Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways
Entrez ID	2976
Gene name	General transcription factor IIIC subunit 2
Gene symbol	GTF3C2
Synonyms (NCBI Gene)	TF3C-betaTFIIIC-BETATFIIIC110
Chromosome	2
Chromosome location	2p23.3

192

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miRTarBase ID	miRNA	Experiments	Reference
MIRT030484	hsa-miR-24-3p	Microarray	19748357
MIRT031765	hsa-miR-16-5p	Proteomics	18668040
MIRT049553	hsa-miR-92a-3p	CLASH	23622248
MIRT047625	hsa-miR-10a-5p	CLASH	23622248
MIRT1037638	hsa-miR-1182	CLIP-seq
MIRT1037639	hsa-miR-122	CLIP-seq
MIRT1037640	hsa-miR-1245b-3p	CLIP-seq
MIRT1037641	hsa-miR-1253	CLIP-seq
MIRT1037642	hsa-miR-1297	CLIP-seq
MIRT1037643	hsa-miR-2116	CLIP-seq
MIRT1037644	hsa-miR-26a	CLIP-seq
MIRT1037645	hsa-miR-26b	CLIP-seq
MIRT1037646	hsa-miR-28-3p	CLIP-seq
MIRT1037647	hsa-miR-3122	CLIP-seq
MIRT1037648	hsa-miR-3123	CLIP-seq
MIRT1037649	hsa-miR-3145-3p	CLIP-seq
MIRT1037650	hsa-miR-3145-5p	CLIP-seq
MIRT1037651	hsa-miR-3153	CLIP-seq
MIRT1037652	hsa-miR-3650	CLIP-seq
MIRT1037653	hsa-miR-3659	CLIP-seq
MIRT1037654	hsa-miR-3685	CLIP-seq
MIRT1037655	hsa-miR-375	CLIP-seq
MIRT1037656	hsa-miR-384	CLIP-seq
MIRT1037657	hsa-miR-3913-5p	CLIP-seq
MIRT1037658	hsa-miR-3925-5p	CLIP-seq
MIRT1037659	hsa-miR-4255	CLIP-seq
MIRT1037660	hsa-miR-4261	CLIP-seq
MIRT1037661	hsa-miR-4265	CLIP-seq
MIRT1037662	hsa-miR-4273	CLIP-seq
MIRT1037663	hsa-miR-4296	CLIP-seq
MIRT1037664	hsa-miR-4299	CLIP-seq
MIRT1037665	hsa-miR-4322	CLIP-seq
MIRT1037666	hsa-miR-4417	CLIP-seq
MIRT1037667	hsa-miR-4433	CLIP-seq
MIRT1037668	hsa-miR-4456	CLIP-seq
MIRT1037669	hsa-miR-4459	CLIP-seq
MIRT1037670	hsa-miR-4465	CLIP-seq
MIRT1037671	hsa-miR-4640-5p	CLIP-seq
MIRT1037672	hsa-miR-4643	CLIP-seq
MIRT1037673	hsa-miR-4668-5p	CLIP-seq
MIRT1037674	hsa-miR-4677-5p	CLIP-seq
MIRT1037675	hsa-miR-4699-5p	CLIP-seq
MIRT1037676	hsa-miR-4705	CLIP-seq
MIRT1037677	hsa-miR-4726-5p	CLIP-seq
MIRT1037678	hsa-miR-4765	CLIP-seq
MIRT1037679	hsa-miR-4768-3p	CLIP-seq
MIRT1037680	hsa-miR-483-3p	CLIP-seq
MIRT1037681	hsa-miR-509-3p	CLIP-seq
MIRT1037682	hsa-miR-513a-5p	CLIP-seq
MIRT1037683	hsa-miR-518d-5p	CLIP-seq
MIRT1037684	hsa-miR-519b-5p	CLIP-seq
MIRT1037685	hsa-miR-519c-5p	CLIP-seq
MIRT1037686	hsa-miR-520c-5p	CLIP-seq
MIRT1037687	hsa-miR-526a	CLIP-seq
MIRT1037688	hsa-miR-526b	CLIP-seq
MIRT1037689	hsa-miR-548q	CLIP-seq
MIRT1037690	hsa-miR-584	CLIP-seq
MIRT1037691	hsa-miR-943	CLIP-seq
MIRT1037638	hsa-miR-1182	CLIP-seq
MIRT1037639	hsa-miR-122	CLIP-seq
MIRT1037641	hsa-miR-1253	CLIP-seq
MIRT1037642	hsa-miR-1297	CLIP-seq
MIRT1037644	hsa-miR-26a	CLIP-seq
MIRT1037645	hsa-miR-26b	CLIP-seq
MIRT1037647	hsa-miR-3122	CLIP-seq
MIRT1037648	hsa-miR-3123	CLIP-seq
MIRT1037649	hsa-miR-3145-3p	CLIP-seq
MIRT1037651	hsa-miR-3153	CLIP-seq
MIRT1037653	hsa-miR-3659	CLIP-seq
MIRT1037657	hsa-miR-3913-5p	CLIP-seq
MIRT1037658	hsa-miR-3925-5p	CLIP-seq
MIRT1037659	hsa-miR-4255	CLIP-seq
MIRT1037660	hsa-miR-4261	CLIP-seq
MIRT1037667	hsa-miR-4433	CLIP-seq
MIRT1037669	hsa-miR-4459	CLIP-seq
MIRT1037670	hsa-miR-4465	CLIP-seq
MIRT1037672	hsa-miR-4643	CLIP-seq
MIRT1037673	hsa-miR-4668-5p	CLIP-seq
MIRT1037675	hsa-miR-4699-5p	CLIP-seq
MIRT1037679	hsa-miR-4768-3p	CLIP-seq
MIRT1037683	hsa-miR-518d-5p	CLIP-seq
MIRT1037684	hsa-miR-519b-5p	CLIP-seq
MIRT1037685	hsa-miR-519c-5p	CLIP-seq
MIRT1037686	hsa-miR-520c-5p	CLIP-seq
MIRT1037687	hsa-miR-526a	CLIP-seq
MIRT1037690	hsa-miR-584	CLIP-seq
MIRT2007565	hsa-miR-1225-3p	CLIP-seq
MIRT2007566	hsa-miR-1909	CLIP-seq
MIRT1037649	hsa-miR-3145-3p	CLIP-seq
MIRT2007567	hsa-miR-3165	CLIP-seq
MIRT1037653	hsa-miR-3659	CLIP-seq
MIRT2007568	hsa-miR-3943	CLIP-seq
MIRT2007569	hsa-miR-4419a	CLIP-seq
MIRT2007570	hsa-miR-4510	CLIP-seq
MIRT2007571	hsa-miR-4650-5p	CLIP-seq
MIRT2007572	hsa-miR-4675	CLIP-seq
MIRT2007573	hsa-miR-4679	CLIP-seq
MIRT2007574	hsa-miR-4693-3p	CLIP-seq
MIRT2007575	hsa-miR-4707-3p	CLIP-seq
MIRT2007576	hsa-miR-4741	CLIP-seq
MIRT2007577	hsa-miR-571	CLIP-seq
MIRT1037638	hsa-miR-1182	CLIP-seq
MIRT1037639	hsa-miR-122	CLIP-seq
MIRT1037640	hsa-miR-1245b-3p	CLIP-seq
MIRT1037641	hsa-miR-1253	CLIP-seq
MIRT1037642	hsa-miR-1297	CLIP-seq
MIRT1037644	hsa-miR-26a	CLIP-seq
MIRT1037645	hsa-miR-26b	CLIP-seq
MIRT1037646	hsa-miR-28-3p	CLIP-seq
MIRT1037647	hsa-miR-3122	CLIP-seq
MIRT1037651	hsa-miR-3153	CLIP-seq
MIRT2240201	hsa-miR-3156-5p	CLIP-seq
MIRT1037653	hsa-miR-3659	CLIP-seq
MIRT1037654	hsa-miR-3685	CLIP-seq
MIRT1037656	hsa-miR-384	CLIP-seq
MIRT1037657	hsa-miR-3913-5p	CLIP-seq
MIRT1037659	hsa-miR-4255	CLIP-seq
MIRT1037660	hsa-miR-4261	CLIP-seq
MIRT1037667	hsa-miR-4433	CLIP-seq
MIRT1037669	hsa-miR-4459	CLIP-seq
MIRT1037670	hsa-miR-4465	CLIP-seq
MIRT1037672	hsa-miR-4643	CLIP-seq
MIRT2007571	hsa-miR-4650-5p	CLIP-seq
MIRT1037673	hsa-miR-4668-5p	CLIP-seq
MIRT1037675	hsa-miR-4699-5p	CLIP-seq
MIRT1037676	hsa-miR-4705	CLIP-seq
MIRT2240202	hsa-miR-4722-5p	CLIP-seq
MIRT1037679	hsa-miR-4768-3p	CLIP-seq
MIRT1037681	hsa-miR-509-3p	CLIP-seq
MIRT1037682	hsa-miR-513a-5p	CLIP-seq
MIRT1037690	hsa-miR-584	CLIP-seq
MIRT2240203	hsa-miR-622	CLIP-seq
MIRT2240204	hsa-miR-891b	CLIP-seq
MIRT2007565	hsa-miR-1225-3p	CLIP-seq
MIRT2543844	hsa-miR-150	CLIP-seq
MIRT2007566	hsa-miR-1909	CLIP-seq
MIRT2543845	hsa-miR-1972	CLIP-seq
MIRT2543846	hsa-miR-3135	CLIP-seq
MIRT2543847	hsa-miR-3137	CLIP-seq
MIRT2543848	hsa-miR-3150b-3p	CLIP-seq
MIRT2007567	hsa-miR-3165	CLIP-seq
MIRT1037653	hsa-miR-3659	CLIP-seq
MIRT2543849	hsa-miR-3929	CLIP-seq
MIRT2007568	hsa-miR-3943	CLIP-seq
MIRT2007569	hsa-miR-4419a	CLIP-seq
MIRT2543850	hsa-miR-4419b	CLIP-seq
MIRT2543851	hsa-miR-4478	CLIP-seq
MIRT2543852	hsa-miR-4481	CLIP-seq
MIRT2543853	hsa-miR-450b-3p	CLIP-seq
MIRT2007570	hsa-miR-4510	CLIP-seq
MIRT2007571	hsa-miR-4650-5p	CLIP-seq
MIRT2543854	hsa-miR-4654	CLIP-seq
MIRT2543855	hsa-miR-4658	CLIP-seq
MIRT2007572	hsa-miR-4675	CLIP-seq
MIRT2007573	hsa-miR-4679	CLIP-seq
MIRT2543856	hsa-miR-4689	CLIP-seq
MIRT2007574	hsa-miR-4693-3p	CLIP-seq
MIRT2007575	hsa-miR-4707-3p	CLIP-seq
MIRT2543857	hsa-miR-4713-3p	CLIP-seq
MIRT2007576	hsa-miR-4741	CLIP-seq
MIRT2543858	hsa-miR-4745-5p	CLIP-seq
MIRT2543859	hsa-miR-4769-5p	CLIP-seq
MIRT2543860	hsa-miR-4784	CLIP-seq
MIRT2007577	hsa-miR-571	CLIP-seq
MIRT2543861	hsa-miR-574-5p	CLIP-seq
MIRT2543862	hsa-miR-638	CLIP-seq
MIRT2543863	hsa-miR-769-3p	CLIP-seq
MIRT2007565	hsa-miR-1225-3p	CLIP-seq
MIRT2543844	hsa-miR-150	CLIP-seq
MIRT2007566	hsa-miR-1909	CLIP-seq
MIRT2543845	hsa-miR-1972	CLIP-seq
MIRT2543846	hsa-miR-3135	CLIP-seq
MIRT2543848	hsa-miR-3150b-3p	CLIP-seq
MIRT2007567	hsa-miR-3165	CLIP-seq
MIRT1037653	hsa-miR-3659	CLIP-seq
MIRT2543849	hsa-miR-3929	CLIP-seq
MIRT2007568	hsa-miR-3943	CLIP-seq
MIRT2007569	hsa-miR-4419a	CLIP-seq
MIRT2543850	hsa-miR-4419b	CLIP-seq
MIRT2543851	hsa-miR-4478	CLIP-seq
MIRT2007570	hsa-miR-4510	CLIP-seq
MIRT2007571	hsa-miR-4650-5p	CLIP-seq
MIRT2543855	hsa-miR-4658	CLIP-seq
MIRT2007572	hsa-miR-4675	CLIP-seq
MIRT2007573	hsa-miR-4679	CLIP-seq
MIRT2543856	hsa-miR-4689	CLIP-seq
MIRT2007574	hsa-miR-4693-3p	CLIP-seq
MIRT2007575	hsa-miR-4707-3p	CLIP-seq
MIRT2007576	hsa-miR-4741	CLIP-seq
MIRT2543860	hsa-miR-4784	CLIP-seq
MIRT2007577	hsa-miR-571	CLIP-seq
MIRT2543861	hsa-miR-574-5p	CLIP-seq

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Transcription factor	Regulation	Reference
NFIC	Unknown	11118217

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GO ID	Ontology	Definition	Evidence	Reference
GO:0000127	Component	Transcription factor TFIIIC complex	IBA
GO:0000127	Component	Transcription factor TFIIIC complex	IDA	17409385
GO:0000995	Function	RNA polymerase III general transcription initiation factor activity	IDA	17409385
GO:0003677	Function	DNA binding	IDA	17409385
GO:0005515	Function	Protein binding	IPI	17409385, 20543138, 32296183, 33961781
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	TAS
GO:0006383	Process	Transcription by RNA polymerase III	IBA
GO:0006383	Process	Transcription by RNA polymerase III	IDA	17409385
GO:0042791	Process	5S class rRNA transcription by RNA polymerase III	IC	17409385
GO:0042797	Process	TRNA transcription by RNA polymerase III	IC	17409385

MIM	HGNC	e!Ensembl
604883	4665	ENSG00000115207

Q8WUA4

Protein name

General transcription factor 3C polypeptide 2 (TF3C-beta) (Transcription factor IIIC 110 kDa subunit) (TFIIIC 110 kDa subunit) (TFIIIC110) (Transcription factor IIIC subunit beta)

Protein function

Required for RNA polymerase III-mediated transcription. Component of TFIIIC that initiates transcription complex assembly on tRNA and is required for transcription of 5S rRNA and other stable nuclear and cytoplasmic RNAs. May play a direct role

PDB

8CLI , 8CLJ , 8CLL

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00400	WD40	600 → 642	WD domain, G-beta repeat	Repeat

Sequence

MDTCGVGYVALGEAGPVGNMTVVDSPGQEVLNQLDVKTSSEMTSAEASVEMSLPTPLPGF
EDSPDQRRLPPEQESLSRLEQPDLSSEMSKVSKPRASKPGRKRGGRTRKGPKRPQQPNPP
SAPLVPGLLDQSNPLSTPMPKKRGRKSKAELLLLKLSKDLDRPESQSPKRPPEDFETPSG
ERPRRRAAQVALLYLQELAEELSTALPAPVSCPEGPKVSSPTKPKKIRQPAACPGGEEVD
GAPRDEDFFLQVEAEDVEESEGPSESSSEPEPVVPRSTPRGSTSGKQKPHCRGMAPNGLP
NHIMAPVWKCLHLTKDFREQKHSYWEFAEWIPLAWKWHLLSELEAAPYLPQEEKSPLFSV
QREGLPEDGTLYRINRFSSITAHPERWDVSFFTGGPLWALDWCPVPEGAGASQYVALFSS
PDMNETHPLSQLHSGPGLLQLWGLGTLQQESCPGNRAHFVYGIACDNGCIWDLKFCPSGA
WELPGTPRKAPLLPRLGLLALACSDGKVLLFSLPHPEALLAQQPPDAVKPAIYKVQCVAT
LQVGSMQATDPSECGQCLSLAWMPTRPHQHLAAGYYNGMVVFWNLPTNSPLQRIRLSDGS
LKLYPFQCFLAHDQAVRTLQWCKANSHFLVSAGSDRKIKFWDLRRPYEPINSIKRFLSTE
LAWLLPYNGVTVAQDNCYASYGLCGIHYIDAGYLGFKAYFTAPRKGTVWSLSGSDWLGTI
AAGDISGELIAAILPDMALNPINVKRPVERRFPIYKADLIPYQDSPEGPDHSSASSGVPN
PPKARTYTETVNHHYLLFQDTDLGSFHDLLRREPMLRMQEGEGHSQLCLDRLQLEAIHKV
RFSPNLDSYGWLVSGGQSGLVRIHFVRGLASPLGHRMQLESRAHFNAMFQPSSPTRRPGF
SPTSHRLLPTP

Sequence length

911

Interactions

View interactions

	Reactome
			RNA Polymerase III Transcription Initiation From Type 1 Promoter RNA Polymerase III Transcription Initiation From Type 2 Promoter

GTF3C2 (general transcription factor IIIC subunit 2)