Gene Gene information from NCBI Gene database.
Entrez ID 29843
Gene name SUMO specific peptidase 1
Gene symbol SENP1
Synonyms (NCBI Gene)
SuPr-2
Chromosome 12
Chromosome location 12q13.11
Summary This gene encodes a cysteine protease that specifically targets members of the small ubiquitin-like modifier (SUMO) protein family. This protease regulates SUMO pathways by deconjugating sumoylated proteins. This protease also functions to process the pre
miRNA miRNA information provided by mirtarbase database.
784
miRTarBase ID miRNA Experiments Reference
MIRT016404 hsa-miR-193b-3p Microarray 20304954
MIRT019847 hsa-miR-375 Microarray 20215506
MIRT021701 hsa-miR-133a-3p Microarray 21396852
MIRT025028 hsa-miR-183-5p Sequencing 20371350
MIRT025428 hsa-miR-34a-5p Sequencing 20371350
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
37
GO ID Ontology Definition Evidence Reference
GO:0004175 Function Endopeptidase activity TAS 10652325
GO:0005515 Function Protein binding IPI 17099698, 21965678, 22878415, 32296183
GO:0005634 Component Nucleus IBA
GO:0005634 Component Nucleus IEA
GO:0005634 Component Nucleus TAS 10652325
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
612157 17927 ENSG00000079387
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q9P0U3
Protein name Sentrin-specific protease 1 (EC 3.4.22.-) (Sentrin/SUMO-specific protease SENP1)
Protein function Protease that catalyzes two essential functions in the SUMO pathway (PubMed:10652325, PubMed:15199155, PubMed:15487983, PubMed:16253240, PubMed:16553580, PubMed:21829689, PubMed:21965678, PubMed:23160374, PubMed:24943844, PubMed:25406032, PubMed
PDB 2CKG , 2CKH , 2G4D , 2IY0 , 2IY1 , 2IYC , 2IYD , 2XPH , 2XRE , 6NNQ
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF02902 Peptidase_C48 464 642 Ulp1 protease family, C-terminal catalytic domain Domain
Tissue specificity TISSUE SPECIFICITY: Highly expressed in testis. Expressed at lower levels in thymus, pancreas, spleen, liver, ovary and small intestine. {ECO:0000269|PubMed:15487983}.
Sequence
MDDIADRMRMDAGEVTLVNHNSVFKTHLLPQTGFPEDQLSLSDQQILSSRQGHLDRSFTC
STRSAAYNPSYYSDNPSSDSFLGSGDLRTFGQSANGQWRNSTPSSSSSLQKSRNSRSLYL
ETRKTSSGLSNSFAGKSNHHCHVSAYEKSFPIKPVPSPSWSGSCRRSLLSPKKTQRRHVS
TAEETVQEEEREIYRQLLQMVTGKQFTIAKPTTHFPLHLSRCLSSSKNTLKDSLFKNGNS
CASQIIGSDTSSSGSASILTNQEQLSHSVYSLSSYTPDVAFGSKDSGTLHHPHHHHSVPH
QPDNLAASNTQSEGSDSVILLKVKDSQTPTPSSTFFQAELWIKELTSVYDSRARERLRQI
EEQKALALQLQNQRLQEREHSVHDSVELHLRVPLEKEIPVTVVQETQKKGHKLTDSEDEF
PEITEEMEKEIKNVFRNGNQDEVLSEAFRLTITRKDIQTLNHLNWLNDEIINFYMNMLME
RSKEKGLPSVHAFNTFFFTKLKTAGYQAVKRWTKKVDVFSVDILLVPIHLGVHWCLAVVD
FRKKNITYYDSMGGINNEACRILLQYLKQESIDKKRKEFDTNGWQLFSKKSQEIPQQMNG
SDCGMFACKYADCITKDRPINFTQQHMPYFRKRMVWEILHRK
LL
Sequence length 644
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    SUMO is proteolytically processed
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
19
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
ARTERIOSCLEROSIS CTD, Disgenet
CTD, Disgenet
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
BIPOLAR DISORDER GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
CORONARY ARTERY DISEASE GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
LUNG ADENOCARCINOMA GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References Evidence Score
Altitude Sickness Associate 26952840
★☆☆☆☆
Found in Text Mining only
Altitude Sickness Stimulate 31617751
★☆☆☆☆
Found in Text Mining only
Arthritis Rheumatoid Associate 17360386
★☆☆☆☆
Found in Text Mining only
Breast Neoplasms Associate 27178176, 30305424, 30732133
★☆☆☆☆
Found in Text Mining only
Burkitt Lymphoma Associate 22901169
★☆☆☆☆
Found in Text Mining only
Carcinogenesis Associate 31969492
★☆☆☆☆
Found in Text Mining only
Carcinoma Hepatocellular Associate 26695141, 31969492, 35807394
★☆☆☆☆
Found in Text Mining only
Carcinoma Non Small Cell Lung Associate 30043429
★☆☆☆☆
Found in Text Mining only
Carcinoma Pancreatic Ductal Associate 25217324
★☆☆☆☆
Found in Text Mining only
Carcinoma Renal Cell Associate 27741516, 28550686
★☆☆☆☆
Found in Text Mining only