Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways
Entrez ID	2948
Gene name	Glutathione S-transferase mu 4
Gene symbol	GSTM4
Synonyms (NCBI Gene)	GSTM4-4GTM4
Chromosome	1
Chromosome location	1p13.3
Summary	Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omeg

179

Show/Hide all (179)

miRTarBase ID	miRNA	Experiments	Reference
MIRT001461	hsa-miR-16-5p	pSILAC	18668040
MIRT001461	hsa-miR-16-5p	Proteomics;Other	18668040
MIRT540188	hsa-miR-8485	PAR-CLIP	21572407
MIRT540189	hsa-miR-4464	PAR-CLIP	21572407
MIRT540187	hsa-miR-4748	PAR-CLIP	21572407
MIRT540186	hsa-miR-329-5p	PAR-CLIP	21572407
MIRT540185	hsa-miR-8064	PAR-CLIP	21572407
MIRT540184	hsa-miR-3135a	PAR-CLIP	21572407
MIRT540182	hsa-miR-4774-3p	PAR-CLIP	21572407
MIRT540183	hsa-miR-507	PAR-CLIP	21572407
MIRT540181	hsa-miR-557	PAR-CLIP	21572407
MIRT540188	hsa-miR-8485	PAR-CLIP	21572407
MIRT540189	hsa-miR-4464	PAR-CLIP	21572407
MIRT540187	hsa-miR-4748	PAR-CLIP	21572407
MIRT540186	hsa-miR-329-5p	PAR-CLIP	21572407
MIRT540185	hsa-miR-8064	PAR-CLIP	21572407
MIRT540184	hsa-miR-3135a	PAR-CLIP	21572407
MIRT540182	hsa-miR-4774-3p	PAR-CLIP	21572407
MIRT540183	hsa-miR-507	PAR-CLIP	21572407
MIRT540181	hsa-miR-557	PAR-CLIP	21572407
MIRT1036640	hsa-miR-24	CLIP-seq
MIRT1036641	hsa-miR-3198	CLIP-seq
MIRT1036642	hsa-miR-342-3p	CLIP-seq
MIRT1036643	hsa-miR-377	CLIP-seq
MIRT1036644	hsa-miR-4284	CLIP-seq
MIRT1036645	hsa-miR-4309	CLIP-seq
MIRT1556480	hsa-miR-1205	CLIP-seq
MIRT1556481	hsa-miR-1207-5p	CLIP-seq
MIRT1556482	hsa-miR-124	CLIP-seq
MIRT1556483	hsa-miR-1286	CLIP-seq
MIRT1556484	hsa-miR-1909	CLIP-seq
MIRT1556485	hsa-miR-3714	CLIP-seq
MIRT1556486	hsa-miR-3910	CLIP-seq
MIRT1556487	hsa-miR-4722-5p	CLIP-seq
MIRT1556488	hsa-miR-4763-3p	CLIP-seq
MIRT1556489	hsa-miR-506	CLIP-seq
MIRT1556490	hsa-miR-940	CLIP-seq
MIRT2007336	hsa-miR-2467-3p	CLIP-seq
MIRT2007337	hsa-miR-2467-5p	CLIP-seq
MIRT2007338	hsa-miR-3132	CLIP-seq
MIRT2007339	hsa-miR-3188	CLIP-seq
MIRT2007340	hsa-miR-3678-3p	CLIP-seq
MIRT2007341	hsa-miR-3975	CLIP-seq
MIRT2007342	hsa-miR-4267	CLIP-seq
MIRT2007343	hsa-miR-4512	CLIP-seq
MIRT2007344	hsa-miR-4649-3p	CLIP-seq
MIRT2007345	hsa-miR-4731-5p	CLIP-seq
MIRT2007346	hsa-miR-485-5p	CLIP-seq
MIRT2388824	hsa-miR-1252	CLIP-seq
MIRT2388825	hsa-miR-3155	CLIP-seq
MIRT2388826	hsa-miR-3155b	CLIP-seq
MIRT2388827	hsa-miR-3974	CLIP-seq
MIRT2388828	hsa-miR-4476	CLIP-seq
MIRT2388829	hsa-miR-4533	CLIP-seq
MIRT2388830	hsa-miR-484	CLIP-seq
MIRT2388831	hsa-miR-493	CLIP-seq
MIRT2543619	hsa-miR-1206	CLIP-seq
MIRT2388824	hsa-miR-1252	CLIP-seq
MIRT2543620	hsa-miR-1266	CLIP-seq
MIRT2543621	hsa-miR-1302	CLIP-seq
MIRT2543622	hsa-miR-130a	CLIP-seq
MIRT2543623	hsa-miR-130b	CLIP-seq
MIRT2543624	hsa-miR-142-3p	CLIP-seq
MIRT1556484	hsa-miR-1909	CLIP-seq
MIRT2007337	hsa-miR-2467-5p	CLIP-seq
MIRT2543625	hsa-miR-2861	CLIP-seq
MIRT2543626	hsa-miR-2909	CLIP-seq
MIRT2543627	hsa-miR-301a	CLIP-seq
MIRT2543628	hsa-miR-301b	CLIP-seq
MIRT2543629	hsa-miR-3119	CLIP-seq
MIRT2543630	hsa-miR-3127-5p	CLIP-seq
MIRT2007338	hsa-miR-3132	CLIP-seq
MIRT2543631	hsa-miR-3147	CLIP-seq
MIRT2388825	hsa-miR-3155	CLIP-seq
MIRT2388826	hsa-miR-3155b	CLIP-seq
MIRT2007339	hsa-miR-3188	CLIP-seq
MIRT2543632	hsa-miR-3202	CLIP-seq
MIRT2543633	hsa-miR-3591-5p	CLIP-seq
MIRT2543634	hsa-miR-3666	CLIP-seq
MIRT2543635	hsa-miR-3670	CLIP-seq
MIRT2543636	hsa-miR-3689a-3p	CLIP-seq
MIRT2543637	hsa-miR-3689c	CLIP-seq
MIRT2543638	hsa-miR-3918	CLIP-seq
MIRT2388827	hsa-miR-3974	CLIP-seq
MIRT2007341	hsa-miR-3975	CLIP-seq
MIRT2543639	hsa-miR-4255	CLIP-seq
MIRT2543640	hsa-miR-4271	CLIP-seq
MIRT2543641	hsa-miR-4278	CLIP-seq
MIRT2543642	hsa-miR-4295	CLIP-seq
MIRT2543643	hsa-miR-4298	CLIP-seq
MIRT2543644	hsa-miR-433	CLIP-seq
MIRT2543645	hsa-miR-4425	CLIP-seq
MIRT2543646	hsa-miR-4446-3p	CLIP-seq
MIRT2543647	hsa-miR-4473	CLIP-seq
MIRT2388828	hsa-miR-4476	CLIP-seq
MIRT2007343	hsa-miR-4512	CLIP-seq
MIRT2543648	hsa-miR-4518	CLIP-seq
MIRT2543649	hsa-miR-4525	CLIP-seq
MIRT2388829	hsa-miR-4533	CLIP-seq
MIRT2543650	hsa-miR-454	CLIP-seq
MIRT2007344	hsa-miR-4649-3p	CLIP-seq
MIRT2543651	hsa-miR-4656	CLIP-seq
MIRT2543652	hsa-miR-4663	CLIP-seq
MIRT2543653	hsa-miR-4671-3p	CLIP-seq
MIRT2543654	hsa-miR-4709-3p	CLIP-seq
MIRT2543655	hsa-miR-4716-3p	CLIP-seq
MIRT2543656	hsa-miR-4725-3p	CLIP-seq
MIRT2543657	hsa-miR-4728-5p	CLIP-seq
MIRT2543658	hsa-miR-4747-5p	CLIP-seq
MIRT2543659	hsa-miR-4796-3p	CLIP-seq
MIRT2388830	hsa-miR-484	CLIP-seq
MIRT2007346	hsa-miR-485-5p	CLIP-seq
MIRT2388831	hsa-miR-493	CLIP-seq
MIRT2543660	hsa-miR-629	CLIP-seq
MIRT2543619	hsa-miR-1206	CLIP-seq
MIRT2682175	hsa-miR-1224-3p	CLIP-seq
MIRT2388824	hsa-miR-1252	CLIP-seq
MIRT2682176	hsa-miR-1260	CLIP-seq
MIRT2682177	hsa-miR-1260b	CLIP-seq
MIRT2543620	hsa-miR-1266	CLIP-seq
MIRT2682178	hsa-miR-1280	CLIP-seq
MIRT2543621	hsa-miR-1302	CLIP-seq
MIRT2543622	hsa-miR-130a	CLIP-seq
MIRT2543623	hsa-miR-130b	CLIP-seq
MIRT2543624	hsa-miR-142-3p	CLIP-seq
MIRT1556484	hsa-miR-1909	CLIP-seq
MIRT2007337	hsa-miR-2467-5p	CLIP-seq
MIRT2543625	hsa-miR-2861	CLIP-seq
MIRT2543626	hsa-miR-2909	CLIP-seq
MIRT2543627	hsa-miR-301a	CLIP-seq
MIRT2543628	hsa-miR-301b	CLIP-seq
MIRT2543629	hsa-miR-3119	CLIP-seq
MIRT2543630	hsa-miR-3127-5p	CLIP-seq
MIRT2007338	hsa-miR-3132	CLIP-seq
MIRT2543631	hsa-miR-3147	CLIP-seq
MIRT2388825	hsa-miR-3155	CLIP-seq
MIRT2388826	hsa-miR-3155b	CLIP-seq
MIRT2682179	hsa-miR-3176	CLIP-seq
MIRT2007339	hsa-miR-3188	CLIP-seq
MIRT2543632	hsa-miR-3202	CLIP-seq
MIRT2543633	hsa-miR-3591-5p	CLIP-seq
MIRT2543634	hsa-miR-3666	CLIP-seq
MIRT2543635	hsa-miR-3670	CLIP-seq
MIRT2543636	hsa-miR-3689a-3p	CLIP-seq
MIRT2543637	hsa-miR-3689c	CLIP-seq
MIRT2543638	hsa-miR-3918	CLIP-seq
MIRT2682180	hsa-miR-3922-3p	CLIP-seq
MIRT2682181	hsa-miR-3922-5p	CLIP-seq
MIRT2388827	hsa-miR-3974	CLIP-seq
MIRT2007341	hsa-miR-3975	CLIP-seq
MIRT2543639	hsa-miR-4255	CLIP-seq
MIRT2543640	hsa-miR-4271	CLIP-seq
MIRT2543641	hsa-miR-4278	CLIP-seq
MIRT2543642	hsa-miR-4295	CLIP-seq
MIRT2543643	hsa-miR-4298	CLIP-seq
MIRT2543644	hsa-miR-433	CLIP-seq
MIRT2543645	hsa-miR-4425	CLIP-seq
MIRT2543646	hsa-miR-4446-3p	CLIP-seq
MIRT2543647	hsa-miR-4473	CLIP-seq
MIRT2388828	hsa-miR-4476	CLIP-seq
MIRT2007343	hsa-miR-4512	CLIP-seq
MIRT2543648	hsa-miR-4518	CLIP-seq
MIRT2543649	hsa-miR-4525	CLIP-seq
MIRT2388829	hsa-miR-4533	CLIP-seq
MIRT2543650	hsa-miR-454	CLIP-seq
MIRT2007344	hsa-miR-4649-3p	CLIP-seq
MIRT2543651	hsa-miR-4656	CLIP-seq
MIRT2543652	hsa-miR-4663	CLIP-seq
MIRT2543653	hsa-miR-4671-3p	CLIP-seq
MIRT2543654	hsa-miR-4709-3p	CLIP-seq
MIRT2543655	hsa-miR-4716-3p	CLIP-seq
MIRT2543656	hsa-miR-4725-3p	CLIP-seq
MIRT2543657	hsa-miR-4728-5p	CLIP-seq
MIRT2543658	hsa-miR-4747-5p	CLIP-seq
MIRT2543659	hsa-miR-4796-3p	CLIP-seq
MIRT2388830	hsa-miR-484	CLIP-seq
MIRT2007346	hsa-miR-485-5p	CLIP-seq
MIRT2388831	hsa-miR-493	CLIP-seq
MIRT2543660	hsa-miR-629	CLIP-seq

Show/Hide all (27)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004364	Function	Glutathione transferase activity	IBA
GO:0004364	Function	Glutathione transferase activity	IDA	8203914, 8373352
GO:0004364	Function	Glutathione transferase activity	IEA
GO:0004364	Function	Glutathione transferase activity	TAS	8349586
GO:0004464	Function	Leukotriene-C4 synthase activity	IDA	27791009
GO:0004464	Function	Leukotriene-C4 synthase activity	IEA
GO:0005515	Function	Protein binding	IPI	25416956, 31515488, 32296183, 32814053, 33961781
GO:0005737	Component	Cytoplasm	IDA	8373352
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	IEA
GO:0005829	Component	Cytosol	TAS
GO:0006629	Process	Lipid metabolic process	IEA
GO:0006749	Process	Glutathione metabolic process	IBA
GO:0006749	Process	Glutathione metabolic process	IDA	8373352
GO:0006749	Process	Glutathione metabolic process	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0016829	Function	Lyase activity	IEA
GO:0018916	Process	Nitrobenzene metabolic process	IEA
GO:0019899	Function	Enzyme binding	IPI	8373352
GO:0042178	Process	Xenobiotic catabolic process	IDA	8373352
GO:0042178	Process	Xenobiotic catabolic process	IEA
GO:0042178	Process	Xenobiotic catabolic process	IEA
GO:0042759	Process	Long-chain fatty acid biosynthetic process	IDA	27791009
GO:0042802	Function	Identical protein binding	IEA
GO:0042803	Function	Protein homodimerization activity	IPI	8373352
GO:0043295	Function	Glutathione binding	IDA	8373352

MIM	HGNC	e!Ensembl
138333	4636	ENSG00000168765

Q03013

Protein name

Glutathione S-transferase Mu 4 (EC 2.5.1.18) (GST class-mu 4) (GST-Mu2) (GSTM4-4) (Leukotriene C4 synthase GSTM4) (EC 4.4.1.20)

Protein function

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles (PubMed:8203914, PubMed:8373352). Catalyzes the conjugation of leukotriene A4 with reduced glutathione (GSH) to form leukotriene C4 (PubMed

PDB

4GTU

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF02798	GST_N	3 → 82	Glutathione S-transferase, N-terminal domain	Domain
PF14497	GST_C_3	105 → 201	Glutathione S-transferase, C-terminal domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Expressed in a wide variety of tissues.

Sequence

MSMTLGYWDIRGLAHAIRLLLEYTDSSYEEKKYTMGDAPDYDRSQWLNEKFKLGLDFPNL
PYLIDGAHKITQSNAILCYIARKHNLCGETEEEKIRVDILENQAMDVSNQLARVCYSPDF
EKLKPEYLEELPTMMQHFSQFLGKRPWFVGDKITFVDFLAYDVLDLHRIFEPNCLDAFPN
LKDFISRFEGLEKISAYMKSSRFLPKPLYTRVAVWGNK

Sequence length

218

Interactions

View interactions

	KEGG		Reactome
	Glutathione metabolism Metabolism of xenobiotics by cytochrome P450 Drug metabolism - cytochrome P450 Drug metabolism - other enzymes Metabolic pathways Platinum drug resistance Pathways in cancer Chemical carcinogenesis - DNA adducts Chemical carcinogenesis - receptor activation Chemical carcinogenesis - reactive oxygen species Hepatocellular carcinoma Fluid shear stress and atherosclerosis		Glutathione conjugation Biosynthesis of maresin conjugates in tissue regeneration (MCTR)

GSTM4 (glutathione S-transferase mu 4)