Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
2944
Gene name Gene Name - the full gene name approved by the HGNC.
Glutathione S-transferase mu 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
GSTM1
Synonyms (NCBI Gene) Gene synonyms aliases
GST1, GSTM1-1, GSTM1a-1a, GSTM1b-1b, GTH4, GTM1, H-B, MU, MU-1
Chromosome Chromosome number
1
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
1p13.3
Summary Summary of gene provided in NCBI Entrez Gene.
Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omeg
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT1036556 hsa-miR-3689a-3p CLIP-seq
MIRT1036557 hsa-miR-3689c CLIP-seq
MIRT1036558 hsa-miR-4728-5p CLIP-seq
MIRT1036559 hsa-miR-2909 CLIP-seq
MIRT1036560 hsa-miR-3126-5p CLIP-seq
Transcription factors
Transcription factor Regulation Reference
MYB Activation 14576818
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0004364 Function Glutathione transferase activity IBA
GO:0004364 Function Glutathione transferase activity IDA 8373352, 9084911
GO:0004364 Function Glutathione transferase activity IEA
GO:0004364 Function Glutathione transferase activity TAS 8403204
GO:0005737 Component Cytoplasm IDA 8373352
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
138350 4632 ENSG00000134184
Protein
UniProt ID P09488
Protein name Glutathione S-transferase Mu 1 (EC 2.5.1.18) (GST HB subunit 4) (GST class-mu 1) (GSTM1-1) (GSTM1a-1a) (GSTM1b-1b) (GTH4)
Protein function Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Involved in the formation of glutathione conjugates of both prostaglandin A2 (PGA2) and prostaglandin J2 (PGJ2) (PubMed:9084911). Particip
PDB 1GTU , 1XW6 , 1XWK , 1YJ6 , 2F3M , 7BEU , 8VOU
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF02798 GST_N 3 82 Glutathione S-transferase, N-terminal domain Domain
PF14497 GST_C_3 105 201 Glutathione S-transferase, C-terminal domain Domain
Tissue specificity TISSUE SPECIFICITY: Liver (at protein level). {ECO:0000269|PubMed:7822249}.
Sequence
Sequence length 218
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Glutathione metabolism
Metabolism of xenobiotics by cytochrome P450
Drug metabolism - cytochrome P450
Drug metabolism - other enzymes
Metabolic pathways
Platinum drug resistance
Pathways in cancer
Chemical carcinogenesis - DNA adducts
Chemical carcinogenesis - receptor activation
Chemical carcinogenesis - reactive oxygen species
Hepatocellular carcinoma
Fluid shear stress and atherosclerosis
  Glutathione conjugation
<
Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Disease merge term Disease name Evidence References Source
Restless Legs Syndrome Restless legs syndrome N/A N/A GWAS
Associations from Text Mining Disease associations identified through Pubtator
Disease Name Relationship Type References
Acute Chest Syndrome Associate 25880856
Adenocarcinoma Associate 8200549
Adenocarcinoma of Lung Associate 12824892
Adenoma Associate 18093316
Age Related Hearing Impairment 1 Associate 17513527
AIDS Associated Nephropathy Associate 29795558
AIDS Related Complex Stimulate 22665971
Alcoholism Associate 26937962
Alzheimer Disease Associate 25542503
Anemia Aplastic Associate 11719393