa-miR-216a	CLIP-seq
MIRT1377056	hsa-miR-3165	CLIP-seq
MIRT1377057	hsa-miR-3197	CLIP-seq
MIRT1377058	hsa-miR-3614-5p	CLIP-seq
MIRT1377059	hsa-miR-3622b-5p	CLIP-seq
MIRT1377060	hsa-miR-3656	CLIP-seq
MIRT1377061	hsa-miR-3926	CLIP-seq
MIRT1377062	hsa-miR-4433	CLIP-seq
MIRT1377063	hsa-miR-4459	CLIP-seq
MIRT1377064	hsa-miR-4486	CLIP-seq
MIRT1377065	hsa-miR-4499	CLIP-seq
MIRT1377066	hsa-miR-455-5p	CLIP-seq
MIRT1377067	hsa-miR-4649-3p	CLIP-seq
MIRT1377068	hsa-miR-4763-5p	CLIP-seq
MIRT1377069	hsa-miR-4768-3p	CLIP-seq
MIRT1377070	hsa-miR-4786-5p	CLIP-seq
MIRT1377071	hsa-miR-548s	CLIP-seq
MIRT1377072	hsa-miR-550a	CLIP-seq
MIRT1377073	hsa-miR-585	CLIP-seq
MIRT1377074	hsa-miR-1205	CLIP-seq
MIRT1377056	hsa-miR-3165	CLIP-seq
MIRT1377057	hsa-miR-3197	CLIP-seq
MIRT1377058	hsa-miR-3614-5p	CLIP-seq
MIRT1377075	hsa-miR-3622a-3p	CLIP-seq
MIRT1377076	hsa-miR-3622b-3p	CLIP-seq
MIRT1377060	hsa-miR-3656	CLIP-seq
MIRT1377077	hsa-miR-3665	CLIP-seq
MIRT1377078	hsa-miR-4289	CLIP-seq
MIRT1377062	hsa-miR-4433	CLIP-seq
MIRT1377063	hsa-miR-4459	CLIP-seq
MIRT1377079	hsa-miR-4640-5p	CLIP-seq
MIRT1377080	hsa-miR-4726-5p	CLIP-seq
MIRT1377069	hsa-miR-4768-3p	CLIP-seq
MIRT1377070	hsa-miR-4786-5p	CLIP-seq
MIRT1377081	hsa-miR-4795-3p	CLIP-seq
MIRT1377082	hsa-miR-604	CLIP-seq
MIRT1377083	hsa-miR-616	CLIP-seq
MIRT1377084	hsa-miR-647	CLIP-seq
MIRT1377085	hsa-miR-656	CLIP-seq
MIRT1377086	hsa-miR-657	CLIP-seq
MIRT1557084	hsa-miR-3689a-3p	CLIP-seq
MIRT1557085	hsa-miR-3689c	CLIP-seq
MIRT1377055	hsa-miR-216a	CLIP-seq
MIRT2112171	hsa-miR-216b	CLIP-seq
MIRT2112172	hsa-miR-3065-3p	CLIP-seq
MIRT2112173	hsa-miR-3122	CLIP-seq
MIRT2112174	hsa-miR-3150a-3p	CLIP-seq
MIRT2112175	hsa-miR-3150b-3p	CLIP-seq
MIRT2112176	hsa-miR-3154	CLIP-seq
MIRT1377056	hsa-miR-3165	CLIP-seq
MIRT2112177	hsa-miR-3175	CLIP-seq
MIRT2112178	hsa-miR-3179	CLIP-seq
MIRT1377057	hsa-miR-3197	CLIP-seq
MIRT2112179	hsa-miR-34a	CLIP-seq
MIRT2112180	hsa-miR-34c-5p	CLIP-seq
MIRT1377058	hsa-miR-3614-5p	CLIP-seq
MIRT1377060	hsa-miR-3656	CLIP-seq
MIRT1557084	hsa-miR-3689a-3p	CLIP-seq
MIRT1557085	hsa-miR-3689c	CLIP-seq
MIRT2112181	hsa-miR-3913-5p	CLIP-seq
MIRT1377062	hsa-miR-4433	CLIP-seq
MIRT2112182	hsa-miR-4434	CLIP-seq
MIRT1377063	hsa-miR-4459	CLIP-seq
MIRT2112183	hsa-miR-4492	CLIP-seq
MIRT2112184	hsa-miR-4498	CLIP-seq
MIRT1377065	hsa-miR-4499	CLIP-seq
MIRT2112185	hsa-miR-449a	CLIP-seq
MIRT2112186	hsa-miR-449b	CLIP-seq
MIRT2112187	hsa-miR-4516	CLIP-seq
MIRT1377067	hsa-miR-4649-3p	CLIP-seq
MIRT1377069	hsa-miR-4768-3p	CLIP-seq
MIRT2112188	hsa-miR-4784	CLIP-seq
MIRT2112189	hsa-miR-762	CLIP-seq
MIRT2112190	hsa-miR-939	CLIP-seq
MIRT1377055	hsa-miR-216a	CLIP-seq
MIRT2112171	hsa-miR-216b	CLIP-seq
MIRT2335411	hsa-miR-513a-3p	CLIP-seq
MIRT1377055	hsa-miR-216a	CLIP-seq
MIRT1377056	hsa-miR-3165	CLIP-seq
MIRT2335412	hsa-miR-3192	CLIP-seq
MIRT1377058	hsa-miR-3614-5p	CLIP-seq
MIRT1377060	hsa-miR-3656	CLIP-seq
MIRT1557084	hsa-miR-3689a-3p	CLIP-seq
MIRT1557085	hsa-miR-3689c	CLIP-seq
MIRT2335413	hsa-miR-3689d	CLIP-seq
MIRT1377061	hsa-miR-3926	CLIP-seq
MIRT2335414	hsa-miR-3929	CLIP-seq
MIRT2335415	hsa-miR-4329	CLIP-seq
MIRT2335416	hsa-miR-4419b	CLIP-seq
MIRT1377062	hsa-miR-4433	CLIP-seq
MIRT1377063	hsa-miR-4459	CLIP-seq
MIRT2335417	hsa-miR-4478	CLIP-seq
MIRT2335418	hsa-miR-4728-5p	CLIP-seq
MIRT1377069	hsa-miR-4768-3p	CLIP-seq
MIRT1377070	hsa-miR-4786-5p	CLIP-seq
MIRT2335419	hsa-miR-485-5p	CLIP-seq
MIRT2335420	hsa-miR-490-3p	CLIP-seq
MIRT1377071	hsa-miR-548s	CLIP-seq
MIRT2629453	hsa-miR-1247	CLIP-seq
MIRT1377053	hsa-miR-1268	CLIP-seq
MIRT1377054	hsa-miR-1268b	CLIP-seq
MIRT2629454	hsa-miR-1273e	CLIP-seq
MIRT2629455	hsa-miR-146a	CLIP-seq
MIRT2629456	hsa-miR-146b-5p	CLIP-seq
MIRT1377055	hsa-miR-216a	CLIP-seq
MIRT2112171	hsa-miR-216b	CLIP-seq
MIRT2112172	hsa-miR-3065-3p	CLIP-seq
MIRT2112173	hsa-miR-3122	CLIP-seq
MIRT2629457	hsa-miR-3162-3p	CLIP-seq
MIRT1377056	hsa-miR-3165	CLIP-seq
MIRT2335412	hsa-miR-3192	CLIP-seq
MIRT1377057	hsa-miR-3197	CLIP-seq
MIRT1377058	hsa-miR-3614-5p	CLIP-seq
MIRT1377059	hsa-miR-3622b-5p	CLIP-seq
MIRT2629458	hsa-miR-3647-3p	CLIP-seq
MIRT1377060	hsa-miR-3656	CLIP-seq
MIRT1557084	hsa-miR-3689a-3p	CLIP-seq
MIRT1557085	hsa-miR-3689c	CLIP-seq
MIRT2335413	hsa-miR-3689d	CLIP-seq
MIRT2112181	hsa-miR-3913-5p	CLIP-seq
MIRT1377061	hsa-miR-3926	CLIP-seq
MIRT1377062	hsa-miR-4433	CLIP-seq
MIRT1377063	hsa-miR-4459	CLIP-seq
MIRT1377064	hsa-miR-4486	CLIP-seq
MIRT1377065	hsa-miR-4499	CLIP-seq
MIRT1377067	hsa-miR-4649-3p	CLIP-seq
MIRT2629459	hsa-miR-4724-5p	CLIP-seq
MIRT2335418	hsa-miR-4728-5p	CLIP-seq
MIRT1377069	hsa-miR-4768-3p	CLIP-seq
MIRT1377070	hsa-miR-4786-5p	CLIP-seq
MIRT2335420	hsa-miR-490-3p	CLIP-seq
MIRT1377071	hsa-miR-548s	CLIP-seq
MIRT1377073	hsa-miR-585	CLIP-seq
MIRT2629453	hsa-miR-1247	CLIP-seq
MIRT2629454	hsa-miR-1273e	CLIP-seq
MIRT2629455	hsa-miR-146a	CLIP-seq
MIRT2629456	hsa-miR-146b-5p	CLIP-seq
MIRT1377055	hsa-miR-216a	CLIP-seq
MIRT2112171	hsa-miR-216b	CLIP-seq
MIRT2112172	hsa-miR-3065-3p	CLIP-seq
MIRT2112173	hsa-miR-3122	CLIP-seq
MIRT2629457	hsa-miR-3162-3p	CLIP-seq
MIRT1377056	hsa-miR-3165	CLIP-seq
MIRT2335412	hsa-miR-3192	CLIP-seq
MIRT1377057	hsa-miR-3197	CLIP-seq
MIRT1377058	hsa-miR-3614-5p	CLIP-seq
MIRT2629458	hsa-miR-3647-3p	CLIP-seq
MIRT1377060	hsa-miR-3656	CLIP-seq
MIRT1557084	hsa-miR-3689a-3p	CLIP-seq
MIRT1557085	hsa-miR-3689c	CLIP-seq
MIRT2335413	hsa-miR-3689d	CLIP-seq
MIRT2112181	hsa-miR-3913-5p	CLIP-seq
MIRT1377061	hsa-miR-3926	CLIP-seq
MIRT1377062	hsa-miR-4433	CLIP-seq
MIRT1377063	hsa-miR-4459	CLIP-seq
MIRT1377065	hsa-miR-4499	CLIP-seq
MIRT2691692	hsa-miR-4537	CLIP-seq
MIRT1377067	hsa-miR-4649-3p	CLIP-seq
MIRT2629459	hsa-miR-4724-5p	CLIP-seq
MIRT2335418	hsa-miR-4728-5p	CLIP-seq
MIRT1377069	hsa-miR-4768-3p	CLIP-seq
MIRT1377070	hsa-miR-4786-5p	CLIP-seq
MIRT2335420	hsa-miR-490-3p	CLIP-seq
MIRT1377071	hsa-miR-548s	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	16189514, 21516116, 25416956, 28514442, 31515488, 32296183, 33961781
GO:0005730	Component	Nucleolus	IDA
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	NAS	11085978
GO:0005886	Component	Plasma membrane	IDA
GO:0006886	Process	Intracellular protein transport	NAS	11085978
GO:0008289	Function	Lipid binding	IEA
GO:0015031	Process	Protein transport	IEA
GO:0016020	Component	Membrane	IEA
GO:0016020	Component	Membrane	NAS	11085978
GO:0030659	Component	Cytoplasmic vesicle membrane	IEA
GO:0031410	Component	Cytoplasmic vesicle	IEA
GO:0035091	Function	Phosphatidylinositol binding	IEA

MIM	HGNC	e!Ensembl
605964	14978	ENSG00000110025

Q9NRS6

Protein name

Sorting nexin-15

Protein function

May be involved in several stages of intracellular trafficking. Overexpression of SNX15 disrupts the normal trafficking of proteins from the plasma membrane to recycling endosomes or the TGN.

PDB

6ECM , 6MBI

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00787	PX	38 → 125	PX domain	Domain
PF04212	MIT	269 → 334	MIT (microtubule interacting and transport) domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Widely expressed. {ECO:0000269|PubMed:11085978}.

Sequence

MSRQAKDDFLRHYTVSDPRTHPKGYTEYKVTAQFISKKDPEDVKEVVVWKRYSDFRKLHG
DLAYTHRNLFRRLEEFPAFPRAQVFGRFEASVIEERRKGAEDLLRFTVHIPALNNSPQLK
EFFRGGEVTRPLEVSRDLHILPPPLIPTPPPDDPRLSQLLPAERRGLEELEVPVDPPPSS
PAQEALDLLFNCESTEEASGSPARGPLTEAELALFDPFSKEEGAAPSPTHVAELATMEVE
SARLDQEPWEPGGQEEEEDGEGGPTPAYLSQATELITQALRDEKAGAYAAALQGYRDGVH
VLLQGVPSDPLPARQEGVKKKAAEYLKRAEEILRLHLSQLPP

Sequence length

342

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (1)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
MIGRAINE DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (1)

Disease Name	Relationship Type	References	Evidence Score
Associations from Text MiningDisease associations identified through Pubtator
Stomach Neoplasms	Associate	33306856	★★★★★ ★☆☆☆☆ Found in Text Mining only

SNX15 (sorting nexin 15)