GUCA2B (guanylate cyclase activator 2B)

Gene
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
2981
Gene name Gene Name - the full gene name approved by the HGNC.
Guanylate cyclase activator 2B
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
GUCA2B
Synonyms (NCBI Gene) Gene synonyms aliases
GCAP-II, UGN
Chromosome Chromosome number
1
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
1p34.2
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a preproprotein that is proteolytically processed to generate multiple protein products, including uroguanylin, a member of the guanylin family of peptides and an endogenous ligand of the guanylate cyclase-C receptor. Binding of this pep
miRNA miRNA information provided by mirtarbase database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways
Show/Hide all(8)
miRTarBase ID miRNA Experiments Reference
MIRT017706 hsa-miR-335-5p Microarray 18185580
MIRT2007864 hsa-miR-4435 CLIP-seq
MIRT2007865 hsa-miR-591 CLIP-seq
MIRT2240513 hsa-miR-4433 CLIP-seq
MIRT2007864 hsa-miR-4435 CLIP-seq
Transcription factors
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways
Show/Hide all(1)
Transcription factor Regulation Reference
HSF1 Repression 22129966
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways
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GO ID Ontology Definition Evidence Reference
GO:0002023 Process Reduction of food intake in response to dietary excess IEA
GO:0005515 Function Protein binding IPI 32296183
GO:0005576 Component Extracellular region IEA
GO:0005576 Component Extracellular region TAS
GO:0007589 Process Body fluid secretion IEA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways
MIM HGNC e!Ensembl
601271 4683 ENSG00000044012
Protein
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways
UniProt ID Q16661
Protein name Guanylate cyclase activator 2B [Cleaved into: Guanylate cyclase C-activating peptide 2 (Guanylate cyclase C-activating peptide II) (GCAP-II); Uroguanylin (UGN)]
Protein function Endogenous activator of intestinal guanylate cyclase. It stimulates this enzyme through the same receptor binding region as the heat-stable enterotoxins. May be a potent physiological regulator of intestinal fluid and electrolyte transport. May
PDB 1UYA , 1UYB
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF02058 Guanylin 26 → 111 Guanylin precursor Family
Tissue specificity TISSUE SPECIFICITY: Stomach and intestine.
Sequence
Sequence length 112
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways
  KEGG   Reactome
  Hormone signaling   Digestion
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