Gene Gene information from NCBI Gene database.
Entrez ID 29766
Gene name Tropomodulin 3
Gene symbol TMOD3
Synonyms (NCBI Gene)
UTMOD
Chromosome 15
Chromosome location 15q21.2
miRNA miRNA information provided by mirtarbase database.
1413
miRTarBase ID miRNA Experiments Reference
MIRT001811 hsa-miR-145-5p Luciferase reporter assay 15131085
MIRT020901 hsa-miR-155-5p Proteomics 18668040
MIRT001811 hsa-miR-145-5p Reporter assay;Other 15131085
MIRT023911 hsa-miR-1-3p Proteomics 18668040
MIRT025516 hsa-miR-34a-5p Proteomics 21566225
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
22
GO ID Ontology Definition Evidence Reference
GO:0003779 Function Actin binding IEA
GO:0005515 Function Protein binding IPI 37126682
GO:0005523 Function Tropomyosin binding IBA
GO:0005523 Function Tropomyosin binding IEA
GO:0005523 Function Tropomyosin binding TAS 10662549
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
605112 11873 ENSG00000138594
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q9NYL9
Protein name Tropomodulin-3 (Ubiquitous tropomodulin) (U-Tmod)
Protein function Blocks the elongation and depolymerization of the actin filaments at the pointed end. The Tmod/TM complex contributes to the formation of the short actin protofilament, which in turn defines the geometry of the membrane skeleton (By similarity).
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF03250 Tropomodulin 5 146 Tropomodulin Family
Tissue specificity TISSUE SPECIFICITY: Ubiquitous. {ECO:0000269|PubMed:10662549}.
Sequence
MALPFRKDLEKYKDLDEDELLGNLSETELKQLETVLDDLDPENALLPAGFRQKNQTSKST
TGPFDREHLLSYLEKEALEHKDREDYVPYTGEKKGKIFIPKQKPVQTFTEEKVSLDPELE
EALTSASDTELCDLAAILGMHNLITN
TKFCNIMGSSNGVDQEHFSNVVKGEKILPVFDEP
PNPTNVEESLKRTKENDAHLVEVNLNNIKNIPIPTLKDFAKALETNTHVKCFSLAATRSN
DPVATAFAEMLKVNKTLKSLNVESNFITGVGILALIDALRDNETLAELKIDNQRQQLGTA
VELEMAKMLEENTNILKFGYQFTQQGPRTRAANAITKNNDLVRKRRVEGDHQ
Sequence length 352
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  Cytoskeleton in muscle cells   Striated Muscle Contraction
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
2
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
ATTENTION DEFICIT HYPERACTIVITY DISORDER GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
AUTISM SPECTRUM DISORDER GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References Evidence Score
Glioblastoma Associate 39684695
★☆☆☆☆
Found in Text Mining only
Hypertension Pulmonary Associate 20081107
★☆☆☆☆
Found in Text Mining only
Idiopathic Pulmonary Fibrosis Associate 20081107
★☆☆☆☆
Found in Text Mining only
Neoplasms Associate 33648511, 39684695
★☆☆☆☆
Found in Text Mining only
Pancreatic Neoplasms Associate 33648511
★☆☆☆☆
Found in Text Mining only
Pulmonary Arterial Hypertension Associate 20081107
★☆☆☆☆
Found in Text Mining only
Pulmonary edema of mountaineers Associate 30254217
★☆☆☆☆
Found in Text Mining only