Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
2957
Gene name Gene Name - the full gene name approved by the HGNC.
General transcription factor IIA subunit 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
GTF2A1
Synonyms (NCBI Gene) Gene synonyms aliases
TF2A1, TFIIA, TFIIA-42, TFIIAL
Chromosome Chromosome number
14
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
14q31.1
Summary Summary of gene provided in NCBI Entrez Gene.
Accurate transcription initiation on TATA-containing class II genes involves the ordered assembly of RNA polymerase II (POLR2A; MIM 180660) and several general initiation factors (summarized by DeJong and Roeder, 1993 [PubMed 8224848]). One of these facto
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT027887 hsa-miR-96-5p Sequencing 20371350
MIRT030695 hsa-miR-21-5p Microarray 18591254
MIRT042458 hsa-miR-424-5p CLASH 23622248
MIRT503309 hsa-miR-4311 HITS-CLIP 19536157
MIRT720236 hsa-miR-6758-5p HITS-CLIP 19536157
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000979 Function RNA polymerase II core promoter sequence-specific DNA binding IDA 29111974
GO:0001091 Function RNA polymerase II general transcription initiation factor binding IPI 8626665
GO:0003677 Function DNA binding IDA 7724559
GO:0005515 Function Protein binding IPI 8006019, 8626665, 24835508, 25416956, 28514442, 31515488, 32296183, 32814053, 33961781, 35271311
GO:0005634 Component Nucleus IDA 10022900
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
600520 4646 ENSG00000165417
Protein
UniProt ID P52655
Protein name Transcription initiation factor IIA subunit 1 (General transcription factor IIA subunit 1) (TFIIAL) (Transcription initiation factor TFIIA 42 kDa subunit) (TFIIA-42) [Cleaved into: Transcription initiation factor IIA alpha chain (TFIIA p35 subunit); Trans
Protein function TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation. TFIIA in a complex with TBP mediates transcriptional activity. {ECO:0000269|PubMed:11030333, ECO:0000269|PubMed:1
PDB 1NVP , 5FUR , 5IY6 , 5IY7 , 5IY8 , 5IY9 , 5IYA , 5IYB , 5IYC , 5IYD , 5M4S , 6MZM , 6O9L , 7EDX , 7EG7 , 7EG8 , 7EG9 , 7EGA , 7EGB , 7EGC , 7EGD , 7EGI , 7EGJ , 7LBM , 7NVR , 7NVS , 7NVT , 7NVU , 7NVY , 7NVZ , 7NW0 , 7ZWC , 7ZWD , 7ZX7 , 7ZX8 , 7ZXE , 8BVW , 8BYQ , 8BZ1 , 8GXQ , 8GXS , 8S51 , 8S52 , 8S5N , 8WAK , 8WAL , 8WAN , 8WAO , 8WAP , 8WAQ , 8WAR
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF03153 TFIIA 13 269 Transcription factor IIA, alpha/beta subunit Family
PF03153 TFIIA 261 376 Transcription factor IIA, alpha/beta subunit Family
Sequence
Sequence length 376
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Basal transcription factors
Viral carcinogenesis
  RNA Polymerase II Pre-transcription Events
RNA polymerase II transcribes snRNA genes
RNA Polymerase II Promoter Escape
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
RNA Polymerase II Transcription Initiation
RNA Polymerase II Transcription Initiation And Promoter Clearance
Estrogen-dependent gene expression
<
Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Disease merge term Disease name Evidence References Source
Schizophrenia Schizophrenia N/A N/A GWAS
Associations from Text Mining Disease associations identified through Pubtator
Disease Name Relationship Type References
Bipolar Disorder Associate 28291257
Cerebral Infarction Associate 24782217
Glioblastoma Associate 34705606
Hypertension Associate 24782217
Obesity Associate 24782217
Ovarian Neoplasms Associate 19724865
Squamous Cell Carcinoma of Head and Neck Inhibit 29097782