GSTT1 (glutathione S-transferase theta 1)

Gene
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
2952
Gene name Gene Name - the full gene name approved by the HGNC.
Glutathione S-transferase theta 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
GSTT1
Synonyms (NCBI Gene) Gene synonyms aliases
-
Chromosome Chromosome number
22
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
22q11.23
Summary Summary of gene provided in NCBI Entrez Gene.
The protein encoded by this gene, glutathione S-transferase (GST) theta 1 (GSTT1), is a member of a superfamily of proteins that catalyze the conjugation of reduced glutathione to a variety of electrophilic and hydrophobic compounds. Human GSTs can be div
miRNA miRNA information provided by mirtarbase database.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(17)
miRTarBase ID miRNA Experiments Reference
MIRT1036664 hsa-miR-1193 CLIP-seq
MIRT1036665 hsa-miR-1294 CLIP-seq
MIRT1036666 hsa-miR-3689d CLIP-seq
MIRT1036667 hsa-miR-4450 CLIP-seq
MIRT1036668 hsa-miR-4710 CLIP-seq
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(12)
GO ID Ontology Definition Evidence Reference
GO:0004364 Function Glutathione transferase activity IBA 21873635
GO:0004364 Function Glutathione transferase activity IDA 9307035, 9434735, 20097269
GO:0004602 Function Glutathione peroxidase activity IDA 9307035, 9434735
GO:0005515 Function Protein binding IPI 25910212
GO:0005737 Component Cytoplasm IBA 21873635
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
600436 4641 HGNC
Protein
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID P30711
Protein name Glutathione S-transferase theta-1 (EC 2.5.1.18) (GST class-theta-1) (Glutathione transferase T1-1)
Protein function Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Acts on 1,2-epoxy-3-(4-nitrophenoxy)propane, phenethylisothiocyanate 4-nitrobenzyl chloride and 4-nitrophenethyl bromide. Displays glutath
PDB 2C3N , 2C3Q , 2C3T
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF13417 GST_N_3 5 → 83 Glutathione S-transferase, N-terminal domain Domain
PF00043 GST_C 111 → 201 Glutathione S-transferase, C-terminal domain Domain
Tissue specificity TISSUE SPECIFICITY: Found in erythrocyte. Expressed at low levels in liver. In lung, expressed at low levels in club cells and ciliated cells at the alveolar/bronchiolar junction. Absent from epithelial cells of larger bronchioles. {ECO:0000269|PubMed:876
Sequence
Sequence length 240
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
  KEGG   Reactome
  Glutathione metabolism
Metabolism of xenobiotics by cytochrome P450
Drug metabolism - cytochrome P450
Drug metabolism - other enzymes
Metabolic pathways
Platinum drug resistance
Pathways in cancer
Chemical carcinogenesis - DNA adducts
Chemical carcinogenesis - receptor activation
Chemical carcinogenesis - reactive oxygen species
Hepatocellular carcinoma
Fluid shear stress and atherosclerosis 		  Glutathione conjugation
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Causal Diseases (10)
Causal
Disease term Disease name dbSNP ID References
Carcinoma Carcinoma, Carcinoma, Spindle-Cell, Undifferentiated carcinoma rs121912654, rs555607708, rs786202962, rs1564055259 20663906
Esophagus neoplasm Squamous cell carcinoma of esophagus rs28934578, rs121918714, rs1567556006, rs1575166666 17173682
Glioblastoma Glioblastoma, Glioblastoma Multiforme rs121913500, rs886042842, rs1555138291, rs1558518449, rs1567176006, rs1558650888 16874663
Hypertension Hypertensive disease rs13306026 22228705
Show/Hide Unknown Diseases (2)
Unknown
Disease term Disease name Evidence References Source
Chromophobe carcinoma Chromophobe Renal Cell Carcinoma 26656529, 18566013 ClinVar
Mental depression Mental Depression, Depressive disorder 18325667 ClinVar
Show/Hide Text Mining Associations (211)
Associations from Text Mining
Disease Name Relationship Type References
Acne Vulgaris Associate 37113088
Adenocarcinoma Associate 38376296
Adenoma Associate 23840148
Age Related Hearing Impairment 1 Associate 17513527
AIDS Associated Nephropathy Associate 29795558
Alzheimer Disease Associate 22486522, 25542503
Anemia Aplastic Associate 11719393
Anemia Hemolytic Associate 16173971
Anemia Sickle Cell Associate 25880856, 27885941
Arsenic Poisoning Associate 31864032