Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	29801
Gene name Gene Name - the full gene name approved by the HGNC.	ZDHHC palmitoyltransferase 8
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	ZDHHC8
Synonyms (NCBI Gene) Gene synonyms aliases	DHHC8, ZDHHCL1, ZNF378
Chromosome Chromosome number	22
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	22q11.21
Summary Summary of gene provided in NCBI Entrez Gene.	This gene encodes a four transmembrane protein that is a member of the zinc finger DHHC domain-containing protein family. The encoded protein may function as a palmitoyltransferase. Defects in this gene may be associated with a susceptibility to schizophr

Show/Hide all(153)

miRTarBase ID	miRNA	Experiments	Reference
MIRT050261	hsa-miR-25-3p	CLASH	23622248
MIRT718261	hsa-miR-3929	HITS-CLIP	19536157
MIRT718260	hsa-miR-4419b	HITS-CLIP	19536157
MIRT718259	hsa-miR-4478	HITS-CLIP	19536157
MIRT718258	hsa-miR-6890-3p	HITS-CLIP	19536157
MIRT718257	hsa-miR-1304-3p	HITS-CLIP	19536157
MIRT718256	hsa-miR-1913	HITS-CLIP	19536157
MIRT718255	hsa-miR-324-3p	HITS-CLIP	19536157
MIRT718254	hsa-miR-5699-5p	HITS-CLIP	19536157
MIRT718253	hsa-miR-4758-3p	HITS-CLIP	19536157
MIRT718252	hsa-miR-3189-5p	HITS-CLIP	19536157
MIRT300511	hsa-miR-4313	HITS-CLIP	19536157
MIRT718251	hsa-miR-296-5p	HITS-CLIP	19536157
MIRT718250	hsa-miR-6724-5p	HITS-CLIP	19536157
MIRT718249	hsa-miR-6773-5p	HITS-CLIP	19536157
MIRT529802	hsa-miR-500b-3p	PAR-CLIP	22012620
MIRT529801	hsa-miR-4690-3p	PAR-CLIP	22012620
MIRT529800	hsa-miR-5685	PAR-CLIP	22012620
MIRT529799	hsa-miR-6859-3p	PAR-CLIP	22012620
MIRT529798	hsa-miR-4786-5p	PAR-CLIP	22012620
MIRT529797	hsa-miR-769-5p	PAR-CLIP	22012620
MIRT718261	hsa-miR-3929	HITS-CLIP	19536157
MIRT718260	hsa-miR-4419b	HITS-CLIP	19536157
MIRT718259	hsa-miR-4478	HITS-CLIP	19536157
MIRT718258	hsa-miR-6890-3p	HITS-CLIP	19536157
MIRT718257	hsa-miR-1304-3p	HITS-CLIP	19536157
MIRT718256	hsa-miR-1913	HITS-CLIP	19536157
MIRT718255	hsa-miR-324-3p	HITS-CLIP	19536157
MIRT718254	hsa-miR-5699-5p	HITS-CLIP	19536157
MIRT718253	hsa-miR-4758-3p	HITS-CLIP	19536157
MIRT718252	hsa-miR-3189-5p	HITS-CLIP	19536157
MIRT300511	hsa-miR-4313	HITS-CLIP	19536157
MIRT718251	hsa-miR-296-5p	HITS-CLIP	19536157
MIRT718250	hsa-miR-6724-5p	HITS-CLIP	19536157
MIRT718249	hsa-miR-6773-5p	HITS-CLIP	19536157
MIRT529802	hsa-miR-500b-3p	PAR-CLIP	22012620
MIRT529801	hsa-miR-4690-3p	PAR-CLIP	22012620
MIRT529800	hsa-miR-5685	PAR-CLIP	22012620
MIRT529799	hsa-miR-6859-3p	PAR-CLIP	22012620
MIRT529798	hsa-miR-4786-5p	PAR-CLIP	22012620
MIRT529797	hsa-miR-769-5p	PAR-CLIP	22012620
MIRT1509043	hsa-miR-1206	CLIP-seq
MIRT1509044	hsa-miR-1225-5p	CLIP-seq
MIRT1509045	hsa-miR-124	CLIP-seq
MIRT1509046	hsa-miR-1285	CLIP-seq
MIRT1509047	hsa-miR-1321	CLIP-seq
MIRT1509048	hsa-miR-3132	CLIP-seq
MIRT1509049	hsa-miR-3151	CLIP-seq
MIRT1509050	hsa-miR-3162-5p	CLIP-seq
MIRT1509051	hsa-miR-3187-5p	CLIP-seq
MIRT1509052	hsa-miR-3607-5p	CLIP-seq
MIRT1509053	hsa-miR-3714	CLIP-seq
MIRT1509054	hsa-miR-3910	CLIP-seq
MIRT1509055	hsa-miR-3937	CLIP-seq
MIRT1509056	hsa-miR-4271	CLIP-seq
MIRT1509057	hsa-miR-4323	CLIP-seq
MIRT1509058	hsa-miR-4456	CLIP-seq
MIRT1509059	hsa-miR-4487	CLIP-seq
MIRT1509060	hsa-miR-4505	CLIP-seq
MIRT1509061	hsa-miR-4670-3p	CLIP-seq
MIRT1509062	hsa-miR-4725-3p	CLIP-seq
MIRT1509063	hsa-miR-4739	CLIP-seq
MIRT1509064	hsa-miR-4747-5p	CLIP-seq
MIRT1509065	hsa-miR-4756-5p	CLIP-seq
MIRT1509066	hsa-miR-485-5p	CLIP-seq
MIRT1509067	hsa-miR-506	CLIP-seq
MIRT1509068	hsa-miR-592	CLIP-seq
MIRT1509069	hsa-miR-597	CLIP-seq
MIRT1509070	hsa-miR-612	CLIP-seq
MIRT1509071	hsa-miR-665	CLIP-seq
MIRT1509072	hsa-miR-125a-5p	CLIP-seq
MIRT1509073	hsa-miR-125b	CLIP-seq
MIRT1509074	hsa-miR-1262	CLIP-seq
MIRT1509075	hsa-miR-342-5p	CLIP-seq
MIRT1509076	hsa-miR-365	CLIP-seq
MIRT1509077	hsa-miR-3914	CLIP-seq
MIRT1509078	hsa-miR-3915	CLIP-seq
MIRT1509079	hsa-miR-3928	CLIP-seq
MIRT1509080	hsa-miR-4319	CLIP-seq
MIRT1509081	hsa-miR-4651	CLIP-seq
MIRT1509082	hsa-miR-4664-5p	CLIP-seq
MIRT1509083	hsa-miR-4667-5p	CLIP-seq
MIRT1509084	hsa-miR-4700-5p	CLIP-seq
MIRT1509085	hsa-miR-4701-3p	CLIP-seq
MIRT1509086	hsa-miR-4731-5p	CLIP-seq
MIRT1509087	hsa-miR-4749-3p	CLIP-seq
MIRT1509088	hsa-miR-544b	CLIP-seq
MIRT1509089	hsa-miR-608	CLIP-seq
MIRT1509090	hsa-miR-637	CLIP-seq
MIRT2153302	hsa-miR-1245b-3p	CLIP-seq
MIRT2153303	hsa-miR-1260	CLIP-seq
MIRT2153304	hsa-miR-1260b	CLIP-seq
MIRT2153305	hsa-miR-1291	CLIP-seq
MIRT2153306	hsa-miR-1324	CLIP-seq
MIRT2153307	hsa-miR-188-3p	CLIP-seq
MIRT2153308	hsa-miR-1912	CLIP-seq
MIRT2153309	hsa-miR-1972	CLIP-seq
MIRT2153310	hsa-miR-199a-5p	CLIP-seq
MIRT2153311	hsa-miR-199b-5p	CLIP-seq
MIRT2153312	hsa-miR-218	CLIP-seq
MIRT2153313	hsa-miR-2278	CLIP-seq
MIRT2153314	hsa-miR-2355-5p	CLIP-seq
MIRT2153315	hsa-miR-3064-5p	CLIP-seq
MIRT2153316	hsa-miR-3156-3p	CLIP-seq
MIRT2153317	hsa-miR-3160-5p	CLIP-seq
MIRT2153318	hsa-miR-3202	CLIP-seq
MIRT2153319	hsa-miR-34a	CLIP-seq
MIRT2153320	hsa-miR-34c-5p	CLIP-seq
MIRT1509052	hsa-miR-3607-5p	CLIP-seq
MIRT2153321	hsa-miR-3612	CLIP-seq
MIRT2153322	hsa-miR-3622b-5p	CLIP-seq
MIRT2153323	hsa-miR-3652	CLIP-seq
MIRT2153324	hsa-miR-4260	CLIP-seq
MIRT1509056	hsa-miR-4271	CLIP-seq
MIRT2153325	hsa-miR-4302	CLIP-seq
MIRT2153326	hsa-miR-4430	CLIP-seq
MIRT2153327	hsa-miR-4436b-3p	CLIP-seq
MIRT2153328	hsa-miR-4443	CLIP-seq
MIRT2153329	hsa-miR-4462	CLIP-seq
MIRT2153330	hsa-miR-4479	CLIP-seq
MIRT2153331	hsa-miR-449a	CLIP-seq
MIRT2153332	hsa-miR-449b	CLIP-seq
MIRT1509060	hsa-miR-4505	CLIP-seq
MIRT2153333	hsa-miR-4508	CLIP-seq
MIRT2153334	hsa-miR-4514	CLIP-seq
MIRT2153335	hsa-miR-4634	CLIP-seq
MIRT2153336	hsa-miR-4643	CLIP-seq
MIRT1509083	hsa-miR-4667-5p	CLIP-seq
MIRT2153337	hsa-miR-4692	CLIP-seq
MIRT1509084	hsa-miR-4700-5p	CLIP-seq
MIRT2153338	hsa-miR-4717-3p	CLIP-seq
MIRT1509062	hsa-miR-4725-3p	CLIP-seq
MIRT1509086	hsa-miR-4731-5p	CLIP-seq
MIRT1509064	hsa-miR-4747-5p	CLIP-seq
MIRT2153339	hsa-miR-4754	CLIP-seq
MIRT2153340	hsa-miR-4755-3p	CLIP-seq
MIRT2153341	hsa-miR-4802-3p	CLIP-seq
MIRT1509066	hsa-miR-485-5p	CLIP-seq
MIRT2153342	hsa-miR-486-3p	CLIP-seq
MIRT1509068	hsa-miR-592	CLIP-seq
MIRT1509069	hsa-miR-597	CLIP-seq
MIRT2153343	hsa-miR-602	CLIP-seq
MIRT2153344	hsa-miR-604	CLIP-seq
MIRT2153345	hsa-miR-636	CLIP-seq
MIRT2153346	hsa-miR-642b	CLIP-seq
MIRT2153347	hsa-miR-648	CLIP-seq
MIRT2153348	hsa-miR-650	CLIP-seq
MIRT2153349	hsa-miR-662	CLIP-seq
MIRT2373619	hsa-miR-711	CLIP-seq
MIRT2153329	hsa-miR-4462	CLIP-seq
MIRT2153346	hsa-miR-642b	CLIP-seq
MIRT2153308	hsa-miR-1912	CLIP-seq
MIRT2153308	hsa-miR-1912	CLIP-seq

Show/Hide all(27)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000139	Component	Golgi membrane	IEA
GO:0000139	Component	Golgi membrane	TAS
GO:0005739	Component	Mitochondrion	IEA
GO:0005794	Component	Golgi apparatus	IBA
GO:0005794	Component	Golgi apparatus	IDA	16647879
GO:0005794	Component	Golgi apparatus	IEA
GO:0005829	Component	Cytosol	TAS
GO:0007626	Process	Locomotory behavior	IEA
GO:0010875	Process	Positive regulation of cholesterol efflux	IBA
GO:0010875	Process	Positive regulation of cholesterol efflux	IDA	19556522
GO:0016020	Component	Membrane	IEA
GO:0016409	Function	Palmitoyltransferase activity	IBA
GO:0016409	Function	Palmitoyltransferase activity	IDA	23034182
GO:0016409	Function	Palmitoyltransferase activity	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0016746	Function	Acyltransferase activity	IEA
GO:0018230	Process	Peptidyl-L-cysteine S-palmitoylation	IDA	19556522
GO:0019706	Function	Protein-cysteine S-palmitoyltransferase activity	IC	19556522
GO:0019706	Function	Protein-cysteine S-palmitoyltransferase activity	IEA
GO:0019706	Function	Protein-cysteine S-palmitoyltransferase activity	TAS
GO:0031966	Component	Mitochondrial membrane	IEA
GO:0034380	Process	High-density lipoprotein particle assembly	TAS
GO:0044794	Process	Host-mediated activation of viral process	IDA	34599882
GO:0098794	Component	Postsynapse	IEA
GO:0098978	Component	Glutamatergic synapse	IEA
GO:0150052	Process	Regulation of postsynapse assembly	IEA
GO:1903078	Process	Positive regulation of protein localization to plasma membrane	IC	19556522

MIM	HGNC	e!Ensembl
608784	18474	ENSG00000099904

Protein

UniProt ID

Q9ULC8

Protein name

Palmitoyltransferase ZDHHC8 (EC 2.3.1.225) (Zinc finger DHHC domain-containing protein 8) (DHHC-8) (Zinc finger protein 378)

Protein function

Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates and therefore functions in several unrelated biological processes (Probable). Through the palmitoylation of ABCA1 regulates the localization of the tra

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01529	DHHC	99 → 224	DHHC palmitoyltransferase	Family

Tissue specificity

TISSUE SPECIFICITY: Widely expressed. {ECO:0000269|PubMed:16647879}.

Sequence

MPRSPGTRLKPAKYIPVATAAALLVGSSTLFFVFTCPWLTRAVSPAVPVYNGIIFLFVLA
NFSMATFMDPGVFPRADEDEDKEDDFRAPLYKNVDVRGIQVRMKWCATCHFYRPPRCSHC
SVCDNCVEDFDHHCPWVNNCIGRRNYRYFFLFLLSLSAHMVGVVAFGLVYVLNHAEGLGA
AHTTITMAVMCVAGLFFIPVIGLTGFHVVLVTRGRTTNEQVTGKFRGGVNPFTRGCCGNV
EHVLCSPLAPRYVVEPPRLPLAVSLKPPFLRPELLDRAAPLKVKLSDNGLKAGLGRSKSK
GSLDRLDEKPLDLGPPLPPKIEAGTFSSDLQTPRPGSAESALSVQRTSPPTPAMYKFRPA
FPTGPKVPFCGPGEQVPGPDSLTLGDDSIRSLDFVSEPSLDLPDYGPGGLHAAYPPSPPL
SASDAFSGALRSLSLKASSRRGGDHVALQPLRSEGGPPTPHRSIFAPHALPNRNGSLSYD
SLLNPGSPGGHACPAHPAVGVAGYHSPYLHPGATGDPPRPLPRSFSPVLGPRPREPSPVR
YDNLSRTIMASIQERKDREERERLLRSQADSLFGDSGVYDAPSSYSLQQASVLSEGPRGP
ALRYGSRDDLVAGPGFGGARNPALQTSLSSLSSSVSRAPRTSSSSLQADQASSNAPGPRP
SSGSHRSPARQGLPSPPGTPHSPSYAGPKAVAFIHTDLPEPPPSLTVQRDHPQLKTPPSK
LNGQSPGLARLGPATGPPGPSASPTRHTLVKKVSGVGGTTYEISV

Sequence length

765

Interactions

View interactions

	Reactome
			HDL assembly

Show/Hide Unknown Diseases (1)

Disease merge term	Disease name	Evidence	References	Source
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Schizophrenia	Schizophrenia	N/A	N/A	GWAS

Show/Hide Text Mining Associations (2)

Disease Name	Relationship Type	References
Associations from Text Mining Disease associations identified through Pubtator
Breast Neoplasms	Associate	35919504
DiGeorge Syndrome	Associate	22763378, 26221035

ZDHHC8 (zDHHC palmitoyltransferase 8)