PARVB (parvin beta)
| Gene | |
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Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
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29780 |
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Gene name
Gene Name - the full gene name approved by the HGNC.
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Parvin beta |
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Gene symbol
Gene Symbol - the official gene symbol approved by the HGNC.
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PARVB |
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Synonyms (NCBI Gene)
Gene synonyms aliases
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CGI-56 |
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Chromosome
Chromosome number
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22 |
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Chromosome location
Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
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22q13.31 |
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Summary
Summary of gene provided in NCBI Entrez Gene.
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This gene encodes a member of the parvin family of actin-binding proteins, which play a role in cytoskeleton organization and cell adhesion. These proteins are associated with focal contacts and contain calponin homology domains that bind to actin filamen |
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miRNA
miRNA information provided by mirtarbase database.
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Gene ontology (GO)
Gene ontology information of associated ontologies with gene provided by GO database.
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Other IDs
Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
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| Protein | ||||||||||||||||
| UniProt ID | Q9HBI1 | |||||||||||||||
| Protein name | Beta-parvin (Affixin) | |||||||||||||||
| Protein function | Adapter protein that plays a role in integrin signaling via ILK and in activation of the GTPases CDC42 and RAC1 by guanine exchange factors, such as ARHGEF6. Is involved in the reorganization of the actin cytoskeleton and formation of lamellipod | |||||||||||||||
| PDB | 4EDL , 4EDM , 4EDN | |||||||||||||||
| Family and domains |
Pfam
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| Tissue specificity | TISSUE SPECIFICITY: Expressed predominantly in heart and skeletal muscle. {ECO:0000269|PubMed:11402068, ECO:0000269|PubMed:11722847}. | |||||||||||||||
| Sequence |
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| Sequence length | 364 | |||||||||||||||
| Interactions | View interactions | |||||||||||||||
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Pathways
Pathway information has different metabolic/signaling pathways associated with genes.
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Associated diseases
Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
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