Gene Gene information from NCBI Gene database.
Entrez ID 29904
Gene name Eukaryotic elongation factor 2 kinase
Gene symbol EEF2K
Synonyms (NCBI Gene)
CaMKIIIHSU93850eEF-2K
Chromosome 16
Chromosome location 16p12.2
Summary This gene encodes a highly conserved protein kinase in the calmodulin-mediated signaling pathway that links activation of cell surface receptors to cell division. This kinase is involved in the regulation of protein synthesis. It phosphorylates eukaryotic
miRNA miRNA information provided by mirtarbase database.
867
miRTarBase ID miRNA Experiments Reference
MIRT021460 hsa-miR-9-5p Microarray 17612493
MIRT051093 hsa-miR-16-5p CLASH 23622248
MIRT036987 hsa-miR-877-3p CLASH 23622248
MIRT440747 hsa-miR-142-3p HITS-CLIP 22473208
MIRT440747 hsa-miR-142-3p HITS-CLIP 22473208
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
33
GO ID Ontology Definition Evidence Reference
GO:0000166 Function Nucleotide binding IEA
GO:0002931 Process Response to ischemia IEA
GO:0004672 Function Protein kinase activity TAS 9144159
GO:0004674 Function Protein serine/threonine kinase activity IEA
GO:0004686 Function Elongation factor-2 kinase activity IBA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
606968 24615 ENSG00000103319
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
O00418
Protein name Eukaryotic elongation factor 2 kinase (eEF-2 kinase) (eEF-2K) (EC 2.7.11.20) (Calcium/calmodulin-dependent eukaryotic elongation factor 2 kinase)
Protein function Threonine kinase that regulates protein synthesis by controlling the rate of peptide chain elongation. Upon activation by a variety of upstream kinases including AMPK or TRPM7, phosphorylates the elongation factor EEF2 at a single site, renders
PDB 5J8H , 5KS5 , 6NX4 , 7SHQ , 8FNY , 8FO6 , 8GM4 , 8GM5
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF02816 Alpha_kinase 139 318 Alpha-kinase family Family
PF08238 Sel1 526 563 Sel1 repeat Repeat
PF08238 Sel1 565 609 Sel1 repeat Repeat
Sequence
MADEDLIFRLEGVDGGQSPRAGHDGDSDGDSDDEEGYFICPITDDPSSNQNVNSKVNKYY
SNLTKSERYSSSGSPANSFHFKEAWKHAIQKAKHMPDPWAEFHLEDIATERATRHRYNAV
TGEWLDDEVLIKMASQPFGRGAMRECFRTKKLSNFLHAQQWKGASNYVAKRYIEPVDRDV
YFEDVRLQMEAKLWGEEYNRHKPPKQVDIMQMCIIELKDRPGKPLFHLEHYIEGKYIKYN
SNSGFVRDDNIRLTPQAFSHFTFERSGHQLIVVDIQGVGDLYTDPQIHTETGTDFGDGNL
GVRGMALFFYSHACNRIC
ESMGLAPFDLSPRERDAVNQNTKLLQSAKTILRGTEEKCGSP
QVRTLSGSRPPLLRPLSENSGDENMSDVTFDSLPSSPSSATPHSQKLDHLHWPVFSDLDN
MASRDHDHLDNHRESENSGDSGYPSEKRGELDDPEPREHGHSYSNRKYESDEDSLGSSGR
VCVEKWNLLNSSRLHLPRASAVALEVQRLNALDLEKKIGKSILGKVHLAMVRYHEGGRFC
EKGEEWDQESAVFHLEHAANLGE
LEAIVGLGLMYSQLPHHILADVSLKETEENKTKGFDY
LLKAAEAGD
RQSMILVARAFDSGQNLSPDRCQDWLEALHWYNTALEMTDCDEGGEYDGMQ
DEPRYMMLAREAEMLFTGGYGLEKDPQRSGDLYTQAAEAAMEAMKGRLANQYYQKAEEAW
AQMEE
Sequence length 725
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  AMPK signaling pathway
Oxytocin signaling pathway
  mTORC1-mediated signalling
Associated diseases Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
1
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
Uterine carcinosarcoma Uncertain significance rs774988075 RCV005929127
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References
Adenocarcinoma of Lung Associate 37300283
Breast Neoplasms Associate 16648488, 20300520, 29239350
Carcinoma Hepatocellular Associate 28060762
Colorectal Neoplasms Associate 24955726
Colorectal Neoplasms Inhibit 31266475
Drug Related Side Effects and Adverse Reactions Associate 19244119, 29239350
Glioblastoma Associate 21278783, 24955726, 40725039
Glioma Associate 19244119, 21278783, 21460616, 21945617
Hypoxia Associate 16648488
Intervertebral Disc Degeneration Associate 35578687