Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	29841
Gene name Gene Name - the full gene name approved by the HGNC.	Grainyhead like transcription factor 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	GRHL1
Synonyms (NCBI Gene) Gene synonyms aliases	LBP32, MGR, NH32, TFCP2L2
Chromosome Chromosome number	2
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	2p25.1
Summary Summary of gene provided in NCBI Entrez Gene.	This gene encodes a member of the grainyhead family of transcription factors. The encoded protein can exist as a homodimer or can form heterodimers with sister-of-mammalian grainyhead or brother-of-mammalian grainyhead. This protein functions as a transcr

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miRTarBase ID	miRNA	Experiments	Reference
MIRT026212	hsa-miR-192-5p	Microarray	19074876
MIRT437584	hsa-miR-125a-5p	Microarray, qRT-PCR	22815788
MIRT437754	hsa-miR-99a-5p	Microarray, qRT-PCR	22815788
MIRT437755	hsa-miR-99b-5p	Microarray, qRT-PCR	22815788
MIRT437756	hsa-miR-100-5p	Microarray, qRT-PCR	22815788
MIRT721325	hsa-miR-1183	HITS-CLIP	19536157
MIRT721324	hsa-miR-200a-5p	HITS-CLIP	19536157
MIRT721323	hsa-miR-200b-5p	HITS-CLIP	19536157
MIRT721322	hsa-miR-1-5p	HITS-CLIP	19536157
MIRT721321	hsa-miR-29a-5p	HITS-CLIP	19536157
MIRT721320	hsa-miR-485-3p	HITS-CLIP	19536157
MIRT721319	hsa-miR-539-3p	HITS-CLIP	19536157
MIRT721325	hsa-miR-1183	HITS-CLIP	19536157
MIRT721324	hsa-miR-200a-5p	HITS-CLIP	19536157
MIRT721323	hsa-miR-200b-5p	HITS-CLIP	19536157
MIRT721322	hsa-miR-1-5p	HITS-CLIP	19536157
MIRT721321	hsa-miR-29a-5p	HITS-CLIP	19536157
MIRT721320	hsa-miR-485-3p	HITS-CLIP	19536157
MIRT721319	hsa-miR-539-3p	HITS-CLIP	19536157
MIRT1033767	hsa-miR-100	CLIP-seq
MIRT1033768	hsa-miR-125a-3p	CLIP-seq
MIRT1033769	hsa-miR-125b	CLIP-seq
MIRT1033770	hsa-miR-1273d	CLIP-seq
MIRT1033771	hsa-miR-142-3p	CLIP-seq
MIRT1033772	hsa-miR-144	CLIP-seq
MIRT1033773	hsa-miR-148a	CLIP-seq
MIRT1033774	hsa-miR-148b	CLIP-seq
MIRT1033775	hsa-miR-152	CLIP-seq
MIRT1033776	hsa-miR-1827	CLIP-seq
MIRT1033777	hsa-miR-190	CLIP-seq
MIRT1033778	hsa-miR-190b	CLIP-seq
MIRT1033779	hsa-miR-192	CLIP-seq
MIRT1033780	hsa-miR-199a-3p	CLIP-seq
MIRT1033781	hsa-miR-199b-3p	CLIP-seq
MIRT1033782	hsa-miR-2053	CLIP-seq
MIRT1033783	hsa-miR-215	CLIP-seq
MIRT1033784	hsa-miR-25	CLIP-seq
MIRT1033785	hsa-miR-2682	CLIP-seq
MIRT1033786	hsa-miR-297	CLIP-seq
MIRT1033787	hsa-miR-298	CLIP-seq
MIRT1033788	hsa-miR-299-5p	CLIP-seq
MIRT1033789	hsa-miR-300	CLIP-seq
MIRT1033790	hsa-miR-302a	CLIP-seq
MIRT1033791	hsa-miR-302b	CLIP-seq
MIRT1033792	hsa-miR-302c	CLIP-seq
MIRT1033793	hsa-miR-302d	CLIP-seq
MIRT1033794	hsa-miR-302e	CLIP-seq
MIRT1033795	hsa-miR-3129-5p	CLIP-seq
MIRT1033796	hsa-miR-3136-5p	CLIP-seq
MIRT1033797	hsa-miR-3148	CLIP-seq
MIRT1033798	hsa-miR-3163	CLIP-seq
MIRT1033799	hsa-miR-3164	CLIP-seq
MIRT1033800	hsa-miR-32	CLIP-seq
MIRT1033801	hsa-miR-340	CLIP-seq
MIRT1033802	hsa-miR-345	CLIP-seq
MIRT1033803	hsa-miR-34a	CLIP-seq
MIRT1033804	hsa-miR-34c-5p	CLIP-seq
MIRT1033805	hsa-miR-3613-3p	CLIP-seq
MIRT1033806	hsa-miR-3613-5p	CLIP-seq
MIRT1033807	hsa-miR-3617	CLIP-seq
MIRT1033808	hsa-miR-363	CLIP-seq
MIRT1033809	hsa-miR-3664-5p	CLIP-seq
MIRT1033810	hsa-miR-367	CLIP-seq
MIRT1033811	hsa-miR-3673	CLIP-seq
MIRT1033812	hsa-miR-3682-5p	CLIP-seq
MIRT1033813	hsa-miR-3714	CLIP-seq
MIRT1033814	hsa-miR-372	CLIP-seq
MIRT1033815	hsa-miR-373	CLIP-seq
MIRT1033816	hsa-miR-381	CLIP-seq
MIRT1033817	hsa-miR-3919	CLIP-seq
MIRT1033818	hsa-miR-3934	CLIP-seq
MIRT1033819	hsa-miR-3978	CLIP-seq
MIRT1033820	hsa-miR-410	CLIP-seq
MIRT1033821	hsa-miR-412	CLIP-seq
MIRT1033822	hsa-miR-4255	CLIP-seq
MIRT1033823	hsa-miR-4282	CLIP-seq
MIRT1033824	hsa-miR-4316	CLIP-seq
MIRT1033825	hsa-miR-4319	CLIP-seq
MIRT1033826	hsa-miR-432	CLIP-seq
MIRT1033827	hsa-miR-4321	CLIP-seq
MIRT1033828	hsa-miR-4325	CLIP-seq
MIRT1033829	hsa-miR-433	CLIP-seq
MIRT1033830	hsa-miR-4436b-5p	CLIP-seq
MIRT1033831	hsa-miR-4439	CLIP-seq
MIRT1033832	hsa-miR-4452	CLIP-seq
MIRT1033833	hsa-miR-449a	CLIP-seq
MIRT1033834	hsa-miR-449b	CLIP-seq
MIRT1033835	hsa-miR-449c	CLIP-seq
MIRT1033836	hsa-miR-4513	CLIP-seq
MIRT1033837	hsa-miR-4522	CLIP-seq
MIRT1033838	hsa-miR-455-3p	CLIP-seq
MIRT1033839	hsa-miR-4639-3p	CLIP-seq
MIRT1033840	hsa-miR-4643	CLIP-seq
MIRT1033841	hsa-miR-4653-3p	CLIP-seq
MIRT1033842	hsa-miR-4659a-3p	CLIP-seq
MIRT1033843	hsa-miR-4659b-3p	CLIP-seq
MIRT1033844	hsa-miR-466	CLIP-seq
MIRT1033845	hsa-miR-4661-5p	CLIP-seq
MIRT1033846	hsa-miR-4666-3p	CLIP-seq
MIRT1033847	hsa-miR-4680-3p	CLIP-seq
MIRT1033848	hsa-miR-4686	CLIP-seq
MIRT1033849	hsa-miR-4724-5p	CLIP-seq
MIRT1033850	hsa-miR-4732-3p	CLIP-seq
MIRT1033851	hsa-miR-4744	CLIP-seq
MIRT1033852	hsa-miR-4764-3p	CLIP-seq
MIRT1033853	hsa-miR-4781-5p	CLIP-seq
MIRT1033854	hsa-miR-4789-3p	CLIP-seq
MIRT1033855	hsa-miR-495	CLIP-seq
MIRT1033856	hsa-miR-519a	CLIP-seq
MIRT1033857	hsa-miR-519b-3p	CLIP-seq
MIRT1033858	hsa-miR-519c-3p	CLIP-seq
MIRT1033859	hsa-miR-520a-3p	CLIP-seq
MIRT1033860	hsa-miR-520b	CLIP-seq
MIRT1033861	hsa-miR-520c-3p	CLIP-seq
MIRT1033862	hsa-miR-520d-3p	CLIP-seq
MIRT1033863	hsa-miR-520e	CLIP-seq
MIRT1033864	hsa-miR-539	CLIP-seq
MIRT1033865	hsa-miR-548aa	CLIP-seq
MIRT1033866	hsa-miR-548an	CLIP-seq
MIRT1033867	hsa-miR-567	CLIP-seq
MIRT1033868	hsa-miR-579	CLIP-seq
MIRT1033869	hsa-miR-582-5p	CLIP-seq
MIRT1033870	hsa-miR-606	CLIP-seq
MIRT1033871	hsa-miR-618	CLIP-seq
MIRT1033872	hsa-miR-630	CLIP-seq
MIRT1033873	hsa-miR-634	CLIP-seq
MIRT1033874	hsa-miR-641	CLIP-seq
MIRT1033875	hsa-miR-660	CLIP-seq
MIRT1033876	hsa-miR-670	CLIP-seq
MIRT1033877	hsa-miR-764	CLIP-seq
MIRT1033878	hsa-miR-92a	CLIP-seq
MIRT1033879	hsa-miR-92b	CLIP-seq
MIRT1033880	hsa-miR-99a	CLIP-seq
MIRT1033881	hsa-miR-99b	CLIP-seq
MIRT1033771	hsa-miR-142-3p	CLIP-seq
MIRT1033773	hsa-miR-148a	CLIP-seq
MIRT1033774	hsa-miR-148b	CLIP-seq
MIRT1033775	hsa-miR-152	CLIP-seq
MIRT1033779	hsa-miR-192	CLIP-seq
MIRT1033780	hsa-miR-199a-3p	CLIP-seq
MIRT1033781	hsa-miR-199b-3p	CLIP-seq
MIRT1033782	hsa-miR-2053	CLIP-seq
MIRT1033783	hsa-miR-215	CLIP-seq
MIRT1033787	hsa-miR-298	CLIP-seq
MIRT1033789	hsa-miR-300	CLIP-seq
MIRT1033790	hsa-miR-302a	CLIP-seq
MIRT1033791	hsa-miR-302b	CLIP-seq
MIRT1033792	hsa-miR-302c	CLIP-seq
MIRT1033793	hsa-miR-302d	CLIP-seq
MIRT1033794	hsa-miR-302e	CLIP-seq
MIRT2006602	hsa-miR-3074-3p	CLIP-seq
MIRT1033795	hsa-miR-3129-5p	CLIP-seq
MIRT1033814	hsa-miR-372	CLIP-seq
MIRT1033815	hsa-miR-373	CLIP-seq
MIRT1033816	hsa-miR-381	CLIP-seq
MIRT1033821	hsa-miR-412	CLIP-seq
MIRT1033822	hsa-miR-4255	CLIP-seq
MIRT1033823	hsa-miR-4282	CLIP-seq
MIRT1033838	hsa-miR-455-3p	CLIP-seq
MIRT1033839	hsa-miR-4639-3p	CLIP-seq
MIRT1033842	hsa-miR-4659a-3p	CLIP-seq
MIRT1033843	hsa-miR-4659b-3p	CLIP-seq
MIRT1033846	hsa-miR-4666-3p	CLIP-seq
MIRT2006603	hsa-miR-4672	CLIP-seq
MIRT2006604	hsa-miR-4803	CLIP-seq
MIRT1033856	hsa-miR-519a	CLIP-seq
MIRT1033857	hsa-miR-519b-3p	CLIP-seq
MIRT1033858	hsa-miR-519c-3p	CLIP-seq
MIRT1033859	hsa-miR-520a-3p	CLIP-seq
MIRT1033860	hsa-miR-520b	CLIP-seq
MIRT1033861	hsa-miR-520c-3p	CLIP-seq
MIRT1033862	hsa-miR-520d-3p	CLIP-seq
MIRT1033863	hsa-miR-520e	CLIP-seq
MIRT1033865	hsa-miR-548aa	CLIP-seq
MIRT1033868	hsa-miR-579	CLIP-seq
MIRT1033869	hsa-miR-582-5p	CLIP-seq
MIRT1033870	hsa-miR-606	CLIP-seq
MIRT1033873	hsa-miR-634	CLIP-seq
MIRT2006605	hsa-miR-873	CLIP-seq
MIRT2239008	hsa-miR-1253	CLIP-seq
MIRT2239009	hsa-miR-1263	CLIP-seq
MIRT1033770	hsa-miR-1273d	CLIP-seq
MIRT2239010	hsa-miR-1281	CLIP-seq
MIRT2239011	hsa-miR-1301	CLIP-seq
MIRT1033776	hsa-miR-1827	CLIP-seq
MIRT2239012	hsa-miR-185	CLIP-seq
MIRT1033779	hsa-miR-192	CLIP-seq
MIRT1033783	hsa-miR-215	CLIP-seq
MIRT2239013	hsa-miR-217	CLIP-seq
MIRT2239014	hsa-miR-2276	CLIP-seq
MIRT1033784	hsa-miR-25	CLIP-seq
MIRT1033785	hsa-miR-2682	CLIP-seq
MIRT1033786	hsa-miR-297	CLIP-seq
MIRT1033789	hsa-miR-300	CLIP-seq
MIRT1033790	hsa-miR-302a	CLIP-seq
MIRT1033791	hsa-miR-302b	CLIP-seq
MIRT1033792	hsa-miR-302c	CLIP-seq
MIRT1033793	hsa-miR-302d	CLIP-seq
MIRT1033794	hsa-miR-302e	CLIP-seq
MIRT1033796	hsa-miR-3136-5p	CLIP-seq
MIRT2239015	hsa-miR-3165	CLIP-seq
MIRT1033800	hsa-miR-32	CLIP-seq
MIRT1033802	hsa-miR-345	CLIP-seq
MIRT1033803	hsa-miR-34a	CLIP-seq
MIRT2239016	hsa-miR-34c-3p	CLIP-seq
MIRT1033804	hsa-miR-34c-5p	CLIP-seq
MIRT1033805	hsa-miR-3613-3p	CLIP-seq
MIRT1033806	hsa-miR-3613-5p	CLIP-seq
MIRT2239017	hsa-miR-3614-5p	CLIP-seq
MIRT1033807	hsa-miR-3617	CLIP-seq
MIRT2239018	hsa-miR-3622a-5p	CLIP-seq
MIRT1033808	hsa-miR-363	CLIP-seq
MIRT1033810	hsa-miR-367	CLIP-seq
MIRT1033813	hsa-miR-3714	CLIP-seq
MIRT1033814	hsa-miR-372	CLIP-seq
MIRT1033815	hsa-miR-373	CLIP-seq
MIRT1033816	hsa-miR-381	CLIP-seq
MIRT2239019	hsa-miR-3914	CLIP-seq
MIRT2239020	hsa-miR-3938	CLIP-seq
MIRT1033820	hsa-miR-410	CLIP-seq
MIRT1033821	hsa-miR-412	CLIP-seq
MIRT2239021	hsa-miR-4256	CLIP-seq
MIRT2239022	hsa-miR-4269	CLIP-seq
MIRT2239023	hsa-miR-4306	CLIP-seq
MIRT1033824	hsa-miR-4316	CLIP-seq
MIRT1033828	hsa-miR-4325	CLIP-seq
MIRT2239024	hsa-miR-4418	CLIP-seq
MIRT2239025	hsa-miR-4423-3p	CLIP-seq
MIRT2239026	hsa-miR-4432	CLIP-seq
MIRT1033831	hsa-miR-4439	CLIP-seq
MIRT2239027	hsa-miR-4444	CLIP-seq
MIRT1033832	hsa-miR-4452	CLIP-seq
MIRT2239028	hsa-miR-4456	CLIP-seq
MIRT2239029	hsa-miR-4457	CLIP-seq
MIRT2239030	hsa-miR-448	CLIP-seq
MIRT1033833	hsa-miR-449a	CLIP-seq
MIRT1033834	hsa-miR-449b	CLIP-seq
MIRT1033835	hsa-miR-449c	CLIP-seq
MIRT1033836	hsa-miR-4513	CLIP-seq
MIRT2239031	hsa-miR-4514	CLIP-seq
MIRT1033838	hsa-miR-455-3p	CLIP-seq
MIRT1033839	hsa-miR-4639-3p	CLIP-seq
MIRT1033840	hsa-miR-4643	CLIP-seq
MIRT2239032	hsa-miR-4644	CLIP-seq
MIRT1033841	hsa-miR-4653-3p	CLIP-seq
MIRT1033842	hsa-miR-4659a-3p	CLIP-seq
MIRT1033843	hsa-miR-4659b-3p	CLIP-seq
MIRT1033844	hsa-miR-466	CLIP-seq
MIRT2239033	hsa-miR-4660	CLIP-seq
MIRT1033846	hsa-miR-4666-3p	CLIP-seq
MIRT2006603	hsa-miR-4672	CLIP-seq
MIRT1033847	hsa-miR-4680-3p	CLIP-seq
MIRT2239034	hsa-miR-4692	CLIP-seq
MIRT2239035	hsa-miR-4693-3p	CLIP-seq
MIRT2239036	hsa-miR-4708-3p	CLIP-seq
MIRT1033849	hsa-miR-4724-5p	CLIP-seq
MIRT2239037	hsa-miR-4733-5p	CLIP-seq
MIRT2239038	hsa-miR-4742-5p	CLIP-seq
MIRT2239039	hsa-miR-4756-3p	CLIP-seq
MIRT2239040	hsa-miR-4762-3p	CLIP-seq
MIRT1033854	hsa-miR-4789-3p	CLIP-seq
MIRT2006604	hsa-miR-4803	CLIP-seq
MIRT2239041	hsa-miR-499-5p	CLIP-seq
MIRT2239042	hsa-miR-5047	CLIP-seq
MIRT2239043	hsa-miR-509-3-5p	CLIP-seq
MIRT2239044	hsa-miR-509-5p	CLIP-seq
MIRT1033856	hsa-miR-519a	CLIP-seq
MIRT1033857	hsa-miR-519b-3p	CLIP-seq
MIRT1033858	hsa-miR-519c-3p	CLIP-seq
MIRT1033859	hsa-miR-520a-3p	CLIP-seq
MIRT1033860	hsa-miR-520b	CLIP-seq
MIRT1033861	hsa-miR-520c-3p	CLIP-seq
MIRT1033862	hsa-miR-520d-3p	CLIP-seq
MIRT1033863	hsa-miR-520e	CLIP-seq
MIRT2239045	hsa-miR-550b	CLIP-seq
MIRT1033867	hsa-miR-567	CLIP-seq
MIRT1033868	hsa-miR-579	CLIP-seq
MIRT2239046	hsa-miR-580	CLIP-seq
MIRT1033870	hsa-miR-606	CLIP-seq
MIRT2239047	hsa-miR-616	CLIP-seq
MIRT2239048	hsa-miR-617	CLIP-seq
MIRT1033874	hsa-miR-641	CLIP-seq
MIRT1033875	hsa-miR-660	CLIP-seq
MIRT1033878	hsa-miR-92a	CLIP-seq
MIRT1033879	hsa-miR-92b	CLIP-seq
MIRT1033785	hsa-miR-2682	CLIP-seq
MIRT1033835	hsa-miR-449c	CLIP-seq
MIRT1033771	hsa-miR-142-3p	CLIP-seq
MIRT1033773	hsa-miR-148a	CLIP-seq
MIRT1033774	hsa-miR-148b	CLIP-seq
MIRT1033775	hsa-miR-152	CLIP-seq
MIRT1033780	hsa-miR-199a-3p	CLIP-seq
MIRT1033781	hsa-miR-199b-3p	CLIP-seq
MIRT1033782	hsa-miR-2053	CLIP-seq
MIRT1033787	hsa-miR-298	CLIP-seq
MIRT1033795	hsa-miR-3129-5p	CLIP-seq
MIRT1033812	hsa-miR-3682-5p	CLIP-seq
MIRT2543027	hsa-miR-421	CLIP-seq
MIRT1033822	hsa-miR-4255	CLIP-seq
MIRT1033845	hsa-miR-4661-5p	CLIP-seq
MIRT2543028	hsa-miR-4709-5p	CLIP-seq
MIRT1033855	hsa-miR-495	CLIP-seq
MIRT2543029	hsa-miR-513c	CLIP-seq
MIRT2543030	hsa-miR-514b-5p	CLIP-seq
MIRT2543031	hsa-miR-543	CLIP-seq
MIRT1033868	hsa-miR-579	CLIP-seq

Transcription factors

Show/Hide all(2)

Transcription factor	Regulation	Reference
HDAC3	Repression	24419085
MYCN	Repression	24419085

Show/Hide all(36)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000785	Component	Chromatin	ISA
GO:0000976	Function	Transcription cis-regulatory region binding	IDA	18288204
GO:0000976	Function	Transcription cis-regulatory region binding	IEA
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA	12175488
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	ISA
GO:0001228	Function	DNA-binding transcription activator activity, RNA polymerase II-specific	IBA
GO:0001228	Function	DNA-binding transcription activator activity, RNA polymerase II-specific	IDA	12175488
GO:0001228	Function	DNA-binding transcription activator activity, RNA polymerase II-specific	IMP	29309642
GO:0002934	Process	Desmosome organization	IEA
GO:0003677	Function	DNA binding	IDA	12175488
GO:0003677	Function	DNA binding	IEA
GO:0003700	Function	DNA-binding transcription factor activity	IDA	12175488
GO:0003700	Function	DNA-binding transcription factor activity	IEA
GO:0005515	Function	Protein binding	IPI	12175488, 28514442, 29309642, 33961781, 35013237
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IDA	18288204, 21081122, 35013237
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	TAS
GO:0006355	Process	Regulation of DNA-templated transcription	IDA	12175488
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IBA
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IEA
GO:0008544	Process	Epidermis development	IEA
GO:0008544	Process	Epidermis development	ISS
GO:0031490	Function	Chromatin DNA binding	IDA	21081122
GO:0042802	Function	Identical protein binding	IPI	12175488
GO:0042803	Function	Protein homodimerization activity	IPI	29309642
GO:0043565	Function	Sequence-specific DNA binding	IDA	18288204
GO:0043565	Function	Sequence-specific DNA binding	IEA
GO:0045616	Process	Regulation of keratinocyte differentiation	IEA
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IDA	12175488, 35013237
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IMP	29309642
GO:0061436	Process	Establishment of skin barrier	IEA
GO:0140297	Function	DNA-binding transcription factor binding	IPI	35013237
GO:1990837	Function	Sequence-specific double-stranded DNA binding	IDA	28473536

MIM	HGNC	e!Ensembl
609786	17923	ENSG00000134317

Protein

UniProt ID

Q9NZI5

Protein name

Grainyhead-like protein 1 homolog (Mammalian grainyhead) (NH32) (Transcription factor CP2-like 2) (Transcription factor LBP-32)

Protein function

Transcription factor involved in epithelial development. Binds directly to the consensus DNA sequence 5'-AACCGGTT-3' (PubMed:12175488, PubMed:18288204, PubMed:29309642). Important regulator of DSG1 in the context of hair anchorage and epidermal

PDB

5MPF , 5MPH , 5MPI

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF04516	CP2	231 → 442	CP2 transcription factor	Family

Tissue specificity

TISSUE SPECIFICITY: Isoform 1 is highly expressed in brain, pancreas, tonsil, placenta and kidney. Isoform 2 is highly expressed in brain and liver. Expressed at very low levels in non-steroidogenic cells. {ECO:0000269|PubMed:10644752, ECO:0000269|PubMed:

Sequence

MTQEYDNKRPVLVLQNEALYPQRRSYTSEDEAWKSFLENPLTAATKAMMSINGDEDSAAA
LGLLYDYYKVPRERRSSTAKPEVEHPEPDHSKRNSIPIVTEQPLISAGENRVQVLKNVPF
NIVLPHGNQLGIDKRGHLTAPDTTVTVSIATMPTHSIKTETQPHGFAVGIPPAVYHPEPT
ERVVVFDRNLNTDQFSSGAQAPNAQRRTPDSTFSETFKEGVQEVFFPSDLSLRMPGMNSE
DYVFDSVSGNNFEYTLEASKSLRQKPGDSTMTYLNKGQFYPITLKEVSSSEGIHHPISKV
RSVIMVVFAEDKSREDQLRHWKYWHSRQHTAKQRCIDIADYKESFNTISNIEEIAYNAIS
FTWDINDEAKVFISVNCLSTDFSSQKGVKGLPLNIQVDTYSYNNRSNKPVHRAYCQIKVF
CDKGAERKIRDEERKQSKRKVSDVKVPLLPSHKRMDITVFKPFIDLDTQPVLFIPDVHFA
NLQRGTHVLPIASEELEGEGSVLKRGPYGTEDDFAVPPSTKLARIEEPKRVLLYVRKESE
EVFDALMLKTPSLKGLMEAISDKYDVPHDKIGKIFKKCKKGILVNMDDNIVKHYSNEDTF
QLQIEEAGGSYKLTLTEI

Sequence length

618

Interactions

View interactions

	Reactome
			PPARA activates gene expression

Show/Hide Unknown Diseases (6)

Disease merge term	Disease name	Evidence	References	Source
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Atrial Fibrillation	Atrial fibrillation	N/A	N/A	GWAS
Breast Cancer	Breast cancer	N/A	N/A	GWAS
Carcinoma	Basal cell carcinoma	N/A	N/A	GWAS
Diabetes	Type 2 diabetes or prostate cancer (pleiotropy)	N/A	N/A	GWAS
Neuroticism	Neuroticism	N/A	N/A	GWAS
Prostate cancer	Prostate cancer	N/A	N/A	GWAS

Show/Hide Text Mining Associations (3)

Disease Name	Relationship Type	References
Associations from Text Mining Disease associations identified through Pubtator
Neoplasms	Inhibit	29301499
Prostatic Neoplasms	Associate	26068399, 36095024
Skin Neoplasms	Inhibit	29301499

GRHL1 (grainyhead like transcription factor 1)