GSTP1 (glutathione S-transferase pi 1)

Gene
Gene SNPs miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
2950
Gene name Gene Name - the full gene name approved by the HGNC.
Glutathione S-transferase pi 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
GSTP1
Synonyms (NCBI Gene) Gene synonyms aliases
DFN7, FAEES3, GST3, GSTP, HEL-S-22, PI
Chromosome Chromosome number
11
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
11q13.2
Summary Summary of gene provided in NCBI Entrez Gene.
Glutathione S-transferases (GSTs) are a family of enzymes that play an important role in detoxification by catalyzing the conjugation of many hydrophobic and electrophilic compounds with reduced glutathione. Based on their biochemical, immunologic, and st
SNPs SNP information provided by dbSNP.
Gene SNPs miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(2)
SNP ID Visualize variation Clinical significance Consequence
rs1695 A>G Not-provided, drug-response Missense variant, coding sequence variant
rs1555022268 TC>CA Likely-pathogenic Intron variant
miRNA miRNA information provided by mirtarbase database.
Gene SNPs miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(5)
miRTarBase ID miRNA Experiments Reference
MIRT006966 hsa-miR-513a-3p Luciferase reporter assay, qRT-PCR, Western blot 22749944
MIRT006966 hsa-miR-513a-3p Luciferase reporter assay, qRT-PCR, Western blot 22749944
MIRT021715 hsa-miR-133a-3p Reporter assay;Microarray 21396852
MIRT029320 hsa-miR-26b-5p Microarray 19088304
MIRT049201 hsa-miR-92a-3p CLASH 23622248
Transcription factors
Gene SNPs miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(9)
Transcription factor Regulation Reference
CDX2 Unknown 22580340
FOS Unknown 8206948
JUN Unknown 8206948
MBD2 Repression 11960994;12543808;19856314
MBD2 Unknown 11406558
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene SNPs miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(78)
GO ID Ontology Definition Evidence Reference
GO:0000122 Process Negative regulation of transcription by RNA polymerase II ISS
GO:0000302 Process Response to reactive oxygen species ISS
GO:0002674 Process Negative regulation of acute inflammatory response NAS 18962899
GO:0004364 Function Glutathione transferase activity IBA
GO:0004364 Function Glutathione transferase activity IDA 1540159, 9084911
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene SNPs miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
134660 4638 ENSG00000084207
Protein
Gene SNPs miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID P09211
Protein name Glutathione S-transferase P (EC 2.5.1.18) (GST class-pi) (GSTP1-1)
Protein function Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Involved in the formation of glutathione conjugates of both prostaglandin A2 (PGA2) and prostaglandin J2 (PGJ2) (PubMed:9084911). Particip
PDB 10GS , 11GS , 12GS , 13GS , 14GS , 16GS , 17GS , 18GS , 19GS , 1AQV , 1AQW , 1AQX , 1EOG , 1EOH , 1GSS , 1KBN , 1LBK , 1MD3 , 1MD4 , 1PGT , 1PX6 , 1PX7 , 1ZGN , 20GS , 22GS , 2A2R , 2A2S , 2GSS , 2J9H , 2PGT , 3CSH , 3CSI , 3CSJ , 3DD3 , 3DGQ , 3GSS , 3GUS , 3HJM , 3HJO , 3HKR , 3IE3 , 3KM6 , 3KMN , 3KMO , 3N9J , 3PGT , 4GSS , 4PGT , 5DAK , 5DAL , 5DCG
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF02798 GST_N 4 → 75 Glutathione S-transferase, N-terminal domain Domain
PF14497 GST_C_3 98 → 197 Glutathione S-transferase, C-terminal domain Domain
Sequence
Sequence length 210
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene SNPs miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
  KEGG   Reactome
  Glutathione metabolism
Metabolism of xenobiotics by cytochrome P450
Drug metabolism - cytochrome P450
Drug metabolism - other enzymes
Metabolic pathways
Platinum drug resistance
Pathways in cancer
Chemical carcinogenesis - DNA adducts
Prostate cancer
Hepatocellular carcinoma
Fluid shear stress and atherosclerosis 		  Glutathione conjugation
Detoxification of Reactive Oxygen Species
Neutrophil degranulation
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Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Gene SNPs miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Unknown Diseases (2)
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Disease merge term Disease name Evidence References Source
Chronic Obstructive Pulmonary Disease Pulmonary disease, chronic obstructive, susceptibility to N/A N/A ClinVar
Dermatitis Atopic dermatitis N/A N/A GWAS
Show/Hide Text Mining Associations (271)
Associations from Text Mining Disease associations identified through Pubtator
Disease Name Relationship Type References
AA amyloidosis Associate 32334487
Acne Vulgaris Associate 37113088
Actinic Prurigo Associate 18288203
Acute Disease Associate 39873985
Acute Kidney Injury Associate 28640195
Adenocarcinoma Associate 12149142, 12937133, 22833520, 26306699, 26447830, 35842220
Adenocarcinoma Inhibit 37347938
Adenocarcinoma Bronchiolo Alveolar Associate 19484794
Adenocarcinoma of Lung Associate 34596453, 38017020
Adenocarcinoma of Lung Stimulate 36709476