GSTM1 (glutathione S-transferase mu 1)

Gene Gene information from NCBI Gene database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID 2944
Gene name Glutathione S-transferase mu 1
Gene symbol GSTM1
Synonyms (NCBI Gene)
GST1GSTM1-1GSTM1a-1aGSTM1b-1bGTH4GTM1H-BMUMU-1
Chromosome 1
Chromosome location 1p13.3
Summary Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omeg
miRNA miRNA information provided by mirtarbase database.
123
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
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miRTarBase ID miRNA Experiments Reference
MIRT1036556 hsa-miR-3689a-3p CLIP-seq
MIRT1036557 hsa-miR-3689c CLIP-seq
MIRT1036558 hsa-miR-4728-5p CLIP-seq
MIRT1036559 hsa-miR-2909 CLIP-seq
MIRT1036560 hsa-miR-3126-5p CLIP-seq
Transcription factors Transcription factors information provided by TRRUST V2 database.
1
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
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Transcription factor Regulation Reference
MYB Activation 14576818
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
23
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GO ID Ontology Definition Evidence Reference
GO:0004364 Function Glutathione transferase activity IBA
GO:0004364 Function Glutathione transferase activity IDA 8373352, 9084911
GO:0004364 Function Glutathione transferase activity IEA
GO:0004364 Function Glutathione transferase activity TAS 8403204
GO:0005737 Component Cytoplasm IDA 8373352
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
138350 4632 ENSG00000134184
Protein Protein information from UniProt database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P09488
Protein name Glutathione S-transferase Mu 1 (EC 2.5.1.18) (GST HB subunit 4) (GST class-mu 1) (GSTM1-1) (GSTM1a-1a) (GSTM1b-1b) (GTH4)
Protein function Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Involved in the formation of glutathione conjugates of both prostaglandin A2 (PGA2) and prostaglandin J2 (PGJ2) (PubMed:9084911). Particip
PDB 1GTU , 1XW6 , 1XWK , 1YJ6 , 2F3M , 7BEU , 8VOU
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF02798 GST_N 3 → 82 Glutathione S-transferase, N-terminal domain Domain
PF14497 GST_C_3 105 → 201 Glutathione S-transferase, C-terminal domain Domain
Tissue specificity TISSUE SPECIFICITY: Liver (at protein level). {ECO:0000269|PubMed:7822249}.
Sequence
Sequence length 218
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
  KEGG  Reactome
  Glutathione metabolism
Metabolism of xenobiotics by cytochrome P450
Drug metabolism - cytochrome P450
Drug metabolism - other enzymes
Metabolic pathways
Platinum drug resistance
Pathways in cancer
Chemical carcinogenesis - DNA adducts
Chemical carcinogenesis - receptor activation
Chemical carcinogenesis - reactive oxygen species
Hepatocellular carcinoma
Fluid shear stress and atherosclerosis 		  Glutathione conjugation
Associated diseases Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
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Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
GSTM1-related disorder Likely benign rs781451004 RCV003893990
Show/Hide Text Mining Associations (243)
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References
Acute Chest Syndrome Associate 25880856
Adenocarcinoma Associate 8200549
Adenocarcinoma of Lung Associate 12824892
Adenoma Associate 18093316
Age Related Hearing Impairment 1 Associate 17513527
AIDS Associated Nephropathy Associate 29795558
AIDS Related Complex Stimulate 22665971
Alcoholism Associate 26937962
Alzheimer Disease Associate 25542503
Anemia Aplastic Associate 11719393