GSTP1 (glutathione S-transferase pi 1)

Gene Gene information from NCBI Gene database.
Gene SNPs miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID 2950
Gene name Glutathione S-transferase pi 1
Gene symbol GSTP1
Synonyms (NCBI Gene)
DFN7FAEES3GST3GSTPHEL-S-22PI
Chromosome 11
Chromosome location 11q13.2
Summary Glutathione S-transferases (GSTs) are a family of enzymes that play an important role in detoxification by catalyzing the conjugation of many hydrophobic and electrophilic compounds with reduced glutathione. Based on their biochemical, immunologic, and st
SNPs SNP information provided by dbSNP.
2
Gene SNPs miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
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SNP ID Visualize variation Clinical significance Consequence
rs1695 A>G Not-provided, drug-response Missense variant, coding sequence variant
rs1555022268 TC>CA Likely-pathogenic Intron variant
miRNA miRNA information provided by mirtarbase database.
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Gene SNPs miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
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miRTarBase ID miRNA Experiments Reference
MIRT006966 hsa-miR-513a-3p Luciferase reporter assayqRT-PCRWestern blot 22749944
MIRT006966 hsa-miR-513a-3p Luciferase reporter assayqRT-PCRWestern blot 22749944
MIRT021715 hsa-miR-133a-3p Reporter assay;Microarray 21396852
MIRT029320 hsa-miR-26b-5p Microarray 19088304
MIRT049201 hsa-miR-92a-3p CLASH 23622248
Transcription factors Transcription factors information provided by TRRUST V2 database.
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Gene SNPs miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
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Transcription factor Regulation Reference
CDX2 Unknown 22580340
FOS Unknown 8206948
JUN Unknown 8206948
MBD2 Repression 11960994;12543808;19856314
MBD2 Unknown 11406558
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
78
Gene SNPs miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
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GO ID Ontology Definition Evidence Reference
GO:0000122 Process Negative regulation of transcription by RNA polymerase II ISS
GO:0000302 Process Response to reactive oxygen species ISS
GO:0002674 Process Negative regulation of acute inflammatory response NAS 18962899
GO:0004364 Function Glutathione transferase activity IBA
GO:0004364 Function Glutathione transferase activity IDA 1540159, 9084911
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
Gene SNPs miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
134660 4638 ENSG00000084207
Protein Protein information from UniProt database.
Gene SNPs miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P09211
Protein name Glutathione S-transferase P (EC 2.5.1.18) (GST class-pi) (GSTP1-1)
Protein function Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Involved in the formation of glutathione conjugates of both prostaglandin A2 (PGA2) and prostaglandin J2 (PGJ2) (PubMed:9084911). Particip
PDB 10GS , 11GS , 12GS , 13GS , 14GS , 16GS , 17GS , 18GS , 19GS , 1AQV , 1AQW , 1AQX , 1EOG , 1EOH , 1GSS , 1KBN , 1LBK , 1MD3 , 1MD4 , 1PGT , 1PX6 , 1PX7 , 1ZGN , 20GS , 22GS , 2A2R , 2A2S , 2GSS , 2J9H , 2PGT , 3CSH , 3CSI , 3CSJ , 3DD3 , 3DGQ , 3GSS , 3GUS , 3HJM , 3HJO , 3HKR , 3IE3 , 3KM6 , 3KMN , 3KMO , 3N9J , 3PGT , 4GSS , 4PGT , 5DAK , 5DAL , 5DCG
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF02798 GST_N 4 → 75 Glutathione S-transferase, N-terminal domain Domain
PF14497 GST_C_3 98 → 197 Glutathione S-transferase, C-terminal domain Domain
Sequence
Sequence length 210
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene SNPs miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
  KEGG  Reactome
  Glutathione metabolism
Metabolism of xenobiotics by cytochrome P450
Drug metabolism - cytochrome P450
Drug metabolism - other enzymes
Metabolic pathways
Platinum drug resistance
Pathways in cancer
Chemical carcinogenesis - DNA adducts
Prostate cancer
Hepatocellular carcinoma
Fluid shear stress and atherosclerosis 		  Glutathione conjugation
Detoxification of Reactive Oxygen Species
Neutrophil degranulation
Associated diseases Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
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Gene SNPs miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Causal Diseases (1)
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
Kala-azar susceptibility 2 Likely pathogenic rs1555022268 RCV000677248
Show/Hide Unknown Diseases (12)
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
- no classification for the single variant rs1138272 -
Abnormality of immune system physiology Benign rs1695 RCV002259310
Cholangiocarcinoma Benign rs1138272 RCV005922916
Colon adenocarcinoma Benign rs1138272 RCV005921914
Show/Hide Text Mining Associations (271)
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References
AA amyloidosis Associate 32334487
Acne Vulgaris Associate 37113088
Actinic Prurigo Associate 18288203
Acute Disease Associate 39873985
Acute Kidney Injury Associate 28640195
Adenocarcinoma Associate 12149142, 12937133, 22833520, 26306699, 26447830, 35842220
Adenocarcinoma Inhibit 37347938
Adenocarcinoma Bronchiolo Alveolar Associate 19484794
Adenocarcinoma of Lung Associate 34596453, 38017020
Adenocarcinoma of Lung Stimulate 36709476