Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene SNPs miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	29775
Gene name	Caspase recruitment domain family member 10
Gene symbol	CARD10
Synonyms (NCBI Gene)	BIMP1CARMA3IMD89
Chromosome	22
Chromosome location	22q13.1
Summary	The caspase recruitment domain (CARD) is a protein module that consists of 6 or 7 antiparallel alpha helices. It participates in apoptosis signaling through highly specific protein-protein homophilic interactions. Like several other CARD proteins, CARD10

Show/Hide all (5)

SNP ID	Visualize variation	Clinical significance	Consequence
rs139006752	G>A	Risk-factor	Coding sequence variant, missense variant
rs200148764	C>T	Risk-factor	Coding sequence variant, missense variant
rs201794655	G>A	Risk-factor	Coding sequence variant, missense variant
rs750643216	G>A	Risk-factor	Coding sequence variant, missense variant
rs1057519378	C>A,T	Risk-factor	Coding sequence variant, missense variant

132

Show/Hide all (132)

miRTarBase ID	miRNA	Experiments	Reference
MIRT020696	hsa-miR-155-5p	Other	20584899
MIRT027101	hsa-miR-103a-3p	Sequencing	20371350
MIRT030440	hsa-miR-24-3p	Microarray	19748357
MIRT031650	hsa-miR-16-5p	Sequencing	20371350
MIRT053495	hsa-miR-146a-5p	In situ hybridizationLuciferase reporter assayqRT-PCRWestern blot	22992343
MIRT053495	hsa-miR-146a-5p	In situ hybridizationLuciferase reporter assayqRT-PCRWestern blot	22992343
MIRT053495	hsa-miR-146a-5p	Luciferase reporter assayQRTPCRWestern blot	24985472
MIRT479989	hsa-miR-424-5p	PAR-CLIP	23592263
MIRT479988	hsa-miR-15a-5p	PAR-CLIP	23592263
MIRT479987	hsa-miR-497-5p	PAR-CLIP	23592263
MIRT479986	hsa-miR-6838-5p	PAR-CLIP	23592263
MIRT479985	hsa-miR-195-5p	PAR-CLIP	23592263
MIRT031650	hsa-miR-16-5p	PAR-CLIP	23592263
MIRT479984	hsa-miR-15b-5p	PAR-CLIP	23592263
MIRT479983	hsa-miR-3664-5p	PAR-CLIP	23592263
MIRT479982	hsa-miR-2278	PAR-CLIP	23592263
MIRT479981	hsa-miR-6873-5p	PAR-CLIP	23592263
MIRT479980	hsa-miR-5697	PAR-CLIP	23592263
MIRT479979	hsa-miR-6501-3p	PAR-CLIP	23592263
MIRT479978	hsa-miR-6840-3p	PAR-CLIP	23592263
MIRT479977	hsa-miR-1247-3p	PAR-CLIP	23592263
MIRT479976	hsa-miR-4532	PAR-CLIP	23592263
MIRT479975	hsa-miR-6730-5p	PAR-CLIP	23592263
MIRT479974	hsa-miR-5008-5p	PAR-CLIP	23592263
MIRT479973	hsa-miR-4481	PAR-CLIP	23592263
MIRT479972	hsa-miR-4745-5p	PAR-CLIP	23592263
MIRT479971	hsa-miR-3175	PAR-CLIP	23592263
MIRT479970	hsa-miR-1343-5p	PAR-CLIP	23592263
MIRT479969	hsa-miR-939-5p	PAR-CLIP	23592263
MIRT479968	hsa-miR-6825-5p	PAR-CLIP	23592263
MIRT479967	hsa-miR-92a-2-5p	PAR-CLIP	23592263
MIRT479966	hsa-miR-4449	PAR-CLIP	23592263
MIRT479965	hsa-miR-491-5p	PAR-CLIP	23592263
MIRT479964	hsa-miR-3150a-3p	PAR-CLIP	23592263
MIRT479963	hsa-miR-6763-5p	PAR-CLIP	23592263
MIRT030440	hsa-miR-24-3p	Luciferase reporter assayqRT-PCRWestern blot	26252200
MIRT030440	hsa-miR-24-3p	Luciferase reporter assayqRT-PCRWestern blot	26252200
MIRT479989	hsa-miR-424-5p	PAR-CLIP	23592263
MIRT479988	hsa-miR-15a-5p	PAR-CLIP	23592263
MIRT479987	hsa-miR-497-5p	PAR-CLIP	23592263
MIRT479986	hsa-miR-6838-5p	PAR-CLIP	23592263
MIRT479985	hsa-miR-195-5p	PAR-CLIP	23592263
MIRT031650	hsa-miR-16-5p	PAR-CLIP	23592263
MIRT479984	hsa-miR-15b-5p	PAR-CLIP	23592263
MIRT479983	hsa-miR-3664-5p	PAR-CLIP	23592263
MIRT479982	hsa-miR-2278	PAR-CLIP	23592263
MIRT479981	hsa-miR-6873-5p	PAR-CLIP	23592263
MIRT479980	hsa-miR-5697	PAR-CLIP	23592263
MIRT479979	hsa-miR-6501-3p	PAR-CLIP	23592263
MIRT479978	hsa-miR-6840-3p	PAR-CLIP	23592263
MIRT479977	hsa-miR-1247-3p	PAR-CLIP	23592263
MIRT479976	hsa-miR-4532	PAR-CLIP	23592263
MIRT479975	hsa-miR-6730-5p	PAR-CLIP	23592263
MIRT479974	hsa-miR-5008-5p	PAR-CLIP	23592263
MIRT479973	hsa-miR-4481	PAR-CLIP	23592263
MIRT479972	hsa-miR-4745-5p	PAR-CLIP	23592263
MIRT479971	hsa-miR-3175	PAR-CLIP	23592263
MIRT479970	hsa-miR-1343-5p	PAR-CLIP	23592263
MIRT479969	hsa-miR-939-5p	PAR-CLIP	23592263
MIRT479968	hsa-miR-6825-5p	PAR-CLIP	23592263
MIRT479967	hsa-miR-92a-2-5p	PAR-CLIP	23592263
MIRT479966	hsa-miR-4449	PAR-CLIP	23592263
MIRT479965	hsa-miR-491-5p	PAR-CLIP	23592263
MIRT479964	hsa-miR-3150a-3p	PAR-CLIP	23592263
MIRT479963	hsa-miR-6763-5p	PAR-CLIP	23592263
MIRT862760	hsa-miR-1207-5p	CLIP-seq
MIRT862761	hsa-miR-1275	CLIP-seq
MIRT862762	hsa-miR-1301	CLIP-seq
MIRT862763	hsa-miR-155	CLIP-seq
MIRT862764	hsa-miR-1915	CLIP-seq
MIRT862765	hsa-miR-3189-3p	CLIP-seq
MIRT862766	hsa-miR-3918	CLIP-seq
MIRT862767	hsa-miR-3944-5p	CLIP-seq
MIRT862768	hsa-miR-425	CLIP-seq
MIRT862769	hsa-miR-4263	CLIP-seq
MIRT862770	hsa-miR-4436b-3p	CLIP-seq
MIRT738165	hsa-miR-455-3p	CLIP-seq
MIRT862771	hsa-miR-4640-5p	CLIP-seq
MIRT862772	hsa-miR-4660	CLIP-seq
MIRT862773	hsa-miR-4665-5p	CLIP-seq
MIRT862774	hsa-miR-4685-5p	CLIP-seq
MIRT862775	hsa-miR-4726-5p	CLIP-seq
MIRT862776	hsa-miR-4763-3p	CLIP-seq
MIRT862777	hsa-miR-5047	CLIP-seq
MIRT862778	hsa-miR-548t	CLIP-seq
MIRT862779	hsa-miR-885-3p	CLIP-seq
MIRT738165	hsa-miR-455-3p	CLIP-seq
MIRT738165	hsa-miR-455-3p	CLIP-seq
MIRT738165	hsa-miR-455-3p	CLIP-seq
MIRT738165	hsa-miR-455-3p	CLIP-seq
MIRT862760	hsa-miR-1207-5p	CLIP-seq
MIRT2193468	hsa-miR-125a-3p	CLIP-seq
MIRT2193469	hsa-miR-146a	CLIP-seq
MIRT2193470	hsa-miR-146b-5p	CLIP-seq
MIRT738165	hsa-miR-455-3p	CLIP-seq
MIRT862771	hsa-miR-4640-5p	CLIP-seq
MIRT2193471	hsa-miR-4649-5p	CLIP-seq
MIRT862774	hsa-miR-4685-5p	CLIP-seq
MIRT862775	hsa-miR-4726-5p	CLIP-seq
MIRT862776	hsa-miR-4763-3p	CLIP-seq
MIRT2193472	hsa-miR-4773	CLIP-seq
MIRT2193473	hsa-miR-508-5p	CLIP-seq
MIRT2193474	hsa-miR-552	CLIP-seq
MIRT2193475	hsa-miR-589	CLIP-seq
MIRT2193476	hsa-miR-591	CLIP-seq
MIRT738165	hsa-miR-455-3p	CLIP-seq
MIRT738165	hsa-miR-455-3p	CLIP-seq
MIRT2446155	hsa-miR-1	CLIP-seq
MIRT2446156	hsa-miR-206	CLIP-seq
MIRT2446157	hsa-miR-4301	CLIP-seq
MIRT2446158	hsa-miR-4491	CLIP-seq
MIRT2446159	hsa-miR-4657	CLIP-seq
MIRT2446160	hsa-miR-4727-3p	CLIP-seq
MIRT2446161	hsa-miR-613	CLIP-seq
MIRT2496631	hsa-miR-1294	CLIP-seq
MIRT862764	hsa-miR-1915	CLIP-seq
MIRT2496632	hsa-miR-3150b-3p	CLIP-seq
MIRT2496633	hsa-miR-3184	CLIP-seq
MIRT2496634	hsa-miR-3607-5p	CLIP-seq
MIRT2496635	hsa-miR-423-5p	CLIP-seq
MIRT2496636	hsa-miR-4316	CLIP-seq
MIRT862770	hsa-miR-4436b-3p	CLIP-seq
MIRT738165	hsa-miR-455-3p	CLIP-seq
MIRT862774	hsa-miR-4685-5p	CLIP-seq
MIRT2496637	hsa-miR-4689	CLIP-seq
MIRT2496638	hsa-miR-4784	CLIP-seq
MIRT862779	hsa-miR-885-3p	CLIP-seq
MIRT862764	hsa-miR-1915	CLIP-seq
MIRT862770	hsa-miR-4436b-3p	CLIP-seq
MIRT738165	hsa-miR-455-3p	CLIP-seq
MIRT862774	hsa-miR-4685-5p	CLIP-seq
MIRT862779	hsa-miR-885-3p	CLIP-seq

Show/Hide all (14)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001772	Component	Immunological synapse	IBA
GO:0005515	Function	Protein binding	IPI	11259443, 32296183
GO:0005737	Component	Cytoplasm	IEA
GO:0005737	Component	Cytoplasm	NAS	11259443
GO:0007250	Process	Activation of NF-kappaB-inducing kinase activity	IDA	11259443
GO:0010604	Process	Positive regulation of macromolecule metabolic process	IEA
GO:0030159	Function	Signaling receptor complex adaptor activity	NAS	11259443
GO:0032449	Component	CBM complex	NAS	15125833
GO:0042981	Process	Regulation of apoptotic process	IEA
GO:0043123	Process	Positive regulation of canonical NF-kappaB signal transduction	IBA
GO:0050776	Process	Regulation of immune response	IBA
GO:0065003	Process	Protein-containing complex assembly	NAS	11259443
GO:0090051	Process	Negative regulation of cell migration involved in sprouting angiogenesis	IMP	24863965
GO:1900182	Process	Positive regulation of protein localization to nucleus	IMP	24863965

MIM	HGNC	e!Ensembl
607209	16422	ENSG00000100065

Q9BWT7

Protein name

Caspase recruitment domain-containing protein 10 (CARD-containing MAGUK protein 3) (Carma 3)

Protein function

Scaffold protein that plays an important role in mediating the activation of NF-kappa-B via BCL10 or EGFR.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00619	CARD	28 → 114	Caspase recruitment domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Detected in adult heart, kidney and liver; lower levels in intestine, placenta, muscle and lung. Also found in fetal lung, liver and kidney.

Sequence

MPGRAEAGEAEEEAGAGSGSEAEEDALWERIEGVRHRLARALNPAKLTPYLRQCRVIDEQ
DEEEVLSTYRFPCRVNRTGRLMDILRCRGKRGYEAFLEALEFYYPEHFTLLTGQEPAQRC
SMILDEEGPEGLTQFLMTEVRRLREARKSQLQREQQLQARGRVLEEERAGLEQRLRDQQQ
AQERCQRLREDWEAGSLELLRLKDENYMIAMRLAQLSEEKNSAVLRSRDLQLAVDQLKLK
VSRLEEECALLRRARGPPPGAEEKEKEKEKEKEPDNVDLVSELRAENQRLTASLRELQEG
LQQEASRPGAPGSERILLDILEHDWREAQDSRQELCQKLHAVQGELQWAEELRDQYLQEM
EDLRLKHRTLQKDCDLYKHRMATVLAQLEEIEKERDQAIQSRDRIQLQYSQSLIEKDQYR
KQVRGLEAERDELLTTLTSLEGTKALLEVQLQRAQGGTCLKACASSHSLCSNLSSTWSLS
EFPSPLGGPEATGEAAVMGGPEPHNSEEATDSEKEINRLSILPFPPSAGSILRRQREEDP
APPKRSFSSMSDITGSVTLKPWSPGLSSSSSSDSVWPLGKPEGLLARGCGLDFLNRSLAI
RVSGRSPPGGPEPQDKGPDGLSFYGDRWSGAVVRRVLSGPGSARMEPREQRVEAAGLEGA
CLEAEAQQRTLLWNQGSTLPSLMDSKACQSFHEALEAWAKGPGAEPFYIRANLTLPERAD
PHALCVKAQEILRLVDSAYKRRQEWFCTRVDPLTLRDLDRGTVPNYQRAQQLLEVQEKCL
PSSRHRGPRSNLKKRALDQLRLVRPKPVGAPAGDSPDQLLLEPCAEPERSLRPYSLVRPL
LVSALRPVVLLPECLAPRLIRNLLDLPSSRLDFQVCPAESLSGEELCPSSAPGAPKAQPA
TPGLGSRIRAIQESVGKKHCLLELGARGVRELVQNEIYPIVIHVEVTEKNVREVRGLLGR
PGWRDSELLRQCRGSEQVLWGLPCSWVQVPAHEWGHAEELAKVVRGRILQEQARLVWVEC
GSSRGCPSSSEA

Sequence length

1032

Interactions

View interactions

	KEGG
	NF-kappa B signaling pathway

Show/Hide Causal Diseases (1)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
Immunodeficiency 89 and autoimmunity	Pathogenic	rs748488870	RCV001787025

Show/Hide Unknown Diseases (15)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
CARD10-related disorder	Uncertain significance; Benign; Likely benign	rs200553561, rs2517793087, rs9610775, rs3817806, rs145143750, rs79861380, rs61742320, rs60611523, rs141880624, rs150575230, rs374177056, rs3817803, rs151290630, rs143997223, rs377009692 View all (15 more)	RCV003923967 RCV003983331 RCV003984659 RCV003984784 RCV003916982 RCV003973840 RCV003973973 RCV003982305 RCV003909658 RCV003961692 RCV003947361 RCV003981249 RCV003927215 RCV003937032 RCV003937221 RCV003959178 RCV003954777 RCV003942274 RCV003946816 RCV003971813 RCV003963829 RCV003976590 RCV003972266 RCV003978937 RCV003978940 RCV003969013 RCV003981339 RCV003915966 RCV003972950 RCV003910532 RCV003930583
Cervical cancer	risk factor; Benign	rs139006752, rs61742320	RCV005893846 RCV005935535
Clear cell carcinoma of kidney	Benign	rs150575230	RCV005933349
Colon adenocarcinoma	risk factor; Benign	rs139006752, rs150575230	RCV005893844 RCV005933348
Familial cancer of breast	Uncertain significance	rs201423754	RCV005932442
Gastric cancer	Benign	rs61742320	RCV005935537
Hepatocellular carcinoma	risk factor	rs139006752	RCV005893845
Lung cancer	risk factor; Benign	rs139006752, rs150575230	RCV005893848 RCV005933353
Malignant tumor of esophagus	Benign	rs61742320	RCV005935534
Melanoma	Benign	rs61742320, rs150575230	RCV005935540 RCV005933352
Ovarian serous cystadenocarcinoma	Benign	rs61742320	RCV005935538
Primary open angle glaucoma	risk factor	rs201794655, rs750643216, rs200148764, rs139006752, rs1057519378	RCV000416608 RCV000416606 RCV000416610 RCV000416609 RCV000416607
Sarcoma	Benign	rs61742320, rs150575230	RCV005935536 RCV005933350
Thymoma	risk factor; Benign	rs139006752, rs61742320	RCV005893847 RCV005935539
Thyroid cancer, nonmedullary, 1	Uncertain significance; Benign	rs201423754, rs150575230	RCV005932443 RCV005933351

Show/Hide Text Mining Associations (24)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Aortic Aneurysm Abdominal	Associate	32138469
Breast Neoplasms	Stimulate	23708960
Breast Neoplasms	Associate	31409895
Carcinogenesis	Associate	23771851, 24018495
Carcinogenesis	Stimulate	31576094
Carcinoma Hepatocellular	Stimulate	24018495
Carcinoma Hepatocellular	Associate	31576094
Carcinoma Non Small Cell Lung	Associate	22615840, 26526492
Carcinoma Ovarian Epithelial	Associate	24833094
Carcinoma Renal Cell	Associate	23771851, 31939627, 34190011
Glaucoma	Associate	29049738, 38241218
Glaucoma Open Angle	Associate	25798827
Glioma	Associate	23893382
Inflammation	Associate	32138469
Influenza Human	Associate	35893690
Lung Neoplasms	Associate	22615840, 26526492
Mouth Neoplasms	Associate	20695076
Neoplasm Metastasis	Associate	23771851
Neoplasms	Associate	22615840, 23771851, 23893382, 23922791, 24443255, 24633921, 31576094, 31939627, 34190011
Neoplasms	Stimulate	24833094
Ovarian Neoplasms	Associate	17724468, 24833094
Pancreatic Neoplasms	Stimulate	24633921
Squamous Cell Carcinoma of Head and Neck	Associate	20695076
Urinary Bladder Neoplasms	Associate	24443255

CARD10 (caspase recruitment domain family member 10)