Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	2947
Gene name Gene Name - the full gene name approved by the HGNC.	Glutathione S-transferase mu 3
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	GSTM3
Synonyms (NCBI Gene) Gene synonyms aliases	GST5, GSTB, GSTM3-3, GSTM3TV2, GTM3, hGSTM3-3
Chromosome Chromosome number	1
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	1p13.3
Summary Summary of gene provided in NCBI Entrez Gene.	Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omeg

Show/Hide all(322)

miRTarBase ID	miRNA	Experiments	Reference
MIRT023377	hsa-miR-122-5p	Proteomics	21750653
MIRT040526	hsa-miR-92b-3p	CLASH	23622248
MIRT676201	hsa-miR-6890-3p	HITS-CLIP	23824327
MIRT676200	hsa-miR-5693	HITS-CLIP	23824327
MIRT676199	hsa-miR-6741-3p	HITS-CLIP	23824327
MIRT676198	hsa-miR-1304-3p	HITS-CLIP	23824327
MIRT676197	hsa-miR-1307-3p	HITS-CLIP	23824327
MIRT676196	hsa-miR-4638-5p	HITS-CLIP	23824327
MIRT676195	hsa-miR-4772-3p	HITS-CLIP	23824327
MIRT676194	hsa-miR-4695-3p	HITS-CLIP	23824327
MIRT676193	hsa-miR-6499-3p	HITS-CLIP	23824327
MIRT676192	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT676191	hsa-miR-6791-3p	HITS-CLIP	23824327
MIRT676190	hsa-miR-6829-3p	HITS-CLIP	23824327
MIRT676189	hsa-miR-4284	HITS-CLIP	23824327
MIRT676188	hsa-miR-143-5p	HITS-CLIP	23824327
MIRT676187	hsa-miR-5001-3p	HITS-CLIP	23824327
MIRT676186	hsa-miR-7641	HITS-CLIP	23824327
MIRT676185	hsa-miR-6836-3p	HITS-CLIP	23824327
MIRT676184	hsa-miR-5698	HITS-CLIP	23824327
MIRT676201	hsa-miR-6890-3p	HITS-CLIP	23824327
MIRT676200	hsa-miR-5693	HITS-CLIP	23824327
MIRT676199	hsa-miR-6741-3p	HITS-CLIP	23824327
MIRT676198	hsa-miR-1304-3p	HITS-CLIP	23824327
MIRT676197	hsa-miR-1307-3p	HITS-CLIP	23824327
MIRT676196	hsa-miR-4638-5p	HITS-CLIP	23824327
MIRT676195	hsa-miR-4772-3p	HITS-CLIP	23824327
MIRT676194	hsa-miR-4695-3p	HITS-CLIP	23824327
MIRT676193	hsa-miR-6499-3p	HITS-CLIP	23824327
MIRT676192	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT676191	hsa-miR-6791-3p	HITS-CLIP	23824327
MIRT676190	hsa-miR-6829-3p	HITS-CLIP	23824327
MIRT676189	hsa-miR-4284	HITS-CLIP	23824327
MIRT676188	hsa-miR-143-5p	HITS-CLIP	23824327
MIRT676187	hsa-miR-5001-3p	HITS-CLIP	23824327
MIRT676186	hsa-miR-7641	HITS-CLIP	23824327
MIRT676185	hsa-miR-6836-3p	HITS-CLIP	23824327
MIRT676184	hsa-miR-5698	HITS-CLIP	23824327
MIRT1036604	hsa-miR-1193	CLIP-seq
MIRT1036605	hsa-miR-1200	CLIP-seq
MIRT1036606	hsa-miR-1206	CLIP-seq
MIRT1036607	hsa-miR-1224-3p	CLIP-seq
MIRT1036608	hsa-miR-1246	CLIP-seq
MIRT1036609	hsa-miR-1260	CLIP-seq
MIRT1036610	hsa-miR-1260b	CLIP-seq
MIRT1036611	hsa-miR-1280	CLIP-seq
MIRT1036612	hsa-miR-1290	CLIP-seq
MIRT1036613	hsa-miR-1343	CLIP-seq
MIRT1036614	hsa-miR-1913	CLIP-seq
MIRT1036615	hsa-miR-192	CLIP-seq
MIRT1036616	hsa-miR-215	CLIP-seq
MIRT1036617	hsa-miR-2355-3p	CLIP-seq
MIRT1036618	hsa-miR-2392	CLIP-seq
MIRT1036619	hsa-miR-3132	CLIP-seq
MIRT1036620	hsa-miR-3167	CLIP-seq
MIRT1036621	hsa-miR-3187-3p	CLIP-seq
MIRT1036622	hsa-miR-3199	CLIP-seq
MIRT1036623	hsa-miR-324-3p	CLIP-seq
MIRT1036624	hsa-miR-3622a-5p	CLIP-seq
MIRT1036625	hsa-miR-3940-3p	CLIP-seq
MIRT1036626	hsa-miR-4324	CLIP-seq
MIRT1036627	hsa-miR-4423-3p	CLIP-seq
MIRT1036628	hsa-miR-4435	CLIP-seq
MIRT1036629	hsa-miR-4438	CLIP-seq
MIRT1036630	hsa-miR-4646-3p	CLIP-seq
MIRT1036631	hsa-miR-4701-5p	CLIP-seq
MIRT1036632	hsa-miR-4715-3p	CLIP-seq
MIRT1036633	hsa-miR-490-5p	CLIP-seq
MIRT1036634	hsa-miR-5095	CLIP-seq
MIRT1036635	hsa-miR-532-3p	CLIP-seq
MIRT1036636	hsa-miR-544b	CLIP-seq
MIRT1036637	hsa-miR-548s	CLIP-seq
MIRT1036638	hsa-miR-588	CLIP-seq
MIRT1036639	hsa-miR-876-5p	CLIP-seq
MIRT1036622	hsa-miR-3199	CLIP-seq
MIRT1556477	hsa-miR-1915	CLIP-seq
MIRT1556478	hsa-miR-4726-3p	CLIP-seq
MIRT1556479	hsa-miR-498	CLIP-seq
MIRT738561	hsa-miR-1178	CLIP-seq
MIRT1036607	hsa-miR-1224-3p	CLIP-seq
MIRT2007325	hsa-miR-1245	CLIP-seq
MIRT1036609	hsa-miR-1260	CLIP-seq
MIRT1036610	hsa-miR-1260b	CLIP-seq
MIRT1036611	hsa-miR-1280	CLIP-seq
MIRT2007326	hsa-miR-1307	CLIP-seq
MIRT1036613	hsa-miR-1343	CLIP-seq
MIRT1556477	hsa-miR-1915	CLIP-seq
MIRT2007327	hsa-miR-1976	CLIP-seq
MIRT1036619	hsa-miR-3132	CLIP-seq
MIRT2007328	hsa-miR-3182	CLIP-seq
MIRT2007329	hsa-miR-378g	CLIP-seq
MIRT2007330	hsa-miR-4279	CLIP-seq
MIRT2007331	hsa-miR-4437	CLIP-seq
MIRT2007332	hsa-miR-4674	CLIP-seq
MIRT2007333	hsa-miR-4691-5p	CLIP-seq
MIRT2007334	hsa-miR-4722-3p	CLIP-seq
MIRT1556478	hsa-miR-4726-3p	CLIP-seq
MIRT2007335	hsa-miR-4731-5p	CLIP-seq
MIRT1556479	hsa-miR-498	CLIP-seq
MIRT738560	hsa-miR-513a-5p	CLIP-seq
MIRT1036635	hsa-miR-532-3p	CLIP-seq
MIRT2239957	hsa-miR-106a	CLIP-seq
MIRT2239958	hsa-miR-106b	CLIP-seq
MIRT2239959	hsa-miR-1184	CLIP-seq
MIRT1036604	hsa-miR-1193	CLIP-seq
MIRT1036605	hsa-miR-1200	CLIP-seq
MIRT1036606	hsa-miR-1206	CLIP-seq
MIRT2239960	hsa-miR-122	CLIP-seq
MIRT1036607	hsa-miR-1224-3p	CLIP-seq
MIRT2007325	hsa-miR-1245	CLIP-seq
MIRT1036608	hsa-miR-1246	CLIP-seq
MIRT1036609	hsa-miR-1260	CLIP-seq
MIRT1036610	hsa-miR-1260b	CLIP-seq
MIRT1036611	hsa-miR-1280	CLIP-seq
MIRT1036612	hsa-miR-1290	CLIP-seq
MIRT2239961	hsa-miR-1301	CLIP-seq
MIRT2007326	hsa-miR-1307	CLIP-seq
MIRT1036613	hsa-miR-1343	CLIP-seq
MIRT2239962	hsa-miR-150	CLIP-seq
MIRT2239963	hsa-miR-17	CLIP-seq
MIRT2239964	hsa-miR-1912	CLIP-seq
MIRT1036614	hsa-miR-1913	CLIP-seq
MIRT1556477	hsa-miR-1915	CLIP-seq
MIRT1036615	hsa-miR-192	CLIP-seq
MIRT2007327	hsa-miR-1976	CLIP-seq
MIRT2239965	hsa-miR-20a	CLIP-seq
MIRT2239966	hsa-miR-20b	CLIP-seq
MIRT1036616	hsa-miR-215	CLIP-seq
MIRT1036618	hsa-miR-2392	CLIP-seq
MIRT2239967	hsa-miR-302a	CLIP-seq
MIRT2239968	hsa-miR-302b	CLIP-seq
MIRT2239969	hsa-miR-302c	CLIP-seq
MIRT2239970	hsa-miR-302d	CLIP-seq
MIRT2239971	hsa-miR-302e	CLIP-seq
MIRT2239972	hsa-miR-31	CLIP-seq
MIRT1036619	hsa-miR-3132	CLIP-seq
MIRT1036620	hsa-miR-3167	CLIP-seq
MIRT2239973	hsa-miR-3194-3p	CLIP-seq
MIRT2239974	hsa-miR-3198	CLIP-seq
MIRT1036622	hsa-miR-3199	CLIP-seq
MIRT1036623	hsa-miR-324-3p	CLIP-seq
MIRT1036624	hsa-miR-3622a-5p	CLIP-seq
MIRT2239975	hsa-miR-3671	CLIP-seq
MIRT2239976	hsa-miR-3688-5p	CLIP-seq
MIRT2239977	hsa-miR-372	CLIP-seq
MIRT2239978	hsa-miR-373	CLIP-seq
MIRT2007329	hsa-miR-378g	CLIP-seq
MIRT2007330	hsa-miR-4279	CLIP-seq
MIRT2239979	hsa-miR-4309	CLIP-seq
MIRT1036626	hsa-miR-4324	CLIP-seq
MIRT2239980	hsa-miR-4418	CLIP-seq
MIRT1036627	hsa-miR-4423-3p	CLIP-seq
MIRT2239981	hsa-miR-4428	CLIP-seq
MIRT2007331	hsa-miR-4437	CLIP-seq
MIRT1036629	hsa-miR-4438	CLIP-seq
MIRT2239982	hsa-miR-4494	CLIP-seq
MIRT2239983	hsa-miR-4522	CLIP-seq
MIRT2239984	hsa-miR-4660	CLIP-seq
MIRT2007332	hsa-miR-4674	CLIP-seq
MIRT2239985	hsa-miR-4677-3p	CLIP-seq
MIRT2239986	hsa-miR-4679	CLIP-seq
MIRT2239987	hsa-miR-4693-3p	CLIP-seq
MIRT2007334	hsa-miR-4722-3p	CLIP-seq
MIRT1556478	hsa-miR-4726-3p	CLIP-seq
MIRT2007335	hsa-miR-4731-5p	CLIP-seq
MIRT2239988	hsa-miR-488	CLIP-seq
MIRT1036633	hsa-miR-490-5p	CLIP-seq
MIRT1556479	hsa-miR-498	CLIP-seq
MIRT2239989	hsa-miR-499a-5p	CLIP-seq
MIRT2239990	hsa-miR-5047	CLIP-seq
MIRT2239991	hsa-miR-509-3-5p	CLIP-seq
MIRT1036634	hsa-miR-5095	CLIP-seq
MIRT2239992	hsa-miR-509-5p	CLIP-seq
MIRT2239993	hsa-miR-512-3p	CLIP-seq
MIRT2239994	hsa-miR-519d	CLIP-seq
MIRT2239995	hsa-miR-520a-3p	CLIP-seq
MIRT2239996	hsa-miR-520b	CLIP-seq
MIRT2239997	hsa-miR-520c-3p	CLIP-seq
MIRT2239998	hsa-miR-520d-3p	CLIP-seq
MIRT2239999	hsa-miR-520e	CLIP-seq
MIRT2240000	hsa-miR-520g	CLIP-seq
MIRT2240001	hsa-miR-520h	CLIP-seq
MIRT1036635	hsa-miR-532-3p	CLIP-seq
MIRT1036636	hsa-miR-544b	CLIP-seq
MIRT2240002	hsa-miR-607	CLIP-seq
MIRT738562	hsa-miR-767-3p	CLIP-seq
MIRT1036639	hsa-miR-876-5p	CLIP-seq
MIRT2240003	hsa-miR-93	CLIP-seq
MIRT2239973	hsa-miR-3194-3p	CLIP-seq
MIRT2388820	hsa-miR-4514	CLIP-seq
MIRT2239983	hsa-miR-4522	CLIP-seq
MIRT2239985	hsa-miR-4677-3p	CLIP-seq
MIRT2239986	hsa-miR-4679	CLIP-seq
MIRT2388821	hsa-miR-4692	CLIP-seq
MIRT2388822	hsa-miR-4778-3p	CLIP-seq
MIRT2239988	hsa-miR-488	CLIP-seq
MIRT2388823	hsa-miR-508-5p	CLIP-seq
MIRT738562	hsa-miR-767-3p	CLIP-seq
MIRT1036605	hsa-miR-1200	CLIP-seq
MIRT2239960	hsa-miR-122	CLIP-seq
MIRT2007326	hsa-miR-1307	CLIP-seq
MIRT1556477	hsa-miR-1915	CLIP-seq
MIRT2007327	hsa-miR-1976	CLIP-seq
MIRT2450843	hsa-miR-3135b	CLIP-seq
MIRT2450844	hsa-miR-3137	CLIP-seq
MIRT2450845	hsa-miR-3149	CLIP-seq
MIRT2450846	hsa-miR-3652	CLIP-seq
MIRT2450847	hsa-miR-411	CLIP-seq
MIRT2007330	hsa-miR-4279	CLIP-seq
MIRT1036626	hsa-miR-4324	CLIP-seq
MIRT2450848	hsa-miR-4430	CLIP-seq
MIRT2450849	hsa-miR-4676-5p	CLIP-seq
MIRT1036632	hsa-miR-4715-3p	CLIP-seq
MIRT2007334	hsa-miR-4722-3p	CLIP-seq
MIRT1556478	hsa-miR-4726-3p	CLIP-seq
MIRT2450850	hsa-miR-4735-5p	CLIP-seq
MIRT2450851	hsa-miR-4755-3p	CLIP-seq
MIRT2450852	hsa-miR-4775	CLIP-seq
MIRT1556479	hsa-miR-498	CLIP-seq
MIRT1036636	hsa-miR-544b	CLIP-seq
MIRT2450853	hsa-miR-575	CLIP-seq
MIRT2450854	hsa-miR-590-3p	CLIP-seq
MIRT1556477	hsa-miR-1915	CLIP-seq
MIRT2007327	hsa-miR-1976	CLIP-seq
MIRT2450845	hsa-miR-3149	CLIP-seq
MIRT2450847	hsa-miR-411	CLIP-seq
MIRT2007330	hsa-miR-4279	CLIP-seq
MIRT1036632	hsa-miR-4715-3p	CLIP-seq
MIRT2007334	hsa-miR-4722-3p	CLIP-seq
MIRT1556478	hsa-miR-4726-3p	CLIP-seq
MIRT2450850	hsa-miR-4735-5p	CLIP-seq
MIRT2450852	hsa-miR-4775	CLIP-seq
MIRT1556479	hsa-miR-498	CLIP-seq
MIRT2450854	hsa-miR-590-3p	CLIP-seq
MIRT2239957	hsa-miR-106a	CLIP-seq
MIRT2239958	hsa-miR-106b	CLIP-seq
MIRT1036605	hsa-miR-1200	CLIP-seq
MIRT2239960	hsa-miR-122	CLIP-seq
MIRT1036607	hsa-miR-1224-3p	CLIP-seq
MIRT2007326	hsa-miR-1307	CLIP-seq
MIRT2239962	hsa-miR-150	CLIP-seq
MIRT2239963	hsa-miR-17	CLIP-seq
MIRT1556477	hsa-miR-1915	CLIP-seq
MIRT2007327	hsa-miR-1976	CLIP-seq
MIRT2239965	hsa-miR-20a	CLIP-seq
MIRT2239966	hsa-miR-20b	CLIP-seq
MIRT2543615	hsa-miR-2276	CLIP-seq
MIRT2239967	hsa-miR-302a	CLIP-seq
MIRT2239968	hsa-miR-302b	CLIP-seq
MIRT2239969	hsa-miR-302c	CLIP-seq
MIRT2239970	hsa-miR-302d	CLIP-seq
MIRT2239971	hsa-miR-302e	CLIP-seq
MIRT2450843	hsa-miR-3135b	CLIP-seq
MIRT2450844	hsa-miR-3137	CLIP-seq
MIRT2450845	hsa-miR-3149	CLIP-seq
MIRT2239973	hsa-miR-3194-3p	CLIP-seq
MIRT1036622	hsa-miR-3199	CLIP-seq
MIRT2543616	hsa-miR-346	CLIP-seq
MIRT1036624	hsa-miR-3622a-5p	CLIP-seq
MIRT2450846	hsa-miR-3652	CLIP-seq
MIRT2239977	hsa-miR-372	CLIP-seq
MIRT2239978	hsa-miR-373	CLIP-seq
MIRT2450847	hsa-miR-411	CLIP-seq
MIRT2007330	hsa-miR-4279	CLIP-seq
MIRT1036626	hsa-miR-4324	CLIP-seq
MIRT1036627	hsa-miR-4423-3p	CLIP-seq
MIRT2450848	hsa-miR-4430	CLIP-seq
MIRT2450849	hsa-miR-4676-5p	CLIP-seq
MIRT1036632	hsa-miR-4715-3p	CLIP-seq
MIRT2007334	hsa-miR-4722-3p	CLIP-seq
MIRT1556478	hsa-miR-4726-3p	CLIP-seq
MIRT2450850	hsa-miR-4735-5p	CLIP-seq
MIRT2450851	hsa-miR-4755-3p	CLIP-seq
MIRT2450852	hsa-miR-4775	CLIP-seq
MIRT2543617	hsa-miR-4788	CLIP-seq
MIRT2543618	hsa-miR-494	CLIP-seq
MIRT1556479	hsa-miR-498	CLIP-seq
MIRT2239993	hsa-miR-512-3p	CLIP-seq
MIRT2239994	hsa-miR-519d	CLIP-seq
MIRT2239995	hsa-miR-520a-3p	CLIP-seq
MIRT2239996	hsa-miR-520b	CLIP-seq
MIRT2239997	hsa-miR-520c-3p	CLIP-seq
MIRT2239998	hsa-miR-520d-3p	CLIP-seq
MIRT2239999	hsa-miR-520e	CLIP-seq
MIRT2240000	hsa-miR-520g	CLIP-seq
MIRT2240001	hsa-miR-520h	CLIP-seq
MIRT1036636	hsa-miR-544b	CLIP-seq
MIRT2450853	hsa-miR-575	CLIP-seq
MIRT2450854	hsa-miR-590-3p	CLIP-seq
MIRT2240003	hsa-miR-93	CLIP-seq
MIRT1036605	hsa-miR-1200	CLIP-seq
MIRT2239960	hsa-miR-122	CLIP-seq
MIRT2007326	hsa-miR-1307	CLIP-seq
MIRT1556477	hsa-miR-1915	CLIP-seq
MIRT2007327	hsa-miR-1976	CLIP-seq
MIRT2543615	hsa-miR-2276	CLIP-seq
MIRT2450843	hsa-miR-3135b	CLIP-seq
MIRT2450844	hsa-miR-3137	CLIP-seq
MIRT2450845	hsa-miR-3149	CLIP-seq
MIRT2239973	hsa-miR-3194-3p	CLIP-seq
MIRT1036622	hsa-miR-3199	CLIP-seq
MIRT2543616	hsa-miR-346	CLIP-seq
MIRT1036624	hsa-miR-3622a-5p	CLIP-seq
MIRT2450846	hsa-miR-3652	CLIP-seq
MIRT2450847	hsa-miR-411	CLIP-seq
MIRT2007330	hsa-miR-4279	CLIP-seq
MIRT1036626	hsa-miR-4324	CLIP-seq
MIRT1036627	hsa-miR-4423-3p	CLIP-seq
MIRT2450848	hsa-miR-4430	CLIP-seq
MIRT2450849	hsa-miR-4676-5p	CLIP-seq
MIRT1036632	hsa-miR-4715-3p	CLIP-seq
MIRT2007334	hsa-miR-4722-3p	CLIP-seq
MIRT1556478	hsa-miR-4726-3p	CLIP-seq
MIRT2450850	hsa-miR-4735-5p	CLIP-seq
MIRT2450851	hsa-miR-4755-3p	CLIP-seq
MIRT2450852	hsa-miR-4775	CLIP-seq
MIRT2543617	hsa-miR-4788	CLIP-seq
MIRT2543618	hsa-miR-494	CLIP-seq
MIRT1556479	hsa-miR-498	CLIP-seq
MIRT1036636	hsa-miR-544b	CLIP-seq
MIRT2450853	hsa-miR-575	CLIP-seq
MIRT2450854	hsa-miR-590-3p	CLIP-seq

Show/Hide all(27)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004364	Function	Glutathione transferase activity	IBA
GO:0004364	Function	Glutathione transferase activity	IDA	8373352, 9545290, 10587441
GO:0004364	Function	Glutathione transferase activity	IEA
GO:0004364	Function	Glutathione transferase activity	TAS	2345169
GO:0005515	Function	Protein binding	IPI	23355646, 28514442, 31515488, 32296183, 33961781
GO:0005634	Component	Nucleus	HDA	21630459
GO:0005737	Component	Cytoplasm	IDA	8373352
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IEA
GO:0005829	Component	Cytosol	TAS
GO:0006749	Process	Glutathione metabolic process	IBA
GO:0006749	Process	Glutathione metabolic process	IDA	8373352, 10587441
GO:0006749	Process	Glutathione metabolic process	IEA
GO:0008065	Process	Establishment of blood-nerve barrier	TAS	2345169
GO:0016740	Function	Transferase activity	IEA
GO:0018916	Process	Nitrobenzene metabolic process	IDA	8373352
GO:0019899	Function	Enzyme binding	IPI	8373352
GO:0035686	Component	Sperm fibrous sheath	IEA
GO:0042178	Process	Xenobiotic catabolic process	IDA	8373352
GO:0042802	Function	Identical protein binding	IEA
GO:0042802	Function	Identical protein binding	IPI	16189514, 19060904, 21516116, 31515488, 32296183
GO:0042803	Function	Protein homodimerization activity	IDA	9545290
GO:0042803	Function	Protein homodimerization activity	IPI	8373352
GO:0043295	Function	Glutathione binding	IDA	8373352
GO:0043627	Process	Response to estrogen	IEP	10037815
GO:0070062	Component	Extracellular exosome	HDA	23533145
GO:0070458	Process	Cellular detoxification of nitrogen compound	IDA	8373352

MIM	HGNC	e!Ensembl
138390	4635	ENSG00000134202

Protein

UniProt ID

P21266

Protein name

Glutathione S-transferase Mu 3 (EC 2.5.1.18) (GST class-mu 3) (GSTM3-3) (hGSTM3-3)

Protein function

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. May govern uptake and detoxification of both endogenous compounds and xenobiotics at the testis and brain blood barriers. {ECO:0000269|Pub

PDB

3GTU

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF02798	GST_N	7 → 86	Glutathione S-transferase, N-terminal domain	Domain
PF00043	GST_C	108 → 196	Glutathione S-transferase, C-terminal domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Testis and brain.

Sequence

MSCESSMVLGYWDIRGLAHAIRLLLEFTDTSYEEKRYTCGEAPDYDRSQWLDVKFKLDLD
FPNLPYLLDGKNKITQSNAILRYIARKHNMCGETEEEKIRVDIIENQVMDFRTQLIRLCY
SSDHEKLKPQYLEELPGQLKQFSMFLGKFSWFAGEKLTFVDFLTYDILDQNRIFDPKCLD
EFPNLKAFMCRFEALEKIAAYLQSDQFCKMPINNKMAQWGNKPVC

Sequence length

225

Interactions

View interactions

	KEGG		Reactome
	Glutathione metabolism Metabolism of xenobiotics by cytochrome P450 Drug metabolism - cytochrome P450 Drug metabolism - other enzymes Metabolic pathways Platinum drug resistance Pathways in cancer Chemical carcinogenesis - DNA adducts Chemical carcinogenesis - receptor activation Chemical carcinogenesis - reactive oxygen species Hepatocellular carcinoma Fluid shear stress and atherosclerosis		Glutathione conjugation

Show/Hide Unknown Diseases (1)

Disease merge term	Disease name	Evidence	References	Source
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Cystic Fibrosis	cystic fibrosis	N/A	N/A	GenCC

Show/Hide Text Mining Associations (44)

Disease Name	Relationship Type	References
Associations from Text Mining Disease associations identified through Pubtator
Acute On Chronic Liver Failure	Associate	22976281
Alzheimer Disease	Associate	23036584
Anemia Sickle Cell	Associate	30663491
Asthma	Associate	31059917
Astrocytoma	Associate	26580399
Bantu siderosis	Stimulate	34083737
Barrett Esophagus	Associate	18664505
Brain Injuries Traumatic	Inhibit	29717219
Brain Neoplasms	Associate	16598069, 21914837
Breast Neoplasms	Associate	15084249, 26125851, 30461653
Carcinogenesis	Associate	24157827
Carcinoma Basal Cell	Associate	9077484
Carcinoma Hepatocellular	Associate	38320622
Carcinoma Renal Cell	Associate	24157827, 29569387, 35096270
Carcinoma Renal Cell	Inhibit	24157827
Chemical and Drug Induced Liver Injury	Associate	22976281
Cholestasis	Inhibit	25798860
Conotruncal cardiac defects	Associate	24585533
COVID 19	Associate	38003341
Cystic Fibrosis	Associate	28289476
Death	Associate	27993795
Emphysema	Associate	19723343
Esophageal Squamous Cell Carcinoma	Associate	33482859
Glioblastoma	Associate	34209254
Glioma	Associate	16598069
Heart Defects Congenital	Associate	24585533
Hypercholesterolemia	Associate	40532247
Lung Diseases	Associate	28289476
Lung Neoplasms	Associate	19887610, 25040976
Lymphoma Non Hodgkin	Associate	19822571
Meningeal Neoplasms	Stimulate	26580399
Meningioma	Associate	16598069
Neoplasms	Inhibit	24157827
Neoplasms	Associate	25719551, 26516624, 26580399, 29569387, 33482859, 34437390
Ovarian Neoplasms	Stimulate	38494731
Pancreatic Neoplasms	Associate	31514732
Precancerous Conditions	Associate	26580399
Precursor Cell Lymphoblastic Leukemia Lymphoma	Associate	23433810
Prostatic Hyperplasia	Associate	19407363
Prostatic Neoplasms	Associate	27993795
Prostatic Neoplasms Castration Resistant	Inhibit	27993795
Prostatic Neoplasms Castration Resistant	Associate	27993795
Pulmonary Disease Chronic Obstructive	Associate	21513434
Stomach Neoplasms	Inhibit	22468085

GSTM3 (glutathione S-transferase mu 3)