Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways
Entrez ID	29780
Gene name	Parvin beta
Gene symbol	PARVB
Synonyms (NCBI Gene)	CGI-56
Chromosome	22
Chromosome location	22q13.31
Summary	This gene encodes a member of the parvin family of actin-binding proteins, which play a role in cytoskeleton organization and cell adhesion. These proteins are associated with focal contacts and contain calponin homology domains that bind to actin filamen

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miRTarBase ID	miRNA	Experiments	Reference
MIRT032339	hsa-let-7b-5p	Proteomics	18668040
MIRT725264	hsa-miR-6893-3p	HITS-CLIP	19536157
MIRT725263	hsa-miR-370-3p	HITS-CLIP	19536157
MIRT725262	hsa-miR-1306-5p	HITS-CLIP	19536157
MIRT725261	hsa-miR-6884-3p	HITS-CLIP	19536157
MIRT725260	hsa-miR-3692-5p	HITS-CLIP	19536157
MIRT725259	hsa-miR-204-3p	HITS-CLIP	19536157
MIRT725258	hsa-miR-4646-5p	HITS-CLIP	19536157
MIRT725257	hsa-miR-4731-5p	HITS-CLIP	19536157
MIRT725256	hsa-miR-5589-5p	HITS-CLIP	19536157
MIRT725255	hsa-miR-4668-5p	HITS-CLIP	19536157
MIRT725253	hsa-miR-3153	HITS-CLIP	19536157
MIRT725254	hsa-miR-6733-5p	HITS-CLIP	19536157
MIRT725252	hsa-miR-6739-5p	HITS-CLIP	19536157
MIRT535485	hsa-miR-3664-5p	HITS-CLIP	21572407
MIRT535483	hsa-miR-4639-3p	HITS-CLIP	21572407
MIRT535482	hsa-miR-3155a	HITS-CLIP	21572407
MIRT535481	hsa-miR-3155b	HITS-CLIP	21572407
MIRT535480	hsa-miR-484	HITS-CLIP	21572407
MIRT535479	hsa-miR-5693	HITS-CLIP	21572407
MIRT535477	hsa-miR-1267	HITS-CLIP	21572407
MIRT535476	hsa-miR-367-5p	HITS-CLIP	21572407
MIRT535475	hsa-miR-6499-3p	HITS-CLIP	21572407
MIRT535474	hsa-miR-3934-3p	HITS-CLIP	21572407
MIRT535473	hsa-miR-3135b	HITS-CLIP	21572407
MIRT535472	hsa-miR-504-3p	HITS-CLIP	21572407
MIRT535471	hsa-miR-122-5p	HITS-CLIP	21572407
MIRT535470	hsa-miR-3622b-5p	HITS-CLIP	21572407
MIRT535469	hsa-miR-3652	HITS-CLIP	21572407
MIRT535468	hsa-miR-4430	HITS-CLIP	21572407
MIRT535467	hsa-miR-143-5p	HITS-CLIP	21572407
MIRT535466	hsa-miR-6794-3p	HITS-CLIP	21572407
MIRT535465	hsa-miR-1178-3p	HITS-CLIP	21572407
MIRT535464	hsa-miR-5698	HITS-CLIP	21572407
MIRT627868	hsa-miR-548c-3p	HITS-CLIP	23824327
MIRT627867	hsa-miR-501-5p	HITS-CLIP	23824327
MIRT627866	hsa-miR-3121-5p	HITS-CLIP	23824327
MIRT535473	hsa-miR-3135b	HITS-CLIP	23824327
MIRT627865	hsa-miR-1287-5p	HITS-CLIP	23824327
MIRT627868	hsa-miR-548c-3p	HITS-CLIP	23824327
MIRT627867	hsa-miR-501-5p	HITS-CLIP	23824327
MIRT627866	hsa-miR-3121-5p	HITS-CLIP	23824327
MIRT535473	hsa-miR-3135b	HITS-CLIP	23824327
MIRT627865	hsa-miR-1287-5p	HITS-CLIP	23824327
MIRT627868	hsa-miR-548c-3p	HITS-CLIP	23824327
MIRT627867	hsa-miR-501-5p	HITS-CLIP	23824327
MIRT627866	hsa-miR-3121-5p	HITS-CLIP	23824327
MIRT535473	hsa-miR-3135b	HITS-CLIP	23824327
MIRT627865	hsa-miR-1287-5p	HITS-CLIP	23824327
MIRT627868	hsa-miR-548c-3p	HITS-CLIP	23824327
MIRT627867	hsa-miR-501-5p	HITS-CLIP	23824327
MIRT627866	hsa-miR-3121-5p	HITS-CLIP	23824327
MIRT535473	hsa-miR-3135b	HITS-CLIP	23824327
MIRT627865	hsa-miR-1287-5p	HITS-CLIP	23824327
MIRT535488	hsa-miR-6729-3p	PAR-CLIP	22012620
MIRT535487	hsa-miR-2355-5p	PAR-CLIP	22012620
MIRT535486	hsa-miR-4797-5p	PAR-CLIP	22012620
MIRT535485	hsa-miR-3664-5p	PAR-CLIP	22012620
MIRT535484	hsa-miR-5007-5p	PAR-CLIP	22012620
MIRT535483	hsa-miR-4639-3p	PAR-CLIP	22012620
MIRT535482	hsa-miR-3155a	PAR-CLIP	22012620
MIRT535481	hsa-miR-3155b	PAR-CLIP	22012620
MIRT535480	hsa-miR-484	PAR-CLIP	22012620
MIRT535479	hsa-miR-5693	PAR-CLIP	22012620
MIRT535478	hsa-miR-1304-3p	PAR-CLIP	22012620
MIRT535477	hsa-miR-1267	PAR-CLIP	22012620
MIRT535476	hsa-miR-367-5p	PAR-CLIP	22012620
MIRT535475	hsa-miR-6499-3p	PAR-CLIP	22012620
MIRT535474	hsa-miR-3934-3p	PAR-CLIP	22012620
MIRT535473	hsa-miR-3135b	PAR-CLIP	22012620
MIRT535472	hsa-miR-504-3p	PAR-CLIP	22012620
MIRT535471	hsa-miR-122-5p	PAR-CLIP	22012620
MIRT535470	hsa-miR-3622b-5p	PAR-CLIP	22012620
MIRT535469	hsa-miR-3652	PAR-CLIP	22012620
MIRT535468	hsa-miR-4430	PAR-CLIP	22012620
MIRT535467	hsa-miR-143-5p	PAR-CLIP	22012620
MIRT535466	hsa-miR-6794-3p	PAR-CLIP	22012620
MIRT535465	hsa-miR-1178-3p	PAR-CLIP	22012620
MIRT535464	hsa-miR-5698	PAR-CLIP	22012620
MIRT496417	hsa-miR-3929	PAR-CLIP	22291592
MIRT496416	hsa-miR-4419b	PAR-CLIP	22291592
MIRT496415	hsa-miR-4478	PAR-CLIP	22291592
MIRT496414	hsa-miR-3613-3p	PAR-CLIP	22291592
MIRT496413	hsa-miR-371b-5p	PAR-CLIP	22291592
MIRT496412	hsa-miR-373-5p	PAR-CLIP	22291592
MIRT496411	hsa-miR-616-5p	PAR-CLIP	22291592
MIRT496410	hsa-miR-1285-3p	PAR-CLIP	22291592
MIRT496409	hsa-miR-3187-5p	PAR-CLIP	22291592
MIRT496408	hsa-miR-5189-5p	PAR-CLIP	22291592
MIRT496407	hsa-miR-612	PAR-CLIP	22291592
MIRT496406	hsa-miR-6860	PAR-CLIP	22291592
MIRT496405	hsa-miR-4505	PAR-CLIP	22291592
MIRT496404	hsa-miR-5787	PAR-CLIP	22291592
MIRT627868	hsa-miR-548c-3p	PAR-CLIP	27292025
MIRT725264	hsa-miR-6893-3p	HITS-CLIP	19536157
MIRT725263	hsa-miR-370-3p	HITS-CLIP	19536157
MIRT725262	hsa-miR-1306-5p	HITS-CLIP	19536157
MIRT725261	hsa-miR-6884-3p	HITS-CLIP	19536157
MIRT725260	hsa-miR-3692-5p	HITS-CLIP	19536157
MIRT725259	hsa-miR-204-3p	HITS-CLIP	19536157
MIRT725258	hsa-miR-4646-5p	HITS-CLIP	19536157
MIRT725257	hsa-miR-4731-5p	HITS-CLIP	19536157
MIRT725256	hsa-miR-5589-5p	HITS-CLIP	19536157
MIRT725255	hsa-miR-4668-5p	HITS-CLIP	19536157
MIRT725253	hsa-miR-3153	HITS-CLIP	19536157
MIRT725254	hsa-miR-6733-5p	HITS-CLIP	19536157
MIRT725252	hsa-miR-6739-5p	HITS-CLIP	19536157
MIRT535485	hsa-miR-3664-5p	HITS-CLIP	21572407
MIRT535483	hsa-miR-4639-3p	HITS-CLIP	21572407
MIRT535482	hsa-miR-3155a	HITS-CLIP	21572407
MIRT535481	hsa-miR-3155b	HITS-CLIP	21572407
MIRT535480	hsa-miR-484	HITS-CLIP	21572407
MIRT535479	hsa-miR-5693	HITS-CLIP	21572407
MIRT535477	hsa-miR-1267	HITS-CLIP	21572407
MIRT535476	hsa-miR-367-5p	HITS-CLIP	21572407
MIRT535475	hsa-miR-6499-3p	HITS-CLIP	21572407
MIRT535474	hsa-miR-3934-3p	HITS-CLIP	21572407
MIRT535473	hsa-miR-3135b	HITS-CLIP	21572407
MIRT535472	hsa-miR-504-3p	HITS-CLIP	21572407
MIRT535471	hsa-miR-122-5p	HITS-CLIP	21572407
MIRT535470	hsa-miR-3622b-5p	HITS-CLIP	21572407
MIRT535469	hsa-miR-3652	HITS-CLIP	21572407
MIRT535468	hsa-miR-4430	HITS-CLIP	21572407
MIRT535467	hsa-miR-143-5p	HITS-CLIP	21572407
MIRT535466	hsa-miR-6794-3p	HITS-CLIP	21572407
MIRT535465	hsa-miR-1178-3p	HITS-CLIP	21572407
MIRT535464	hsa-miR-5698	HITS-CLIP	21572407
MIRT627868	hsa-miR-548c-3p	HITS-CLIP	23824327
MIRT627867	hsa-miR-501-5p	HITS-CLIP	23824327
MIRT627866	hsa-miR-3121-5p	HITS-CLIP	23824327
MIRT535473	hsa-miR-3135b	HITS-CLIP	23824327
MIRT627865	hsa-miR-1287-5p	HITS-CLIP	23824327
MIRT627868	hsa-miR-548c-3p	HITS-CLIP	23824327
MIRT627867	hsa-miR-501-5p	HITS-CLIP	23824327
MIRT627866	hsa-miR-3121-5p	HITS-CLIP	23824327
MIRT535473	hsa-miR-3135b	HITS-CLIP	23824327
MIRT627865	hsa-miR-1287-5p	HITS-CLIP	23824327
MIRT627868	hsa-miR-548c-3p	HITS-CLIP	23824327
MIRT627867	hsa-miR-501-5p	HITS-CLIP	23824327
MIRT627866	hsa-miR-3121-5p	HITS-CLIP	23824327
MIRT535473	hsa-miR-3135b	HITS-CLIP	23824327
MIRT627865	hsa-miR-1287-5p	HITS-CLIP	23824327
MIRT627868	hsa-miR-548c-3p	HITS-CLIP	23824327
MIRT627867	hsa-miR-501-5p	HITS-CLIP	23824327
MIRT627866	hsa-miR-3121-5p	HITS-CLIP	23824327
MIRT535473	hsa-miR-3135b	HITS-CLIP	23824327
MIRT627865	hsa-miR-1287-5p	HITS-CLIP	23824327
MIRT535488	hsa-miR-6729-3p	PAR-CLIP	22012620
MIRT535487	hsa-miR-2355-5p	PAR-CLIP	22012620
MIRT535486	hsa-miR-4797-5p	PAR-CLIP	22012620
MIRT535485	hsa-miR-3664-5p	PAR-CLIP	22012620
MIRT535484	hsa-miR-5007-5p	PAR-CLIP	22012620
MIRT535483	hsa-miR-4639-3p	PAR-CLIP	22012620
MIRT535482	hsa-miR-3155a	PAR-CLIP	22012620
MIRT535481	hsa-miR-3155b	PAR-CLIP	22012620
MIRT535480	hsa-miR-484	PAR-CLIP	22012620
MIRT535479	hsa-miR-5693	PAR-CLIP	22012620
MIRT535478	hsa-miR-1304-3p	PAR-CLIP	22012620
MIRT535477	hsa-miR-1267	PAR-CLIP	22012620
MIRT535476	hsa-miR-367-5p	PAR-CLIP	22012620
MIRT535475	hsa-miR-6499-3p	PAR-CLIP	22012620
MIRT535474	hsa-miR-3934-3p	PAR-CLIP	22012620
MIRT535473	hsa-miR-3135b	PAR-CLIP	22012620
MIRT535472	hsa-miR-504-3p	PAR-CLIP	22012620
MIRT535471	hsa-miR-122-5p	PAR-CLIP	22012620
MIRT535470	hsa-miR-3622b-5p	PAR-CLIP	22012620
MIRT535469	hsa-miR-3652	PAR-CLIP	22012620
MIRT535468	hsa-miR-4430	PAR-CLIP	22012620
MIRT535467	hsa-miR-143-5p	PAR-CLIP	22012620
MIRT535466	hsa-miR-6794-3p	PAR-CLIP	22012620
MIRT535465	hsa-miR-1178-3p	PAR-CLIP	22012620
MIRT535464	hsa-miR-5698	PAR-CLIP	22012620
MIRT496417	hsa-miR-3929	PAR-CLIP	22291592
MIRT496416	hsa-miR-4419b	PAR-CLIP	22291592
MIRT496415	hsa-miR-4478	PAR-CLIP	22291592
MIRT496414	hsa-miR-3613-3p	PAR-CLIP	22291592
MIRT496413	hsa-miR-371b-5p	PAR-CLIP	22291592
MIRT496412	hsa-miR-373-5p	PAR-CLIP	22291592
MIRT496411	hsa-miR-616-5p	PAR-CLIP	22291592
MIRT496410	hsa-miR-1285-3p	PAR-CLIP	22291592
MIRT496409	hsa-miR-3187-5p	PAR-CLIP	22291592
MIRT496408	hsa-miR-5189-5p	PAR-CLIP	22291592
MIRT496407	hsa-miR-612	PAR-CLIP	22291592
MIRT496406	hsa-miR-6860	PAR-CLIP	22291592
MIRT496405	hsa-miR-4505	PAR-CLIP	22291592
MIRT496404	hsa-miR-5787	PAR-CLIP	22291592
MIRT1214908	hsa-let-7a	CLIP-seq
MIRT1214909	hsa-let-7b	CLIP-seq
MIRT1214910	hsa-let-7c	CLIP-seq
MIRT1214911	hsa-let-7d	CLIP-seq
MIRT1214912	hsa-let-7e	CLIP-seq
MIRT1214913	hsa-let-7f	CLIP-seq
MIRT1214914	hsa-let-7g	CLIP-seq
MIRT1214915	hsa-let-7i	CLIP-seq
MIRT1214916	hsa-miR-1294	CLIP-seq
MIRT1214917	hsa-miR-1302	CLIP-seq
MIRT1214918	hsa-miR-202	CLIP-seq
MIRT1214919	hsa-miR-3074-5p	CLIP-seq
MIRT1214920	hsa-miR-3151	CLIP-seq
MIRT1214921	hsa-miR-3160-3p	CLIP-seq
MIRT1214922	hsa-miR-342-5p	CLIP-seq
MIRT1214923	hsa-miR-370	CLIP-seq
MIRT1214924	hsa-miR-4298	CLIP-seq
MIRT1214925	hsa-miR-4450	CLIP-seq
MIRT1214926	hsa-miR-4458	CLIP-seq
MIRT1214927	hsa-miR-4487	CLIP-seq
MIRT1214928	hsa-miR-4500	CLIP-seq
MIRT1214929	hsa-miR-4645-3p	CLIP-seq
MIRT1214930	hsa-miR-4651	CLIP-seq
MIRT1214931	hsa-miR-4663	CLIP-seq
MIRT1214932	hsa-miR-4664-5p	CLIP-seq
MIRT1214933	hsa-miR-483-3p	CLIP-seq
MIRT1214934	hsa-miR-486-3p	CLIP-seq
MIRT1214935	hsa-miR-491-5p	CLIP-seq
MIRT1214936	hsa-miR-505	CLIP-seq
MIRT1214937	hsa-miR-558	CLIP-seq
MIRT1214938	hsa-miR-578	CLIP-seq
MIRT1214939	hsa-miR-608	CLIP-seq
MIRT1214940	hsa-miR-98	CLIP-seq
MIRT1214919	hsa-miR-3074-5p	CLIP-seq
MIRT1214921	hsa-miR-3160-3p	CLIP-seq
MIRT1214923	hsa-miR-370	CLIP-seq
MIRT1214927	hsa-miR-4487	CLIP-seq
MIRT1214931	hsa-miR-4663	CLIP-seq
MIRT1214937	hsa-miR-558	CLIP-seq
MIRT1214919	hsa-miR-3074-5p	CLIP-seq
MIRT1214921	hsa-miR-3160-3p	CLIP-seq
MIRT2290251	hsa-miR-3188	CLIP-seq
MIRT1214922	hsa-miR-342-5p	CLIP-seq
MIRT1214923	hsa-miR-370	CLIP-seq
MIRT1214925	hsa-miR-4450	CLIP-seq
MIRT1214927	hsa-miR-4487	CLIP-seq
MIRT1214930	hsa-miR-4651	CLIP-seq
MIRT1214931	hsa-miR-4663	CLIP-seq
MIRT1214932	hsa-miR-4664-5p	CLIP-seq
MIRT2290252	hsa-miR-4765	CLIP-seq
MIRT1214935	hsa-miR-491-5p	CLIP-seq
MIRT1214937	hsa-miR-558	CLIP-seq
MIRT1214939	hsa-miR-608	CLIP-seq
MIRT2290252	hsa-miR-4765	CLIP-seq
MIRT1214919	hsa-miR-3074-5p	CLIP-seq
MIRT1214921	hsa-miR-3160-3p	CLIP-seq
MIRT1214923	hsa-miR-370	CLIP-seq
MIRT1214927	hsa-miR-4487	CLIP-seq
MIRT1214931	hsa-miR-4663	CLIP-seq
MIRT1214937	hsa-miR-558	CLIP-seq
MIRT2588480	hsa-miR-1305	CLIP-seq
MIRT2588481	hsa-miR-607	CLIP-seq

Show/Hide all (33)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003779	Function	Actin binding	IBA
GO:0003779	Function	Actin binding	IEA
GO:0005515	Function	Protein binding	IPI	18325335
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	TAS
GO:0005856	Component	Cytoskeleton	IEA
GO:0005886	Component	Plasma membrane	IDA
GO:0005886	Component	Plasma membrane	IEA
GO:0005925	Component	Focal adhesion	IBA
GO:0005925	Component	Focal adhesion	IDA	22869380
GO:0005925	Component	Focal adhesion	IEA
GO:0007155	Process	Cell adhesion	IEA
GO:0015629	Component	Actin cytoskeleton	IBA
GO:0015629	Component	Actin cytoskeleton	IDA
GO:0016020	Component	Membrane	IEA
GO:0030017	Component	Sarcomere	IEA
GO:0030018	Component	Z disc	IEA
GO:0030027	Component	Lamellipodium	IBA
GO:0030027	Component	Lamellipodium	IDA	18325335
GO:0030027	Component	Lamellipodium	IEA
GO:0030031	Process	Cell projection assembly	IMP	15005707
GO:0030032	Process	Lamellipodium assembly	IBA
GO:0030032	Process	Lamellipodium assembly	IMP	18325335
GO:0030036	Process	Actin cytoskeleton organization	IBA
GO:0030036	Process	Actin cytoskeleton organization	IEA
GO:0030036	Process	Actin cytoskeleton organization	IMP	15005707
GO:0034446	Process	Substrate adhesion-dependent cell spreading	IBA
GO:0042995	Component	Cell projection	IEA
GO:0070161	Component	Anchoring junction	IEA
GO:0071963	Process	Establishment or maintenance of cell polarity regulating cell shape	IBA
GO:0071963	Process	Establishment or maintenance of cell polarity regulating cell shape	IMP	15005707
GO:0120031	Process	Plasma membrane bounded cell projection assembly	IEA

MIM	HGNC	e!Ensembl
608121	14653	ENSG00000188677

Q9HBI1

Protein name

Beta-parvin (Affixin)

Protein function

Adapter protein that plays a role in integrin signaling via ILK and in activation of the GTPases CDC42 and RAC1 by guanine exchange factors, such as ARHGEF6. Is involved in the reorganization of the actin cytoskeleton and formation of lamellipod

PDB

4EDL , 4EDM , 4EDN

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00307	CH	87 → 195	Calponin homology (CH) domain	Domain
PF00307	CH	254 → 362	Calponin homology (CH) domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Expressed predominantly in heart and skeletal muscle. {ECO:0000269|PubMed:11402068, ECO:0000269|PubMed:11722847}.

Sequence

MSSAPRSPTPRPRRMKKDESFLGKLGGTLARKRRAREVSDLQEEGKNAINSPMSPALVDV
HPEDTQLEENEERTMIDPTSKEDPKFKELVKVLLDWINDVLVEERIIVKQLEEDLYDGQV
LQKLLEKLAGCKLNVAEVTQSEIGQKQKLQTVLEAVHDLLRPRGWALRWSVDSIHGKNLV
AILHLLVSLAMHFRAPIRLPEHVTVQVVVVRKREGLLHSSHISEELTTTTEMMMGRFERD
AFDTLFDHAPDKLSVVKKSLITFVNKHLNKLNLEVTELETQFADGVYLVLLMGLLEDYFV
PLHHFYLTPESFDQKVHNVSFAFELMLDGGLKKPKARPEDVVNLDLKSTLRVLYNLFTKY
KNVE

Sequence length

364

Interactions

View interactions

	KEGG		Reactome
	Focal adhesion		Cell-extracellular matrix interactions Regulation of cytoskeletal remodeling and cell spreading by IPP complex components

PARVB (parvin beta)