Gene Gene information from NCBI Gene database.
Entrez ID 2957
Gene name General transcription factor IIA subunit 1
Gene symbol GTF2A1
Synonyms (NCBI Gene)
TF2A1TFIIATFIIA-42TFIIAL
Chromosome 14
Chromosome location 14q31.1
Summary Accurate transcription initiation on TATA-containing class II genes involves the ordered assembly of RNA polymerase II (POLR2A; MIM 180660) and several general initiation factors (summarized by DeJong and Roeder, 1993 [PubMed 8224848]). One of these facto
miRNA miRNA information provided by mirtarbase database.
422
miRTarBase ID miRNA Experiments Reference
MIRT027887 hsa-miR-96-5p Sequencing 20371350
MIRT030695 hsa-miR-21-5p Microarray 18591254
MIRT042458 hsa-miR-424-5p CLASH 23622248
MIRT503309 hsa-miR-4311 HITS-CLIP 19536157
MIRT720236 hsa-miR-6758-5p HITS-CLIP 19536157
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
27
GO ID Ontology Definition Evidence Reference
GO:0000979 Function RNA polymerase II core promoter sequence-specific DNA binding IDA 29111974
GO:0001091 Function RNA polymerase II general transcription initiation factor binding IPI 8626665
GO:0003677 Function DNA binding IDA 7724559
GO:0005515 Function Protein binding IPI 8006019, 8626665, 24835508, 25416956, 28514442, 31515488, 32296183, 32814053, 33961781, 35271311
GO:0005634 Component Nucleus IDA 10022900
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
600520 4646 ENSG00000165417
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P52655
Protein name Transcription initiation factor IIA subunit 1 (General transcription factor IIA subunit 1) (TFIIAL) (Transcription initiation factor TFIIA 42 kDa subunit) (TFIIA-42) [Cleaved into: Transcription initiation factor IIA alpha chain (TFIIA p35 subunit); Trans
Protein function TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation. TFIIA in a complex with TBP mediates transcriptional activity. {ECO:0000269|PubMed:11030333, ECO:0000269|PubMed:1
PDB 1NVP , 5FUR , 5IY6 , 5IY7 , 5IY8 , 5IY9 , 5IYA , 5IYB , 5IYC , 5IYD , 5M4S , 6MZM , 6O9L , 7EDX , 7EG7 , 7EG8 , 7EG9 , 7EGA , 7EGB , 7EGC , 7EGD , 7EGI , 7EGJ , 7LBM , 7NVR , 7NVS , 7NVT , 7NVU , 7NVY , 7NVZ , 7NW0 , 7ZWC , 7ZWD , 7ZX7 , 7ZX8 , 7ZXE , 8BVW , 8BYQ , 8BZ1 , 8GXQ , 8GXS , 8S51 , 8S52 , 8S5N , 8WAK , 8WAL , 8WAN , 8WAO , 8WAP , 8WAQ , 8WAR
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF03153 TFIIA 13 269 Transcription factor IIA, alpha/beta subunit Family
PF03153 TFIIA 261 376 Transcription factor IIA, alpha/beta subunit Family
Sequence
Sequence length 376
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  Basal transcription factors
Viral carcinogenesis
  RNA Polymerase II Pre-transcription Events
RNA polymerase II transcribes snRNA genes
RNA Polymerase II Promoter Escape
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
RNA Polymerase II Transcription Initiation
RNA Polymerase II Transcription Initiation And Promoter Clearance
Estrogen-dependent gene expression