Gene Gene information from NCBI Gene database.
Entrez ID 2947
Gene name Glutathione S-transferase mu 3
Gene symbol GSTM3
Synonyms (NCBI Gene)
GST5GSTBGSTM3-3GSTM3TV2GTM3hGSTM3-3
Chromosome 1
Chromosome location 1p13.3
Summary Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omeg
miRNA miRNA information provided by mirtarbase database.
322
miRTarBase ID miRNA Experiments Reference
MIRT023377 hsa-miR-122-5p Proteomics 21750653
MIRT040526 hsa-miR-92b-3p CLASH 23622248
MIRT676201 hsa-miR-6890-3p HITS-CLIP 23824327
MIRT676200 hsa-miR-5693 HITS-CLIP 23824327
MIRT676199 hsa-miR-6741-3p HITS-CLIP 23824327
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
27
GO ID Ontology Definition Evidence Reference
GO:0004364 Function Glutathione transferase activity IBA
GO:0004364 Function Glutathione transferase activity IDA 8373352, 9545290, 10587441
GO:0004364 Function Glutathione transferase activity IEA
GO:0004364 Function Glutathione transferase activity TAS 2345169
GO:0005515 Function Protein binding IPI 23355646, 28514442, 31515488, 32296183, 33961781
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
138390 4635 ENSG00000134202
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P21266
Protein name Glutathione S-transferase Mu 3 (EC 2.5.1.18) (GST class-mu 3) (GSTM3-3) (hGSTM3-3)
Protein function Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. May govern uptake and detoxification of both endogenous compounds and xenobiotics at the testis and brain blood barriers. {ECO:0000269|Pub
PDB 3GTU
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF02798 GST_N 7 86 Glutathione S-transferase, N-terminal domain Domain
PF00043 GST_C 108 196 Glutathione S-transferase, C-terminal domain Domain
Tissue specificity TISSUE SPECIFICITY: Testis and brain.
Sequence
Sequence length 225
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  Glutathione metabolism
Metabolism of xenobiotics by cytochrome P450
Drug metabolism - cytochrome P450
Drug metabolism - other enzymes
Metabolic pathways
Platinum drug resistance
Pathways in cancer
Chemical carcinogenesis - DNA adducts
Chemical carcinogenesis - receptor activation
Chemical carcinogenesis - reactive oxygen species
Hepatocellular carcinoma
Fluid shear stress and atherosclerosis
  Glutathione conjugation