Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	2949
Gene name Gene Name - the full gene name approved by the HGNC.	Glutathione S-transferase mu 5
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	GSTM5
Synonyms (NCBI Gene) Gene synonyms aliases	GSTM5-5, GTM5
Chromosome Chromosome number	1
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	1p13.3
Summary Summary of gene provided in NCBI Entrez Gene.	Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omeg

Show/Hide all(180)

miRTarBase ID	miRNA	Experiments	Reference
MIRT610530	hsa-miR-99a-3p	HITS-CLIP	23824327
MIRT610529	hsa-miR-99b-3p	HITS-CLIP	23824327
MIRT610528	hsa-miR-6796-3p	HITS-CLIP	23824327
MIRT610527	hsa-miR-8485	HITS-CLIP	23824327
MIRT610526	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT610525	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT610524	hsa-miR-6793-3p	HITS-CLIP	23824327
MIRT663037	hsa-miR-197-3p	HITS-CLIP	23824327
MIRT610527	hsa-miR-8485	HITS-CLIP	23824327
MIRT610526	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT610525	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT610527	hsa-miR-8485	HITS-CLIP	23824327
MIRT610526	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT610525	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT610527	hsa-miR-8485	HITS-CLIP	23824327
MIRT610526	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT610525	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT610524	hsa-miR-6793-3p	HITS-CLIP	23824327
MIRT610527	hsa-miR-8485	HITS-CLIP	23824327
MIRT610526	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT610525	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT610524	hsa-miR-6793-3p	HITS-CLIP	23824327
MIRT610527	hsa-miR-8485	HITS-CLIP	23824327
MIRT610526	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT610525	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT610524	hsa-miR-6793-3p	HITS-CLIP	23824327
MIRT610527	hsa-miR-8485	HITS-CLIP	23824327
MIRT610526	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT610525	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT610524	hsa-miR-6793-3p	HITS-CLIP	23824327
MIRT610530	hsa-miR-99a-3p	HITS-CLIP	23824327
MIRT610529	hsa-miR-99b-3p	HITS-CLIP	23824327
MIRT610528	hsa-miR-6796-3p	HITS-CLIP	23824327
MIRT610527	hsa-miR-8485	HITS-CLIP	23824327
MIRT610526	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT610525	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT610524	hsa-miR-6793-3p	HITS-CLIP	23824327
MIRT610530	hsa-miR-99a-3p	HITS-CLIP	23824327
MIRT610529	hsa-miR-99b-3p	HITS-CLIP	23824327
MIRT610528	hsa-miR-6796-3p	HITS-CLIP	23824327
MIRT610527	hsa-miR-8485	HITS-CLIP	23824327
MIRT610526	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT610525	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT610524	hsa-miR-6793-3p	HITS-CLIP	23824327
MIRT663037	hsa-miR-197-3p	HITS-CLIP	23824327
MIRT610527	hsa-miR-8485	HITS-CLIP	23824327
MIRT610526	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT610525	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT610527	hsa-miR-8485	HITS-CLIP	23824327
MIRT610526	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT610525	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT610527	hsa-miR-8485	HITS-CLIP	23824327
MIRT610526	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT610525	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT610524	hsa-miR-6793-3p	HITS-CLIP	23824327
MIRT610527	hsa-miR-8485	HITS-CLIP	23824327
MIRT610526	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT610525	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT610524	hsa-miR-6793-3p	HITS-CLIP	23824327
MIRT610527	hsa-miR-8485	HITS-CLIP	23824327
MIRT610526	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT610525	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT610524	hsa-miR-6793-3p	HITS-CLIP	23824327
MIRT610527	hsa-miR-8485	HITS-CLIP	23824327
MIRT610526	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT610525	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT610524	hsa-miR-6793-3p	HITS-CLIP	23824327
MIRT610530	hsa-miR-99a-3p	HITS-CLIP	23824327
MIRT610529	hsa-miR-99b-3p	HITS-CLIP	23824327
MIRT610528	hsa-miR-6796-3p	HITS-CLIP	23824327
MIRT610527	hsa-miR-8485	HITS-CLIP	23824327
MIRT610526	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT610525	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT610524	hsa-miR-6793-3p	HITS-CLIP	23824327
MIRT1036646	hsa-miR-1254	CLIP-seq
MIRT1036647	hsa-miR-2682	CLIP-seq
MIRT1036648	hsa-miR-3116	CLIP-seq
MIRT1036649	hsa-miR-3134	CLIP-seq
MIRT1036650	hsa-miR-329	CLIP-seq
MIRT1036651	hsa-miR-346	CLIP-seq
MIRT1036652	hsa-miR-3714	CLIP-seq
MIRT1036653	hsa-miR-4266	CLIP-seq
MIRT1036654	hsa-miR-449c	CLIP-seq
MIRT1036655	hsa-miR-4534	CLIP-seq
MIRT1036656	hsa-miR-4652-5p	CLIP-seq
MIRT1036657	hsa-miR-4695-5p	CLIP-seq
MIRT1036658	hsa-miR-4716-3p	CLIP-seq
MIRT1036659	hsa-miR-4779	CLIP-seq
MIRT1036660	hsa-miR-4802-5p	CLIP-seq
MIRT1036661	hsa-miR-622	CLIP-seq
MIRT1036662	hsa-miR-661	CLIP-seq
MIRT1036663	hsa-miR-765	CLIP-seq
MIRT1036650	hsa-miR-329	CLIP-seq
MIRT2240004	hsa-miR-149	CLIP-seq
MIRT2240005	hsa-miR-3064-5p	CLIP-seq
MIRT2240006	hsa-miR-371-5p	CLIP-seq
MIRT2240007	hsa-miR-371b-5p	CLIP-seq
MIRT2240008	hsa-miR-4756-3p	CLIP-seq
MIRT2240009	hsa-miR-4794	CLIP-seq
MIRT2240010	hsa-miR-513c	CLIP-seq
MIRT2240011	hsa-miR-514b-5p	CLIP-seq
MIRT1036661	hsa-miR-622	CLIP-seq
MIRT2543661	hsa-miR-1258	CLIP-seq
MIRT2543662	hsa-miR-127-5p	CLIP-seq
MIRT2543663	hsa-miR-1276	CLIP-seq
MIRT2543664	hsa-miR-130a	CLIP-seq
MIRT2543665	hsa-miR-130b	CLIP-seq
MIRT2543666	hsa-miR-1909	CLIP-seq
MIRT2543667	hsa-miR-301a	CLIP-seq
MIRT2543668	hsa-miR-301b	CLIP-seq
MIRT1036649	hsa-miR-3134	CLIP-seq
MIRT2543669	hsa-miR-3150a-3p	CLIP-seq
MIRT2543670	hsa-miR-3153	CLIP-seq
MIRT2543671	hsa-miR-3160-3p	CLIP-seq
MIRT2543672	hsa-miR-3175	CLIP-seq
MIRT2543673	hsa-miR-3666	CLIP-seq
MIRT1036653	hsa-miR-4266	CLIP-seq
MIRT2543674	hsa-miR-4274	CLIP-seq
MIRT2543675	hsa-miR-4295	CLIP-seq
MIRT2543676	hsa-miR-4300	CLIP-seq
MIRT2543677	hsa-miR-4311	CLIP-seq
MIRT2543678	hsa-miR-4473	CLIP-seq
MIRT1036655	hsa-miR-4534	CLIP-seq
MIRT2543679	hsa-miR-454	CLIP-seq
MIRT1036656	hsa-miR-4652-5p	CLIP-seq
MIRT2543680	hsa-miR-4671-3p	CLIP-seq
MIRT1036657	hsa-miR-4695-5p	CLIP-seq
MIRT2543681	hsa-miR-4706	CLIP-seq
MIRT1036658	hsa-miR-4716-3p	CLIP-seq
MIRT2543682	hsa-miR-4728-5p	CLIP-seq
MIRT2543683	hsa-miR-4749-5p	CLIP-seq
MIRT1036659	hsa-miR-4779	CLIP-seq
MIRT1036660	hsa-miR-4802-5p	CLIP-seq
MIRT2543684	hsa-miR-491-5p	CLIP-seq
MIRT2543685	hsa-miR-583	CLIP-seq
MIRT2543686	hsa-miR-7	CLIP-seq
MIRT2543687	hsa-miR-744	CLIP-seq
MIRT1036663	hsa-miR-765	CLIP-seq
MIRT2543688	hsa-miR-920	CLIP-seq
MIRT2543689	hsa-miR-939	CLIP-seq
MIRT2543661	hsa-miR-1258	CLIP-seq
MIRT2543662	hsa-miR-127-5p	CLIP-seq
MIRT2543663	hsa-miR-1276	CLIP-seq
MIRT2543664	hsa-miR-130a	CLIP-seq
MIRT2543665	hsa-miR-130b	CLIP-seq
MIRT2543666	hsa-miR-1909	CLIP-seq
MIRT2543667	hsa-miR-301a	CLIP-seq
MIRT2543668	hsa-miR-301b	CLIP-seq
MIRT1036649	hsa-miR-3134	CLIP-seq
MIRT2543669	hsa-miR-3150a-3p	CLIP-seq
MIRT2543670	hsa-miR-3153	CLIP-seq
MIRT2543671	hsa-miR-3160-3p	CLIP-seq
MIRT2543672	hsa-miR-3175	CLIP-seq
MIRT2543673	hsa-miR-3666	CLIP-seq
MIRT1036653	hsa-miR-4266	CLIP-seq
MIRT2543674	hsa-miR-4274	CLIP-seq
MIRT2543675	hsa-miR-4295	CLIP-seq
MIRT2543676	hsa-miR-4300	CLIP-seq
MIRT2543677	hsa-miR-4311	CLIP-seq
MIRT2543678	hsa-miR-4473	CLIP-seq
MIRT1036655	hsa-miR-4534	CLIP-seq
MIRT2543679	hsa-miR-454	CLIP-seq
MIRT1036656	hsa-miR-4652-5p	CLIP-seq
MIRT2543680	hsa-miR-4671-3p	CLIP-seq
MIRT1036657	hsa-miR-4695-5p	CLIP-seq
MIRT2543681	hsa-miR-4706	CLIP-seq
MIRT1036658	hsa-miR-4716-3p	CLIP-seq
MIRT2543682	hsa-miR-4728-5p	CLIP-seq
MIRT2543683	hsa-miR-4749-5p	CLIP-seq
MIRT1036659	hsa-miR-4779	CLIP-seq
MIRT2682182	hsa-miR-4786-3p	CLIP-seq
MIRT1036660	hsa-miR-4802-5p	CLIP-seq
MIRT2543684	hsa-miR-491-5p	CLIP-seq
MIRT2543685	hsa-miR-583	CLIP-seq
MIRT2682183	hsa-miR-671-5p	CLIP-seq
MIRT2543686	hsa-miR-7	CLIP-seq
MIRT2543687	hsa-miR-744	CLIP-seq
MIRT1036663	hsa-miR-765	CLIP-seq
MIRT2543688	hsa-miR-920	CLIP-seq
MIRT2543689	hsa-miR-939	CLIP-seq

Show/Hide all(14)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004364	Function	Glutathione transferase activity	IBA
GO:0004364	Function	Glutathione transferase activity	IDA	10587441
GO:0004364	Function	Glutathione transferase activity	IEA
GO:0004364	Function	Glutathione transferase activity	TAS	8473333
GO:0005515	Function	Protein binding	IPI	25416956, 28514442, 31515488, 32296183, 33961781
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	TAS
GO:0006749	Process	Glutathione metabolic process	IBA
GO:0006749	Process	Glutathione metabolic process	IDA	10587441
GO:0006749	Process	Glutathione metabolic process	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0042802	Function	Identical protein binding	IEA
GO:0042802	Function	Identical protein binding	IPI	25416956, 32296183

MIM	HGNC	e!Ensembl
138385	4637	ENSG00000134201

Protein

UniProt ID

P46439

Protein name

Glutathione S-transferase Mu 5 (EC 2.5.1.18) (GST class-mu 5) (GSTM5-5)

Protein function

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF02798	GST_N	3 → 82	Glutathione S-transferase, N-terminal domain	Domain
PF00043	GST_C	104 → 192	Glutathione S-transferase, C-terminal domain	Domain

Sequence

MPMTLGYWDIRGLAHAIRLLLEYTDSSYVEKKYTLGDAPDYDRSQWLNEKFKLGLDFPNL
PYLIDGAHKITQSNAILRYIARKHNLCGETEEEKIRVDILENQVMDNHMELVRLCYDPDF
EKLKPKYLEELPEKLKLYSEFLGKRPWFAGDKITFVDFLAYDVLDMKRIFEPKCLDAFLN
LKDFISRFEGLKKISAYMKSSQFLRGLLFGKSATWNSK

Sequence length

218

Interactions

View interactions

	KEGG		Reactome
	Glutathione metabolism Metabolism of xenobiotics by cytochrome P450 Drug metabolism - cytochrome P450 Drug metabolism - other enzymes Metabolic pathways Platinum drug resistance Pathways in cancer Chemical carcinogenesis - DNA adducts Chemical carcinogenesis - receptor activation Chemical carcinogenesis - reactive oxygen species Hepatocellular carcinoma Fluid shear stress and atherosclerosis		Glutathione conjugation

Show/Hide Unknown Diseases (2)

Disease merge term	Disease name	Evidence	References	Source
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Hypothyroidism	Hypothyroidism	N/A	N/A	GWAS
Multiple Sclerosis	Multiple sclerosis	N/A	N/A	GWAS

Show/Hide Text Mining Associations (24)

Disease Name	Relationship Type	References
Associations from Text Mining Disease associations identified through Pubtator
Adenocarcinoma of Lung	Associate	35729618
Carcinoma Adenoid Cystic	Associate	21692051
Carcinoma Hepatocellular	Associate	36685007
Carcinoma Non Small Cell Lung	Associate	21792076
Cardiomyopathy Dilated	Inhibit	27711126
Colorectal Neoplasms	Associate	32953885, 34629820
Diabetes Mellitus Type 2	Associate	36834424
Drug Related Side Effects and Adverse Reactions	Associate	33802702, 36952646
Ehlers Danlos syndrome type 3	Associate	27518164
Glioblastoma	Associate	21156036
Hemorrhage	Associate	36952646
Irritable Bowel Syndrome	Associate	26670691
Joint Instability	Associate	27518164
Lung Neoplasms	Associate	35729618
Macular Degeneration	Inhibit	22410570
Macular Degeneration	Associate	25897651
Neoplasms	Associate	33802702, 35729618
Ovarian Diseases	Associate	31646556
Precursor Cell Lymphoblastic Leukemia Lymphoma	Associate	36952646
Prodromal Symptoms	Associate	34862210
Sarcoma	Associate	35143416
Urinary Bladder Neoplasms	Associate	33802702
Uterine Cervical Neoplasms	Associate	39372720
Weight Loss	Associate	39519120

GSTM5 (glutathione S-transferase mu 5)